Hi all

 

Decisions support systems in health are aimed at reducing the probability of harm and increasing the probability of positive outcomes. While there are certain events in medicine that are 100% deterministic – decapitation causes death, the majority of health issues, diagnostic tests and treatment options are based on probabilities.

 

The very basis of medication therapy is probabilistic if one looks at the whole clinical trials process. The fact that NPS has decided that there is an apparent inadequacy of drug-interactions knowledge base doesn’t guarantee that the probability of outcomes will improve if one doesn’t address some pretty basic building blocks and that the work needs to be mindful of what is happening now and how they can quantifiably improve that situation.

 

Yet has the NPS looked at how they will improve the sensitivity and specificity of what they are trying to achieve with this exercise.

 

How will the medications be coded and classified in the knowledge base and how will the clinical systems talk to this knowledge base? There is no standard medication code set at the product level that is then classified at generic, therapeutic class etc. that all vendors are using. NEHTA and others are obviously keen to get this sorted.

 

Apparently there is no one knowledge base that appears up to the task hence the need to review the literature and synthesis of experiences to provide a clearly articulated risk value. I am not sure whether what is being articulated is clearly identifying the inadequacies in terms of quantification of poor outcomes, risks etc. It appears based on individual opinions and focus groups rather than extensive quantifiable research.

 

It is a little bit alarming that the PIs have been questioned to their usefulness, when isn’t that a fundamental requirement under TGA type rulings? Shouldn’t PIs be better kept up to date? Should the CMI also be reflective of changes in evidence?

 

There is evidence that drs don’t record drug allergies, diagnoses/history or keep complete medication record so whether you have a super drug interactions data base is not going to help much if drs don’t record these things. Drs don’t record these things for a number of reasons. Shouldn’t we be improving our understanding of these things and improve this area. It could be argued if these were better recorded the relevant increase and decrease in probabilities would be more effective than a super knowledge base and would have better flow on effects to other areas in healthcare.

 

I think you will find that a dr is more likely to get litigated against as a result of keeping poor records rather than whether they were using one knowledge base over another.

 

I would like to know how many drug interactions are happening that will not happen if this super knowledge base is going to come in to play. Of course various people are saying it is optional and given that not everyone agrees with NPS this will also affect its usefulness and uptake. We have seen debate on 1st line treatment for hypertension most common problem in general practice but only occurs about 6 per 100 encounters. There are hundreds and thousands of other condition combinations that people have.

 

Keep in mind always that decisions support systems SUPPORT clinical judgment. Many drs would argue of course that clinical independence affords them the right to treat the patient given the patients specific circumstances in a way that they feel will provide the best probably outcomes for that patient in consultation with the patient. I believe that this is largely evidenced based and does give the patient a good chance of a positive outcome, but I am sure we can improve the odds.

 

Geoffrey Sayer

HealthLink Ltd

 


From: [EMAIL PROTECTED] [mailto:[EMAIL PROTECTED] On Behalf Of James Reeve
Sent: Monday, 19 June 2006 4:16 p.m.
To: [email protected]
Subject: [GPCG_TALK] NPS drug interaction project

 

NPS is convening an expert panel to review existing drug interaction decision support in prescribing and dispensing software in Australia. If shortcomings are identified, the panel will review a range of reference sources to identify the most appropriate one for use in the Australian setting. NPS is not developing drug interaction information knowledge bases – there are a number of quality information resources already available in Australia and overseas.

NPS is also investigating the feasibility of offering drug interaction decision support via a Web service, using the drug interaction reference source identified by the expert panel. The Web service would be maintained by NPS, while the drug interaction information would continue to be maintained by the developers of the information. By offering drug interaction information as a Web service, NPS hopes to create an opportunity for interested vendors to link prescribing or dispensing software directly to a single source of quality drug interaction information. Users can then choose whether they use existing drug interaction decision support, or use the content delivered by NPS (or both).

The rationale for this project stems from consultation in 2002 with general practitioners (GPs) using 5 different prescribing software packages. GPs thought that drug interaction alerts were not always relevant to the prescribing decision. One reason for this is the inclusion of many theoretical and minor drug interactions. NPS reviewed drug interaction information offered by 4 commonly used prescribing packages in Australia and found variability in the detection of drug interactions and the advice offered. The evidence-base for drug interactions is poor, and therefore improving the quality of the information is difficult. It is hoped that this project will contribute to a process of improving drug interaction decision support offered by prescribing and dispensing software.

James Reeve
Manager, Pharmaceutical Decision Support
National Prescribing Service Limited
Address: Suite 4, 65 Oxford Street Collingwood VIC 3066
Mailing address: PO Box 1143 Collingwood VIC 3066

T: 03 9412 5504
F: 03 9416 3325
M: 0403 571 646
Switch: 02 8217 8700
Internal extension: 504
Email:
[EMAIL PROTECTED]
Web:
www.nps.org.au

 

 

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