which method are you trying to implement? If #3, then you need to run 
mris_preproc separately for each subject, and then run that fscalc command


On 11/07/2017 11:33 AM, lanbo Wang wrote:
> Hi Douglas,
>
> Thanks for your reply.
> I created the fsgd file as you show me, and run code like this. Am I 
> right?
> 1.
> mris_preproc --fsgd Subject.xhemi.dat \
>   --target fsaverage_sym --hemi lh \
>   --xhemi --paired-diff \
>   --srcsurfreg fsaverage_sym.sphere.reg \
>   --meas thickness \
>   --out lh.lh-rh.thickness.age.sm00.mgh \
>  --s subj_02_1  --s subj_04_1  --s subj_05_1  --s subj_06_1  --s 
> subj_08_1  --s subj_09_1  --s subj_10_1 --s subj_11_1  --s subj_12_1  
> --s subj_13_1  --s subj_14_1  --s subj_15_1  --s subj_16_1  --s 
> subj_17_1 --s subj_18_1  --s subj_20_1  --s subj_21_1  --s subj_22_1  
> --s subj_24_1  --s subj_25_1  --s subj_26_1 --s subj_27_1  --s 
> subj_29_1  --s subj_32_1
>
> 2.
> mri_glmfit --y lh.lh-rh.thickness.age.sm10.mgh --glmdir 
> glm.lh.lh-rh.thickness.age.sm10 \
> --fsgd Subject.xhemi.dat \
> --C Avg-thickness-age-Cor.mtx \
> --surf fsaverage_sym lh
>
> Attachment is fsgd and Avg-thickness-age-cor.mtx.
>
> All best,
> Lanbo Wang
>
>
> On Tue, Nov 7, 2017 at 10:18 AM, Bruce Fischl 
> <fis...@nmr.mgh.harvard.edu <mailto:fis...@nmr.mgh.harvard.edu>> wrote:
>
>     Hi Danny
>
>     you need to give us more information if you want us to help you.
>     Please include the command you ran and the entire screen output.
>
>     cheers
>     Bruce
>
>
>     On Tue, 7 Nov 2017, Danny Deng wrote:
>
>         Dear FDs,
>         I encountered an odd situation:
>
>         My free surfer will always shut down when I run command.
>
>         My MacOS version is 10.12.6 (16G29) processor: 1.6 GHz Intel
>         Core i5
>
>         I don’t know if the compatibility is fine with my download
>         version (MacOS Lion OS X 10.7 (64b
>         intel)Stable v6.0.0)
>
>         Please kindly suggest.
>
>         Thanks ver much
>
>         Best Regards,Danny Deng
>
>
>               On Nov 7, 2017, at 7:14 AM, Douglas N Greve
>         <gr...@nmr.mgh.harvard.edu <mailto:gr...@nmr.mgh.harvard.edu>>
>         wrote:
>
>
>
>         On 11/06/2017 12:03 PM, lanbo Wang wrote:
>               Dear experts,
>
>               I have two questions about hemisphere analysis:
>
>               1) When I run left-right hemisphere paired t-test, can I
>         add age as
>               covariate? If use fsgd to add covariate, to this paired
>         t-test
>               analysis, how to make the fsgd table?
>
>         use this one-group, one-covariate example
>         https://surfer.nmr.mgh.harvard.edu/fswiki/Fsgdf1G1V
>         <https://surfer.nmr.mgh.harvard.edu/fswiki/Fsgdf1G1V>
>               2) I want to reorganize the hemisphere from left-right to
>               symptom-nosymptom according to body symptom side record
>         and compare
>               different between symptom hemisphere and nosymptom
>         hemisphere. Can I
>               use freesurfer to do it?
>
>         Yes, though it is a little tricky with multiple ways, each
>         complicated
>         in its own way.
>         1. Create your own design matrix. You can use the one created by
>         mri_glmfit to start. Assuming you want
>         symptomHemi-nosymptomHemi, then,
>         in each subject whose symptomHemi is rh, multiply its line in
>         the design
>         matrix by -1. Then pass this design matrix to mri_glmfit with --X
>         instead of passing an FSGD file.
>         2. Load the output of mris_preproc into matlab, eg, y =
>         MRIread('y.mgh');, then change the sign as in #1 above, eg,
>         y.vol(:,:,:,10) = -y.vol(:,:,:,10); and so on for each applicable
>         subject. Then save the data with MRIwrite(y,'new.y.mgh');,
>         then run
>         mri_glmfit as normal with the new file.
>         3. Run mris_preproc for each subject separately to generate an
>         lh.lh-rh.thickness.sm00.subject10.mgh file. Then change the
>         sign as in
>         #1 above with
>         fscalc lh.lh-rh.thickness.sm00.subject10.mgh mul -1 -o
>         lh.lh-rh.thickness.sm00.subject10.mgh
>         Then run mri_concat to concatenate all the subjects together
>         in the same
>         order as they are listed in the FSGD file, then use this stack
>         as input
>         the mri_glmfit
>
>
>               Thanks for your patient and help.
>
>               All best,
>               Lanbo Wang
>
>
>               _______________________________________________
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>
>         --
>         Douglas N. Greve, Ph.D.
>         MGH-NMR Center
>         gr...@nmr.mgh.harvard.edu <mailto:gr...@nmr.mgh.harvard.edu>
>         Phone Number: 617-724-2358 <tel:617-724-2358>
>         Fax: 617-726-7422 <tel:617-726-7422>
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-- 
Douglas N. Greve, Ph.D.
MGH-NMR Center
gr...@nmr.mgh.harvard.edu
Phone Number: 617-724-2358
Fax: 617-726-7422

Bugs: surfer.nmr.mgh.harvard.edu/fswiki/BugReporting
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www.nmr.mgh.harvard.edu/facility/filedrop/index.html
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