Hi Bob,
Thanks for the clarification. Would you agree that the conditional means are more trustworthy, in case there is a relevant difference? In my specific dataset, there are 5 subjects for whom the conditional means yield a much better individual fit, than the "post-hoc" eta's. I believe that in Monolix, the individual parameter estimates are the conditional means, no? In my example Kind regards, Filip -----Oorspronkelijk bericht----- Van: Bauer, Robert [mailto:[email protected]] Verzonden: di 7/08/2012 18:28 Aan: De Ridder, Filip [JRDBE]; [email protected] Onderwerp: RE: NM7.2 SAEM with LIKE Filip: The $TABLE results are obtained from a "post-hoc" assessment at the best fit eta values (modal, EBE), regardless of the method used. To evaluate $TABLE parameters at the conditional mean positions, you may select FNLETA=0. Robert J. Bauer, Ph.D. Vice President, Pharmacometrics, R&D ICON Development Solutions 7740 Milestone Parkway Suite 150 Hanover, MD 21076 Tel: (215) 616-6428 Mob: (925) 286-0769 Email: [email protected] Web: www.iconplc.com<http://www.iconplc.com/> ________________________________ From: [email protected] [mailto:[email protected]] On Behalf Of De Ridder, Filip [JRDBE] Sent: Tuesday, August 07, 2012 10:18 AM To: [email protected] Subject: [NMusers] NM7.2 SAEM with LIKE Dear All, With NM7.2/SAEM, the root.phi output file contains the conditional means (and variances) of the individual phi's (mu(i)+eta(i)) - which is great! I found that the these values can be different from what you get from a $TABLE in more classical way: $PRED MU_1=THETA(1) K=MU_1+ETA(1) ... $TABLE K ... For a some subjects, these are very different, and the ones coming from the $TABLE are clearly less optimal, yielding a bad individual fit, as judged from IPRE calculated in $PRED. I guess one part of the solution is using CPRED and CPREDI - but unfortunately I cannot use these as I (have to) use LIKELIHOOD in $EST (M3 method for BLQ-data). Kind regards, Filip De Ridder Janssen R&D, Beerse, Belgium. ICON plc made the following annotations. ------------------------------------------------------------------------------ This e-mail transmission may contain confidential or legally privileged information that is intended only for the individual or entity named in the e-mail address. If you are not the intended recipient, you are hereby notified that any disclosure, copying, distribution, or reliance upon the contents of this e-mail is strictly prohibited. If you have received this e-mail transmission in error, please reply to the sender, so that ICON plc can arrange for proper delivery, and then please delete the message. Thank You, ICON plc South County Business Park Leopardstown Dublin 18 Ireland Registered number: 145835
