Solving from powder data

[Bruce A. Weir]

I have been trying to solve some organic (no heavy elements) crystal
structures from x-ray powder data (not synchrotron) but with limited
success. The first step, after indexing, has been structure factor
extraction via FULLPROF and then trying to get a solution with SHELX97.
Unfortunately, SHELX isn't really designed for use with powder data and
I rarely get a good solution. Can anyone suggest some alternative method
which might give better results?