https://link.springer.com/article/10.1186/s12936-025-05666-2

*Authors: *Athar Hussain, Muhammad Shoaib & Muhammad Latif

*08 December 2025*

*Abstract*
*Background*
Climate change is expected to reshape malaria transmission dynamics in
tropical and subtropical regions. Stratospheric Aerosol Injection (SAI), a
proposed solar geoengineering strategy to reduce global warming, could have
unintended consequences for vector-borne diseases such as malaria. This
study investigates how SAI, through the Stratospheric Aerosol
Geoengineering Large Ensemble (GLENS-SAI) scenario, could alter malaria
transmission patterns across seven South Asian countries—Afghanistan,
Bangladesh, Bhutan, Iran, India, Nepal, and Pakistan—compared with an
unmitigated warming scenario over coming decades.

*Methods*
Using the VECTRI malaria model, malaria transmission dynamics were
simulated from 2020 to 2097 under two climate pathways: the GLENS-SAI
simulations, designed to stabilize global temperatures at 2020 levels, and
the high-emissions Representative Concentration Pathway (RCP) 8.5—the
control scenario (CTRL), representing unmitigated climate change. The model
incorporated climatic and demographic factors to simulate vector density,
Entomological Inoculation Rate (EIR), and malaria cases. Spatial patterns
were assessed using distribution maps, while temporal variability was
examined through time-series analysis. Statistical comparisons employed
regional averages, anomaly detection, and significance testing.

*Results*
The findings reveal a redistribution of malaria transmission dynamics under
the GLENS-SAI scenario, reflected in variations in vector density, EIR, and
malaria cases. Compared to CTRL, the GLENS-SAI scenario reduces malaria
transmission intensity across South Asia, though spatial heterogeneity
persists. Significant declines in EIR are observed in India, Nepal,
Bangladesh, northern Pakistan, southern Iran, and the Afghanistan-Pakistan
border region, indicating the suppressive effect of the GLENS-SAI scenario
on malaria transmission. However, localized increases in EIR are projected
in southeastern Pakistan, western Afghanistan, north-central and eastern
Iran, and northern Nepal. These shifts are likely driven by SAI-induced
changes in temperature and precipitation, influencing mosquito survival and
reproductive dynamics. Additionally, the annual malaria transmission cycle
shortens in amplitude and duration across several endemic areas, suggesting
a shift in seasonal transmission patterns and altered windows of disease
risk throughout South Asia.

*Conclusions*
While the GLENS-SAI scenario may reduce malaria transmission across much of
South Asia, localized increases highlight the need for region-specific
public health strategies. These findings underscore the importance of
incorporating GLENS-SAI scenario impacts into malaria control planning to
address spatially varied effects.

*Source: Springer Nature Link*

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