I think you’re right that the decline is way too fast to be accounted for, by 
cancer. If it were me, I would give him a high dose of prednisone – 20 mg for 
maybe two days, and then drop back to 5 mg. I would also try him on the 
Winstrol, but in the very short-term, I think it may be the prednisolone which 
might do the best good. However, of course, you’re shooting in the dark because 
it is not clear what your target is. Try the high dose prednisone for a few 
days and see if he responds.

I don’t think that the chemo makes sense if the vet hasn’t identified a tumour 
and of course, the side effects are likely to worsen your cat’s condition. The 
good thing about what I am suggesting is that it may or may not work, but it is 
unlikely to leave him in a worse state, which cannot be said for the chemo. I 
would therefore try the prednisolone and Winstrol before I agreed to more chemo 
if it were my cat.

Amani

From: Felvtalk <felvtalk-boun...@felineleukemia.org> On Behalf Of Katy Brown
Sent: October 18, 2018 3:28 PM
To: felvtalk@felineleukemia.org
Subject: Re: [Felvtalk] Batman Felv Positive Having Neurological issues.

Amani,
That is very insightful. I’m not convinced he has lymphoma because his decline 
was so rapid. Within hours he went from walking to having completely rigid 
legs. And today he is starting to decline. I’m wondering if there is something 
else I can give him besides the 5 mg of Prednisolone and the Clindamycin.
The vet said he he keeps declining we could do another form of Chemo which is 
very aggressive and has other side affects and would be a Hail Mary to buy him 
another few days?
I’m just not convinced he has cancer. Even though he is FeLV positive he is 
young to develop a cancer?
Sent from my iPhone

On Oct 18, 2018, at 12:54 PM, Amani Oakley 
<aoak...@oakleylegal.com<mailto:aoak...@oakleylegal.com>> wrote:
I actually had a few similar experiences. Once it involved two very young 
kittens. Once it involved a cat about a year old. In my opinion, the two 
different experiences had two different causative agents, and at the risk of 
boring you silly, I will try to explain both. Neither, by the way, was well 
understood by the vets, leading me again to the inevitable conclusion that cat 
health is very poorly studied (no where near dog health) and because cats 
respond different to disease and medication, (whereas dogs respond very much 
like people), then science and medicine is way behind in understanding cats.

With respect to the kittens, it was my view that they actually had (and one of 
them still has) Lyme disease. The area I picked them up was one very well-known 
to be endemic for Lyme disease. They had an alternating lameness – once picking 
up one paw which seemed very swollen and sore – and then next day, picking up 
the other paw. I looked this up and saw that this alternating lameness was 
described in dogs with Lyme disease. However, my vet believed that it might be 
calici virus. I didn’t agree with her, but let her treat for calici virus 
(including vaccination). The acute phase of the response seemed to be limited 
in time, and both kittens seemed to get better on their own. However, their 
brother lapsed into a coma – was literally unresponsive for hours while I sat 
up with him. I didn’t know what to do, and my view was that either there was 
inflammation of the meninges (sac surrounding the brain) or an inflammation of 
the brain itself, causing increased intracranial pressure which might also 
result in loss of consciousness. I superdosed him with transdermal prednisone, 
took him to bed with me and kept checking him for hours. Then, suddenly, at 
about 4 in the morning, he just bounded awake, and began playing and 
galavanting all over the bed. Meanwhile, though, one of his two sisters has 
never been the same. She lost HUGE amounts of weight, and even now, as a 2+ 
year old cat, she weighs less than many kittens and she is all bones. I have 
been treating her with a combination of Winstrol, Doxycycline, high prednisone 
doses and magnesium (her muscles don’t work right – like they are constantly 
spastic, and she walks in a funny tip toe way, and has poor coordination 
jumping on things and going up stairs, etc.) Anyhow, she is starting to get 
better, starting to put on weight and starting to walk better. I am convinced 
this was and is Lyme disease, though scientists and vets say that cats don’t 
get it. I don’t know how they know this, because they DO NOT TEST cats for it.

