Hi Hebert,

Do you mind if I forward this info to my vet so she can give me her opinion on 
Staph Protein A?

Thanks
Amy

--- On Sat, 8/8/09, hebert ferrarezzi <hferrare...@hotmail.com> wrote:

> From: hebert ferrarezzi <hferrare...@hotmail.com>
> Subject: Re: [Felvtalk] Staph Protein A
> To: "felvtalk@felineleukemia.org" <felvtalk@felineleukemia.org>
> Date: Saturday, August 8, 2009, 9:58 PM
> 
> Dear Gary
> I have used Staphoccocal Protein-A, from Sigma Aldrich:
> Product: P6031 - 1MG, Protein A from Staphylococcus aureus;
> Soluble, essentially salt-free, lyophilized powder;  or
> Product: P3838 - 1MG, Protein A from Staphylococcus aureus;
> Soluble, Cowan Strain, essentially salt-free, lyophilized
> powder. 
> http://www.sigmaaldrich.com/etc/medialib/docs/Sigma/productinformationsheet2/p3838pis.Par.0001.File.tmp/p3838pis.pdf
> 
> 
>  
> 
> It is important to note that transgenic Protein A expressed
> in Escherichia colli, although having the same
> immunoglobulin binding properties, does not have the same
> superantigenic properties as the native one. The difference
> may be due to a bit of contamination with other
> superantigens from Staphlococcus aureus (perhaps with staph
> entherotoxin-A during product extraction and purification).
> So the transgenic version does not serve to our intent.
> 
> This product is currently used as a chemical reagent, and
> not as a medication (except in experimental studies). You
> have to register before buying and affiliation to some
> university or research institute is wanted (maybe you can
> get an aid from another person).
> 
> Although I am a researcher, I was not made any experiment
> with my FelV+ cats, so I cannot be sure if apparently
> hopeful outcomes were not merely by chance. I just think the
> subject merits more attention, considering the earlier
> surprising results obtained by scientists.  I am also
> aware of a subsequent statistically controlled study carried
> on by Vet-researchers found no significant difference from
> the placebo group. But I am also aware that unknown
> variables, then unsuspected (such a little bit of
> contamination mentioned above, certainly a trait neither
> standard nor regularly desired by the fabricants), can
> account for different results obtained by different
> researchers in different circumstances.
> 
> By the way, tree of my four FelV+ cats have already gone
> (crossed the bridge as you say), Pupa and Mãe victims of
> lymphoma, and Porchops due an idiopathic cystitis
> (apparently not felv-related).  All the four got
> considerable improvement in most blood counts during and
> after treatment and never suffered from FelV-related
> opportunistic infections. Jorge, the one that remains in
> this world, is doing very fine, thanks, being asymptomatic
> up to now.  Early experiments using protein A have
> reported that 28% of the cats respond positively to the
> treatment. I think the attempt was not deceiving yet.
> 
>  
> 
> Best wishes for you all.
> 
> Hebert
> 
>  
> > From: gcru...@centurytel.net
> > To: felvtalk@felineleukemia.org
> > Date: Fri, 7 Aug 2009 16:17:53 -0500
> > Subject: [Felvtalk] Staph Protein A
> > 
> > Has anyone on the list ever used Staph Protein A for
> treatment of FeLV cats?
> > If so, where did you get it? I just talked with two of
> the manufacturers
> > that are listed on the Felineleukemia.org site and
> both said they could not
> > sell it except to a research facility. They said if a
> vet wanted it, he
> > would have to be doing a research study and his
> application for it would be
> > reviewed by the company to see if they though he met
> their criteria. They
> > would not sell it simply for treatment use.
> > 
> > I will keep looking, but it seems a shame that
> something with all the
> > promise of Staph Protein A (and a LOT cheaper than
> LTCI) can't be purchased
> > to save kitties.
> > 
> > Gary
> > 
> > 
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