Dear All,
With NM7.2/SAEM, the root.phi output file contains the conditional means (and variances) of the individual phi's (mu(i)+eta(i)) - which is great! I found that the these values can be different from what you get from a $TABLE in more classical way: $PRED MU_1=THETA(1) K=MU_1+ETA(1) ... $TABLE K ... For a some subjects, these are very different, and the ones coming from the $TABLE are clearly less optimal, yielding a bad individual fit, as judged from IPRE calculated in $PRED. I guess one part of the solution is using CPRED and CPREDI - but unfortunately I cannot use these as I (have to) use LIKELIHOOD in $EST (M3 method for BLQ-data). Kind regards, Filip De Ridder Janssen R&D, Beerse, Belgium.
