Hi Navin, I have a couple of things to add. As Dr. Holford suggested, use NSUB option in $SIMULATION to simulate 5000 patients with single subject data. You could also add a REPI option in your control stream which might help you later to sort simulations.(http://www.cognigencorp.com/nonmem/nm/99may202003.html). Here is a simple set up example of a PKPD model data file for one patient i would create for simulation. ID TIME AMT DV EVID TYPE 1 0 10 0 1 1 1 0 0 0 0 2 1 1 0 0 0 1 1 1 0 0 0 2 1 2 0 0 0 1 1 2 0 0 0 2 Now, even if you want to build a large database, its possible with Microsoft Access (other than SAS and SPLUS) as it is capable of handling much larger data than Excel 2003 (As far as I know). After creating a database you can export it as .csv file and use it as a input for your NONMEM control stream. However, I believe Microsoft Access would be helpful when you have large data to process after simulations. Hope it helps. Best Regards Nitin Mehrotra Postdoc Research Fellow Dept Pharmaceutical Sciences UTHSC, Memphis, TN-USA
navin goyal <[EMAIL PROTECTED]> wrote: Hello everybody, I am trying to simulate PKPD data for 5000 patients, with each patient having around 100 time points. How could I create a data file for this simulation?? Any help is appreciated. Thanks Navin --------------------------------- Sucker-punch spam with award-winning protection. Try the free Yahoo! Mail Beta.
