Lesley Williams
Assistant Director Primary Care Strategy
Londonwide LMCs and Londonwide Enterprise Ltd
Tel:  020 7387 2034 ext *221
Direct Dial:  020 3818 6221
Mobile: 07768 109690
Email: [email protected]<mailto:[email protected]>
Web: www.lmc.org.uk<http://www.lmc.org.uk/>
Twitter: @LondonwideLMCs


Dear all

Please see below in case this has not come through your usual channels.

Kind regards

Lesley



Lesley Williams

Assistant Director Primary Care Strategy

Londonwide LMCs and Londonwide Enterprise Ltd

Tel:  020 7387 2034 ext *221

Direct Dial:  020 3818 6221

Mobile: 07768 109690

Email: [email protected]<mailto:[email protected]>

Web: 
www.lmc.org.uk<https://eur02.safelinks.protection.outlook.com/?url=http%3A%2F%2Fwww.lmc.org.uk%2F&data=05%7C01%7CLesley.Williams%40lmc.org.uk%7Cb404c2656c604c11f4c008da7b033ded%7C5670c82635004dfd9a7fc45939b3c53f%7C0%7C0%7C637957551100765190%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=slwUo9MerxHRuIsXplSVtqXxTgbcB1pnnnj9HrZMH4Y%3D&reserved=0>

Twitter: @LondonwideLMCs




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From: EVANS, Nick (NHS NORTH WEST LONDON ICB - W2U3Z) 
<[email protected]<mailto:[email protected]>>
Sent: 10 August 2022 12:11
To: EVANS, Nick (NHS NORTH WEST LONDON ICB - W2U3Z) 
<[email protected]<mailto:[email protected]>>
Subject: Implementation of the NHS National Framework Agreement for the Supply 
of DOACs in England for Adults with Atrial Fibrillation



Sent on behalf of the Medicines Management team for the attention of NW London 
PCN Clinical Directors - please disseminate to members



The North West London Atrial Fibrillation Working Group has provided guidance 
for 
clinicians<https://eur02.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.nwlondonics.nhs.uk%2Fprofessionals%2Freferral-guidelines-and-clinical-documents%2Fcardiology&data=05%7C01%7CLesley.Williams%40lmc.org.uk%7Cb404c2656c604c11f4c008da7b033ded%7C5670c82635004dfd9a7fc45939b3c53f%7C0%7C0%7C637957551100765190%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=FfsTbHzSEs4m3hHGW4A5D4DNNSVkSl984wUXy1eF3Mo%3D&reserved=0>
 to support them in adopting the principal commissioning recommendation from 
the NHS National Framework Agreement for the Supply of DOACs in England.



The NHS Investment and Impact Fund 2022/23 indicator CVD-06 measures the number 
of patients who are currently prescribed Edoxaban, as a percentage of patients 
on the QOF Atrial Fibrillation register and with a CHA2DS2-VASc score of 2 or 
more (1 or more for patients that are not female) and who are currently 
prescribed a direct-acting oral anticoagulant (DOAC): 
https://www.england.nhs.uk/wp-content/uploads/2022/03/B1357-investment-and-impact-fund-2022-23-updated-guidance-march-2022.pdf<https://eur02.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.england.nhs.uk%2Fwp-content%2Fuploads%2F2022%2F03%2FB1357-investment-and-impact-fund-2022-23-updated-guidance-march-2022.pdf&data=05%7C01%7CLesley.Williams%40lmc.org.uk%7Cb404c2656c604c11f4c008da7b033ded%7C5670c82635004dfd9a7fc45939b3c53f%7C0%7C0%7C637957551100765190%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=bCEsSAFLC7i6VLg8oPN09CuyAFBK8y3PUl0A8b2eIbM%3D&reserved=0>



NHS Commissioning recommendation for patients commencing treatment for Atrial 
Fibrillation - subject to the criteria specified in the relevant NICE 
technology appraisal guidance:

  *   Clinicians should use edoxaban where this is clinically appropriate.

  *   If edoxaban is contraindicated or not clinically appropriate for the 
specific patient then, subject to the criteria specified in the relevant NICE 
technology appraisal guidance, clinicians should then consider rivaroxaban 
first, then apixaban or dabigatran.

NW London Atrial Fibrillation Working Group recommendations

  *   If edoxaban is contraindicated or not clinically appropriate for the 
specific patient, the contraindication or reason(s) that it is not clinically 
appropriate should be documented in patients' notes.

  *   Existing DOAC patients already established on an alternative DOAC for 
Atrial Fibrillation should continue on their current DOAC (provided they are 
not experiencing adverse events of concern and provided their current DOAC is 
not contraindicated).

Please note: This NW London document has taken its key principles for 
initiating new patients on edoxaban when clinically appropriate from the NHS 
England guidance as outlined in the document, 'Anticoagulation for non-valvular 
atrial fibrillation (NVAF) following NHSE DOAC commissioning 
recommendations'.<https://eur02.safelinks.protection.outlook.com/?url=https%3A%2F%2Fevessio.s3.amazonaws.com%2Fcustomer%2F8603be9c-b8c3-49ef-86d2-e4ccb958c5d1%2Fevent%2F9ea04726-5981-493a-871e-91a7eba91159%2Fmedia%2FGeneral_Content%2F2b4b1529-node_FINAL_Guidance_on_prescribing_anticoagulation_in_NVAF_July_22_v2.pdf&data=05%7C01%7CLesley.Williams%40lmc.org.uk%7Cb404c2656c604c11f4c008da7b033ded%7C5670c82635004dfd9a7fc45939b3c53f%7C0%7C0%7C637957551100765190%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=P7z3m03Jt8o%2B10XRufmerIxj5gPd7zwmlgFPIXJDwi8%3D&reserved=0>



For guidance on switching (e.g. from one DOAC to edoxaban), please refer to the 
national guidance document, 'Anticoagulation for non-valvular atrial 
fibrillation (NVAF) following NHSE DOAC commissioning 
recommendations.<https://eur02.safelinks.protection.outlook.com/?url=https%3A%2F%2Fevessio.s3.amazonaws.com%2Fcustomer%2F8603be9c-b8c3-49ef-86d2-e4ccb958c5d1%2Fevent%2F9ea04726-5981-493a-871e-91a7eba91159%2Fmedia%2FGeneral_Content%2F2b4b1529-node_FINAL_Guidance_on_prescribing_anticoagulation_in_NVAF_July_22_v2.pdf&data=05%7C01%7CLesley.Williams%40lmc.org.uk%7Cb404c2656c604c11f4c008da7b033ded%7C5670c82635004dfd9a7fc45939b3c53f%7C0%7C0%7C637957551100765190%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=P7z3m03Jt8o%2B10XRufmerIxj5gPd7zwmlgFPIXJDwi8%3D&reserved=0>


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