subject:"\[ccp4bb\] Postdoctoral position"

Re: [ccp4bb] Postdoctoral position at the Sussex Drug Discovery Centre

2024-05-13 Thread Erika Mancini

Dear ccp4bb community,

There are just a few days left to apply for this position - deadline 17th of 
May.
Many thanks


We have a postdoctoral position available to join the Drug Discovery team at 
the Sussex Drug Discovery Centre (SDDC) under the supervision of Prof Erika 
Mancini and Prof John Spencer.
The successful candidate will work in a multidisciplinary environment on an 
exciting and emerging area of oncology drug discovery and interact closely with 
our cellular biology and medicinal chemistry teams.
The Post-doc will be involved in high-throughput X-ray crystallography, 
fragment-based screening and structure-based drug design and will be 
responsible for crystallisation, structure determination, structural and 
biophysical analysis of protein-ligand complexes.
This is a one year contract funded by Omaze-Blood Cancer UK for a collaborative 
project with the group of Prof Nerlov at the University of Oxford.

For more information on the job and how to apply, please visit the following 
link:
https://jobs.sussex.ac.uk/job/91c964e4-e58f-4504-aafe-ca239bf7220b

[https://cdn1.site-media.eu/images/1200x630/6990143/logo-black.png]
Research Fellow Ref 30876 - Job page - University of Sussex Job 
Search
jobs.sussex.ac.uk
For any questions, feel free to send me an email.
Erika




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[ccp4bb] Postdoctoral position - Ion Channels

2024-05-07 Thread Krishna Chinthalapudi

Dear All,



Applications are invited for a joint postdoctoral scientist position in the
laboratories of Dr. Thomas Hund and Dr. Krishna Chinthalapudi in The Davis
Heart and Lung Research Institute at the Ohio State University. The
research project focuses on understanding the role of ion channels in
health and disease. We combine state-of-the-art structural biology
approaches including cryo-EM, X-ray crystallography, and electrophysiology
with biochemical, biophysical, and cell biological methods to investigate
how ion channels function in health and disease.



Our laboratories are equipped with state-of-the-art instrumentation for the
proposed studies and have generous access to a Titan Krios G3i Cryo-TEM
equipped with a K3 direct electron detector, imaging phase plates, and an
image spherical aberration corrector. In addition, our labs have access to
Glacios with a Falcon III detector and Ceta-D camera for MicroED analysis
at the world-class Center for Electron Microscopy and Analysis (CEMAS) at
the Ohio State University.



Applicants must have a Ph.D. in structural biology, biochemistry, or a
related field. Expertise in molecular biology techniques, membrane protein
expression and purification, electrophysiology, and/or high-resolution
imaging are desirable.



To be considered for this position, please email your curriculum vitae, a
short cover letter with research experience and interests, and contact
information for three references to Krishna Chinthalapudi
(*krishna.chinthalap...@osumc.edu
*) and Thomas Hund (thomas.h...@osumc.edu).



Thank you,

Krishna



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[ccp4bb] Postdoctoral position at the Sussex Drug Discovery Centre

2024-04-28 Thread Erika Mancini

Dear ccp4bb community,

We have a postdoctoral position available to join the Drug Discovery team at 
the Sussex Drug Discovery Centre (SDDC) under the supervision of Prof Erika 
Mancini and Prof John Spencer.
The successful candidate will work in a multidisciplinary environment on an 
exciting and emerging area of oncology drug discovery and interact closely with 
our cellular biology and medicinal chemistry teams.
The Post-doc will be involved in high-throughput X-ray crystallography, 
fragment-based screening and structure-based drug design and will be 
responsible for crystallisation, structure determination, structural and 
biophysical analysis of protein-ligand complexes.
This is a one year contract funded by Omaze-Blood Cancer UK for a collaborative 
project with the group of Prof Nerlov at the University of Oxford.

For more information on the job and how to apply, please visit the following 
link:
https://jobs.sussex.ac.uk/job/91c964e4-e58f-4504-aafe-ca239bf7220b

[https://cdn1.site-media.eu/images/1200x630/6990143/logo-black.png]
Research Fellow Ref 30876 - Job page - University of Sussex Job 
Search
jobs.sussex.ac.uk
For any questions, feel free to send me an email.
Erika




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[ccp4bb] Postdoctoral Position - Institut de Biologie Structurale (IBS/PATBAC) - Grenoble - France

2024-04-26 Thread Carlos CONTRERAS-MARTEL


Dear CCP4 community,

a postdoctoral research position financed by the National Research 
Agency is on offer by the Bacterial Pathogenesis Group (DR Andréa 
DESSEN) at the IBS (Institut de Biologie Structurale) in Grenoble. Our 
group focuses on the study of the various mechanisms used by the 
bacteria to initiate an infection and concentrates on the bacterial 
cell-wall, virulence factors and secretion systems.


