Hi Hebert, Do you mind if I forward this info to my vet so she can give me her opinion on Staph Protein A?
Thanks Amy --- On Sat, 8/8/09, hebert ferrarezzi <[email protected]> wrote: > From: hebert ferrarezzi <[email protected]> > Subject: Re: [Felvtalk] Staph Protein A > To: "[email protected]" <[email protected]> > Date: Saturday, August 8, 2009, 9:58 PM > > Dear Gary > I have used Staphoccocal Protein-A, from Sigma Aldrich: > Product: P6031 - 1MG, Protein A from Staphylococcus aureus; > Soluble, essentially salt-free, lyophilized powder; or > Product: P3838 - 1MG, Protein A from Staphylococcus aureus; > Soluble, Cowan Strain, essentially salt-free, lyophilized > powder. > http://www.sigmaaldrich.com/etc/medialib/docs/Sigma/productinformationsheet2/p3838pis.Par.0001.File.tmp/p3838pis.pdf > > > > > It is important to note that transgenic Protein A expressed > in Escherichia colli, although having the same > immunoglobulin binding properties, does not have the same > superantigenic properties as the native one. The difference > may be due to a bit of contamination with other > superantigens from Staphlococcus aureus (perhaps with staph > entherotoxin-A during product extraction and purification). > So the transgenic version does not serve to our intent. > > This product is currently used as a chemical reagent, and > not as a medication (except in experimental studies). You > have to register before buying and affiliation to some > university or research institute is wanted (maybe you can > get an aid from another person). > > Although I am a researcher, I was not made any experiment > with my FelV+ cats, so I cannot be sure if apparently > hopeful outcomes were not merely by chance. I just think the > subject merits more attention, considering the earlier > surprising results obtained by scientists. I am also > aware of a subsequent statistically controlled study carried > on by Vet-researchers found no significant difference from > the placebo group. But I am also aware that unknown > variables, then unsuspected (such a little bit of > contamination mentioned above, certainly a trait neither > standard nor regularly desired by the fabricants), can > account for different results obtained by different > researchers in different circumstances. > > By the way, tree of my four FelV+ cats have already gone > (crossed the bridge as you say), Pupa and Mãe victims of > lymphoma, and Porchops due an idiopathic cystitis > (apparently not felv-related). All the four got > considerable improvement in most blood counts during and > after treatment and never suffered from FelV-related > opportunistic infections. Jorge, the one that remains in > this world, is doing very fine, thanks, being asymptomatic > up to now. Early experiments using protein A have > reported that 28% of the cats respond positively to the > treatment. I think the attempt was not deceiving yet. > > > > Best wishes for you all. > > Hebert > > > > From: [email protected] > > To: [email protected] > > Date: Fri, 7 Aug 2009 16:17:53 -0500 > > Subject: [Felvtalk] Staph Protein A > > > > Has anyone on the list ever used Staph Protein A for > treatment of FeLV cats? > > If so, where did you get it? I just talked with two of > the manufacturers > > that are listed on the Felineleukemia.org site and > both said they could not > > sell it except to a research facility. They said if a > vet wanted it, he > > would have to be doing a research study and his > application for it would be > > reviewed by the company to see if they though he met > their criteria. They > > would not sell it simply for treatment use. > > > > I will keep looking, but it seems a shame that > something with all the > > promise of Staph Protein A (and a LOT cheaper than > LTCI) can't be purchased > > to save kitties. > > > > Gary > > > > > > _______________________________________________ > > Felvtalk mailing list > > [email protected] > > http://felineleukemia.org/mailman/listinfo/felvtalk_felineleukemia.org > > _________________________________________________________________ > Novo Internet Explorer 8. Baixe agora, é grátis! > http://brasil.microsoft.com.br/IE8/mergulhe/?utm_source=MSN%3BHotmail&utm_medium=Tagline&utm_campaign=IE8 > _______________________________________________ > Felvtalk mailing list > [email protected] > http://felineleukemia.org/mailman/listinfo/felvtalk_felineleukemia.org > _______________________________________________ Felvtalk mailing list [email protected] http://felineleukemia.org/mailman/listinfo/felvtalk_felineleukemia.org
