Platelet counts can lag the rest of the blood in returning to normal
levels.  That was my experience since being dx last October.  My WBC
and RBC counts went below normal within three weeks of starting 400
Gleevec, but my platelets which had started near 500 actually went much
higher (close to 1 million) and stayed very high for another six weeks.
 My onc said that a lag in platelet counts returning to normal happens
regularly in many people.  So don't feel like you are alone in this
weird blood count issue, having low WBC and a high platelet count that
initially goes even higher.  My platelet count finally returned to
normal, but then it starting going too low, and then became relatively
stable at the 3 month point.

You definitely need to hang in there with the daily Gleevec.  The
advice you got about the platelets showing how you are progressing is
not very valid in the first few months, but may be in the longer term.
The first indication I ever had of anything wrong with me was a very
high platelet count a year before the diagnosis, which was ignored by
my doctor.

Although you are concerned about the high platelet count now, in a few
months you will probably be concerned that it is going too low.  These
things just take time to stabilize.  Even when they do get closer to
normal ranges, CML blood counts rarely look truly "normal", just
acceptable.

If the WBC count is well below acceptable levels, then booster drugs
are a good option to keep you on Gleevec, which is extremely important.
--Trey
dx Oct 2005


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