Yes, a saturated transistor behaves similar to a short-circuit, but in 
order to do so it must still be properly biased.

The basic rule is: a bipolar transistor will conduct collector current when 
the base-emitter junction is forward-biased.

For an NPN transistor, the base & collector both need to be positive with 
respect to the emitter
For PNP, base & collector need to be negative wrt emitter.

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MOSFETs are "similar" to bipolar transistor, though trickier because they 
generally have reverse-diodes between source ("emitter") and drain 
("collector"). For *most* applications, the reverse-diode is a godsend and 
has no undesireable effects. They dont require any static drive current 
(the gate is synonymous with the base of a bipolar), but they do require 
several volts to turn-on rather than ~0.7V for a bipolar device.

I've used bipolar and MOSFET drivers for nixies; which one to use depends 
upon the application.

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