[ccp4bb] postdoctoral positions available

[Shaun Olsen]

Dear Colleagues,

A postdoctoral position is immediately available for a highly motivated 
individual interested in elucidating molecular mechanisms of ubiquitin 
signaling and DNA repair.  Research is focused on the enzymatic machinery 
responsible for protein ubiquitination and large protein complexes involved in 
regulating DNA repair and immunity.  These issues will be addressed using a 
multidisciplinary approach that includes cryo-EM and X-ray crystallography, 
complemented with biochemical/biophysical techniques and cell-based assays.

Successful candidates will join the vibrant scientific community at UT Health 
San Antonio and enjoy abundant access to state-of-the-art cryo-EM 
instrumentation including a Glacios TEM equipped with a Falcon 4 direct 
electron detector and Selectris Imaging Filter that are the centerpiece of our 
brand new cryo-EM facility.  Access to outstanding X-ray crystallography and 
NMR resources are also available.

Candidates should hold a recently obtained PhD in biochemistry, chemistry, or 
related subject.  Demonstrated expertise in cryo-EM is highly desirable, though 
individuals with expertise in protein chemistry, and/or the biochemical 
analysis of protein ubiquitination and/or DNA repair will also be considered.  
Experience with protein expression in insect and mammalian cells is a plus.

Recent publications highlighting our research interests:
*Structural insights into BCDX2 complex function in homologous recombination 
[https://www.nature.com/articles/s41586-023-06219-w]
*Cryo-EM structures of Uba7 reveal the molecular basis for ISG15 activation and 
E1-E2 thioester transfer [https://www.nature.com/articles/s41467-023-39780-z]
*Crystal structures reveal catalytic and regulatory mechanisms of the 
dual-specificity ubiquitin/FAT10 E1 enzyme Uba6 
[https://www.nature.com/articles/s41467-022-32613-5]
*Activity profiling and crystal structures of inhibitor-bound SARS-CoV-2 
papain-like protease: A framework for anti-COVID-19 drug design 
[https://www.science.org/doi/10.1126/sciadv.abd4596]

Interested candidates should e-mail a cover letter, CV, and the names of three 
references to: ols...@uthscsa.edu.

Best,

-Shaun



To unsubscribe from the CCP4BB list, click the following link:
https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB=1

This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list 
hosted by www.jiscmail.ac.uk, terms & conditions are available at 
https://www.jiscmail.ac.uk/policyandsecurity/

[ccp4bb] Postdoctoral Positions available at Yale School of Medicine

[Alon, Assaf]

Dear Colleagues

The Alon lab at Yale Medical School has openings for outstanding recently 
graduated scientists who are excited about our research. We seek individuals 
with a passion for research and a strong background in biochemistry, structural 
(cryo-EM, x-ray), molecular or cell biology

We are focused on gaining mechanistic insights into the activation, signaling, 
and ligand recognition of understudied and interesting membrane receptors for 
sterol signaling molecules

We apply a multidisciplinary approach, combining structural biology, 
biophysics, pharmacology, drug discovery, and cell biology

Visit our lab webpage for details: 
https://www.thealonlab.org

A complete list of Dr. Alon’s publications is available at: 
https://www.ncbi.nlm.nih.gov/myncbi/1R_B6vwLTh1/bibliography/public/

Candidates must have a PhD degree or equivalent in biological sciences with not 
more than 1 year of postdoctoral training. Interested candidates should have 
training and experience in two or more of the following:

Protein purification from E. coli, insect and/or mammalian cells
Structural biology (X-ray or cryoEM)
Biochemical and biophysical techniques
Cell biology and imaging (experience with generating CRISPR KO lines is 
preferred)
Computational techniques related to structure or drug discovery such as 
protein design, MD simulations, and virtual docking

Interested applicants should send a cover letter, CV, a 1-page research 
summary, and contact information for three references to Dr. Assaf Alon 
(assaf.a...@yale.edu)

—Assaf

Assaf Alon, Ph.D.
Assistant Professor
Department of Pharmacology
Yale University School of Medicine
333 Cedar Street
SHM B326A
203-737-6238
www.thealonlab.org




To unsubscribe from the CCP4BB list, click the following link:
https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB=1

This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list 
hosted by www.jiscmail.ac.uk, terms & conditions are available at 
https://www.jiscmail.ac.uk/policyandsecurity/

[ccp4bb] Postdoctoral Positions available at Scripps Research

[Robyn Stanfield]

Fully funded postdoctoral positions are available in the laboratory of Prof. 
Ian Wilson at Scripps Research  (http://wilson.scripps.edu, email: 
wil...@scripps.edu) for highly motivated candidates who are interested in 
immune recognition and inhibition of microbial pathogens. Specifically, we are 
looking for individuals interested in working on projects focused on 
structure-based design of vaccine candidates, as well as antibody and small 
molecule therapeutics against microbial pathogens. Candidates with prior 
experience in structural biology with interests in virology, immunology, 
infectious disease, antibody and antigen characterization, and 
design/development of vaccines and therapeutics, are encouraged to apply.  For 
more information and the full job posting see:  
https://www.scripps.edu/careers/  under the Department of Integrative 
Structural and Computational Biology, Wilson lab.




