> Miguel, do you suppose the secret to solvent-accessible surfaces is to
> express them in terms of isosurfaces?

This is the way that it is frequently done.

I chose not to go down that path because I felt that the performance was
unacceptable for proteins of any size.

This marching-cubes algorithm that we are using for isosurfaces generates
a huge number of triangles. That is fine if you have hardware to support
your triangle rendering ... but we have a software graphics engine that is
relatively slow at rendering triangles.

So, this algorithm really gets slow when you have proteins of any size.
That is why I avoided doing it.

The path that I have (repeatedly) gone down is to use a different
algorithm to generate the sasurface.

HOWEVER ... I have not been able to come up with an implementation that
doesn't have other problems. Put more bluntly, I have put a *lot* amount
of effort into my 'better' algorithm over the past two years, and I have
nothing to show for it.

So, the marching-cubes algorithm for solvent-accessible surfaces would be
better than nothing ... and today we have nothing.


Miguel



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