Hello Bert,

Thank you for taking the time to try to answer.

1) I know this, however if one is interested in only interaction between two 
specific factors then in R one uses I(A*B*C) meaning 3-way anova for that and 
not the implicit 2-ways that would otherwise be computed.

2) True, but it fails.

3) No, I don't have any factors with one level, I never said that. It would not 
be a 2^k experiment otherwise, my OP states this clearly, this is a 2^k 
experimental design ___2___

4) this is only your judgmental attitude that many people unfortunately have in 
some of these lists, focussing on ad-hominem judgements or even attacks to try 
to prove their superiority without actually answering nor adding any value to 
the question at hand. I have taken many graduate courses in subjects that have 
all Statistics in the title and passed all of them. However, as an experienced 
Software Engineer working for more than 10 years in the field, I can tell you 
that there is a huge difference between solving toy problems to implementing 
real-life complex projects.  Same rules apply here, one thing is the toy 
examples one finds in R books and course exercises and another totally 
different story is the real life data I am trying to model. I'm a student in 
the quantitative part and learning, so I do have some gaps, I am curious and 
trying to learn and I think there is no shame in that. If this makes you upset 
maybe you should ask to split the list in two or more: "Advanc!
 ed-PhD-black-belt-10th-dan-in-Statistics-and-R level" list and "newbies" list.

Best regards,
Giovanni

On Nov 21, 2011, at 3:55 PM, Bert Gunter wrote:

> Giovanni:
> 
> 1. Please read ?formula and/or An Introduction to R for how to specify
> linear models in R.
> 
> 2. Correct specification of what you want (if I understand correctly) is
> log(R) ~ A*B + C + D
> 
> 3. ... which presumably will also fail because some of your factors
> have only one level, which means that you cannot use them in your
> model.
> 
> 4. ... which, in turn, suggests you don't know what your doing
> statistically and should seek local assistance, especially in trying
> to interpret a fit to an unbalanced model (you can't do it as you
> probably think you can).
> 
> I should say in your defense that posts on this list indicate that
> point 4 is a widely shared problem among posters here.
> 
> Cheers,
> Bert
> 
> On Mon, Nov 21, 2011 at 5:02 AM, Giovanni Azua <brave...@gmail.com> wrote:
>> Hello,
>> 
>> Couple of clarifications:
>> - A,B,C,D are factors and I am also interested in possible interactions but 
>> the model that comes out from aov R~A*B*C*D violates the model assumptions
>> - My 2^k is unbalanced i.e. missing data and an additional level I also 
>> include in one of the factors i.e. C
>> - I was referring in the OP to the 4-way interactions and not 2-way, I'm 
>> sorry for my confusion.
>> - I tried to create an aov model with less interactions this way but I get 
>> the following error:
>> 
>> model.aov <- aov(log(R)~A+B+I(A*B)+C+D,data=throughput)
>> Error in `contrasts<-`(`*tmp*`, value = "contr.treatment") :
>>  contrasts can be applied only to factors with 2 or more levels
>> In addition: Warning message:
>> In Ops.factor(A, B) : * not meaningful for factors
>> 
>> Here I was trying to say: do a one-way anova except for the A and B factors 
>> for which I would like to get their 2-way interactions ...
>> 
>> Thanks in advance,
>> Best regards,
>> Giovanni
>> 
>> On Nov 21, 2011, at 12:04 PM, Giovanni Azua wrote:
>> 
>>> Hello,
>>> 
>>> I know there is plenty of people in this group who can give me a good 
>>> answer :)
>>> 
>>> I have a 2^k model where k=4 like this:
>>> Model 1) R~A*B*C*D
>>> 
>>> If I use the "*" in R among all elements it means to me to explore all 
>>> interactions and include them in the model i.e. I think this would be the 
>>> so called 2-way anova. However, if I do this, it leads to model violations 
>>> i.e. the homoscedasticity is violated, the normality assumption of the 
>>> sample errors i.e. residuals is violated etc. I tried correcting the issues 
>>> using different standard transformations: log, sqrt, Box-Cox forms etc but 
>>> none really improve the result. In this case even though the model 
>>> assumptions do not hold, some of the interactions are found to 
>>> significatively influence the response variable. But then shall I trust the 
>>> results of this Model 1) given that the assumptions do not hold?
>>> 
>>> Then I try this other model where I exclude the interactions (is this the 
>>> 1-way anova?):
>>> Model 2) R~A+B+C+D
>>> 
>>> In this one the model assumptions hold except the existence of some 
>>> outliers and a slightly heavy tail in the QQ-plot.
>>> 
>>> Given that the assumptions for Model 1) do not hold, I assume I should 
>>> ignore the results altogether for Model 1) or? or instead can I safely use 
>>> the Sum Sq. of Model 1) to get my table of percent of variations?
>>> 
>>> This to me was a bit counter-intuitive since I assumed that if there was 
>>> collinearity among factors (and there is e.g. I(A*B*C)) the Model 1) and I 
>>> included those interactions, my model would be more accurate ... ok this 
>>> turned into a brand new topic of model selection but I am mostly interested 
>>> in the question: if model is violated can I or must I not use the results 
>>> e.g. Sum Sqr for that model?
>>> 
>>> Can anyone advice please?
>>> 
>>> btw I have bought most books on R and statistical analysis. I have 
>>> researched them all and the ANOVA coverage is very shallow in most of them 
>>> specially in the R-sy ones, they just offer a slightly pimped up version of 
>>> the R-help.
>>> 
>>> I am also unofficially following a course on ANOVA from the university I am 
>>> registered in and most examples are too simplistic and either the 
>>> assumptions just hold easily or the assumptions don't hold and nothing 
>>> happens.
>>> 
>>> Thanks in advance,
>>> Best regards,
>>> Giovanni
>>> 
>> 
>> 
>>        [[alternative HTML version deleted]]
>> 
>> ______________________________________________
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>> 
> 
> 
> 
> -- 
> 
> Bert Gunter
> Genentech Nonclinical Biostatistics
> 
> Internal Contact Info:
> Phone: 467-7374
> Website:
> http://pharmadevelopment.roche.com/index/pdb/pdb-functional-groups/pdb-biostatistics/pdb-ncb-home.htm

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