On Thursday 15 February 2007 15:07, Cedric Meyerowitz wrote:
> Worldwide Risperdal got the indication for behaviour disturbance in
> Dementia.  Although Zyprexa often works well, they don't have the
> indication. At one stage they promoted Zyprexa for Dementia with aggression
> etc.  They actually had to withdraw their promotional material on this
> about 2 years ago.  They don't have the data yet.  Risperdal does./

Firstly, there is no worldwide indication.
There are "official" indications which manufactirersr have to apply for with 
the relevant authorities in each country - some countries may have mutual 
acceptance agreements in place, most don't. Manufactirers usually don't 
bother with the costly registration process in countries where they don't see 
a sufficient market

Then there are "de facto" indications (so called "off label" prescriptions) - 
doctors having experienced a beneficial result of a drug for certain 
indications which may not be listed as official (eg Amitriptyline for chronic 
pain, AFAIK still not listed officially for that indication but nearly every 
pain clinic using it to that purpose)

Both are entirely irrelevant for "PBS authority indication" which has been 
devised as a (sometimes foul) compromise between bureaucrats, health 
professionals and politicians; and since the PBS is a system unique to Oz 
(and something Oz can be proud of IMHO too!) anything that happns "worldwide" 
remains irrelevant to it

Assuming the government keeps it's own web PBS listing up to date, what I can 
find on 
http://pbs.gov.au/html/healthpro/search/results?term=Risperdal&publication=GE 
suggests that Risperidone is not subsidized for the indication you mention

And we are back to another typical Australian idiosyncrasy: disinformation, 
lack of information, artificial barriers to information, inefficient and 
unpredictable uinformation exchange.
We are both professionals with comparable training and background and yet 
neither of us (or at least one of us, namely me) is utterly confused about 
how to legally prescribe either Risperidone or Olanzapine under PBS benefits.

Horst
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