To unsubscribe from the CCP4BB list, click the following link:
https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB=1

This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list 
hosted by www.jiscmail.ac.uk, terms & conditions are available at 
https://www.jiscmail.ac.uk/policyandsecurity/

[ccp4bb] Postdoctoral positions available on protein misfolding in Atlanta, GA

[Lieberman, Raquel L]

The Lieberman lab in the School of Chemistry & Biochemistry at Georgia 
Institute of Technology in Atlanta, GA invites applications for Postdoctoral 
Fellows.
Our research projects focus on molecular aspects of protein misfolding in one 
of two systems related to human disease. Our interdisciplinary lab combines 
biochemical, biophysical, and cell biology methods with structural biology 
approaches (X-ray crystallography, small angle X-ray or neutron scattering, 
NMR, cryoEM). We seek to better understand what differentiates diseased 
proteins from their wild-type counterparts, and use this information to develop 
new diagnostics and therapies. More information is available on our website 
http://ww2.chemistry.gatech.edu/lieberman/.
Candidates must have a Ph.D. degree in life sciences, chemistry, biological 
physics, and related fields. Hands-on expertise and publication record in any 
(but not all!) of the following areas is also required: protein biochemistry 
(e.g. enzyme, binding assays, membrane proteins), biophysics (e.g. 
spectroscopy, kinetics of aggregation, AFM imaging), cell biology (e.g. 
mammalian cell culture, Western blotting), or structural biology (e.g. 
crystallography, SAXS, SEC-MALS, NMR).  Experience with molecular biology, 
protein expression and purification are also desirable.
To be considered for a position, please send an email to Raquel Lieberman, 
raquel.lieber...@chemistry.gatech.edu.
 Include your curriculum vitae as well as a short cover letter describing 
research experience, and why you think you would be a good fit for our research 
team.
Georgia Institute of Technology is a top public university in the USA located 
in the urban heart of Atlanta, GA. Georgia Tech is committed to recruiting, 
developing, retaining, and engaging a diverse cadre of students, faculty, and 
staff with a wide variety of backgrounds, perspectives, interests, and talents.

-
Raquel L. Lieberman, Ph. D.
Professor
School of Chemistry & Biochemistry
Georgia Institute of Technology
901 Atlantic Dr. NW
Atlanta, GA 30332-0400



To unsubscribe from the CCP4BB list, click the following link:
https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB=1

[ccp4bb] Postdoctoral positions available in Duke-NUS, Singapore

[Sheemei Lok]

CryoEM post-doctoral positions are available at the Duke-NUS Graduate Medical 
School, Singapore. Duke-NUS Graduate Medical School is a global partnership 
between Duke University in the US and the National University of Singapore. Two 
post-doctoral positions with competitive salary packages are available at the 
laboratory of Shee-Mei Lok (http://www.loksheemeilab.com/) in the Emerging 
Infectious Disease program of the Duke-NUS.  Projects undertaken by the 
post-doc will lead to further understanding of the neutralization mechanism of 
various antiviral therapeutics against flavivirus/alphaviruses viruses. 
Individuals with experience in x-ray crystallography and/or cryoEM image 
reconstruction are highly desirable.Interested individuals should send their 
CV, experience, research interest, and a list of three referees to Dr Shee-mei 
Lok at this email:sheemei@duke-nus.edu.sg.  Regards, Shee-Mei LokAssociate 
Professor/National Research Foundation InvestigatorProgram in Emerging 
Infectious DiseasesDuke-NUS Medical SchoolKTP BuildingLevel 9 8 college 
RoadSingapore 169857Ph:65-65165840 Associate Professor/Principal 
InvestigatorCenter for BioImaging SciencesDepartment of Biological 
SciencesNational University of SingaporeSingapore 



To unsubscribe from the CCP4BB list, click the following link:
https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB=1

[ccp4bb] Postdoctoral positions available

[Barondeau, David P]

Postdoctoral positions are available immediately in the Barondeau lab at Texas 
A University investigating structure-function properties of the mitochondrial 
iron-sulfur cluster biosynthetic complex.  This project has components of 
structural biology, bioinorganic chemistry, enzymology, and chemical biology.
https://www.chem.tamu.edu/rgroup/barondeau/website/documents/Barondeau-lab-postdoc-PhD-positions.pdf

The project is funded by NIH (renewed in 2017) and focuses on 
structure-function properties of the human Fe-S cluster assembly complex. Fe-S 
clusters are ancient protein cofactors that are required for some of the most 
important reactions in biology. Conserved biosynthetic pathways build and 
distribute these clusters to the hundreds, if not thousands, of proteins that 
require Fe-S clusters for their function. In humans, an Fe-S assembly complex 
located in the mitochondrial matrix is responsible for synthesizing Fe-S 
clusters. Defects in the biogenesis of iron-sulfur clusters are directly 
associated with myopathy, neurodegenerative ataxia and ataxia-susceptibility, 
and contribute to genomic instability, the development of cancer, and aging. 
The structural core of this assembly complex consists of cysteine desulfurase 
(NFS1), eukaryotic-specific LYR protein (ISD11), and acyl carrier protein (ACP) 
subunits and is referred to as the SDA complex. We recently reported crystal 
and electron microscopy structures along with functional properties of the 
mitochondrial cysteine desulfurase (NFS1-ISD11-ACP) complex 
(https://www.ncbi.nlm.nih.gov/pubmed/28634302). This manuscript describes 
lock-and-key interactions between the acyl-chain of ACP and ISD11 along with a 
novel cysteine desulfurase architecture.

Highlights of this study:
http://www.science.tamu.edu/news/story.php?story_ID=1812#.WUlPlmjyuUl
https://www-ssrl.slac.stanford.edu/content/science/highlight/2017-09-30/structure-human-cysteinedesulfurase-complex

Objectives of the project
 1. Apply biophysical methods (X-ray crystallography, SAXS, EM, and mass 
spectrometry based methods) to determine the interactions between the three 
accessory proteins and the core SDA complex that constitute the fully 
functional Fe-S cluster assembly complex.
 2. Elucidate the determinants that drive quaternary structure and activity 
differences between NFS1 and its prokaryotic homolog IscS.
 3. Explore how the composition of the acyl-chain associated with ACP and 
post-translational modifications influence the structure of the assembly 
complex and its ability to synthesize Fe-S clusters.
 4. Determine molecular details of the frataxin activation mechanism for 
Fe-S cluster biosynthesis as a step towards a treatment for Friedreich's ataxia.
 5. Investigate the roles of individual proteins in Fe-S cluster assembly 
and distribution networks using a chemical biology approach coupled to global 
fit kinetic analysis. This strategy takes advantage of an intein-based strategy 
to incorporate fluorophore labels that can be used to report cluster content 
(http://pubs.acs.org/doi/10.1021/ja510998s).