See details in :

https://emploi.cnrs.fr/Offres/CDD/UMR5075-CYNDAV-062/Default.aspx

--
 Carlos CONTRERAS MARTEL, Ph.D.
 (CRHC CNRS)

 carlos.contreras-mar...@ibs.fr

 "Bacterial Pathogenesis Group"
Institut de Biologie Structurale
 UMR5075 CEA-CNRS-UGA

  IBS (PATBAC)
  Campus EPN
  71, avenue des Martyrs
  CS 10090
  38044 Grenoble CEDEX 9
  FRANCE


 tel : (+33) (0)4 57 42 86 41

http://www.ibs.fr/groupes/groupe-pathogenie-bacterienne/?lang=fr
http://www.ibs.fr/groups/bacterial-pathogenesis-group/?lang=en



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[ccp4bb] Postdoctoral Position in X-ray Crystallography Available

2024-04-23 Thread Alise Mendoza

A postdoctoral position in X-ray crystallography is open in Dr. Fang Li's
laboratory at the Department of Pharmacology, University of Minnesota
Medical School. The focus of our research is on understanding the
biochemical and structural mechanisms behind viral infections and cancer,
and on developing therapeutic strategies against these diseases. Further
information about Dr. Li's lab is available at
http://www.msi.umn.edu/~lifang.

Applicants are required to have a PhD in X-ray crystallography and should
have first-authored publications in peer-reviewed journals specifically on
crystallography. The salary for this position conforms to NIH standards.

To apply, please submit a statement of research interest and your CV to
cook0...@umn.edu.

Additionally, please arrange for two reference letters to be sent directly
to the same email address.



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[ccp4bb] PostDoctoral Position in GPCR Structural Biology at USC, Los Angeles

2024-04-17 Thread Cornelius Gati

PostDoctoral Position in GPCR Structural Biology at USC, Los Angeles


The position is available starting immediately in the Department of Biological 
Sciences at the University of Southern California and is initially limited to 2 
years, with possible extension.


Our research focuses on the structural biology of G protein-coupled receptors 
involved in neurobiology and immunology, using single particle cryoEM, 
complemented with biophysical assays.


USC has a suite of research facilities and has recently commissioned a 
brand-new cryoEM facility:

• CryoEM suite: Titan Krios with GIF Quantum energy filter and K3 detector, 
Glacios with Falcon 4 detector, Talos Arctica with CCD/side entry holder for NS 
and screening
• Core facility for insect- and mammalian cell expression
• High performance computing for data processing/analysis


Qualified candidates must have a Ph.D. degree with a solid background in 
structural biology and biophysics/biochemistry. Previous work with membrane 
protein purification and experience with cryoEM data analysis is a plus. A 
successful candidate is expected to be highly skilled and self-motivated and is 
willing to work in a collaborative environment. The Postdoctoral salary depends 
on qualifications and relevant experiences according to USC standards.


Interested candidates should apply directly with Cornelius Gati at 
gati[at]usc.edu. Please attach a cover letter, Curriculum 
Vitae, research statement, publication list and a reference letter. There is no 
deadline for this posting and applications will be evaluated on a rolling basis.


Current group website: https://dornsife.usc.edu/gati/



Recent work from our group includes:


Molecular basis of anaphylatoxin binding, activation, and signaling bias at 
complement receptors.

Yadav MK, Maharana J, Yadav R, Saha S, Sarma P, Soni C, Singh V, Saha S, 
Ganguly M, Li XX, Mohapatra S, Mishra S, Khant HA, Chami M, Woodruff TM, 
Banerjee R*, Shukla AK*, Gati C*. Cell. (2023)


Structural basis of GABA reuptake inhibition.

Motiwala Z, Aduri NG, Shaye H, Han GW, Lam JH, Katritch V, Cherezov V, Gati C*. 
Nature. 606 (2022) 820-826


Structural basis of metabotropic GABA receptor activation.

Shaye H, Ishchenko A, Lam JH, Han GW, Xue L, Rondard P, Pin JP, Katritch V, 
Gati C*, Cherezov V*. Nature. 584 (2020) 298-303


A mycobacterial ABC transporter mediates the uptake of hydrophilic compounds.

Rempel S, Gati C*, Nijland M, Thangaratnarajah C, Karyolaimos A, de Gier JW, 
Guskov A, Slotboom DJ*. Nature. 580 (7803) (2020) 409-412



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[ccp4bb] Postdoctoral Position in Antibody Design of Ion Channel modulators

2024-02-28 Thread Paul Miller

Applications are invited for a postdoctoral researcher position to study 
antibody design and molecular mechanisms of modulation of ion channels. You 
will be part of the Modular Activator and Silencer Therapeutics (MAST) team 
developing novel platforms of antibodies, E3 ligase-mediated degraders, and 
proteases, to advance drug discovery, with the opportunity for superb 
mentorship support from the programme, which involves the labs of Laura Itzhaki 
(degraders; PMID 33623657), Paul Miller (ion channel antibodies; PMID 
35140402), Florian Holfelder (proteases; PMID 36765057), Mark Howarth 
(antibodies; PMID 36865256), Catherine Wilson (degraders; PMID 32286286), and 
Pietro Sormanni (antibody design; PMID 37024501)



The applicant will develop synthetic libraries of conformational antibodies 
that can act as modulators of ion channels, identify hits from phage display, 
and demonstrate proof-of-concept modulation by solving cryo-EM structures (and 
by electrophysiology). This project provides opportunities for creative protein 
engineering, including database mining (to build structural antibody 
libraries), machine learning (AI) approaches to antibody design, phage display, 
and cryo-EM of ion channels.



