Orang Israel yang hanya beberapa juta dan nggk punyapetro dollar, itu masih
sempat bikin penelitian begini..
Orang Arab yang kauhlebih banyak dan yang punyapetrodollar boleh dibilang nggak
ada yang sanggup bikin penelitian begini.
Mereka lebih senang menghabiskan waktu mereka untuk saling berbunuhan, bikin
onar dan nyari-nyari ayat yang katanya saintifik di al-Mushaf...
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Web address:
http://www.sciencedaily.com/releases/2008/06/
080604101546.htm
Synthetic Molecules Hold Promise For New Family Of Anti-cancer Drugs
enlarge
Prof. Shimon Gatt (left) and Dr. Arie Dagan in their laboratory at the Hebrew
University--Hadassah Medical School. (Credit: Hebrew University photo by Sasson
Tiram)
ScienceDaily (June 4, 2008) — Synthetic molecules designed by two Hebrew
University of Jerusalem researchers have succeeded in reducing and even
eliminating the growth of human malignant tissues in mice, while having no
toxic effects on normal tissue.
The molecules developed by Dr. Arie Dagan and Prof. Shimon Gatt of the
Department of Biochemistry of the Hebrew University-Hadassah Medical School
affected the metabolism of various sphingolipids and consequently those of
cancer cells. Sphingolipids are a family of complex lipid molecules that are
involved in signaling pathways that mediate cell growth, differentiation and
death.
Several of the most active molecules developed by Dagan and Gatt are
derivatives of ceramide (a member of the sphingolipid family). Ceramide induces
programmed cell death (apoptosis) in a variety of cancer cells.
The natural levels of ceramide in cancer cells are generally too low to induce
a therapeutic effect. In preclinical studies to date, various treatments with
the synthetic molecules resulted in an elevation of ceramide levels in cancer
cells, thereby leading to their death by apoptosis. In addition, these
synthetic molecules appear to be synergistic with chemotherapeutic drugs.
Dagan and Gatt state that their studies demonstrated that their synthetic
compounds reduced considerably the sizes of pancreatic, prostate and breast
tumors with little or no effects on normal cells and tissues. The researchers
see this as a precursor to the development of a new generation of anti-cancer
drugs that induce, selectively, apoptosis only to tumorous cells. These drugs
are expected to be highly effective while inducing fewer side effects than
current anti-cancer drugs.
Prof. Shimon Gatt and Dr. Arie Dagan's development of synthetic sphingolipid
analogs as anti-cancer drugs is patented by Yissum, the technology transfer
company of the Hebrew University of Jerusalem. Yissum licensed the technology
to BioLineRx, a clinical stage drug development company traded on the Tel Aviv
Stock Exchange,, for the development of these synthetic molecules as
anti-cancer drugs.
For their work in developing these harbingers of a possible new generation of
anti-cancer drugs, Dr. Arie Dagan and Prof. Shimon Gatt were among those
receiving the Kaye Award for Innovation June 4 during the 71st meeting of the
Hebrew University of Jerusalem Board of Governors.
Adapted from materials provided by The Hebrew University of Jerusalem.
Need to cite this story in your essay, paper, or report? Use one of the
following formats:
APA
MLA
The Hebrew University of Jerusalem (2008, June 4). Synthetic Molecules Hold
Promise For New Family Of Anti-cancer Drugs. ScienceDaily. Retrieved August 19,
2008, from http://www.sciencedaily.com /releases/2008/06/080604101546.htm
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