To apply for a Postdoctoral position (initial application deadline February 
1st, 2018), see link below:
https://tamus.wd1.myworkdayjobs.com/en-US/TAMU_External/job/College-Station-TAMU/Postdoctoral-Research-Associate-1_R-000735

Please also feel free to contact me at 
barond...@tamu.edu for more information.


-
David P. Barondeau
Associate Professor
Department of Chemistry
Texas A University
301 Old College Main
College Station, TX 77843
Office: ILSB 1196A
Phone: (979) 458-0735
http://www.chem.tamu.edu/rgroup/barondeau/

[ccp4bb] Postdoctoral positions available

[Barondeau, David P]

Dear all,

   We are looking to fill postdoctoral positions in my lab.  See below.

Postdoctoral positions in the Barondeau lab at Texas A University Department 
of Chemistry are available immediately for highly motivated, creative 
individuals with a strong interest in biophysical and/or bioinorganic 
chemistry. Our labs are located in the Interdisciplinary Life Sciences building 
(http://vpr.tamu.edu/resources/ilsb), where we have access to state-of-the-art 
facilities for structural biology, mass spectrometry, and enzymology.

Our group is focused on understanding metallocofactor assembly and the 
functional tuning partnership between metallocofactors and their protein 
environments.

Project 1.  Structure-function studies of the human Fe-S assembly complex. This 
project combines recombinant DNA methods with enzymology, chemical biology, and 
structural methods and is funded by the NIH (renewed in 2017). We recently 
reported crystal and EM structures along with functional properties of the 
mitochondrial cysteine desulfurase (NFS1-ISD11-ACP) complex 
(https://www.ncbi.nlm.nih.gov/pubmed/28634302).
Highlights of our study:

  *   http://www.science.tamu.edu/news/story.php?story_ID=1812#.WUlPlmjyuUl
  *   
https://f1000.com/prime/article?articleId=727738370_medium=email_source=ts
  *   
https://www-ssrl.slac.stanford.edu/content/science/highlight/2017-09-30/structure-human-cysteine-desulfurase-complex

We report lock-and-key or anchoring interactions between the acyl-chain of ACP 
and ISD11 (a member of the eukaryotic-specific LYRM protein superfamily) along 
with a novel cysteine desulfurase architecture. This core cysteine desulfurase 
complex also binds three additional proteins, including the Friedreich's ataxia 
protein frataxin, to generate the fully functional Fe-S cluster assembly 
complex. Our objectives are to elucidate structural properties for how these 
additional proteins bind to the core complex and provide mechanistic details of 
how allosteric protein interactions, lipid binding, and post-translational 
modifications modulate Fe-S cluster biosynthesis.

Project 2. Fluorophore labeling and kinetic interrogation of Fe-S assembly 
pathways. This project (funded by the NSF) combines chemical biology, 
fluorescent plate reader and circular dichroism based assays and global fit 
kinetic analysis to elucidate the function of proteins in bacterial Fe-S 
assembly and transfer pathways. We have previously reported an intein-based 
approach to fluorophore label Fe-S proteins with rhodamine and then use 
fluorescence to monitor cluster content. This approach has the advantage of 
only monitoring Fe-S clusters bound to the protein or protein complex that is 
labeled with the fluorophore. For additional information see 
http://pubs.acs.org/doi/10.1021/ja510998s and 
http://pubs.acs.org/doi/abs/10.1021/acschembio.6b00632. Our objectives are to 
test the proposed roles of iron donor, activator/inhibitor, chaperone, 
intermediate carrier and cluster conversion proteins as well as evaluate 
kinetic vs thermodynamic control in transfer and regulatory pathways.

Contact Dr. David Barondeau (barond...@tamu.edu) for 
additional details.
To apply for a position, please submit a brief description of research 
interests, career goals, CV, and contact information for three references.



-
David P. Barondeau
Associate Professor
Department of Chemistry
Texas A University
301 Old College Main
College Station, TX 77843
Office: ILSB 1196A
Phone: (979) 458-0735
http://www.chem.tamu.edu/rgroup/barondeau/

[ccp4bb] Postdoctoral Positions available - Baxter Laboratory

[Richard Baxter]

Opportunities exist for up to two postdoctoral scholars, available August 1, 
2017, to investigate innate immunity in insects, its role in development, and 
in the transmission of infectious diseases. You will join an interdisciplinary 
group using biochemistry, biophysics, structural biology, and cell-based assays 
in collaboration with experts at the organismal level. Your objective will be 
to elucidate novel molecular mechanisms of immunity, and new connections 
between invertebrate and human immune responses, that can be leveraged to 
predict and disrupt disease transmission.
For more information, visit http://baxterlab.yale.edu.

Applicants should have a Ph.D. in chemistry, biophysics, biochemistry, 
molecular biology, or related discipline, record of peer-reviewed publication, 
and familiarity with standard laboratory techniques such as PCR/molecular 
biology, protein expression and purification, and analysis of proteins and 
nucleic acids by spectroscopy, electrophoresis, etc. The following skills are 
of specific interest:

Project 1: Structural analysis of complement-like proteins in the immune 
response of Anopheles gambiae to Plasmodium infection. Expertise in structural 
techniques such as x-ray crystallography, electron microscopy, small angle 
x-ray scattering, and/or mass-spectrometry techniques for quantitation. 
Experience in eukaryotic cell culture, especially baculovirus expression vector 
systems (BEVS).