The applicant will have completed a PhD (or soon to be awarded one), and will 
have relevant wet-lab experience that includes protein engineering and/or 
structural biology (cryo-EM or X-ray crystallography) and/or phage display 
and/or computational approaches to analysing protein and antibody structure.



Recent relevant publications are:



Kasaragod VB, Mortensen M, Hardwick SW, Wahid AA, Dorovykh V, Chirgadze DY, 
Smart TG, Miller PS.

Mechanisms of inhibition and activation of extrasynaptic alpha-beta GABAA 
receptors. Nature, 2022, Feb, 602(7897), p. 529-533. PMID: 35140402. 
https://www.nature.com/articles/s41586-022-04402-z



Kasaragod VB, Malinauskas T, Wahid AA, Lengyel J, Knoflach F, Hardwick SW, 
Jones CF, Chen W-N, Lucas X, Omari K, Chirgadze DY, Aricescu AR, Cecere G, 
Hernandez M-C, Miller PS.

The molecular basis of drug selectivity for *5 subunit-containing GABAA 
receptors. Nature Structure and Molecular Biology, 2023, Dec, 30(12), 
p.1936-1946. PMID: 37903907.

https://www.nature.com/articles/s41594-023-01133-1



Ramon, Aubin, Montader Ali, Misha Atkinson, Alessio Saturnino, Kieran Didi, 
Cristina Visentin, Stefano Ricagno, Xing Xu, Matthew Greenig, and Pietro 
Sormanni.

Assessing Antibody and Nanobody Nativeness for Hit Selection and Humanization 
with AbNatiV.

Nature Machine Intelligence, 15 January 2024.

https://doi.org/10.1038/s42256-023-00778-3





Application Closing date: 24th March 2024

Project start date: 14th May 2024 with flexibility in the precise start date 
and continue for 24 months in the first instance.

For more details and to apply: https://www.jobs.cam.ac.uk/job/45358/

Informal enquiries about the position can be made to Dr Paul Miller 
(pm...@cam.ac.uk)

For enquiries about the online application process please contact Debbie 
Stanley, phar...@lists.cam.ac.uk

Paul Miller (he/him), PhD
University Lecturer in Pharmacology
Department of Pharmacology
University of Cambridge
Tennis Court Road
Cambridge
CB2 1PD
+44 1223 761267
https://www.phar.cam.ac.uk/research/miller



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[ccp4bb] Postdoctoral position

2024-02-26 Thread Hernando J Sosa

The Sosa Laboratory in the Albert Einstein College of Medicine is currently 
seeking a highly motivated and talented Postdoctoral Researcher to join our 
group. Research in our lab is dedicated to uncovering the mechanisms of action 
of various biological macromolecular machines, employing a diverse set of 
experimental approaches. The successful candidate will play a key role in 
elucidating the mechanisms underlying the function of members of the kinesin 
superfamily of motor proteins, including their pathogenic variants.



Applicants for this position should hold a Ph.D. in Biophysics, Biochemistry, 
Cell Biology, or a closely related field. A strong background and expertise in 
cryo-EM techniques are highly desirable. The ideal candidate will have a proven 
track record of productivity and scientific contributions, as evidenced by 
publications in peer-reviewed journals. Excellent communication and 
interpersonal skills, along with the ability to work both independently and 
collaboratively in a team-oriented research environment, are essential.



Interested applicants are invited to submit their application materials, 
including a Curriculum Vitae (CV), professional references, and a cover letter 
highlighting relevant experience and research interests, via email to:  
hernando.s...@einsteinmed.edu.  The 
position is available for an immediate start, and applications will be 
considered until the position is filled.



We offer a competitive salary commensurate with experience, access to 
state-of-the-art research facilities and resources, as well as opportunities 
for professional development and career advancement in a collaborative and 
stimulating research environment. For a complete list of the postdoctoral 
salary ranges, please visit our website:

https://www.einsteinmed.edu/research/belfer-institute/postdoctoral-policies/. 
The salary for this position exceeds the guidelines set by the NIH, ensuring 
competitive compensation.



The Albert Einstein College of Medicine is an Equal Opportunity/Affirmative 
Action Employer. All qualified applicants will receive consideration for 
employment without regard to race, color, religion, sex, sexual orientation, 
gender identity, national origin, age, protected veteran or disabled status, or 
genetic information. Einstein seeks candidates whose skills, and personal and 
professional experience, have prepared them to contribute to our commitment to 
diversity and excellence, and the communities we serve.

