Bonjour � tous
Je traduis un texte sur la pharmacocin�tique d'un anxiolytique, et un
certain nombre de termes me posent probl�mes. Je vous les soumets, en
esp�rant que certains sp�cialistes pourront me r�pondre. Comme d'ahbitude,
c'est urgent. Les termes qui me posent probl�me sont entre **.
*clinical expert report* (c'est le titre du texte, une suggestion de
traduction ?)
Peak plasma concentration are reached within 1-2 h after oral
administration of an *immediate-release formulation* (formule � lib�ration
imm�diate ?) and 3-5 h after the *slow-release formulation* (� lib�ration
prolong�e ?).
In patients with hepatic cirrhosis, the *first-pass metabolism*
(m�tabolisme de premier passage ?) is reduced.
The pharmacoKinetics of X in *non-linear*, because of *saturable* binding
of X to *ACE* in plasma and tissues.
After administration of *radiolabelled* X, one thrid of the *label* is
recovered in the urine.
pharmacokinetic *rationale* for X
>From a clinical point of view, an important parameter for a once daily
antihypertensive is the ratio of blood pressure reduction at both peak and
trough in e review article on trough-to-peak ratios of severalm calcium
antagonists and ACE inhibitors a mean *T/P* ratio of 75 %. La phrase toute
enti�re n'est pas claire pour moi.
As there was no experience with *compensated liver insufficiency (non
cirrhotic liver disease)*, the kinetics of X was studied...
The investigation of bioequivalence between *the fixed combination
(association fixe ?), the free combination (association libre ?) and the
single drugs in capsules* was performed in a *parallel group design*.
The two incidences of *AV block II* (je ne suis pas sure du "II", car le
fax est mauvais) which were recorded during the pharmacokinetics studies
occurred in volunterrs receiving X only.
Merci d'avance.
PS : toutes les propositions de sites o� je pourrais trouver des r�pones
sont �galement les bienvenues.
Val�rie
