Thank you very much for the reply.  I guess I will have to see if I can find
someone with a research company or university who would purchase it for me
as I have not found anyone doing and research with FeLV cats at this time.

If I am thinking of the same study that had a 28% positive outcome, they
said if you didn't count the very sick cats who died after only one or two
treatments, it was 46%.

What protocol did you use on your cats and for how long?


-----Original Message-----
From: felvtalk-boun...@felineleukemia.org
[mailto:felvtalk-boun...@felineleukemia.org] On Behalf Of hebert ferrarezzi
Sent: Saturday, August 08, 2009 8:58 PM
To: felvtalk@felineleukemia.org
Subject: Re: [Felvtalk] Staph Protein A

Dear Gary
I have used Staphoccocal Protein-A, from Sigma Aldrich:
Product: P6031 - 1MG, Protein A from Staphylococcus aureus; Soluble,
essentially salt-free, lyophilized powder;  or Product: P3838 - 1MG, Protein
A from Staphylococcus aureus; Soluble, Cowan Strain, essentially salt-free,
lyophilized powder. 


It is important to note that transgenic Protein A expressed in Escherichia
colli, although having the same immunoglobulin binding properties, does not
have the same superantigenic properties as the native one. The difference
may be due to a bit of contamination with other superantigens from
Staphlococcus aureus (perhaps with staph entherotoxin-A during product
extraction and purification). So the transgenic version does not serve to
our intent.

This product is currently used as a chemical reagent, and not as a
medication (except in experimental studies). You have to register before
buying and affiliation to some university or research institute is wanted
(maybe you can get an aid from another person).

Although I am a researcher, I was not made any experiment with my FelV+
cats, so I cannot be sure if apparently hopeful outcomes were not merely by
chance. I just think the subject merits more attention, considering the
earlier surprising results obtained by scientists.  I am also aware of a
subsequent statistically controlled study carried on by Vet-researchers
found no significant difference from the placebo group. But I am also aware
that unknown variables, then unsuspected (such a little bit of contamination
mentioned above, certainly a trait neither standard nor regularly desired by
the fabricants), can account for different results obtained by different
researchers in different circumstances.

By the way, tree of my four FelV+ cats have already gone (crossed the bridge
as you say), Pupa and Mãe victims of lymphoma, and Porchops due an
idiopathic cystitis (apparently not felv-related).  All the four got
considerable improvement in most blood counts during and after treatment and
never suffered from FelV-related opportunistic infections. Jorge, the one
that remains in this world, is doing very fine, thanks, being asymptomatic
up to now.  Early experiments using protein A have reported that 28% of the
cats respond positively to the treatment. I think the attempt was not
deceiving yet.


Best wishes for you all.



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