___
Hernando Sosa, PhD.
Dept. of Biochemistry
Albert Einstein College of Medicine
1300 Morris Park Av.
Bronx NY 10461
phone (718) 430-3456
emai:  hernando.sosa@einsteinmed.edu
___





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[ccp4bb] Postdoctoral position - Ion Channels

2024-02-24 Thread Krishna Chinthalapudi

Dear All,



Applications are invited for a joint postdoctoral scientist position in the
laboratories of Dr. Thomas Hund and Dr. Krishna Chinthalapudi in The Davis
Heart and Lung Research Institute at the Ohio State University. The
research project focuses on understanding the role of ion channels in
health and disease. We combine state-of-the-art structural biology
approaches including cryo-EM, X-ray crystallography, and electrophysiology
with biochemical, biophysical, and cell biological methods to investigate
how ion channels function in health and disease.



Our laboratories are equipped with state-of-the-art instrumentation for the
proposed studies and have generous access to a Titan Krios G3i Cryo-TEM
equipped with a K3 direct electron detector, imaging phase plates, and an
image spherical aberration corrector. In addition, our labs have access to
Glacios with a Falcon III detector and Ceta-D camera for MicroED analysis
at the world-class Center for Electron Microscopy and Analysis (CEMAS) at
the Ohio State University.



Applicants must have a Ph.D. in structural biology, biochemistry, or a
related field. Expertise in molecular biology techniques, membrane protein
expression and purification, electrophysiology, and/or high-resolution
imaging are desirable.



To be considered for this position, please email your curriculum vitae, a
short cover letter with research experience and interests, and contact
information for three references to Krishna Chinthalapudi
(*krishna.chinthalap...@osumc.edu
*) and Thomas Hund (thomas.h...@osumc.edu).



Thank you,

Krishna



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[ccp4bb] Postdoctoral position is available in the laboratory of Dr Igor Barsukov (University of Liverpool UK)

2024-02-15 Thread Antonyuk, Svetlana

Postdoctoral Position in Structural Biology of Cell-Matrix Adhesion

We are currently recruiting for a 3-year postdoctoral position in the field of 
Structural Biology of Cell-Matrix Adhesion at the Biochemistry and Cell Biology 
department of Liverpool University, UK. This position is funded by the BBSRC 
and offers a unique opportunity to contribute to cutting-edge research in the 
laboratory of Dr. Igor Barsukov.

As a successful candidate, you will have a strong background and expertise in 
either protein NMR spectroscopy or X-ray crystallography. Your primary focus 
will be on studying the structure and function of protein complexes involved in 
the formation of cell-matrix fibrillar adhesions, which play a crucial role in 
tissue formation, integrity, and regeneration. Recent research in our 
laboratory has highlighted the regulatory role of the adaptor protein tensin in 
fibrillar adhesions, particularly through its interactions with integrins and 
other proteins within the adhesion complexes. However, the precise mechanisms 
underlying this regulation, particularly the ability of tensin to form 
molecular condensates through phase separation, are not fully understood. In 
this position, you will utilize a wide range of biophysical techniques and 
advanced protein modifications to investigate the molecular details of tensin 
condensation and its interaction with integrin and other adhesion proteins.

Our department offers a supportive and technology-rich research environment for 
structural biology and biochemistry. This includes access to state-of-the-art 
facilities such as a High-Field NMR facility equipped with 600, 700, and 800 
MHz spectrometers with high-sensitivity cryo probes. We also have a Barkla 
X-ray crystallography facility with regular access to powerful synchrotron 
radiation facilities, as well as a protein analysis facility with advanced 
instruments for studying protein interactions.

To be considered for this position, you should hold a PhD degree in Biological 
Sciences or Chemistry. The post is available for a duration of 3 years. For 
more information, please contact Dr. Igor Barsukov at i...@liverpool.ac.uk.

To apply for this position and for more detailed information, please visit 
http://tinyurl.com/5e35csak. The closing date for applications is 15-Feb-2024





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[ccp4bb] Postdoctoral position at the Karolinska Institute, Stockholm

2024-02-06 Thread Opher Gileadi

A highly motivated, skilled and experienced post-doctoral research fellow in 
protein production/structural biology is needed to work at SGC-Karolinska in 
our IMI (EU and Pharma) funded EUbOPEN project. You will be part of a 
collaborative research environment, driving the characterization of human 
disease-linked genes at the protein level: developing or implementing 
expression and purification strategies, characterizing the proteins 
biophysically and biochemically, developing activity assays and supporting the 
development of antibody and/or small-molecule reagents. For selected targets 
you will pursue structural studies. Your work will involve a variety of target 
classes, with a focus on inflammation and autoimmunity-related targets.

Application deadline: Feb 27.

https://ki.varbi.com/se/what:job/jobID:699513/



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[ccp4bb] Postdoctoral position University of Oxford (UK)

2024-02-05 Thread Abimael Cruz Migoni

Title: Postdoctoral position University of Oxford (UK)

Weatherall Institute of Molecular Medicine, John Radcliffe Hospital,
Headington, Oxford OX3 9DU

About the role

Working with Prof. Peter McHugh's research group to contribute to the study of
DNA repair.

