THANK YOU Amani. Going to try to help this guy before he needs a blood
transfusion.
Maribel
"The greatness of a nation can be judged by the way its animals are treated."
-Mohandas Ghandi
On Tuesday, February 19, 2019, 1:12:50 PM EST, Amani Oakley
<aoak...@oakleylegal.com> wrote:
Yes – you can use the meds. They don’t even need to be refrigerated and if
anything the concern would be that being kept in the fridge may expose them to
moisture. They can be kept at room temperature and dry and they will not
“expire”. Many meds are like this.
See this link for an interesting discussion about “expiring”
medications.https://www.propublica.org/article/the-myth-of-drug-expiration-dates
Amani
From: Felvtalk <felvtalk-boun...@felineleukemia.org> On Behalf Of Maribel Piloto
Sent: February 19, 2019 1:03 PM
To: felvtalk@felineleukemia.org
Subject: [Felvtalk] Shelf life for Winstrol
Hi all,
Around May 2018 I had an anemic Leuk+ cat named Flaqui and bought the regimen
Amani mentions in the e-mail below this one with the Winstrol, Doxy and
Prednisolone. I never got a chance to use the meds with Flaqui as she passed
before I could do so. Today I just received the results from bloodwork of
another Leuk+ cat I have named Buster. His Hematocrit is at 11.5 and I would
like to start him on this regimen before he gets any more anemic. Do you all
know if I could still use the meds? They have been kept on the door of my
fridge since I got them.
Here are Buster's other numbers...
Glucose - 62 Low (normal is 80-200)
Sodium 143
Potassium 4.6
Chloride 113
CO2 13 Low (normal is 15-28)
Sodium/Potassium 31
Anion Gap 22
Serum Osmolality 309
Urea Nitrogen 56.5 High (normal is 15-37.5)
Creatinine 2.0
BUN/Creatinine 28
Total Protein 6.6
Albumin 2.4
Globulin 4.2
A/G Ratio 0.6
Calcim 6.7 Low (8.9-10.9)
Phosphorus 4.8 (2.4-8.0)
CL/P Ratio 24
Bilirubin Total 0.02
Bilirubin Direct 0.02
Alk Phospatase 17
ALT (SGPT) 21
AST (SGOT) 27
GGT 1
Creatine Kinase 139
Cholesterol 158
Triglycerides 30
Amylase 1261
Leukocytes WBC 24.7 High (5.0-17.5)
Erythrocytes RBC 2.54 Low (5.50-10.0)
Hemoglobin 3.4 Low (8.0-15.0)
Hematocrit 11.5 Low (24-46)
MCV 45
MCH 13.2
MCHC 29.1 Low (30-38)
Seg Neutrophils 73
Band Neutrophils 0
Lymphocytes 22
Monocytes 4
"The greatness of a nation can be judged by the way its animals are treated."
-Mohandas Ghandi
From: Felvtalk [mailto:felvtalk-boun...@felineleukemia.org]On Behalf Of Sandy
Sent: May-10-18 8:48 PM
To: Maribel Piloto; felvtalk@felineleukemia.org
Subject: Re: [Felvtalk] Anemia and Aranesp
This is long because I just copied this whole conversation - but your answer
lies in this combination of drugs - make no mistake this will work if your vet
will give it a try - there is nothing to lose - BUT you and the vet need to act
immediately. - good luck. You will probably get more responses - Sandy W
Winstrol – 1 mg twice a day
Doxycycline – 1/5 to ¼ tablet (100 mg) twice a day
Prednisolone – ½ 5 mg tablet, twice a day
If there are problems with the intestines (vomiting, constipation, slow moving
stools, stools of large diameters, all of which might be indicative of the
effect of the virus on the intestines) you can try adding ¼ tablet of
apometocloprimide.
If the haematocrit level is REALLY REALLY low – like below 5-8, you might
consider starting the Winstrol at 2 mg twice a day for a week, to try and
kickstart things quickly, but given that there is going to be a likely increase
in liver enzymes with the use of Winstrol, recognize that this might also
increase the liver enzymes faster.
