Looks like you have enough bypass caps; just be sure to place them as close 
as possible to the supply pins on the ICs. Good to see you have separate 
clk & data lines to the HV5530's; you now have total flexibility to avoid 
timing problems.

Be sure to provide enough spacing around high-voltage signals on your PCB. 
Here's a handy calculator: http://www.smps.us/pcbtracespacing.html

The only suggestion is to add an ESD bleeding resistor of 1Meg (approx; not 
critical)  between your circuit GND and the actual power-line ground if you 
have that connection in the case.  You already have a resistive path from 
your HV to GND which will discharge your HV cap.

When I have multiple PC boards that are cabled together, I always have 
ESD/bleed resistors between all power supplies and GND. Usually, the 
largest & cheapest SMT resistor I can buy, which is 10meg, suffices for HV 
supplies.

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