The post holder will be responsible for characterising repair factors through
structural biology techniques, with a focus on cryo-electron microscopy. Ideal
candidates should have expertise in molecular cloning, protein expression,
purification, and structural methods, preferably in crystallography and
electron microscopy. Knowledge of DNA modification enzymes and a background in
DNA damage and repair fields are highly desirable.
Your responsibilities encompass testing hypotheses, managing academic research,
developing scientific techniques, characterizing nucleases, staying updated on
DNA repair advancements, and contributing to projects and grant proposals.
You'll attend meetings, present reports, engage in scientific presentations,
write for publication, and ensure compliance with safety protocols.
Additionally, you'll manage lab equipment, provide guidance to team members,
train juniors, and participate in public engagement activities.

The post will be based at the Weatherall Institute of Molecular Medicine, John
Radcliffe Hospital, Headington, Oxford OX3 9DU , and is offered on a full-time
basis, fixed-term for 2 years in first instance.

Please apply via this link:

https://my.corehr.com/pls/uoxrecruit/erq_jobspec_version_4.display_form?p_company=10_internal_external=E_display_in_irish=N_process_type=_applicant_no=_form_profile_detail=_display_apply_ind=Y_refresh_search=Y_recruitment_id=170882

Dr. Abimael Cruz Migoni
Postdoctoral Scientist

Prof. Peter McHugh lab
Weatherall Institute of Molecular Medicine,
Dept. of Oncology
University of Oxford
John Radcliffe Hospital/Headley Way,
Oxford OX3 9DS

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[ccp4bb] postdoctoral position - time-resolved serial crystallography

2024-02-05 Thread Przemyslaw Nogly

Dear All,

We have an exciting opening for a postdoctoral position in my group at the 
Jagiellonian University to investigate photoreceptor proteins with 
time-resolved serial crystallography.

For details and applications:
https://www.nature.com/naturecareers/job/12813689/postdoctoral-researcher-at-the-dioscuri-centre-for-structural-dynamics-of-receptors/?LinkSource=PremiumListing
Closing date is 17.03.2024

Best regards,
Przemek

Przemyslaw Nogly, Ph.D.
Group Leader of the Dioscuri Centre for Structural Dynamics of Receptors
Faculty of Biochemistry, Biophysics and Biotechnology
Jagiellonian University
Gronostajowa 7, Room C041
30-387 Krakow, Poland
+48 12 664 6339 
https://noglylab.eu/



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[ccp4bb] Postdoctoral position at Center for Structural Biology (CBS) in Montpellier, France

2024-01-24 Thread William Bourguet

 Dear colleagues,

Our team “Nuclear receptors as integrators of endogenous and environmental
signals” (https://www.cbs.cnrs.fr/index.php/en/home-equipea5) has an
opening for a 2-year postdoctoral research fellow funded by the French
National Research Agency.

Project
A number of compounds present in the environment act as endocrine
disruptors and cause adverse effects in humans and wild-life by interfering
with the normal signaling of various cellular targets. Mounting data
suggest a link between the increasing exposure to these chemicals and the
development of diseases including reproduction defects, hormone-related
cancers, or metabolic disorders. Our team is using a battery of structural,
biophysical and cell-based approaches to provide a rational framework for
better understanding and combating the impact of environmental pollutants
on human health. The position requires the applicant to work on structural
and biochemical characterization of various receptors including the
peroxisome proliferator activated receptor γ (PPARγ), the pregnane X
receptor (PXR) and the aryl hydrocarbon receptor (AHR).

Qualifications
Applicants must hold a PhD in biological sciences (preferably in
biochemistry or structural biology), and should have a strong background in
protein expression and purification, cryogenic electron microscopy and/or
X-ray crystallography.

Anticipated starting date:
1st of September 2024

Application
The application, including CV, motivation letter and 2 reference letters,
should be sent to William Bourguet (william.bourg...@cbs.cnrs.fr)

Recent publications of the team in the field:
- Kwong HS, et al. Structural insights into the activation of human Aryl
Hydrocarbon Receptor by the environmental contaminant benzo[a]pyrene and
structurally related compounds. J Mol Biol. 2023 Dec 20:168411.
- Gruszczyk J, et al. Cryo-EM structure of the agonist-bound Hsp90-XAP2-AHR
cytosolic complex. Nat Commun. 2022 Nov 16;13(1):7010.
- Delfosse V, et al. Mechanistic insights into the synergistic activation
of the RXR-PXR heterodimer by endocrine disruptor mixtures. Proc Natl Acad
Sci U S A. 2021 Jan 5;118(1):e2020551118.

