When I have never had a long response of 0.000 response. I was off Gleevec for 6 1/2 years, when had to go back on Gleevec. I have actually reduced Gleevec to 300mg because CML likes to to work on my blood. I run from 0.000 to 0.00.3 on my Bcd-abl every 3-6 months. It is not being called resistance, but my controlled CML world seems to stay very controlled at this point. So if they put you on Gleevec again it should be Okay. When I went back on 400 mg of Gleevec it started decreasing my hemg. and I was headed for more transfusions. When my ONC lowered it to 300mg we could get Procrit to build my hemg so that I don't have to have a transfusion. I was diagnosed in 2002.
Keep a positive mind and know that will help to pass this bump in the road. Gleevec has the most history for our ONC to work with and that is the reason I have remained on Gleevec, Other health problems makes the newer drugs make changing to them not the best choice. Richard H. On Wednesday, May 18, 2016 at 8:05:48 PM UTC-5, Raj wrote: > > Hello All, > I am new to the group. Hope you can help answer my question. > History: I was diagnosed CML in 2001. After 2-3 years On gleevec 400mg, I > was in major molecular response and then undetectable (0.000) for around > > 10 years or so.. > Now suddenly last month in my last Bcd-abl it showed that I am > 0.018 and repeating it after a month, it's 0.021 so little bit higher than > last one.. > Is it considered gleevec resistance? Where I need to switch? > > BTW: > I missed 3 doses or so in the last month and that is > Where it (Bcd-abl by PCR) came 0.018 but not sure if 3 days can be that > critical. Also I don't take medicine at the same time sometimes with > breakfast sometimes with late lunch. Can that suddenly change the > response? > > Any thoughts or similar situation insight is much appreciated.. > Thanks > Raj > > -- -- [CMLHope] A support group of http://cmlhope.com ------------------------------------------------- You received this message because you are subscribed to the Google Groups "CMLHope" group. To post to this group, send email to [email protected] To unsubscribe from this group, send email to [email protected] For more options, visit this group at http://groups.google.com/group/CMLHope --- You received this message because you are subscribed to the Google Groups "CMLHope" group. To unsubscribe from this group and stop receiving emails from it, send an email to [email protected]. For more options, visit https://groups.google.com/d/optout.
