Hi, I personally know 4-5 CML Dads on Gleevec who had babies and all are doing fine. I think if you look back into this group's archives, you will see some messages on this. Just this month, an article was published in Hematology on successful pregnancies of partners of men on Gleevec and I am giving a paraphrase, if you need the full article, mail to me, privately.
"Hematology, 2007 issue titled 'Successful Pregnancies involving men with chronic myeloid leukemia on Imatinib therapy' There have been some reports on pregnanciies involving men on Gleevec with a few spontaneous abortions. In the 5 patients described here, there were 5 successful pregnancies after median duration of Gleevec of 18 months before conception and median age of 45 years. 3 patients were on Gleevec dose of 600mg or greater at the time of conception. 2 patients had a CCR and 2 patients had a MCR while the 5 th patient had a partial response. Sperm counts and androgen levels were not performed on the men since no report of impotence was made. Partners of the men had uneventful normal deliveries and the babies were all healthy. Other records of males on Gleevec fathering babies are as follows. In a 2006 report, there were 8 men, median age 35 yrs at a median dose of 700mg a day and exposure to Gleevec median 20 months before conception whose partners became pregnant. There was one spontaneous abortion and of the 7 successful pregnancies, one baby was born with gut malrotation and there had to be surgical intervention. In a 2003 report, 4 successful pregnancies were reported, two therapeutic abortions, one spontaneous abortion and one death in utero at 13 weeks in 8 of 13 completed pregnancies involving male patients on Gleevec. In 7 male patients, median age 60 years, gynacomastia (breast enlargement) has been reported at a dose of 600-800mg a day along with low testesterone levels. Gynacomastia was thought to be due to Gleevec inhibiting the C-kit and PDGFr enzymes in testicular". I wish you a successful pregnancy and I am sure both you and your husband are so much looking forward to the new arrival! Best Wishes, Anjana Roy's caregiver 400mg Gleevec PCR 3-log reduction On Apr 19, 3:00 am, <[EMAIL PROTECTED]> wrote: > I am pregnet my husband has been on gleevec for two years, does anyone know > if there are anyside affects for the unborn child? I called COH and they said > it was not an easy answer and sent us an e-mail with all the side effects of > gleevec, but not much on the question. thank you --~--~---------~--~----~------------~-------~--~----~ [CMLHope] A support group of http://cmlhope.com ------------------------------------------------- You received this message because you are subscribed to the Google Groups "CMLHope" group. To post to this group, send email to [email protected] To unsubscribe from this group, send email to [EMAIL PROTECTED] For more options, visit this group at http://groups.google.com/group/CMLHope -~----------~----~----~----~------~----~------~--~---