Project 2: Functional analysis of Drosophila thioester-containing proteins in 
immunity and development. Expertise in cell-based assays such as flow 
cytometry, microscopy, RNAi knockdown and qPCR, Analysis of protein-protein 
interactions by proteomics/mass-spectrometry. Experience in eukaryotic cell 
culture, including genetic manipulation or antibody production.

Interested applicants please send (i) cover letter, (ii) curriculum vitae, and 
(iii) name and contact information for three references to Prof. Richard Baxter 
by email: richard.bax...@yale.edu.

[ccp4bb] postdoctoral positions available at SIBYLS, Advance Light Source, Lawrence Berkeley National Laboratory

[Michal Hammel]

Details below for a postdoctoral position now open with the SIBYLS group at the 
Advanced Light Source as part of a collaborative project between Lawrence 
Berkeley National Laboratory (LBNL) and the National Cancer Institute (NCI).

Please Email Jane Tanamachi (jtanama...@lbl.gov) for more information or 
questions.

 Are you looking to apply your skills in Integrative Structural Biology to the 
development of new approaches to explore organization of functional bacterial 
chromosome? The SIBYLS Group at Lawrence Berkeley National Laboratory is 
seeking a Postdoctoral Fellow in the field of Integrative Structural Biology. 
The SIBYLS group utilizes a multidisciplinary approach to study the structures 
and functional mechanisms of large macromolecular assemblies in promoting 
chromatin reorganization and transcriptional regulation. Our long-term goal is 
to modulate the functions of important DNA control elements and regulatory 
proteins or RNA’s for the prevention and treatment of various microbial 
infections or cancers.  SIBYLS is also a world class synchrotron resource for 
structural biologists located at the Advanced Light Source, Lawrence Berkeley 
National Lab. SIBYLS scientists maintain productive research programs in 
chromatin remodeling, DNA damage responses, and genome stability. In addition, 
SIBYLS staff has excellent access and exposure to unique facilities, including 
the National Center for X-ray Tomography, the Joint Genome Institute sequencing 
facility, and the Molecular Foundry nanoscience facility. The SIBYLS group also 
has strong interactions with its neighbor, the University of California 
Berkeley, providing an unmatched research environment that combines a 
world-class academic research environment with unique national user facilities.

Essential:Under the general supervision of Dr. Michal Hammel  (LBNL) perform 
research including molecular and biophysical analyses of nucleoprotein 
assemblies in vitro  and cellular imaging at the mesoscale. Approaches to be 
used include: (1) Soft X-ray tomography at the cell level (2)  Static and 
time-resolved studies by small angle X-ray scattering (SAXS) at the nanoscale 
level  (3) Crystallographic studies at the atomic scale (4) Integration of 
crystallographic structures, solution data and cell imaging to obtain 
biologically relevant structures (5) Biochemical and biophysical assays of 
complexes to define conditions that affect their assembly and activities.   (6) 
In the collaboration with Dr. Sankar Adhya (NCI) integrate results from 
specialized cellular biology techniques.

 

Candidates for postdoctoral positions should:

·   Hold or will have a Ph.D. degree in biophysics, bioinformatics, 
biochemistry or cell biology 

·   Passionate about using structural data to influence key scientific 
decisions

·   Strong hands-on skills in molecular biology and protein biochemistry

·   Proven ability to write own scripts in Linux environment and to utilize 
cheminformatics tools

·   Broad knowledge in protein characterization, biophysics and 
bioinformatics with experience in homology modeling and simulation will be 
helpful to drive projects forward

·   Outstanding candidates with different skill sets will be taken into 
consideration, spanning from structural biologists with experience in 
structural biology to cell biologists. 

·   Experiences in SAXS,  SXT or Cryo-EM  preferred but not mandatory



Period:  one year position with  possibility of renewal



Links:

http://sibyls.als.lbl.gov/ 
http://ncxt.lbl.gov/ 
http://newscenter.lbl.gov/2016/07/29/molecular-switch-triggers-bacterial-pathogenicity/
 



__
Michal Hammel PhD
Scientist at Advanced Light Source
Lawrence Berkeley National Laboratory
 
1 Cyclotron Road   MS 6R2100
Berkeley, CA 94720
(phone) 510-495-8179
(cell) 510-457-6317 
 
 mham...@lbl.gov

[ccp4bb] Postdoctoral positions available in Melbourne, Australia - protein chemistry and enzymology of DNA repair

[Andrew Deans]

Two Postdoctoral Positions are available in the Genome Stability Unit @ St 
Vincent's Institute in Melbourne, Australia.

The Genome Stability Unit studies familial cancer syndromes that cause 
predisposition to breast/ovarian cancer, leukaemias and other solid tumours. 
These families inherit a defect in the ability to maintain genome stability and 
accumulate mutations at a faster rate, thus cancer occurs earlier in life with 
a higher probability. This mechanism of genome stability is intricate and 
involves a number of signalling and DNA repair pathways. We reconstitute these 
pathways biochemically using recombinant proteins and synthetic DNA molecules. 
Together with local and international partners, we aim to understand DNA repair 
function and suitability for drug targeting. We are looking for full-time 
postdoctoral leaders of two fully-funded projects:
Project 1: Functional analysis of new breast cancer predisposition genes.

Offers the challenge of developing a new biochemical functional test for 
several breast cancer predisposition genes linked to defects in DNA repair. 
This project is funded by the National Breast Cancer Foundation, and the 
postdoc would participate in a large Australia-wide consortium into familial 
breast cancer predisposition. Experimental approaches include working with 
patient samples, producing recombinant proteins, assaying DNA repair activity 
in vivo and in vitro, and integrating findings with data collected from over 
11,000 individuals from predisposed families. Structural biology components to 
the project are available to those with experience/interest, and the Institute 
is close to the Australian Synchrotron beam line.
Project 2: Development of new chemotherapy sensitisers.

