Hi Suzieq I can totally sympathize with your pcr jumps. I had reached PCR-U on gleevec about 5 years ago. Iy was shortlived and withing 6 months my PCR started showing pos (this is before the new PCR tests were used), FISH tests started up and eventually by blood counts started to rise. It was definitely relapse. After 6 months I started the sprycel trial. It took about 9 months to reach pcr-u again (whew!). But at 12 months the pcr numbers started going up. from pcr-u to .003. Yikes!!! I knew for sure it was relapse. But people assured me that jumps like that do happen and my dr said it does happen so we'll wait and see what the next 3 month BMB showed. Sure enough the next one (and the next 2 3-month BMBs after that) showed pcr-u as well! THANKFULLY!!! My blood counts stayed perfectly normal through this... So hang in there and know that jumps DO happen! -karen
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