Dr. Douglas,

I try #3 method, when I run mri_glmfit, get error.
The code I used:
[mtobia@localhost lh.lh-rh.thickness]$ mri_glmfit --y
lh.lh-rh.thickness.sm10.mgh --glmdir glm.lh.lh-rh.thickness.sm10 --osgm
--surf fsaverage_sym lh
Reading source surface
/HD4/subjects_results_symptom//fsaverage_sym/surf/lh.white
Number of vertices 163842
Number of faces    327680
Total area         61972.710938
AvgVtxArea       0.378247
AvgVtxDist       0.693419
StdVtxDist       0.190498

$Id: mri_glmfit.c,v 1.196.2.8 2012/11/01 18:51:41 greve Exp $
cwd /HD4/subjects_results_symptom/lh.lh-rh.thickness
cmdline mri_glmfit --y lh.lh-rh.thickness.sm10.mgh --glmdir
glm.lh.lh-rh.thickness.sm10 --osgm --surf fsaverage_sym lh
sysname  Linux
hostname localhost.localdomain
machine  x86_64
user     mtobia
FixVertexAreaFlag = 1
UseMaskWithSmoothing     1
OneSampleGroupMean 1
y
/HD4/subjects_results_symptom/lh.lh-rh.thickness/lh.lh-rh.thickness.sm10.mgh
logyflag 0
usedti  0
labelmask
/HD4/subjects_results_symptom//fsaverage_sym/label/lh.cortex.label
maskinv 0
glmdir glm.lh.lh-rh.thickness.sm10
IllCondOK 0
ReScaleX 1
DoFFx 0
Creating output directory glm.lh.lh-rh.thickness.sm10
Loading y from
/HD4/subjects_results_symptom/lh.lh-rh.thickness/lh.lh-rh.thickness.sm10.mgh
Saving design matrix to glm.lh.lh-rh.thickness.sm10/Xg.dat
Normalized matrix condition is 1
Matrix condition is 1
Found 146902 points in label.
Pruning voxels by thr: 0.000000
Found 146902 voxels in mask
Saving mask to glm.lh.lh-rh.thickness.sm10/mask.mgh
Reshaping mriglm->mask...
search space = 79288.081914
DOF = 0
ERROR: DOF = 0

The code I used before this one is
How can I resolve this problem.

Thanks,
Lanbo


On Tue, Nov 7, 2017 at 6:10 PM, Douglas N Greve <gr...@nmr.mgh.harvard.edu>
wrote:

