On 17 Dec 2018, at 19:08, Rob Thompson <r...@chronomics.com> wrote:
> I have compiled bcftools with all the required -lcurl -lcrypto -lssl libs.
> 
> I can read from a public S3 file fine, but as soon as its make private I just 
> get:
> Failed to open FILE.vcf.gz: Permission denied
> 
> AWS credentials are set in ~/.aws/credentials. I have tried exporting them, 
> pre-signed urls, with https instead of s3:// but nothing seems to work.

Assuming you have compiled HTSlib as well, try

        htsfile -vvvvvv s3://FILE.vcf.gz

Cranking up the verbosity this high turns on libcurl's logging of the HTTP 
headers etc sent and received, which will provide some clues.

    John 



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