Story number two involves a kitten I got who was described as a “wobbly” kitten 
and it was assumed that his mom had suffered a viral infection when he was in 
utero, which can result in this type of neurological damage (and it can be much 
worse). However, when he was very little, he suddenly and without warning, 
decided to squat and pee right in the middle of our bed, and he had never done 
this before. He was looking straight at me and I felt that he didn’t know why 
he was doing what he was doing. Not too long after (a few weeks or maybe a 
month), he started showing some very alarming neurological symptoms, including 
a loss of muscle control in the back end. His rectum seemed not tight but loose 
and stool just “fell out” rather than being pushed out. His back legs in 
particular also became very very weak, and he developed a “tripod stance” – 
both back legs together – his back end would sway and he would fall down. My 
knowledge with humans is that this occurs when there is damage to nerves in the 
spinal column, or pressure on them from a herniated disc, or something like 
that (cauda equina syndrome). I took him to the emergency clinic, but I had 
already started him on Winstrol and Prednisolone, assuming that the 
Prednisolone would help with reduction of swelling in the spinal canal and thus 
take pressure off the affected nerves, and the Winstrol might help in healing 
whatever injury there was in the spinal column. By the time they could do an 
MRI on him, he was regaining all function and his gait had become normal. The 
MRI was inconclusive, with the vets thinking that they could possible see the 
remains of a lesion, right in the area where one would expect it to be to 
affect rectal control and muscle function of the back legs, but the lesion 
appeared to be healed over so they couldn’t tell if that was the cause or if 
the lesion was old or new.

It sounds to me like the prednisone you used in your case, has a similar 
effect. There was swelling somewhere, likely in the spinal column as you 
surmise, and the prednisone helped bring down the swelling.

Amani

From: Felvtalk 
<felvtalk-boun...@felineleukemia.org<mailto:felvtalk-boun...@felineleukemia.org>>
 On Behalf Of katy brown
Sent: October 18, 2018 12:21 PM
To: Felvtalk@felineleukemia.org<mailto:Felvtalk@felineleukemia.org>
Subject: [Felvtalk] Batman Felv Positive Having Neurological issues.

Hello,
I have an amazing cat named Batman who a year ago as a kitten tested positive 
for FelV. His brother also texted positive, after 2 other tests later on after 
the antibodies from the mother had cleared, Batman still tested positive while 
his brother was negative.

Fast forward a year and both of them were doing great. I was away on vacation 
and left them with a full time cat sitter, who notice about a week ago that 
Batman was not going up stairs as much, but we figured this could be to him 
just adjusting to a new person in his home. When I arrived back home I 
immediately noticed he was not moving well and as the day progressed he was 
losing more mobility in his front paws. I took him to the emergency room where 
they thought he had experienced a trauma, and discharged him with 2 types of 
pain meds. The pain meds were a disaster, and he lost further mobility. From 
there we took him to Pennsylvania Vet. Hospital, which is supposed to be one of 
the best in the country, they realized he was having neurological issues, did a 
bunch of testing, his vitals and blood work were all good. An x-ray revealed no 
masses in his chest or spine. At this point they felt it was a cancer in his 
column, most likely lymphoma. The Vet thought that he was quite young even 
given his FeLV positive status to have lymphoma, but given how fast he was 
becoming completely paralyzed, there were not many other diagnosis that fit the 
bill. The vet started him on Prednisolone and Clindamycin, and within hours he 
regained movement in his legs and was walking again. Yesterday he was jumping 
and scratching on his post again, and eating and drinking. Last night his 
behavior changed and he kept trying to hide which is very unlike him, however I 
thought that maybe he was just tired, he had gone from completely paralyzed to 
jumping in 3 days. But this morning it was apparent that he was not ok, he did 
eat after much encouragement, but has moved very very little. I have called the 
Vet and am waiting to hear back but I'm not optimistic. Has anyone had this 
experience? I don't want to put him down if there is a chance he could come 
back but he is hardly moving and seems like him trying to hide was him trying 
to find a place to pass away quietly. Batman is so young and he is the sweetest 
cat I have ever owned, and his brother can't get along with out him.  I will 
try anything to keep him alive but I want him to have a good quality life. Any 
suggestions would be appreciated.

Also I apologize if I did not use this forum correctly. I wasn't sure if I 
emailed the group or how it works so I hope this does work.
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