Best wishes.
---
William Bourguet
Nuclear receptors as integrators of endogenous and environmental signals
Center for Structural Biology
CNRS UMR5048 / INSERM U1054 / UM
29 rue de Navacelles
34090 Montpellier, France
Phone: 33 4 67 41 7702
Fax: 33 4 67 41 7913
http://www.cbs.cnrs.fr/index.php/en/home-equipea5



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[ccp4bb] Postdoctoral position in Structural Biology at the University of Toronto

2024-01-18 Thread Jeffrey Lee

Postdoctoral position in Structural Biology at the University of Toronto

We are seeking an enthusiastic and self-motivated Postdoctoral Fellow to study 
the mechanisms of fertilization in the Lee Lab at the University of Toronto, 
Department of Laboratory Medicine and Pathobiology. The Postdoctoral Fellow 
will lead research efforts on a Bill and Melinda Gates Foundation funded 
project to develop non-hormonal contraceptives targeting essential membrane 
glycoproteins involved in human sperm and egg attachment. The research will 
entail protein-protein interaction studies, crystallography, and protein 
engineering.

Qualifications:
*PhD in Biochemistry, Structural Biology, Biophysics, or a related field
*Experience with cloning, protein expression, and protein purification methods
*Experience with insect or mammalian cell culture is a benefit
*Solid practical and theoretical understanding in X-ray crystallography
*Strong publication record (candidates must have first authored publications)
*Fluent in English (written and oral)
*Strong scientific writing skills
*Excellent problem solving, interpersonal, communication and presentation skills

The position is available immediately. University of Toronto is well equipped 
with state-of-the-art equipment for molecular biology, protein expression and 
purification, biophysics and structural biology (crystallography, NMR and 
cryo-EM). Please visit the Lee Lab website (https://www.leelab-utoronto.com) 
for more information.

Interested candidates are invited to send your CV, a brief description of 
research interest and experience, names of three references by email to: Prof. 
Jeff Lee
jeff@utoronto.ca

All qualified candidates are encouraged to apply by Feb 15, 2024, but the 
position will remain open until filled

. We thank all applicants for their interest, however only those shortlisted 
for interviews will be contacted.




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[ccp4bb] Postdoctoral position in Cambridge UK

2023-12-19 Thread Marko Hyvonen

Dear colleagues,


We have an exciting postdoctoral opportunity in our group to work with Bicycle 
Therapeutics. Looking for motivated candidates with green protein fingers and 
experience in structural biology.

12 months post to start with. Details of the position and link to our 
application portal found at https://www.jobs.cam.ac.uk/job/44349/

Feel free to email me with questions.

Do spread the word! (also in Twitter/X and LinkedIn)

Best wishes, Marko

-
Marko Hyvönen
Professor of Protein Biochemistry
Department of Biochemistry
University of Cambridge
mh...@cam.ac.uk
https://hyvonen.bioc.cam.ac.uk
@HyvonenGroup





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[ccp4bb] Postdoctoral Position at SUNY Binghamton University, New York

2023-12-04 Thread ssolmaz

Dear all,

The research group of Dr. Sozanne Solmaz is looking to recruit a
postdoctoral research associate. The Solmaz laboratory investigates the
molecular mechanisms for precise, bi-directional positioning of the cell
nucleus by microtubules motors. These cellular transport pathways are
essential for the generation of the majority of the cells in the brain and
associated mutations cause devastating brain and muscle developmental
diseases, including spinal muscular atrophy, which is the most common
genetic cause of death in infants. The successful candidate will combine
cutting edge structural biology approaches (X-ray crystallography and
cryo-electron microscopy) with biophysical techniques, protein
biochemistry, neuroscience and cell biology to investigate how teams of
opposing motor complexes collaborate to achieve correct timing,
directionality and velocity for the positioning of the cell nucleus during
brain development (e.g. eLife 2022, doi: 10.7554/eLife.74714, PLoS Genet.
2023, doi: 0.1371/journal.pgen.1010642). The ideal candidate for this
position will be highly motivated to work both independently to
successfully execute the required studies outlined in our NIH-funded R01
grant and will also thrive in a highly collaborative and interdisciplinary
environment where they interact with other scientists. Binghamton
University is a top-ranked public university in Upstate New York with a
vibrant research community and low cost of living.

Additional information can be found on the lab webpage:

https://ssolmaz7.wixsite.com/sozannesolmaz

Full publication list:
https://www.ncbi.nlm.nih.gov/myncbi/18yYo5cdBfekq/bibliography/public/

*Apply at the following link**:*

https://rfbu.interviewexchange.com/jobofferdetails.jsp;jsessionid=D3E5E3750753744A15A0DB886D685BEB?JOBID=170221

*Eligibility Requirements*

- PhD degree or equivalent in Biochemistry, Biophysics, Structural
Biology, Chemistry, Pharmacy or a related area, before the start date.
- The application package should include a CV, a research statement
summarizing past research, a cover letter and three letters of
recommendation.
- No other experience required. Experience in protein purification,
biophysical characterization, structural biology or cell biology is a plus.

*Applications will be reviewed on a rolling basis until the position is
filled. *The start date is flexible.