Offers the challenge of identifying new drugs for the treatment of cancer, and 
cancer predisposition disorders. In this project the postdoc would undertake 
preclinical analysis of drug hits identified as inhibitors or activators of DNA 
repair signalling. There would be a particular focus on the Fanconi Anaemia DNA 
repair pathway, for which the lab has international expertise.  Elements of the 
project include biochemical reconstitution of DNA repair processes, and 
assaying and improvement of drugs identified in lab-based screens.

Coming from a strong scientific background, you will be expected to have:
* creativity and scientific curiosity
* independence and ability to collaborate
* a PhD in biology, medicine or chemistry discipline (or completing in early 
2017)
* a track record of producing quality results in a laboratory setting
* at least one first author paper in a strong, peer-reviewed publication

Nice-to-have (but we can teach you if you don't):
* knowledge of DNA repair pathways and processes
* expertise in protein chemistry, cell biology, genetics or oncology (project 1)
* expertise in protein chemistry, drug screening, preclinical development 
(project 2)

Australian postdoc salaries are considerably higher than in the US or Europe 
$74,689-$93,888 (dependent upon experience).
+9.5% superannuation
+generous $15,900 tax-exempt salary packaging
Melbourne is considered one of the world's most liveable cities, and is one of 
the top six biotech hubs:
Research themes and publications http://genomestability.weebly.com
Applications (or enquiries) should be addressed to Dr Andrew Deans 
ade...@svi.edu.au (for project 1) or Dr Wayne Crismani wcrism...@svi.edu.au 
(for project 2). Applications should include a cover letter addressing 
suitability and ambition for the position, 2-3 page CV and academic referee 
contact information. Please apply by January 31, 2017.

[ccp4bb] Postdoctoral Positions Available

[Quyen Hoang]

Postdoctoral Positions at Indiana University School of Medicine 

My lab will have two postdoc positions available, one immediately and the other 
in April 2015. A summary of what we do can be found at 
http://snri.iusm.iu.edu/people/primary-investigators/quyen-q-hoang-ph-d/ 
http://snri.iusm.iu.edu/people/primary-investigators/quyen-q-hoang-ph-d/
No particular skill sets are required. We use a wide range of techniques 
including computational chemistry, molecular biology, protein biochemistry, 
enzymology, X-ray crystallography and other biophysical methods, yeast 
genetics, cell biology, and a little bit of C. elegans. I will show you these 
techniques as they become applicable to your project(s), but you must come with 
a desire to learn and a passion to understand the biological systems at the 
molecular level.

If you are interested, please email your CV and 3 reference letters to 
qqho...@iu.edu mailto:qqho...@iu.edu.

Cheers,

Quyen

[ccp4bb] Postdoctoral positions available at the University of Pittsburgh, Pittsburgh, PA, United States - Structural and molecular pharmacology of GPCRs

[Cheng Zhang]

We have immediate openings for postdoctoral fellows in the lab of Dr. Cheng
Zhang in the Department of Pharmacology and Chemical Biology at School of
Medicine, University of Pittsburgh at Pittsburgh, PA, United States. Our
lab is a newly established lab that focus on the studies of a family of
cell surface receptors - G protein-coupled receptors (GPCRs). The aim is to
understand the molecular mechanisms of the signal transduction by GPCRs,
which represent 30-40% of current drug targets, and to explore the
molecular pharmacology to facilitate future drug design. The initial
research effort will focus on the structural characterization of several
GPCRs that function in inflammation and calcium metabolism in complex with
different ligands and signaling effectors. The main approach is X-ray
crystallography, complemented by EM and NMR methods. The obtained
structural information will be used in the following structure-based drug
design to find new chemicals as potential drugs with desired
pharmacological properties. Also structure-based development of
macro-biomolecules such as antibodies and peptides as potential
pharmaceuticals that can modulate the functional properties of GPCRs is
another research direction. So far several GPCRs as important drug targets
have been successfully prepared in the lab, which are ready for further
structural studies. The potential candidates are expected to perform
structural studies on these receptors and/or develop other biophysical and
cell-based experiments to examine the signaling behaviors of these
receptors in respond to different ligands/drugs.


Interested candidates should be highly motivated and have a PhD with strong
background in one or several of the followings: 1) Molecular cloning and
recombinant protein expression and purification. Experienced in protein
characterization using various biochemical and biophysical methods such as
pull-down, western blot, mass spec, ITC etc. 2) Protein X-ray
Crystallography. 3) Recombinant protein expression in mammalian cells.
Making stable cell lines. FACS setups. Experience with confocol or TIRF is
optional but would be a plus. 4) Antibody production and engineering.
Producing antibodies in hybridoma cells. Antibody characterization by
ELISA. Experience in phage display or yeast display would be a major plus.


We offer a quite exciting and vibrating working environment. There are
several laboratories in the department that focus on the studies of GPCRs.
You will be working with enthusiastic professionals studying GPCRs from
difference perspectives. An competitive salary will be provided based on
previous research experience and accomplishments. The initial appointment
will be one year with the potential to renew every year depending on the
progress of the projects. As for living, Pittsburgh is a very nice city to
live. It has been elected as one of the most livable cities in the US for
years with a diversity of people and culture.


For more information about the lab and the department, please see:
http://www.pharmacology.us/Faculty/ChengZhang


To apply, please send a CV with cover letter to Dr. Cheng Zhang at
chengzh1...@gmail.com. 2-3 reference letters will be requested if you are
shortlisted for call interview.

