I've built more than a few amps, some with nixies (valve amps) and several 
with uP control.

Its not just the SMPS & potential multiplex noise - you also have the CPU 
clock and its contribution (just love all those square waves) - everything 
from the main clock to serial ports & I2C etc.

Of course its doable, but keep the analogue & digital parts of the system 
well apart - use a star ground and ensure no earth return or power supply 
is shared between the A & D parts.

Cheers

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