Best regards,

Sozanne Solmaz, Ph. D.
Associate Professor of Biological Chemistry
Department of Chemistry, State University of New York at Binghamton
PO Box 6000, Binghamton, NY 13902
Office: Smart Energy Building Room SN1045
25 Murray Hill Road, Vestal, NY, 13850
https://ssolmaz7.wixsite.com/sozannesolmaz

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[ccp4bb] Postdoctoral position in X-ray crystallography in Flaherty Lab - Purdue University

2023-11-28 Thread Flaherty, Daniel P

Hello All,

I wanted to make the community aware of an NIH funded postdoctoral research 
associate position for a structural biologist/X-ray crystallography in my 
group. The position will work to solve the first structures of bacterial 
carbonic anhydrases from pathogenic species of bacteria with and without small 
molecule inhibitors developed in our group.

Please visit https://www.flahertylab.com/positions for more details and 
applications can be submitted at 
https://careers.purdue.edu/job/West-Layayette-Post-Doc-Research-Associate-IN/814628700/

Position is open immediately until filled. Reach out if you have any questions.

Dan

--
Daniel P. Flaherty, PhD
Associate Professor of Medicinal Chemistry
Department of Medicinal Chemistry and Molecular Pharmacology
College of Pharmacy
Purdue University
575 Stadium Mall Dr.
West Lafayette, IN 47907

Email: dfla...@purdue.edu
Phone: 765-494-4761
Lab Website: www.flahertylab.com
Twitter: @FlahertyLab








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[ccp4bb] Postdoctoral position in structural biology at the Institut Pasteur

2023-11-20 Thread Pablo Guardado Calvo

Dear all,

A two-year postdoctoral position is available in my group at the Institut
Pasteur (Paris, France). We investigate the molecular mechanism of viral
entry into target cells combining structural biology, biophysics,
computational and virology approaches. The goal is to use the resulting
information to develop vaccines and therapies. You can check our previous
work in: Serris et al. Cell (2020, PMIDs: 32937107), Guardado-Calvo et al.
Science (2017, 29097548) or Mitler et al. Science Translational Medicine
(2023, 37315110).

We are looking for a person with a good track record and an excellent
motivation to pursue a career in structural virology. The postdoctoral
fellow will be in charge of characterising protein complexes using
cryo-electron microscopy and of setting up functional assays to
characterise their activity in vitro. The group is hosted in friendly and
dynamic environment with extensive opportunities to learn new techniques
and establish collaborations. We have fully equipped P1 and P2 labs and the
Institut Pasteur is equipped with start-of-the-art microscopes, including
two 200 kV Glacios and a 300 kV Titan Krios equipped with a Falcon 4
detector and an energy filter. The synchrotron Soleil is less than 1 hour
from the Institut and we have fluid access to the crystallography and
biophysics platforms, which are excellently equipped.

Required qualifications
• A PhD in structural biology, biochemistry, biophysics or virology.
• Documented experience in at least one of the following techniques:
structural biology (cryo-electron microscopy or crystallography) or
virology (neutralisation or fusion assays).
• Good interpersonal skills

The application should contain
1. A letter of motivation (1 page) with a short description of your
research interests.
2. A CV, including a list of relevant skills, experiences and a full
publication list.
3. Names and e-mail addresses of 2-3 reference persons, indicating their
professional relation to you.

The starting date is negotiable. Ideally around February/March 2024. The
deadline for this application is the 20th December 2023.

Informal inquiries and application should be sent to Pablo Guardado-Calvo (
guard...@pasteur.fr)

For more information, just follow this link:

https://research.pasteur.fr/en/job/postdoctoral-position-in-structural-biology-of-poxviruses/

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[ccp4bb] Postdoctoral position in structural biology at the Institut Pasteur

2023-11-19 Thread Pablo Guardado Calvo

Dear all,

A two-year postdoctoral position is available in my junior group at the
Institut Pasteur (Paris, France). We investigate the molecular mechanism of
viral entry into target cells combining structural biology, biophysics,
computational and virology approaches. The goal is to use the resulting
information to develop vaccines and therapies. You can check our previous
work in: Serris et al. Cell (2020, PMIDs: 32937107), Guardado-Calvo et al.
Science (2017, 29097548) or Mitler et al. Science Translational Medicine
(2023, 37315110).

The starting date is negotiable. Ideally around February/March 2024. The
deadline for this application is the 20th December 2023.

Informal inquiries and application should be sent to Pablo Guardado-Calvo (
guard...@pasteur.fr)

For more information, just follow this link:

https://research.pasteur.fr/en/job/postdoctoral-position-in-structural-biology-of-poxviruses/

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[ccp4bb] postdoctoral position in the field of gamma-herpesvirus structural biology

2023-11-17 Thread Jeff Perry

Hi All,

We have a new post-doc position open at the City of Hope Medical Center, full 
job is description is at:

https://www.cityofhopejobs.org/job/postdoctoral-fellow-structural-biology-research-us-ca-duarte-10021910-44/


Briefly, the laboratories of Dr. Jeff Perry, a Structural Biologist, and Javier 
Gordon Ogembo, a Vaccinologist, are currently seeking a highly motivated and 
talented individual to fill a postdoctoral position in the field of 
gamma-herpesvirus structural biology. The goal of the postdoctoral candidate 
will be to elucidate the mechanisms of gamma-herpesvirus entry and contribute 
to vaccine development.

