____________________________________ From: [email protected] To: [email protected] Sent: 9/8/2014 11:25:12 A.M. Eastern Daylight Time Subj: Re: proton pump inhibitors found this on Gleevec
Hi Susan and you are so welcome. That Gleevec for my five years was a trip no one want to go on, but we made it through, thanks heavens! I had the sores, rash, eye bleeds, hair loss and etc. but I didn't have bone pain. This was a blessing for sure. My onc at the time told me one of his male patients had severe bone pain that he could barely stand at all. I did have awful cramps in my hands and feet. And Gleevec never put me into remission. My blood counts were all over the place. Finally after 5 years it just quit working at all. I took Tasigna that didn't work and am now on Sprycel. Sprycel finally put me in remission, but have been losing that remission slowly as of late, and my hair is falling out again. Good to hear from you, Blessing, Jeanie<3 In a message dated 9/7/2014 12:06:06 P.M. Eastern Daylight Time, [email protected] writes: Jeanie: Thank you so much for taking the time to look this up. In my case, this really affected me and Dr. Druker agreed with me to get off of it after I already did…but then he suggested Nexium and I absolutely refused. Like I said, the Gleevec muscles spasms are quite painful to begin with…imagine that discomfort times 10 and that is what happened to me two days after beginning the Prilosec. Not going there again! I do not know if you truly remember me but I am the patient who is Dr. Druker's QUEEN for side effects…Dr. D. put me on his top 10% of all his patients with almost every reaction possible with Gleevec…the only thing I never had was the skin rash…just had eye bleeds, was transfusion dependent until the dosage was reduced to 250 mg, need every three month testing of the PCR and the PK levels. In either case, besides the blood blisters and the fragile skin, possible neuropathy and very easy bruising, etc. this just touches the surface of my reactions…oh, forgot when first on Gleevec and speaking to Zavie at the beginning, I had a low grade temperature…because I have a high tolerance to pain, I did not know I was experiencing bone pain…very weird. Again, thank you so much for looking this up for me! Hugs, Susan On Sep 7, 2014, at 8:35 AM, [email protected]_ (mailto:[email protected]) wrote: Effect of a proton pump inhibitor on the pharmacokinetics of imatinib. _Egorin MJ_ (http://www.ncbi.nlm.nih.gov/pubmed?term=Egorin%20MJ[Author]&cauthor=true&cauthor_uid=19740393) 1, _Shah DD_ (http://www.ncbi.nlm.nih.gov/pubmed?term=Shah%20DD[Author]&cauthor=true&cauthor_uid=19740393) , _Christner SM_ (http://www.ncbi.nlm.nih.gov/pubmed?term=Christner%20SM[Author]&cauthor=true&cauthor_uid=19740393) , _Yerk MA_ (http://www.ncbi.nlm.nih.gov/pubmed?term=Yerk%20MA[Author]&cauthor=true&cauthor_uid=19740393) , _Komazec KA_ (http://www.ncbi.nlm.nih.gov/pubmed?term=Komazec%20KA[Author]&cauthor=true&cauthor_uid=19740393) , _Appleman LR_ (http://www.ncbi.nlm.nih.gov/pubmed?term=Appleman%20LR[Author]&cauthor=true&cauthor_uid=19740393) , _Redner RL_ (http://www.ncbi.nlm.nih.gov/pubmed?term=Redner%20RL[Author]&cauthor=true&ca uthor_uid=19740393) , _Miller BM_ (http://www.ncbi.nlm.nih.gov/pubmed?term=Miller%20BM[Author]&cauthor=true&cauthor_uid=19740393) , _Beumer JH_ (http://www.ncbi.nlm.nih.gov/pubmed?term=Beumer%20JH[Author]&cauthor=true&cauthor_ uid=19740393) . _Author information_ (http://www.ncbi.nlm.nih.gov/pubmed/19740393#) Abstract AIMS: Imatinib mesylate (Gleevec/Glivec), which has revolutionized the treatment of chronic myeloid leukemias (CML) and gastrointestinal stromal tumours (GIST), has been reported to cause gastric upset. Consequently, proton pump inhibitors (PPI) are frequently co-administered with imatinib. Because PPI can elevate gastric pH and delay gastric emptying or antagonize ATP-binding-cassette transporters, they could influence imatinib absorption and pharmacokinetics. We aimed to evaluate whether use of omeprazole has a significant effect on imatinib pharmacokinetics. METHODS: Twelve healthy subjects were enrolled in a two-period, open-label, single-institution, randomized cross-over, fixed-schedule