> which code. I gave 3 options below, which one did you use?
>
>
> On 11/07/2017 02:43 PM, lanbo Wang wrote:
> > I try to use this code to compare left and right hemisphere by paired
> > t-test  and add age as covariate.
> >
> > Thanks,
> > Lanbo
> >
> > On Tue, Nov 7, 2017 at 11:40 AM, Douglas N Greve
> > <gr...@nmr.mgh.harvard.edu <mailto:gr...@nmr.mgh.harvard.edu>> wrote:
> >
> >     which method are you trying to implement? If #3, then you need to run
> >     mris_preproc separately for each subject, and then run that fscalc
> >     command
> >
> >
> >     On 11/07/2017 11:33 AM, lanbo Wang wrote:
> >     > Hi Douglas,
> >     >
> >     > Thanks for your reply.
> >     > I created the fsgd file as you show me, and run code like this. Am
> I
> >     > right?
> >     > 1.
> >     > mris_preproc --fsgd Subject.xhemi.dat \
> >     >   --target fsaverage_sym --hemi lh \
> >     >   --xhemi --paired-diff \
> >     >   --srcsurfreg fsaverage_sym.sphere.reg \
> >     >   --meas thickness \
> >     >   --out lh.lh-rh.thickness.age.sm00.mgh \
> >     >  --s subj_02_1  --s subj_04_1  --s subj_05_1  --s subj_06_1  --s
> >     > subj_08_1  --s subj_09_1  --s subj_10_1 --s subj_11_1  --s
> >     subj_12_1
> >     > --s subj_13_1  --s subj_14_1  --s subj_15_1  --s subj_16_1  --s
> >     > subj_17_1 --s subj_18_1  --s subj_20_1  --s subj_21_1  --s
> >     subj_22_1
> >     > --s subj_24_1  --s subj_25_1  --s subj_26_1 --s subj_27_1  --s
> >     > subj_29_1  --s subj_32_1
> >     >
> >     > 2.
> >     > mri_glmfit --y lh.lh-rh.thickness.age.sm10.mgh --glmdir
> >     > glm.lh.lh-rh.thickness.age.sm10 \
> >     > --fsgd Subject.xhemi.dat \
> >     > --C Avg-thickness-age-Cor.mtx \
> >     > --surf fsaverage_sym lh
> >     >
> >     > Attachment is fsgd and Avg-thickness-age-cor.mtx.
> >     >
> >     > All best,
> >     > Lanbo Wang
> >     >
> >     >
> >     > On Tue, Nov 7, 2017 at 10:18 AM, Bruce Fischl
> >     > <fis...@nmr.mgh.harvard.edu <mailto:fis...@nmr.mgh.harvard.edu>
> >     <mailto:fis...@nmr.mgh.harvard.edu
> >     <mailto:fis...@nmr.mgh.harvard.edu>>> wrote:
> >     >
> >     >     Hi Danny
> >     >
> >     >     you need to give us more information if you want us to help
> you.
> >     >     Please include the command you ran and the entire screen
> output.
> >     >
> >     >     cheers
> >     >     Bruce
> >     >
> >     >
> >     >     On Tue, 7 Nov 2017, Danny Deng wrote:
> >     >
> >     >         Dear FDs,
> >     >         I encountered an odd situation:
> >     >
> >     >         My free surfer will always shut down when I run command.
> >     >
> >     >         My MacOS version is 10.12.6 (16G29) processor: 1.6 GHz
> Intel
> >     >         Core i5
> >     >
> >     >         I don’t know if the compatibility is fine with my download
> >     >         version (MacOS Lion OS X 10.7 (64b
> >     >         intel)Stable v6.0.0)
> >     >
> >     >         Please kindly suggest.
> >     >
> >     >         Thanks ver much
> >     >
> >     >         Best Regards,Danny Deng
> >     >
> >     >
> >     >               On Nov 7, 2017, at 7:14 AM, Douglas N Greve
> >     >         <gr...@nmr.mgh.harvard.edu
> >     <mailto:gr...@nmr.mgh.harvard.edu>
> >     <mailto:gr...@nmr.mgh.harvard.edu <mailto:gr...@nmr.mgh.harvard.edu
> >>>
> >     >         wrote:
> >     >
> >     >
> >     >
> >     >         On 11/06/2017 12:03 PM, lanbo Wang wrote:
> >     >               Dear experts,
> >     >
> >     >               I have two questions about hemisphere analysis:
> >     >
> >     >               1) When I run left-right hemisphere paired t-test,
> >     can I
> >     >         add age as
> >     >               covariate? If use fsgd to add covariate, to this
> >     paired
> >     >         t-test
> >     >               analysis, how to make the fsgd table?
> >     >
> >     >         use this one-group, one-covariate example
> >     > https://surfer.nmr.mgh.harvard.edu/fswiki/Fsgdf1G1V
> >     <https://surfer.nmr.mgh.harvard.edu/fswiki/Fsgdf1G1V>
> >     >         <https://surfer.nmr.mgh.harvard.edu/fswiki/Fsgdf1G1V
> >     <https://surfer.nmr.mgh.harvard.edu/fswiki/Fsgdf1G1V>>
> >     >               2) I want to reorganize the hemisphere from
> >     left-right to
> >     >               symptom-nosymptom according to body symptom side
> >     record
> >     >         and compare
> >     >               different between symptom hemisphere and nosymptom
> >     >         hemisphere. Can I
> >     >               use freesurfer to do it?
> >     >
> >     >         Yes, though it is a little tricky with multiple ways, each
> >     >         complicated
> >     >         in its own way.
> >     >         1. Create your own design matrix. You can use the one
> >     created by
> >     >         mri_glmfit to start. Assuming you want
> >     >         symptomHemi-nosymptomHemi, then,
> >     >         in each subject whose symptomHemi is rh, multiply its
> >     line in
> >     >         the design
> >     >         matrix by -1. Then pass this design matrix to mri_glmfit
> >     with --X
> >     >         instead of passing an FSGD file.
> >     >         2. Load the output of mris_preproc into matlab, eg, y =
> >     >         MRIread('y.mgh');, then change the sign as in #1 above, eg,
> >     >         y.vol(:,:,:,10) = -y.vol(:,:,:,10); and so on for each
> >     applicable
> >     >         subject. Then save the data with MRIwrite(y,'new.y.mgh');,
> >     >         then run
> >     >         mri_glmfit as normal with the new file.
> >     >         3. Run mris_preproc for each subject separately to
> >     generate an
> >     >         lh.lh-rh.thickness.sm00.subject10.mgh file. Then change
> the
> >     >         sign as in
> >     >         #1 above with
> >     >         fscalc lh.lh-rh.thickness.sm00.subject10.mgh mul -1 -o
> >     >         lh.lh-rh.thickness.sm00.subject10.mgh
> >     >         Then run mri_concat to concatenate all the subjects
> together
> >     >         in the same
> >     >         order as they are listed in the FSGD file, then use this
> >     stack
> >     >         as input
> >     >         the mri_glmfit
> >     >
> >     >
> >     >               Thanks for your patient and help.
> >     >
> >     >               All best,
> >     >               Lanbo Wang
> >     >
> >     >
> >     >               _______________________________________________
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> >     >
> >     >
> >     >         --
> >     >         Douglas N. Greve, Ph.D.
> >     >         MGH-NMR Center
> >     > gr...@nmr.mgh.harvard.edu <mailto:gr...@nmr.mgh.harvard.edu>
> >     <mailto:gr...@nmr.mgh.harvard.edu <mailto:gr...@nmr.mgh.harvard.edu
> >>
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> >     <tel:617-726-7422>>
> >     >
> >     >         Bugs: surfer.nmr.mgh.harvard.edu/fswiki/BugReporting
> >     <http://surfer.nmr.mgh.harvard.edu/fswiki/BugReporting>
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> >     <http://surfer.nmr.mgh.harvard.edu/fswiki/BugReporting>>
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> >     --
> >     Douglas N. Greve, Ph.D.
> >     MGH-NMR Center
> >     gr...@nmr.mgh.harvard.edu <mailto:gr...@nmr.mgh.harvard.edu>
> >     Phone Number: 617-724-2358 <tel:617-724-2358>
> >     Fax: 617-726-7422 <tel:617-726-7422>
> >
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> --
> Douglas N. Greve, Ph.D.
> MGH-NMR Center
> gr...@nmr.mgh.harvard.edu
> Phone Number: 617-724-2358
> Fax: 617-726-7422
>
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