Sherri I also should have mentioned the very important requirement that the vet should put Bogie on Doxycycline as well. I always forget this. I forget because my Zander was originally on Doxycycline and it was not helping, and I don't think it can on its own, so I always forget the vital role it played in Zander's recovery. While the Winstrol/prednisone is building up the body and increasing red cell production, Doxycycline acts to inhibit RNA replication, which is how the virus reproduces. Doxycycline is an antibiotic, and everyone will tell you that it can't kill a virus, and it doesn't. However, it prevents the numbers of the virus from continuing to climb, while the body is repairing itself.
This is a key part of the treatment in my opinion. Otherwise, as you're fighting to increase the red cell count and the other cell lines with the Winstrol, the virus just keeps killing other cells. (That's how viruses replicate - they infiltrate a cell, and commandeer it's cellular machinery, and "force" the cell to produce millions more viruses. The cell then explodes, or dies, releasing all these new viruses into the system. The Doxycycline helps to interfere with this process.) Sorry - I should have mentioned this before (and I have in dozens of my posts), but, of course, the stumbling block usually is getting the Winstrol. Amani From: Felvtalk [mailto:[email protected]] On Behalf Of Sherri Godschalk Sent: August-26-16 5:34 PM To: [email protected] Subject: Re: [Felvtalk] Bogie's First 5 days on Stanozolol Amani, Thanks for all the valuable information. It actually calms me. He has a lab in house and these were the results from this week. (I don't have any from the prior visits to the other vet, but the new vet does) RBC 2.43 M/ul 6.65-12.2 LOW HCT 15.3 % 30.3-52.3 LOW HGB 5.3 g/dL 9.8-16.2 LOW MCV 62.6 fl 35.9-53.1 HIGH MCH 21.8 pg 11.8-17.3 HIGH RETIC 61.5 K/ul 3.0-50.0 HIGH LYM 7.75 K/uL 0.92-6.88 HIGH MONO 1.58 K/uL 0.05-0.67 HIGH EOS 0.10 K/uL 0.17-1.57 LOW BASO 0.00 K/uL 0.01-.26 LOW PLT 50 K/uL 151-600 LOW I haven't got the chance to research what all of this means. There were several other levels on this sheet that were all within range. Do you see ANYTHING positive in these results? The first 6 look very bad to me. Thanks again for writing. From: Felvtalk <[email protected]<mailto:[email protected]>> on behalf of Amani Oakley <[email protected]<mailto:[email protected]>> Reply-To: <[email protected]<mailto:[email protected]>> Date: Friday, August 26, 2016 at 3:29 PM To: "[email protected]<mailto:[email protected]>" <[email protected]<mailto:[email protected]>> Subject: Re: [Felvtalk] Bogie's First 5 days on Stanozolol Sherri Don't be disappointed. The key is that the haematocrit is starting to rise and is not going down any further. Remember how few days the drug has had to work. It is literally having to go into bone marrow and turn back on progenitor cells in the bone marrow that have been infiltrated by the FeLV virus, and are therefore destroyed or inactive. Also, did he do a reticulocyte count? That should hopefully also start going up because those are one of the immature forms of the red cells. Another is nucleated red blood cells. At maturity, the red cells lose the nucleus (except in birds and maybe reptiles). However, the instrument used to count the red cells cannot differentiate a nucleated red cell from a white cell (which will have a nucleus) so unless there is a manual count done, the automated instrument results may count any nucleated red cells as white cells. This isn't too critical, but it will not show you whether any of these immature red cell forms are developing. Also, while the haematocrit is important, you should also look at the platelet count (which, I remember correctly, was low for Bogie) and the white cell counts. I found that the Winstrol started improving all the different cell lines, though admittedly, it appeared that the improvement started with the red cells. I am not sure I agree with your vet taking Bogie off the Winstrol though, because it is an anabolic steroid and is literally rebuilding bone, muscle, etc. With a debilitated cat, I think you've got to keep them on for a long while. However, your vet has been helpful and more progressive than most, so . . . Amani From: Felvtalk [mailto:[email protected]] On Behalf Of Sherri Godschalk Sent: August-26-16 7:03 AM To: [email protected]<mailto:[email protected]> Subject: Re: [Felvtalk] Bogie's First 5 days on Stanozolol Thanks Ardy. We had Bogeys first blood test after 7 days and her HCT was only still at 15.4. Slight increase. She is pretty functional at this level. Still sleeping a lot. But eats, goes up and down stairs, bats at the dogs. The vet didn't seem surprised that it hadn't gone up more. It hadn't gone down. Considers her "stable". He doesn't want to see her for a month to test again. He wants her to be off of the Stanozolol for one week starting next Wed and then put her back on it the following week for two more. I was a bit disappointed that her blood results weren't better although I could tell just with her energy level that she hadn't improved much. Hopefully she just needs more time on it for it to take hold. I wish there was something more that I could do. I feel so helpless. Thanks for writing, From: Felvtalk <[email protected]<mailto:[email protected]>> on behalf of Ardy Robertson <[email protected]<mailto:[email protected]>> Reply-To: <[email protected]<mailto:[email protected]>> Date: Friday, August 26, 2016 at 12:07 AM To: <[email protected]<mailto:[email protected]>> Subject: Re: [Felvtalk] Bogie's First 5 days on Stanozolol Best wishes to you Sherri and to Bogie!! I do believe this drug combo (Stanozolol and Prednisone) helped my Tigger also, it's just that I started him on it too late. Tigger's bloodwork showed amazing improvement but I believe his diagnosis was very late since he had tested negative as a kitten, and at age 5 years they told me he had it since kittenhood but must have been shedding the virus when tested. I sincerely hope Bogie can benefit from this treatment since she is younger at her diagnosis. Also very happy that you have a cooperating vet! Ardy From: Felvtalk [mailto:[email protected]] On Behalf Of Amani Oakley Sent: Sunday, August 21, 2016 9:30 PM To: [email protected]<mailto:[email protected]> Subject: Re: [Felvtalk] Bogie's First 5 days on Stanozolol Hi Sherri I am happy to hear of your experience so far, but like you, I held my breath for a very long time with Zander. Please keep us all updated. Amani From: Felvtalk [mailto:[email protected]] On Behalf Of Sherri Godschalk Sent: August-21-16 10:36 PM To: [email protected]<mailto:[email protected]> Subject: [Felvtalk] Bogie's First 5 days on Stanozolol I wanted to update everyone here about how this medication is affecting the health of my FELV positive 1 year old kitten. Bogie got her diagnosis just under 3 weeks ago. The first vet I saw tried Prednisone and an antibiotic for 2 weeks and it did nothing for here severe anemia. (Her only symptom) I was told at that time that there was nothing that could help her and to just keep her comfortable as she dies. Changed vets. New vet...Was prescribed 2mg of Stanozolol once a day along with the Pred once a day. This morning, Bogie got her 5th dose of Stanozolol. She appears to be less anemic. Has more energy, sleeping less and more interested in playing and is eating and drinking well enough on her own. Her gums are slightly more pink as well. There hasn't been any side effects that I have seen with this combination. Except I have to pill her twice a day but she is getting used to that a little bit. I don't want to speak to soon, but I believe just from how she is acting, that this drug is helping my kitten make some red blood cells. She goes in this week for a blood test so I will know if it is actually doing that . Today is the happiest day we have had in the house in over a month. I will reply to this thread to keep the group posted. Wish us luck! Best. 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