Susan, that is really great news and I'm so happy for you. Enjoy the beautiful weather.
Marcie Sent from my iPad > On Sep 8, 2014, at 6:26 PM, "'Susan Zimmerman' via CMLHope" > <[email protected]> wrote: > > Hi all, > > Just wanted to report the most beautiful summer/fall day ever today! Sorry > for those in Phoenix with the flooding, but I decided to go to the lake and > enjoy my day. Took my nook and a lounge chair, parked and enjoyed a great > time! I'm thinking today through Wednesday here will be maybe our last good > summer days. > > Also, my count again came down on the bcr/abl. Last test showed two weeks > ago that my number is .35!!! (Last test showed 1.70). I am elated. Also > test results from the liver enzyme today showed I am almost back to normal in > that. They were way up, and I was hoping I could go off the med for awhile, > but got good news that apparently my body is getting used to bosutinib. (100 > mg a day). The ALT count was 68 and the norm is 52. The ASP was in the > normal range. Hooray!!! > > Jeannie, I'm not happy to hear your sprycel is giving you problems. I'm sure > you will be well-researched about staying on it or trying another, etc. It's > a tough thing! I have no others to fall back on, as you do. So you can be > thankful for alternatives! I am so very thankful for the way all this is > going for me. Like Kareem Abdul Jabbar has said, "I will die of something > else, but not CML!!!" I think most of us are in that boat, thanks to the > medicine. > > Praying also for Marty to receive a transplant soon!!! All the rest of you > are also in my thoughts and prayers. > > Happy Fall, everyone! Susan > > -----Original Message----- > From: ICANDOALLTTC via CMLHope <[email protected]> > To: CMLHope <[email protected]> > Sent: Mon, Sep 8, 2014 11:30 am > Subject: [CMLHope] Fwd: proton pump inhibitors found this on Gleevec susan > and all > > > > From: [email protected] > To: [email protected] > Sent: 9/8/2014 11:25:12 A.M. Eastern Daylight Time > Subj: Re: proton pump inhibitors found this on Gleevec > > Hi Susan and you are so welcome. That Gleevec for my five years was a trip > no one want to go on, but we made it through, thanks heavens! I had the > sores, rash, eye bleeds, hair loss and etc. but I didn't have bone pain. > This was a blessing for sure. My onc at the time told me one of his male > patients had severe bone pain that he could barely stand at all. I did have > awful cramps in my hands and feet. And Gleevec never put me into remission. > My blood counts were all over the place. Finally after 5 years it just quit > working at all. I took Tasigna that didn't work and am now on Sprycel. > Sprycel finally put me in remission, but have been losing that remission > slowly as of late, and my hair is falling out again. > Good to hear from you, > Blessing, > Jeanie<3 > > In a message dated 9/7/2014 12:06:06 P.M. Eastern Daylight Time, > [email protected] writes: > Jeanie: > > Thank you so much for taking the time to look this up. > > In my case, this really affected me and Dr. Druker agreed with me to get off > of it after I already did…but then he suggested Nexium and I absolutely > refused. Like I said, the Gleevec muscles spasms are quite painful to begin > with…imagine that discomfort times 10 and that is what happened to me two > days after beginning the Prilosec. Not going there again! > > I do not know if you truly remember me but I am the patient who is Dr. > Druker's QUEEN for side effects…Dr. D. put me on his top 10% of all his > patients with almost every reaction possible with Gleevec…the only thing I > never had was the skin rash…just had eye bleeds, was transfusion dependent > until the dosage was reduced to 250 mg, need every three month testing of the > PCR and the PK levels. In either case, besides the blood blisters and the > fragile skin, possible neuropathy and very easy bruising, etc. this just > touches the surface of my reactions…oh, forgot when first on Gleevec and > speaking to Zavie at the beginning, I had a low grade temperature…because I > have a high tolerance to pain, I did not know I was experiencing bone > pain…very weird. > > Again, thank you so much for looking this up for me! > > Hugs, > Susan >> On Sep 7, 2014, at 8:35 AM, [email protected] wrote: >> >> Effect of a proton pump inhibitor on the pharmacokinetics of imatinib. >> Egorin MJ1, Shah DD, Christner SM, Yerk MA, Komazec KA, Appleman LR, Redner >> RL, Miller BM, Beumer JH. >> Author information >> Abstract >> AIMS: >> Imatinib mesylate (Gleevec/Glivec), which has revolutionized the treatment >> of chronic myeloid leukemias (CML) and gastrointestinal stromal tumours >> (GIST), has been reported to cause gastric upset. Consequently, proton pump >> inhibitors (PPI) are frequently co-administered with imatinib. Because PPI >> can elevate gastric pH and delay gastric emptying or antagonize >> ATP-binding-cassette transporters, they could influence imatinib absorption >> and pharmacokinetics. We aimed to evaluate whether use of omeprazole has a >> significant effect on imatinib pharmacokinetics. >> METHODS: >> Twelve healthy subjects were enrolled in a two-period, open-label, >> single-institution, randomized cross-over, fixed-schedule study. In one >> period, each subject received 400 mg imatinib orally. In the other period, >> 40 mg omeprazole (Prilosec) was administered orally for 5 days, and on day 5 >> it was administered 15 min before 400 mg