I've owned both at the same time.  I tested extensively against each
other.  I was never able to see any difference in sharpness when viewed
as a 6' projected slide, a 13"x19" print or through a 10x loupe on a
light table.

IMO, the non-IS had no advantages other than price.

OTOH, the IS version had the following advantages:

Very close focusing without the aid of tubes or extenders.  Close to
Macro.  Much closer than non-IS ver.

Manual focusing much smoother.  The non-IS was more a metal-to-metal
feel.  The IS ver. was much smoother.

Tripod Collar.  IS version smooth as silk.  No slippage.  Non-IS ver.
more metal-to-metal.  Kinda Klunky.  Hard to keep tight.  A nuisance if
you've ever attached a flash to the camera body and had to shoot in the
vertical position without a Tripod Collar.

AF seemed faster with the IS ver.

Even if you do not hand hold, the IS works great when using a beanbag or
monopod.  If you ever do hand hold, the advantage is obvious.  While
Canon does not recommend using IS in mode 1 with a tripod, I found I
could tell no difference if I used a tripod which is very stable and
sturdy and used proper techniques.  I did not do this on purpose.  I
would forget to check.

There were other minor reasons too.  Hope this helps.

Ray Amos
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