study. In one period, each subject received 400 mg imatinib orally. In the other period, 40 mg omeprazole (Prilosec) was administered orally for 5 days, and on day 5 it was administered 15 min before 400 mg imatinib. Plasma concentrations of imatinib and its active N-desmethyl metabolite CGP74588 were assayed by LC-MS, and data were analyzed non-compartmentally. RESULTS: PPI administration did not significantly affect the imatinib area under the plasma concentration vs time curve (AUC) (34.1 microg ml(-1) h alone vs 33.1 microg ml(-1) h with omeprazole, P= 0.64; 80% power), maximum plasma concentration (C(max)) (2.04 microg ml(-1) alone vs 2.02 microg ml(-1) with omeprazole, P= 0.97), or half-life (13.4 h alone vs 14.1 h with omeprazole, P= 0.13). CONCLUSIONS: Our results indicate that the use of omeprazole does not significantly affect the pharmacokinetics of imatinib, as opposed to, for example, dasatinib where PPI decreased AUC and C(max) two-fold. Don't know when this study was done, but it seems Gleevec is different than Sprycel. I was on Gleevec for 5 years, and I do think it affects the stomach. I was on the proton pump inhibitor while in the hospital but when I went on Sprycel, the leaflet said no, so I quit them. They never seemed to help me anyway. Great study, Blessings Jeanie<3 In a message dated 9/5/2014 9:54:31 A.M. Eastern Daylight Time, [email protected]_ (mailto:[email protected]) writes: And I'm on Gleevec Sent on the new Sprint Network from my Samsung Galaxy S®4. -------- Original message -------- From: [email protected]_ (mailto:[email protected]) Date:09/05/2014 8:48 AM (GMT-05:00) To: [email protected]_ (mailto:[email protected]) Subject: proton pump inhibitors That is so strange; you aren't supposed to be taking those proton pump inhibitors at all at least that's what is says on my Sprycel leaflet; Check you leaflet for drug not to take with your meds. Blessings, Jeanie<3 In a message dated 9/1/2014 10:58:06 A.M. Eastern Daylight Time, [email protected]_ (mailto:[email protected]) writes: Silent reflux just means I have no symptoms...no heartburn BUT experience hoarseness and other symptoms. Dr. Druker asked me to try prilosec. I did and was off it in two days...the muscle spasms were worse than the Gleevec spasms...never imagined anything worse...but it was. ..up all night except for 3 hours of sleep. I wrote Dr. Druker after reading about side effects on the internet. He then wanted me to try Nexium...told him I'm done being a guinea pig...would try diet eating alone Hugs, Susan Sent on the new Sprint Network from my Samsung Galaxy S®4. -------- Original message -------- From: [email protected]_ (mailto:[email protected]) Date:09/01/2014 10:53 AM (GMT-05:00) To: [email protected]_ (mailto:[email protected]) Subject: Re: Jaw pain, etc Hi Susan and so sorry to hear about your reflux. Be careful about proton pump inhibitors as you are not supposed to be on those when on your TKIs as least that is what my Sprycel booklet states. It says you can take antiacids 2 hours before or 2 hours after your meds. This is things like Tums. No, no hoarseness, but my ear fills full and my jaw hurts at the point of the hinge. What is silent reflux? Thanks, Blessings, Jeanie<3 In a message dated 9/1/2014 9:03:08 A.M. Eastern Daylight Time, [email protected]_ (mailto:[email protected]) writes: Jeannie: I was just self diagnosed with silent reflux...have had it a long time. Do you have hoarseness, too? Anyway, you might wNt to ask your doctor or ENT. Hugs, Susan Rosenthal Sent from my iPad = -- -- [CMLHope] A support group of http://cmlhope.com ------------------------------------------------- You received this message because you are subscribed to the Google Groups "CMLHope" group. To post to this group, send email to [email protected] To unsubscribe from this group, send email to [email protected] For more options, visit this group at http://groups.google.com/group/CMLHope --- You received this message because you are subscribed to the Google Groups "CMLHope" group. To unsubscribe from this group and stop receiving emails from it, send an email to [email protected]. 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