imatinib. Plasma concentrations of >> imatinib and its active N-desmethyl metabolite CGP74588 were assayed by >> LC-MS, and data were analyzed non-compartmentally. >> RESULTS: >> PPI administration did not significantly affect the imatinib area under the >> plasma concentration vs time curve (AUC) (34.1 microg ml(-1) h alone vs 33.1 >> microg ml(-1) h with omeprazole, P= 0.64; 80% power), maximum plasma >> concentration (C(max)) (2.04 microg ml(-1) alone vs 2.02 microg ml(-1) with >> omeprazole, P= 0.97), or half-life (13.4 h alone vs 14.1 h with omeprazole, >> P= 0.13). >> CONCLUSIONS: >> Our results indicate that the use of omeprazole does not significantly >> affect the pharmacokinetics of imatinib, as opposed to, for example, >> dasatinib where PPI decreased AUC and C(max) two-fold. >> >> Don't know when this study was done, but it seems Gleevec is different than >> Sprycel. I was on Gleevec for 5 years, and I do think it affects the >> stomach. >> I was on the proton pump inhibitor while in the hospital but when I went on >> Sprycel, the leaflet said no, so I quit them. They never seemed to help me >> anyway. >> Great study, >> Blessings >> Jeanie<3 >> >> In a message dated 9/5/2014 9:54:31 A.M. Eastern Daylight Time, >> [email protected] writes: >> And I'm on Gleevec >> >> >> Sent on the new Sprint Network from my Samsung Galaxy S®4. >> >> >> -------- Original message -------- >> From: [email protected] >> Date:09/05/2014 8:48 AM (GMT-05:00) >> To: [email protected] >> Subject: proton pump inhibitors >> >> That is so strange; you aren't supposed to be taking those proton >> pump inhibitors at all at least that's what is says on my Sprycel leaflet; >> Check you leaflet for drug not to take with your meds. >> Blessings, >> Jeanie<3 >> >> >> In a message dated 9/1/2014 10:58:06 A.M. Eastern Daylight Time, >> [email protected] writes: >> Silent reflux just means I have no symptoms...no heartburn BUT experience >> hoarseness and other symptoms. >> >> Dr. Druker asked me to try prilosec. I did and was off it in two days...the >> muscle spasms were worse than the Gleevec spasms...never imagined anything >> worse...but it was. ..up all night except for 3 hours of sleep. >> >> I wrote Dr. Druker after reading about side effects on the internet. He >> then wanted me to try Nexium...told him I'm done being a guinea pig...would >> try diet eating alone >> >> Hugs, >> Susan >> >> Sent on the new Sprint Network from my Samsung Galaxy S®4. >> >> >> -------- Original message -------- >> From: [email protected] >> Date:09/01/2014 10:53 AM (GMT-05:00) >> To: [email protected] >> Subject: Re: Jaw pain, etc >> >> Hi Susan and so sorry to hear about your reflux. Be careful about proton >> pump inhibitors as you are not supposed to be on those when on your TKIs as >> least that is what my Sprycel booklet states. It says you can take >> antiacids 2 hours before or 2 hours after your meds. This is things like >> Tums. >> No, no hoarseness, but my ear fills full and my jaw hurts at the point of >> the hinge. >> What is silent reflux? >> Thanks, >> Blessings, >> Jeanie<3 >> >> >> In a message dated 9/1/2014 9:03:08 A.M. Eastern Daylight Time, >> [email protected] writes: >> Jeannie: >> >> I was just self diagnosed with silent reflux...have had it a long time. >> >> Do you have hoarseness, too? >> >> Anyway, you might wNt to ask your doctor or ENT. >> >> Hugs, >> Susan Rosenthal >> >> Sent from my iPad > > = > -- > -- > [CMLHope] > A support group of http://cmlhope.com > ------------------------------------------------- > > You received this message because you are subscribed to the Google Groups > "CMLHope" group. > To post to this group, send email to [email protected] > To unsubscribe from this group, send email to > [email protected] > For more options, visit this group at http://groups.google.com/group/CMLHope > --- > You received this message because you are subscribed to the Google Groups > "CMLHope" group. > To unsubscribe from this group and stop receiving emails from it, send an > email to [email protected]. > For more options, visit https://groups.google.com/d/optout. > -- > -- > [CMLHope] > A support group of http://cmlhope.com > ------------------------------------------------- > > You received this message because you are subscribed to the Google Groups > "CMLHope" group. > To post to this group, send email to [email protected] > To unsubscribe from this group, send email to > [email protected] > For more options, visit this group at http://groups.google.com/group/CMLHope > --- > You received this message because you are subscribed to the Google Groups > "CMLHope" group. > To unsubscribe from this group and stop receiving emails from it, send an > email to [email protected]. > For more options, visit https://groups.google.com/d/optout. -- -- [CMLHope] A support group of http://cmlhope.com ------------------------------------------------- You received this message because you are subscribed to the Google Groups "CMLHope" group. To post to this group, send email to [email protected] To unsubscribe from this group, send email to [email protected] For more options, visit this group at http://groups.google.com/group/CMLHope --- You received this message because you are subscribed to the Google Groups "CMLHope" group. To unsubscribe from this group and stop receiving emails from it, send an email to [email protected]. For more options, visit https://groups.google.com/d/optout.
