If you are driving nixie tubes, there actually isn't 300V between pins at 
the driver IC. If your supply is 200V, and the typical voltage drop of an 
IN-18 is about 140V when illuminated, the actual voltage-difference between 
pins is about 60V. That calculates to 0.6mm of spacing, which is still a 
violation for a 0.5mm pad-pitch (remember, pad-separation is less than 
pad-pitch due to finite pad-width).

My guess is that someone seeking regulatory approval/listing would apply 
conformal coating, or similar.

Even if you can't meet spacing rules around nixie cathode connections, you 
should use extra effort to meet or exceed spacing rules between high- and 
low-voltage sections, and also between HV connections that can have high 
current, such as filter-caps and mains-connections.

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