Hope this helps! Amani
From: Felvtalk [mailto:felvtalk-boun...@felineleukemia.org] On Behalf Of gary
Sent: January-27-17 4:04 PM
To: felvtalk@felineleukemia.org
Subject: Re: [Felvtalk] My baby recently diagnosed with FeLV
Amani,
Could you please give the dosages used for Zander's Protocol? I know they must
have been previously given, but I cannot seem to find them.
Thanks, Gary
On 9/16/2016 8:52 AM, Amani Oakley wrote:
Hi Sherri
I hope you got some good news today. However, as you know, my experience is
that the Winstrol needs to be used long term before the red cells are back into
the normal range. I continue to recommend use of the Doxycyline to interfere
with viral RNA synthesis. The Winstrol does not attack the virus, though I
believe it makes the cat stronger overall and able to fight back. But at the
outset of the treatment regime, I believe you must have the Doxycycline on
board to try and reduce the viral load, or at least, keep it from rising.
Amani
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Hi Liz
The only thing that works to turn back on red cell production is Winstrol
(Stanazolol). It is an ANABOLIC steroid (as opposed to most steroids we are
used to getting, like prednisone, which is a corticosteroid.
Anabolic steroids are ones which build muscle, tissue, etc.
Adding Winstrol to the combination of medication you have your cat on right
now, would be the best thing to do. The Doxycycline acts to slow down or
inhibit the reproduction of the FeLV virus by interfering the RNA duplication.
The prednisone is helpful in keeping inflammation at bay, but neither of these
helps to increase the red cells. The Winstrol acts directly and very quickly on
the bone marrow and seems to get red cells generated again, quite promptly. At
least it did for my Zander, and I have been contacted directly by several
people from this group, who have reported to me that they also saw almost
immediate (within 3 days) evidence of their cats’ gums/ears/pads pinkening up.
The problem is that Winstrol is a controversial drug because it is also what
professional athletes use to get bigger, stronger and faster. Quite
unfortunately (since none of our cats are entering the Olympics) that
association with doping scandals has cast a shadow on its use in both animal
and people medicine. In human medicine, it is the only drug found to be
effective in treating hereditary angioedema and anemia.
Here is a blurb I found about it:
Winstrol was first invented in 1959. Soon after that, the UK based Winthrop
Laboratories created a prescription medicine from it. Later, in 1961,
Winthrop’s patent was bought by the US based Sterling that started
manufacturing and selling the drug in the American markets.
In the beginning, Winstrol was used for a variety of medical reasons. But
later, by the 1970s, the FDA had restricted its use to only promoting growth
and treating osteoporosis. In the 1980s, there was a termination of the
manufacture of anabolic steroids in the American market. But Winstrol was among
those steroids which not only survived, but thrived in the 1980s and 1990s.
During this period, its use was reinforced as a cure for anemia – as it had the
power to boost red blood cell count, and was used as a treatment for facial
swelling or angioedema.
When the manufacture of Winstrol was finally discontinued, Ovation
Pharmaceuticals bought the rights to manufacture it, in 2003. However, Ovation
Pharmaceuticals have ceased their operations now, so the Winstrol products
available today in the American markets are only generic and not pharmaceutical
grade. Outside the USA, however, several large brands still manufacture and
sell Winstrol.
Genuine Stanozolol can be distinguished in water suspensions because it
separates from the liquid into micrometer particles. These particles will fall
to the bottom if the container is not disturbed for a few hours. The crystals
have a milky white color.
Winstrol can not only be used for humans, but it has veterinary uses as well.
Weakened or injured animals can be treated with Winstrol in order to promote
red blood cell count, strengthen bones, stimulate appetite, and enhance muscle
growth. It has also reportedly been used to dope horses in US horse races.
If your vet is willing to try this, he/she will need to order it from a
compounding pharmacy.
The dose should be 1 mg 2 times a day for a cat. If your cat is in poor shape
and needs an immediate boost, start him on 2 mg x 2 times a day for a week or
so, and then drop down to the lower dose.
Your vet will undoubtedly say that Winstrol is known to cause liver damage.