[ccp4bb] Postdoctoral positions available at EMBL Hamburg

[margret]

Dear all,
I would like to draw your attention to two postdoctoral Vacancy Notices 
in the research group of Dr. Matthias Wilmanns at the EMBL Hamburg Unit:


*Vacancy Notice: HH_00065*
Postdoctoral Fellowship on Structure of Signaling segments in Muscle 
Filament Proteins


Project Outline: Many large muscle filament proteins have extended 
segments of signaling and kinase domains. In an interdisciplinary 
approach with proteomics and cell biology collaborators,
we wish to investigate the functions of these domains in vitro and an in 
vivo. We use combined structural biology approaches, with X-ray 
crystallography being the core method, to characterize

their mechanism of action.

http://ig14.i-grasp.com//fe/tpl_embl01.asp?newms=jjid=52770aid=15470

*
**Vacancy Notice : HH_00067*
Postdoctoral Fellowship in Structural and functional relations of the 
Von Willebond Factor.


Project Outline: The Von Willebrand Factor comprises a large 
multi-domain protein assembly and has crucial roles in blood 
coagulation. Its function is regulated by shear forces. In collaboration
with clinicians, biologists and physicists we are interested in the 
overall structure of this protein and its domains by hybrid structural 
biology approaches.


http://ig14.i-grasp.com//fe/tpl_embl01.asp?newms=jjid=52784aid=15470




best regards
Margret

[ccp4bb] Postdoctoral positions available at Weill Cornell Medical College, New York, NY

[Crina Nimigean]

Exciting research opportunities in the ion channel structure and mechanism area 
are available for two highly motivated post-doctoral fellows at the Weill 
Cornell Medical College in New York City, Department of Anesthesiology. The 
research focuses on analyzing ion channel function with electrophysiology and 
biochemistry as well as ion channel structure with X-ray crystallography. The 
goal of the work in the lab is to develop a mechanistic understanding of 
permeation, selectivity, and ligand gating in ion channels. More specifically, 
the projects involve investigation of the location of the gates in MthK 
potassium channels and the mechanism for ligand binding and activation in 
prokaryotic cyclic nucleotide-gated channels. More information about the lab 
can be found at: http://physiology.med.cornell.edu/faculty/nimigean/lab/

Qualifications and experience: Qualified candidates should have a Ph.D. degree 
and strong background in protein biochemistry and X-ray crystallography, and/or 
in ion channel electrophysiology. Excellent verbal and written English 
communication skills, and ability to work in close collaboration with other 
researchers are required. Qualified applicants should send a cover letter, CV, 
and the names of three references by email to Crina Nimigean at 
crn2...@med.cornell.edu. AA-EOE.






-
Crina Nimigean, Ph.D.
Weill Cornell Medical College
Associate Professor of Physiology and Biophysics in Anesthesiology
Associate Professor of Biochemistry
http://physiology.med.cornell.edu/faculty/nimigean/lab/

Department of Anesthesiology, Box 124
525 East 68th Street, Room A-1050
New York, NY 10065
Phone: (212) 746 5947
Fax: (212) 746 4879

[ccp4bb] postdoctoral positions available for experimental and computational methods for XFEL-based crystallography

[Axel Brunger]

Postdoctoral Positions Available for Experimental and Computational Methods 
Developments for XFEL-based Crystallography



Faculty and staff of the SLAC Accelerator National Laboratory and Stanford 
University are leading an effort to develop methods for structure determination 
of challenging biological systems with the LCLS X-ray free electron laser. The 
effort includes collaborations with Lawrence Berkeley National Laboratory, 
Univ. of California at Berkeley, Univ. of California at Los Angeles, and 
California Institute of Technology. Particular emphasis is on small crystal 
characterization, novel sample delivery systems, data processing, experimental 
phasing, and refinement at low resolution.



Extensive experience in computational or experimental crystallography is 
desirable. Candidates should submit a resume and a list of three references to 
Axel Brunger, Chair of the Bioimaging Working Group at SLAC, 
brun...@stanford.edu.



Axel T. Brunger

Investigator,  Howard Hughes Medical Institute
Professor of Molecular and Cellular Physiology
Stanford University

Web:http://atbweb.stanford.edu
Email:  brun...@stanford.edu  
Phone:  +1 650-736-1031
Fax:+1 650-745-1463

[ccp4bb] Postdoctoral Positions Available - Structural Biologist or Biochemist at UT Southwestern Medical Center

[Xin Liu]

Postdoctoral positions are available for highly motivated scientists in the 
laboratory of Dr. Xin Liu at the University of Texas Southwestern Medical 
Center at Dallas 
(http://www.utsouthwestern.edu/fis/faculty/127166/xin-liu.html). 

The research of the laboratory is focused on the regulation of chromatin 
organization and its impacts on transcription and human diseases. We are 
particularly interested in elucidating the molecular and biophysical basis of 
chromatin dynamics including chromatin looping mediated by macromolecular 
complexes during transcriptional activation and repression. Applicants with 
background and interest in structural biology, protein and nucleic acid 
biochemistry, chromatin and transcription biology, or biophysical methodology 
are encouraged to apply. 

Candidates should submit a CV, a list of three references, and a brief 
statement of research accomplishments and career goals by e-mail to: 
xin@utsouthwestern.edu
 

Xin Liu, Ph.D.
Assistant Professor 
Cecil H. and Ida Green Center for Reproductive Biology Sciences 
Molecular Biophysics Graduate Program
The University of Texas Southwestern Medical Center at Dallas 

5323 Harry Hines Boulevard
J7.104A 
Dallas, TX 75390-8511 
Phone (office): 214-648-2493
Phone (lab): 214-648-4516 
Fax: 214-648-0383 
E-mail: xin@utsouthwestern.edu

[ccp4bb] Postdoctoral positions available

[Liang Tang]

A postdoctoral position is available immediately for a highly motivated 
individual to study structures and functions of proteins and protein 
complexes involved in assembly and genome packaging of DNA viruses such 
as human herpesviruses and bacteriophages by means of X-ray 
crystallography and electron cryo-microscopy in the laboratory of Dr. 
Liang Tang at the Department of Molecular Biosciences, University of 
Kansas (http://www.molecularbiosciences.ku.edu/faculty/tang.html).  The 
position is funded by NIH.  The laboratory has easy access to a Rigaku 
RU-H3RHB X-ray generator with an R-axis IV++ imaging plate system and a 
200kV FEI transmission electron microscope equipped with field emission 
gun, both located on campus. The successful candidate must ideally have 
a recent Ph.D. in biochemistry or a related field with a strong 
background in protein crystallography. For more information and to 
apply, go to: https://jobs.ku.edu and search with the job number 
00067319. Review of applications will begin shortly and will continue 
until the position is filled. University of Kansas is an EO/AA Employer.


