Recently i have used galaxy to find corresponding amino acids to a list of
SNPs that i have. i used aaChange tool from the tool panel for this
purpose. After obtaining the result i checked the correctness of this
results by searching dbSNP for randomly chosen SNPs. however, some of those
SNPs mapped to incorrect amino acid,
The SNP( rs11549096), was mapped by Galaxy to the change ( Asp:Tyr/His, ) ,
Searching the dbSNP for this SNP Shows that the Change should be Asp :Asn
and the link for this SNP in the dbSNP is :
So, the reference is correct in all cases i searched (more than a
thousand), the position of change in the aa is correct, *but* the
alternative aa is not correct in all cases.
What causes this mistake, and how to solve this problem?
Note: my list contains hundreds of thousands of SNPs, so, i can not check
each one of them.
prompt response is appreciated,
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