The first answer to this is, so what? FeLV will almost invariably result in the
premature death of cats. The vets have nothing which is directly effective to
fight FeLV. Things like Interferon may or may not assist but such a treatment
is again a side treatment where you are hoping to boost your cat’s immune
system, rather than a direct attack on the virus. It is also quite indirect in
that IF the interferon helps, it will be more long term, and only if it manages
to boost the immune system enough to permit your cat’s system to try and fight
the virus, and when/if the virus is inhibited enough, then MAYBE (if the virus
hasn’t already destroyed all the progenitor cells in the bone marrow) will red
cell production begin to climb again. Winstrol is the only medication that I
know of, (and believe me, I have looked!) that seems to work by turning back on
those progenitor cells or possibly promoting the growth of new ones since it
also works to enhance the production of bone cells (effective against
osteoporosis).
The second answer, regarding the liver damage, is that the only information
about this is quite suspect, coming out of a very poorly designed research
study where the cats in the study were given doses found effective on HUSKY
SLED DOGS for lord’s sake! The cats were given a LOADING DOSE via intravenous
injection, of 25 mg – more than 10 times the recommended daily dose for cats.
That’s the only study which has found this supposed link between Winstrol and
liver damage. And even in that study, with those remarkably ridiculous doses,
the cats in that study only had elevated liver enzymes (no tumours, etc.) and
the liver enzymes dropped back to normal levels when the Winstrol was
discontinued. This is consistent with my experience as well. I refused to stop
the Winstrol for my cat, when the enzymes went up, because he was going to die
with the low red cell count he had. I kept him on Winstrol for around 10
months, before the red cells were in a normal range. During that ten month
period, I would wean him down a few times, but ALWAYS the red cells would
immediately drop again, so it was more than clear that it was the Winstrol
making the numbers rise. So, in the end, he had Winstrol pretty much for the
duration of 10 months and his liver enzymes went right back to normal again,
once I discontinued the Winstrol – NO lasting damage. This was also my
experience with a second cat with a nasal sarcoma, and where I used the
Winstrol to keep her appetite up and reduce the swelling (she was 16). The
enzymes went quite high at the outset of my use of Winstrol, but went back to
normal when I weaned her off for a bit and then again when I ultimately took
her off the Winstrol.
Get the Winstrol if you can, and use it in combination with the prednisone
(which I am told also helps to protect the liver when the Winstrol is used) and
Doxycycline.
Amani
From: Felvtalk [mailto:felvtalk-boun...@felineleukemia.org] On Behalf Of Liz
McCarty
Sent: September-15-16 1:40 PM
To: felvtalk@felineleukemia.org
Subject: [Felvtalk] My baby recently diagnosed with FeLV
Hi everyone,
Looking for support, suggestions, and information. I've never had a cat with
FeLV. We took our 1 year old, Hodor, to the vet because he seemed lethargic and
in his stool there was a piece of floss that was red. At the vet things
escalated and they told us he was severely anemic and would need a transfusion
that day. I took off work and rushed him to a specialist. The vet there told us
she would run an FeLV test before doing anything in case we wanted to avoid the
extra tests and procedures. She told us he was FeLV positive and persistently
talked to me and my fiance about euthanizing him which was out of the question
for us. I took him to the vet thinking it was going to be minor and then she's
talking to me about killing him! We went forward with the blood transfusion.
It's been almost 3 weeks now. They had him on doxycycline in case there was a
bacterial cause, and prednisone. Last week he started interferon... Does anyone
have experience with that and know if it was effective? I also started him on
Pet Tinic. Any other suggestions? Any insight into whether you think he will
be able to pull through? He doesn't have cancer, they ran the tests but don't
know if it's in the bone marrow. I'm scared. We have another one year old,
unrelated, and they are best friends. It breaks my heart to think they might be
separated. She's not FeLV positive.
Additionally I have set up a go fund me to help with the costs we incurred, and
I want to donate half to FeLV research if anyone is interested.
http://www.gofundme.com/2mzdpgk
Mainly looking for support and advice. Thank you in advance.
Elizabeth McCarty, ASW #36438
On May 10, 2018 at 4:09 PM Maribel Piloto <pilo...@bellsouth.net> wrote:
Hi all,
I have a Leuk+ girl who is getting very anemic. Her name is Flaqui. She
showed up at one of the colonies I feed a couple of months ago (already spayed)
and was so thin I thought she was an elderly cat with not much time left so I
took her home to give her some comfort in her final days. When I took her to
the vet it turned out that she isn't that old (vet things 4-5) but she's Leuk+.
