I have taken Propantheline for sweating for 44 years and Ditropan for bladder
spasticity until I had my urinary diversion in 1987. This is what I heard
through the years, although not in as much detail. Quotes from Wikipedia, the
1st source that came up in my search.
1. Propantheline bromide (INN) is an antimuscarinic agent used for the
treatment of excessive sweating (hyperhidrosis), cramps or spasms of the
stomach, intestines (gut) or bladder, and involuntary urination (enuresis). It
can also be used to control the symptoms of irritable bowel syndrome and
similar conditions. This agent can also be used for patients who experience
intense GI symptoms while tapering off of TCAs. [1]
Contents [hide]
* 1 Indications
* 2 Adverse effects
* 3 Mechanism of action
* 4 References
[edit]Indications
By relaxing the gut muscle, propantheline can relieve pain in conditions caused
by spasm of the muscle in the gut. Relaxing the smooth muscle in
the bladder prevents the involuntary spasms that can allow leakage of urinefrom
the bladder in the condition known as enuresis (involuntary urination in
adults). Propantheline can also be used to treat excessive sweating because
acetylcholine block also reduces secretions such as sweat and tears.
2. Oxybutynin (Ditropan, Lyrinel XL, Lenditro (South Africa)) is
an anticholinergic medication used to relieve urinary and bladder difficulties,
including frequent urination and inability to control urination (urge
incontinence), bydecreasing muscle spasms of the
bladder.[2] It competitively antagonizes the M1, M2, and M3 subtypes of
the muscarinic acetylcholine receptor. It also has direct spasmolytic effects
on bladder smooth muscle as acalcium antagonist and local anesthetic, but at
concentrations far above those used clinically. It is available orally in
generic formulation or as the brand-names Ditropan, Lyrinel XL, or Ditrospam,
as a transdermal patch under the brand name Oxytrol, and as a topical gel under
the brand name Gelnique.
Oxybutynin is also a possible treatment of hyperhidrosis (hyper-active
sweating).
________________________________
From: Lori Taylor <[email protected]>
To: Larry Willis <[email protected]>; [email protected]
Sent: Wednesday, December 19, 2012 12:19 PM
Subject: Re: Fwd: [QUAD-L] Propantheline
Here's my 2 cents on the comparison......
Ditropan and propantheline are created for the same purpose...to tighten the
sphincter muscle to eliminate urine leakage. I take ditropan/oxybutynin 5mg
2x/day. But, I view propantheline as a 'pain pill for quads' b/c when we have
pain we sweat and this drug stops it. Or at least, minimizes it. I was
introduced to it by another quad around 20 years ago and was amazed at the
difference it made in my daily living. When it was thought that they stopped
making it, I panicked. So, since a few years back, I've stock-piled it and
refill every chance I can. All I know is, that it works for me, my doc
understands, and it helps me from taking a bunch of addictive, mind-altering
pain meds.
Hope this helps...
Lori
________________________________
From: Larry Willis <[email protected]>
To: [email protected]
Sent: Wed, December 19, 2012 8:03:45 AM
Subject: Fwd: [QUAD-L] Propantheline
I have somehow missed the boat on propantheline. This is the first time I have
heard of it. I've been taking ditropan (oxybutynin) for sweating. Does anyone
know how the two compare? Is one better than the other? I need some serious
enlightenment, guys.
Sent from my iPad
Begin forwarded message:
Resent-From: [email protected]
>From: Nan <[email protected]>
>Date: December 18, 2012, 7:51:03 PM EST
>To: "[email protected]" <[email protected]>, quad-list
><[email protected]>
>Subject: Re: [QUAD-L] Propantheline
>Reply-To: Nan <[email protected]>
>
>
Wow, that's for sure!!!
>
>
>Nan
>
>
>
>________________________________
> From: "[email protected]" <[email protected]>
>To: Lori Taylor <[email protected]>; quad-list <[email protected]>
>Sent: Tuesday, December 18, 2012 7:47 PM
>Subject: Re: [QUAD-L] Propantheline
>
>
>I have tried to split the pills but they are so small, also I found that a
>half works about half as long. I am completely lost with out my propantheline.
>I hope they never stop making them or all of us are going to have to do battle
>with the drug co.....ha ha!
>
>Meredith
>
>>________________________________
> From: "Lori Taylor" <[email protected]>
>To: "greg" <[email protected]>, [email protected]
>Sent: Tuesday, December 18, 2012 2:00:22 PM
>Subject: Re: [QUAD-L] Propantheline
>
>
>Hey Greg,
>
>I'm glad to hear Propantheline is working for you. I know it works real well
>for me too. I'm not a doctor, but have been a quad for over 34 years. So, I
>feel the need to give you a bit of caution...
>Sweating and rapid heart rate--heart beating hard are a quad's '6th
>sense'...pain sensory and is a part of dysreflexia...
>
>I cut my 15mg propantheline in half. That way, I can see if I can stop the
>sweating w/out my mouth drying out too bad and w/out my heart beating too
>hard. If I feel ok, but am still sweating after a bit, I take the other
>half. Please be careful b/c what you're dsaying about your heart beat could
>be a recipe for disaster. I'm only saying this b/c I know that feeling.
>
>Please consiider 1/2 a pill.
>
>
>
>
>
>
>
>________________________________
> From: greg <[email protected]>
>To: [email protected]
>Sent: Tue, December 18, 2012 1:31:49 PM
>Subject: [QUAD-L] Propantheline
>
>I sweat so bad during my b-program, it is very uncomfortable. I mean buckets.
>A few people here mentioned Propantheline. I tried it and it worked great. I
>took 15mg.
>The only issues I had was dry mouth for a few hours and my heart beat hard for
>just a bit.
>I really hope it continues to work well, it is so much better.
>I just pop one before I start.
>Thanks everyone for the
tip.
>Greg
>
>
>
>
