I have succesfully achieved this functionality by adding PCIe USB controllers 
and using PCIe passthrough to isolate them to specific domain VMs. With USB 
extension cables it is as simple to use as if VMs were separate physical hosts, 
no problems whatsoever detected.
USB controllers were produced by Unitek brand, generic chinese brand, PCie x1 
card and 3.5 external bay USB front panel. All guests detected the devices 
without any problem.

And as for GPU, I chose to use a separate machine and utilize VNC and Nvidia 
Gamestream to game on Qubes Box, using one of the VMs as a Gamestream client. 
It required minimal troubleshooting due to the usage of unofficial Moonlight 
app for the client.

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