I decided to keep her in my room where I have another Leuk+ guy. I'm
building a little catio for them outside one of the bedroom windows so they can
enjoy the outside.
Flaqui's numbers in January 2018 were...
RBC - 4.15 M/ul (5.00-10.00) LOW
HCT - 20.2% (30.0-45.0) LOW
HGB 6.8 g/dl (9.0-15.1) LOW
MCV 48.7 fL (41.0-58.0)
MCH - 16.5 pg (12.0-20.0)
MCHC - 33.8 g/dL (29.0-37.5)
RDW - 20.5% (17.3-22.0)
%RETIC - 1.3%
RETIC - 53.2 K/uL (3.0-50.0) HIGH
WBC - 15.30 K/uL (5.50-19.50)
EOS - 1.8 K/uL (0.10-0.79) HIGH
PLT - 663 K/uL (175-600)
Everything else was normal
I started her on Liqui-Tinic which is a supplement containing iron and B-12
among other things. Also giving her Vetri-DMG. She initially had very bad
diarrhea but I managed to clear this with Metronidazole. She's also been
dewormed and got Revolution. Despite eating and showing an interest in food,
she has been losing weight (down to 5 lbs) so last week I had bloodwork done
again. Here are the results...
RBC - 3.79 M/ul (5.00-10.00) LOW
HCT - 14.8% (30.0-45.0) LOW
HGB 8.1 g/dl (9.0-15.1) LOW
MCV 39.2 fL (41.0-58.0) LOW
MCH - 21.4 pg (12.0-20.0) HIGH
MCHC - --- g/dL (29.0-37.5)
RDW - 21.7% (17.3-22.0)
%RETIC - 1.1%
RETIC - 40.7 K/uL (3.0-50.0)
WBC - 22.73. K/uL (5.50-19.50) HIGH
NEU - 18.48 K/uL (2.50-12.50) HIGH
PLT 698 K/uL (175-600) HIGH
Everything else was normal
My vet told me to start her on Clavamox since the white blood cell count was
high which is indicative on an infection somewhere. I was really alarmed by
the HCT number because I had a cat with chronic renal failure and anemia some
years back and I know that once the HCT numbers get below 20% it can be very
dangerous. With that cat, Grayson, I used Aranesp very successfully to treat
his anemia. He eventually succumbed to the kidney failure but the Aranesp kept
his anemia at bay.
I've been reading that blood transfusions are one of the things to do with
Leuk+ cats once the HCT numbers get low but blood transfusions in my area
(South FL) are in the $1000 range and I manage 6 colonies and have other cats
at home with medical needs including one that needs a full mouth extraction for
stomatitis and I just can't spend that type of money on Flaqui.
Do you guys think that Aranesp is something that would work on her? She does
not have kidney problems. However, based on the reticulocyte levels, she does
seem to have non-regenerative anaemia. I read this document at Tanya's
Comprehensive Guide to Feline Chronic Kidney Disease that explains that the
reticulocyte level needs to be adjusted based on PCV...
In particular, since reticulocytes are commonly expressed in percentage terms,
they need to be adjusted to allow for the degree of anaemia, i.e. 1%
reticulocytes in a cat with a PCV of 20% is twice as many as 1% reticulocytes
in a cat with a PCV of 10%.
Let's assume your cat's PCV is 18% and the measured reticulocyte count is
0.75%. You multiply the PCV by the measured count, then divide the result by
the normal PCV level (35% for many laboratories). In this instance, you would
get an adjusted result of 0.39%, which indicates non-regeneration.
In contrast, if your cat's PCV was 13% and the measured reticulocyte count was
0.75%, your adjusted result would be 0.28. This also indicates
non-regeneration, but it is more severe (i.e. the lower the corrected value,
the lower the regenerative response).
Flaqui's adjusted reticulocyte level is 14.8HCT X 1.1 RET = 16.28/35 = .46
which indicates non-regeneration.
Any help would be appreciated. Flaqui has been doing better the last couple of
days. I think the Clavamox helped - but I really wish I could improve those
HCT numbers.
Maribel & Flaqui.
"The greatness of a nation can be judged by the way its animals are treated."
-Mohandas Ghandi
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