Interesting! Someone who I think was a nurse, can't remember who, was
appalled that the injections were NOT being pulled back to be sure there
was no blood. They were watching the endless TV videos of injections
being given. From this article, it seems they were on to something.
Jan
On 5/07/2021 11:05 am, Kim Holburn wrote:
https://www.biorxiv.org/content/10.1101/2021.06.29.450356v1.abstract
Thrombocytopenia and splenic platelet directed immune responses after
intravenous ChAdOx1 nCov-19 administration.
Vaccines against SARS-CoV-2 are based on a range of novel vaccine
platforms, with adenovirus-based approaches (like ChAdOx1 nCov-19)
being one of them. Recently a rare and novel complication of
SARS-CoV-2 targeted adenovirus vaccines has emerged: thrombosis with
thrombocytopenia syndrome (TTS). TTS is characterized by low platelet
counts, clot formation at unusual anatomic sites and
platelet-activating PF4-polyanion antibodies reminiscent of
heparin-induced thrombocytopenia. Here, we employ /in vitro/ and /in
vivo/ models to characterize the possible mechanisms of this
platelet-targeted autoimmunity. We show that intravenous but not
intramuscular injection of ChAdOx1 nCov-19 triggers
platelet-adenovirus aggregate formation and platelet activation.
After intravenous injection, these aggregates are phagocytosed by
macrophages in the spleen and platelet remnants are found in the
marginal zone and follicles. This is followed by a pronounced B-cell
response with the emergence of circulating antibodies binding to
platelets. Our work contributes to the understanding of TTS and
highlights accidental intravenous injection as potential mechanism
for post-vaccination TTS. Hence, safe intramuscular injection, with
aspiration prior to injection, could be a potential preventive
measure when administering adenovirus-based vaccines.
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