Hi Jen, I am sorry that you are not feeling well post-op. I know it must be hard. I truly believe that you will feel better when you are on the correct hormone replacements. You can take hormone replacements for life, but you will always have to monitor your hormones and the amount of replacement hormones that you need. You will need a very knowledgeable and experienced neuroendocrinologist as well as a reproductive endocrinologist. It will take you and your doctors time to adjust your meds so you can start to feel better. Are you currently taking prednisone/cortef (for adrenal insufficiency), DDAVP (for D.I.), and levoxyl (or another thyroid med)? What replacements are you on? I am sorry that you are having such a hard time post-op. Why did your surgeon perform a craniotomy? Did you have a large tumor? It sounds like the pituitary was damaged during the surgery, which would cause the hypopituitarism (hormone deficiency.) Did your surgeon make you aware of the possibility of hypopituitarism before surgery? Were you told that you are panhypopit (completely pituitary hormone deficient)? Please inform yourself and research as much as you can about your disease and treatments. We are glad to help you find information. We have several pages of links about pituitary tumors, prolactinomas, and hypopituitarism under "Article Links" and "Research Links." We would also be happy to help you find any more information that you are interested in. It is very important to be an informed patient. Please let me know how I can help you learn more about pituitary disease. You're in my prayers. Take care. Meri | 