Dennis,
 I'll show you how to do it in Excel someday.  But the answer is to use
the SUBPROBLEMS option in the SIMULATION record

SUBPROBLEMS=n
     Requests that the entire NONMEM problem is to be repeated n times
     in  succession  (including all NONMEM steps:  simulation, estima-
     tion, covariance, table, scatterplot). Each  subproblem  includes
     the  Simulation Step, but the random sources are simply continued
     from subproblem to subproblem.  If n=0 or n=1, there is only  one
     subproblem;  this  is  the  default.  May also be coded SUBPROBS,
     NSUBPROBLEMS, NSUBPROBS.


Mark Sale MD
Next Level Solutions, LLC
www.NextLevelSolns.com
 
> 
> 
> > -------- Original Message --------
> > Subject: Re: [NMusers] create simulation file for 5000 patients ?
> > From: "navin goyal" <[EMAIL PROTECTED]>
> > Date: Tue, February 27, 2007 10:28 pm
> > To: "Dennis Fisher" <[EMAIL PROTECTED]>, [email protected]
> > 
> > thanks for the reply.
> > 
> > Could  excel help me if I had less patients say around  100-200.
> > I mean.. could i generate an excel file then ??
> > How could I do it ??
> > 
> > Thanks again.
> > Navin
> > 
> > 
> > 
> >  On 2/27/07, Dennis Fisher <[EMAIL PROTECTED]> wrote: use R or Splus
> > Excel would be a disaster - it is capped at ~ 64000 lines.
> >  
> >   Dennis Fisher MD  P < (The "P Less Than" Company)  Phone: 1-866-PLessThan 
> > (1-866-753-7784)  Fax: 1-415-564-2220  www.PLessThan.com 
> > On Feb 27, 2007, at 1:39 PM, navin goyal wrote: 
> > Hello everybody,
> > I am trying to simulate PKPD data for 5000 patients, with each patient 
> > having around 100 time points.
> > How could I create a data file for this simulation?? 
> > Any help is appreciated. 
> > Thanks
> > 
> >  Navin
> > 
> > 
> >

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