Using these estimates from the phi file may not always be possible/easy. One example is with between-occasion variability (BOV) on PK parameter(s). The .phi file will provide one single phi value while the individual PK parameter will be different between occasions.
Regards Navin Goyal On Tue, Aug 7, 2012 at 6:30 PM, Bauer, Robert <[email protected]>wrote: > ** > Filip: > In your case it may be that conditional means are more appropriate than > conditional modes, but I would not necessarily conclude that in general. > I do not know what Monolix reports regarding individual parameters. > > > Robert J. Bauer, Ph.D. ** **** > > Vice President, Pharmacometrics, R&D**** > > ICON Development Solutions > > 7740 Milestone Parkway > > Suite 150 > > Hanover, MD 21076**** > > Tel: (215) 616-6428 > > Mob: (925) 286-0769**** > > Email: [email protected]**** > > Web: www.iconplc.com > > > ------------------------------ > *From:* De Ridder, Filip [JRDBE] [mailto:[email protected]] > *Sent:* Tuesday, August 07, 2012 3:08 PM > *To:* Bauer, Robert; [email protected] > *Subject:* RE: NM7.2 SAEM with LIKE > > > > Hi Bob, > > Thanks for the clarification. Would you agree that the conditional means > are more trustworthy, in case there is a relevant difference? In my > specific dataset, there are 5 subjects for whom the conditional means yield > a much better individual fit, than the "post-hoc" eta's. > I believe that in Monolix, the individual parameter estimates are the > conditional means, no? In my example > > Kind regards, > > Filip > -----Oorspronkelijk bericht----- > Van: Bauer, Robert [mailto:[email protected]<[email protected]> > ] > Verzonden: di 7/08/2012 18:28 > Aan: De Ridder, Filip [JRDBE]; [email protected] > Onderwerp: RE: NM7.2 SAEM with LIKE > > Filip: > The $TABLE results are obtained from a "post-hoc" assessment at the best > fit eta values (modal, EBE), regardless of the method used. To evaluate > $TABLE parameters at the conditional mean positions, you may select > FNLETA=0. > > Robert J. Bauer, Ph.D. > Vice President, Pharmacometrics, R&D > ICON Development Solutions > 7740 Milestone Parkway > Suite 150 > Hanover, MD 21076 > Tel: (215) 616-6428 > Mob: (925) 286-0769 > Email: [email protected] > Web: www.iconplc.com<http://www.iconplc.com/> > > > ________________________________ > From: [email protected] > [mailto:[email protected]<[email protected]>] > On Behalf Of De Ridder, Filip [JRDBE] > Sent: Tuesday, August 07, 2012 10:18 AM > To: [email protected] > Subject: [NMusers] NM7.2 SAEM with LIKE > > Dear All, > > With NM7.2/SAEM, the root.phi output file contains the conditional means > (and variances) of the individual phi's (mu(i)+eta(i)) - which is great! > I found that the these values can be different from what you get from a > $TABLE in more classical way: > > $PRED > MU_1=THETA(1) > K=MU_1+ETA(1) > ... > $TABLE K ... > > For a some subjects, these are very different, and the ones coming from > the $TABLE are clearly less optimal, yielding a bad individual fit, as > judged from IPRE calculated in $PRED. > > I guess one part of the solution is using CPRED and CPREDI - but > unfortunately I cannot use these as I (have to) use LIKELIHOOD in $EST (M3 > method for BLQ-data). > > > Kind regards, > > Filip De Ridder > Janssen R&D, Beerse, Belgium. > > > > ICON plc made the following annotations. > > ------------------------------------------------------------------------------ > This e-mail transmission may contain confidential or legally privileged > information > that is intended only for the individual or entity named in the e-mail > address. If you > are not the intended recipient, you are hereby notified that any > disclosure, copying, > distribution, or reliance upon the contents of this e-mail is strictly > prohibited. If > you have received this e-mail transmission in error, please reply to the > sender, so that > ICON plc can arrange for proper delivery, and then please delete the > message. > Thank You, > ICON plc > South County Business Park > Leopardstown > Dublin 18 > Ireland > Registered number: 145835 > > > ICON plc made the following annotations. > ------------------------------------------------------------------------------ > This e-mail transmission may contain confidential or legally privileged > information > that is intended only for the individual or entity named in the e-mail > address. If you > are not the intended recipient, you are hereby notified that any disclosure, > copying, > distribution, or reliance upon the contents of this e-mail is strictly > prohibited. If > you have received this e-mail transmission in error, please reply to the > sender, so that > ICON plc can arrange for proper delivery, and then please delete the message. > Thank You, > ICON plc > South County Business Park > Leopardstown > Dublin 18 > Ireland > Registered number: 145835 > > >
