Dear Jan,
Propylthiouracil, as with all anti-thyroid drugs, should be taken at the lowest possible dose during pregnancy as they can induce hypothyroidism in the fetus, although Propylthiouracil has lower rate of placental transfer than some of the other anti-thyroid medications. It is a categoroy C which means it is a drug which has, or is suspected of causing harmful efects on the human fetus or neonate without causing malformations. These effects may be reversible. It is also secreted in breast milk although in smaller amounts that some other anti-thyroid drugs. (Australian Medicines Handbook 2000) So it's really a case of weighing-up the pro's and con's.
Hope this helps. Lea.
Leanne Wynne
Midwife in charge of "Women's Business"
Mildura Aboriginal Health Service Mob 0418 371862
>From: [EMAIL PROTECTED] >Reply-To: [EMAIL PROTECTED] >To: <[EMAIL PROTECTED]> >CC: <[EMAIL PROTECTED]> >Subject: [ozmidwifery] graves disease and breastfeeding >Date: Tue, 21 Oct 2003 15:26:22 +1000 > >I have a client who has graves disease. She is taking 3 50 mgs propylthiouracil 3 times a day. I would like to know if anyone has any information regarding the effects this medication may have on breastfeeding a 7 week old boy. The boy has no thyroid problems. Also, if this medication is increased will there be any effects on the breastfeeding. > >Thanks for any help you can give me.jan > >
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