--
Liang Tang, Ph.D.
Assistant Professor of Biochemistry and Microbiology
Department of Molecular Biosciences, University of Kansas
8041 Haworth, 1200 Sunnyside Avenue, Lawrence, KS 66045
Voice: 785-864-5838  Fax: 785-864-5294
Email: ta...@ku.edu  HTTP://carbon.bio.ku.edu/
__

[ccp4bb] Postdoctoral positions available

[Liang Tang]

Hi All,

We are seeking highly motivated individuals to fill in postdoctoral 
positions to study structures and functions of proteins and protein 
complexes involved in assembly and genome packaging of complex DNA 
viruses such as human herpesviruses and bacteriophages by means of X-ray 
crystallography and electron cryo-microscopy in the laboratory of Dr. 
Liang Tang at the Department of Molecular Biosciences, University of 
Kansas (http://www.molecularbiosciences.ku.edu/faculty/tang.html).  The 
positions are funded by NIH.  The laboratory has easy access to a Rigaku 
RU-H3RHB X-ray generator with an R-axis IV++ imaging plate system and a 
200kV FEI transmission electron microscope equipped with field emission 
gun both located on campus, and has regular access to synchrotron 
radiation beamlines. Successful candidates must ideally have a recent 
Ph.D. in biochemistry or a related field with a strong background in 
protein crystallography. For more information and to apply, go to: 
https://jobs.ku.edu and search with the job number 00067319. Review of 
applications will begin shortly and will continue until the positions 
are filled. University of Kansas is an EO/AA Employer.


--
Liang Tang, Ph.D.
Assistant Professor of Biochemistry and Microbiology
Department of Molecular Biosciences, University of Kansas
8041 Haworth, 1200 Sunnyside Avenue, Lawrence, KS 66045
Voice: 785-864-5838  Fax: 785-864-5294
Email: ta...@ku.edu  HTTP://carbon.bio.ku.edu/

[ccp4bb] Postdoctoral positions available

[Sylvia Fanucchi]

  

SARChI POSTDOCTORAL FELLOWSHIPS IN PROTEIN BIOCHEMISTRY AND STRUCTURAL
BIOLOGY AT THE UNIVERSITY OF THE WITWATERSRAND SOUTH AFRICA

 

Postdoctoral positions in protein biochemistry and structural biology
are available for suitably qualified PhD graduates to pursue research
into improving our understanding of the relationship between protein
structure and function - one of the foremost challenges in post-genomic
biology. To this end, our research interests are consolidated into two
main areas: (1) the stability, dynamics and folding mechanisms of
multidomain and oligomeric proteins, and, (2) the structural and
energetic foundations of molecular recognition between proteins and
other molecules such as drugs, proteins and membranes. Proteins under
investigation are of relevance to human health and include proteins
involved in molecular toxicology, oxidative stress, cancer, apoptosis
and HIV/AIDS.

 

Excellent in-house facilities are available for protein expression,
purification and crystallisation as well as for state-of-the-art
biophysical techniques such as protein crystallography, UV/Vis, CD and
fluorescence spectroscopy, isothermal titration calorimetry, and
stopped-flow kinetics.

 

Successful candidates should have a PhD degree in biochemistry,
molecular biology, chemistry or crystallography. Good communication
(written and verbal) and interpersonal skills, and computer literacy are
absolute requirements.

 

Interested applicants should send a letter of motivation, CV, PhD
synopsis, certified copy of PhD degree, and a list of three references
with their email addresses to: Prof Heini Dirr, School of Molecular and
Cell Biology, University of the Witwatersrand, Johannesburg 2050, South
Africa. E-mail heinrich.d...@wits.ac.za.


htmlpfont face = verdana size = 0.8 color = navyThis communication 
is intended for the addressee only. It is confidential. If you have received 
this communication in error, please notify us immediately and destroy the 
original message. You may not copy or disseminate this communication without 
the permission of the University. Only authorized signatories are competent to 
enter into agreements on behalf of the University and recipients are thus 
advised that the content of this message may not be legally binding on the 
University and may contain the personal views and opinions of the author, which 
are not necessarily the views and opinions of The University of the 
Witwatersrand, Johannesburg. All agreements between the University and 
outsiders are subject to South African Law unless the University agrees in 
writing to the contrary./font/p/html
image001.jpg

[ccp4bb] Postdoctoral Positions Available in Structural Biophysics and Protein Engineering in Rockville, Maryland, USA

[Scott Walsh]

Postdoctoral Positions Available in Structural Biophysics and Protein 
Engineering in 
Rockville, Maryland, USA

Two NIH funded postdoctoral position are available for highly motivated 
individuals at the 
Center for the Advanced Research in Biotechnology (CARB) at the University of 
Maryland 
Biotechnology Institute in Rockville, Maryland, USA.  Several research projects 
are available 
to study the interleukin-7 signaling pathway at the structural, biochemical, 
and biophysical 
levels.  Candidates must have a Ph.D. degree in biochemistry or a related 
field, with 
experience in molecular biology, bacterial and insect cell protein expression 
and 
purification.  Prior experience in structural (X-ray crystallography or NMR 
spectroscopy) and  
biophysical techniques is preferred.  Salary will be commensurate upon 
experience.  For 
further information or to apply for the positions please send a cover letter, 
CV, and two 
references to Dr. Scott Walsh (email: wal...@umbi.umd.edu).

