This is not necessarily a problem. The "e" in eTIV means "estimate". It is a slight hack where the registration to MNI space is used to compute an estimate of the TIV, so it is not based on a segmentation or any real image processing, so it is sometimes quite off. This ratio was really just meant to be a flag to catch your attention. Now that it has it, just look at the skull stripping and see if it looks ok. If it does, then ignore the flag.

On 6/25/2025 6:49 PM, Krystalyn Edwards-Calma wrote:
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Aloha,

I am using Version 7.4.1. After running recon-all for multiple subjects, I noticed 
the Brain mask is larger than the intracranial volume (Mask-to-eTIV > 1). I 
attempted multiple different skull stripping methods, however, the mask-to-eTIV is 
always > 1. Any suggestions on how to fix this? Mahalo for your help.

Malama pono,

Krystalyn Edwards-Calma
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