[ccp4bb] postdoctoral positions available in Duke-NUS, Singapore

[Sheemei Lok]

Crystallography and/or cryoEM post-doctoral positions are available at the 
Duke-NUS Graduate Medical School, Singapore.

Duke-NUS Graduate Medical School is a global partnership between Duke 
University in the US and the National University of Singapore. Post-doctoral 
positions with competitive salary packages are available at the laboratory of 
Shee-Mei Lok in the Emerging Infectious Disease program of the Duke-NUS.  
Projects undertaken by the post-doc will lead to further understanding of the 
neutralization mechanism of various antiviral therapeutics against flavivirus 
and influenza virus [Li et al., 2008 (Science 319:1830-4) and Lok et al., 2008 
(Nat. Struct. Mol. Biol. 15:312-7)]. Individuals with experience in 
crystallography and/or cryoEM image reconstruction are highly desirable.
Interested individuals should send their CV, experience, research interest, and 
a list of three referees to Dr Shee-mei Lok (sheemei@duke-nus.edu.sg).


  

[ccp4bb] Postdoctoral positions available, Xiamen, China

[aidong]

A structural biology lab has now several openings.  This lab conducts  
two aspects of research using X-ray crystallography and other  
biochemical approaches.  One is to understand how a limited number of  
transcriptional factors regulate a large amount of genes.  Our model  
is that two or more transcription factors work together and further  
recruit other protein modification factors to form high-order  
regulatory assemblies on gene promoters.  Another is to study how the  
extracellular signals transfer to a specific set of transcription  
factors.  This involves ligand-protein and protein-protein interaction  
and the proteins associated with cell membranes.  For some details,  
please see http://life.xmu.edu.cn/teacher/HTML/1760.html.  Those who  
have Ph.D in any biology or chemistry disciplines are welcome to  
apply.  Experience in protein biochemistry and/or cell biology will be  
in higher priority.  Training in crystallography will be big plus.




Xiamen island is the most beautiful city, and Xiamen University has  
one of few best university campus over China.  It is so comfortable to  
live that it grows a big foreigner community.  Please see www.xmu.edu.cn/english 
 for university and http://www.amoymagic.com for Xiamen.




Successful candidates will be provided with a standard package from  
Xiamen University including convenient low-cost apartment, medical  
insurance and family assistance.  If interested, please send your CV  
and contacts of 3 referees to Dr. Aidong Han through a...@xmu.edu.cn.   
Thank your attention. 

[ccp4bb] Postdoctoral Positions Available in Structural Biophysics in Maryland, USA

[Scott Walsh]

Postdoctoral Positions Available in Structural Biophysics in Maryland, USA

 Several NIH funded postdoctoral positions are available at the Center for the 
Advanced Research in Biotechnology (CARB) at the University of Maryland 
Biotechnology Institute in Rockville, Maryland, USA.  Several research projects 
are available to study the interleukin-7 signaling pathway at the structural, 
biochemical, and biophysical levels.  Candidates must have a Ph.D. degree in 
biochemistry or a related field, with experience in molecular biology, protein 
expression and purification.  Prior experience in structural (X-ray 
crystallography or NMR spectroscopy) and biophysical techniques is preferred. 
Salary will be commensurate upon experience.  For further information or to 
apply for the positions please send a cover letter, CV, and two references to 
Dr. Scott Walsh (email: [EMAIL PROTECTED]).

 

[ccp4bb] postdoctoral positions available in Bethesda Maryland, USA

[Shuishu Wang]

Postdoctoral Positions Available in Protein Crystallography

Two postdoctoral positions are available at the Department of
Biochemistry, Uniformed Services University, Bethesda, Maryland, USA,
to perform structural and biochemical research on potential drug
target proteins from Mycobacterium tuberculosis.  The candidates will
be involved in recombinant protein expression and purification,
biochemical analysis, and crystal structure determination.  Candidates
must have a Ph.D. degree in biochemistry or a related field, with
experience in protein expression and purification.  Prior experience
in X-ray crystallography is preferred. Uniformed Services University
is located across the street from the National Institute of Health
(NIH) campus in Bethesda, Maryland.  For more details about the lab,
department, and university, please visit http://www.usuhs.mil/bio/.
Interested persons please send CV with names of at least two referees
by e-mail to:

Shuishu Wang
Assistant Professor
Department of Biochemistry
Uniformed Services University
4301 Jones Bridge Road
Bethesda, Maryland 20814

e-mail: [EMAIL PROTECTED]

[ccp4bb] Postdoctoral positions available in Norwich, UK

[Mark Banfield]

Hi everyone,

I'd like to bring to the attention of anyone looking for a postdoc position
in structural biology that I currently have two vacancies in my lab., which
is based in Norwich in the UK.

These projects are focussed on structure/function studies of 'effector'
proteins from microbial pathogens.

For further details of the projects, the laboratory and how to apply please
see either:

1. http://jobs.jic.ac.uk/Details.asp?vacancyID=1904

2. http://www.uea.ac.uk/hr/jobs/ra/ra479.htm

The positions are also advertised on http://www.jobs.ac.uk and
http://naturejobs.com.

Please note the closing dates for applications are next week. Informal
enquiries are welcome to the address below.

Mark 

-- 
Dr Mark Banfield
Dept. of Biological Chemistry
John Innes Centre
Norwich
NR4 7UH
UK
email: [EMAIL PROTECTED]