If you are looking for a challenging and exciting opportunity to advance your 
research career in oncogenic gamma-herpesviruses and cancer, we invite you to 
join our multi-disciplinary team. Our labs are part of the Beckman Research 
Institute of City of Hope, a world-renowned National Comprehensive Cancer 
Center located just 20 miles from Los Angeles. City of Hope provides access to 
state-of-the-art facilities and resources excellent for transitional science, 
as well as a vibrant and collaborative research community. The Beckman Research 
Institute of City of Hope has several facilities that are approved by the FDA 
for the production of investigational drugs and biologics for use in clinical 
trials. These facilities are designed to meet rigorous regulatory standards and 
ensure the safety and efficacy of products developed at City of Hope. As a 
postdoctoral fellow in our labs, you will have the opportunity to access these 
facilities and work alongside leading experts in the field, contributing to 
cutting-edge research projects aimed at advancing our understanding the 
mechanisms of viral entry, oncovirology, vaccinology, and studying the 
interactions between viruses and host cells. In addition to the opportunity to 
work on exciting research projects, City of Hope offers excellent benefits, and 
a supportive work environment that encourages career development and 
advancement.


Thanks,

Jeff


Jeff Perry, Ph.D.
Assistant Professor,
MDET, City of Hope Medical Center,
Biomedical Research Center,
1218 S. Fifth Avenue,
Monrovia, CA 91016
Office: (626) 218-4031
cityofhope.org/jeff-perry-lab 



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[ccp4bb] PostDoctoral Position in GPCR Structural Biology at USC, Los Angeles

2023-10-23 Thread Cornelius Gati

PostDoctoral Position in GPCR Structural Biology at USC, Los Angeles


The position is available starting immediately in the Department of Biological 
Sciences at the University of Southern California and is initially limited to 2 
years, with possible extension.


Our research focuses on the structural biology of G protein-coupled receptors 
involved in neurobiology and immunology, using single particle cryoEM, 
complemented with biophysical assays.


USC has a suite of research facilities and has recently commissioned a 
brand-new cryoEM facility:

• CryoEM suite: Titan Krios with GIF Quantum energy filter and K3 detector, 
Glacios with Falcon 4 detector, Talos Arctica with CCD/side entry holder for NS 
and screening
• Core facility for insect- and mammalian cell expression
• High performance computing for data processing/analysis


Qualified candidates must have a Ph.D. degree with a solid background in 
structural biology and biophysics/biochemistry. Previous work with membrane 
protein purification and experience with cryoEM data analysis is a plus. A 
successful candidate is expected to be highly skilled and self-motivated and is 
willing to work in a collaborative environment. The Postdoctoral salary depends 
on qualifications and relevant experiences according to USC standards.


Interested candidates should apply directly with Cornelius Gati at 
gati[at]usc.edu. Please attach a cover letter, Curriculum Vitae, research 
statement, publication list and a reference letter. There is no deadline for 
this posting and applications will be evaluated on a rolling basis.


Current group website: https://dornsife.usc.edu/gati/



Recent work from our group includes:


Molecular basis of anaphylatoxin binding, activation, and signaling bias at 
complement receptors.

Yadav MK, Maharana J, Yadav R, Saha S, Sarma P, Soni C, Singh V, Saha S, 
Ganguly M, Li XX, Mohapatra S, Mishra S, Khant HA, Chami M, Woodruff TM, 
Banerjee R*, Shukla AK*, Gati C*. Cell. (2023)


Structural basis of GABA reuptake inhibition.

Motiwala Z, Aduri NG, Shaye H, Han GW, Lam JH, Katritch V, Cherezov V, Gati C*. 
Nature. 606 (2022) 820-826


Structural basis of metabotropic GABA receptor activation.

Shaye H, Ishchenko A, Lam JH, Han GW, Xue L, Rondard P, Pin JP, Katritch V, 
Gati C*, Cherezov V*. Nature. 584 (2020) 298-303


A mycobacterial ABC transporter mediates the uptake of hydrophilic compounds.

Rempel S, Gati C*, Nijland M, Thangaratnarajah C, Karyolaimos A, de Gier JW, 
Guskov A, Slotboom DJ*. Nature. 580 (7803) (2020) 409-412




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[ccp4bb] Postdoctoral position - Cryo-EM and Biochemistry of Molecular Motors

2023-09-12 Thread Krishna Chinthalapudi

Dear All,



We are excited to announce the opening of a joint postdoctoral scientist
position in the laboratories of Dr. Sarah Heissler and Dr. Krishna
Chinthalapudi at the Ohio State University. This exceptional opportunity
focuses on groundbreaking research to unravel the role of myosin motors and
cytoskeletal proteins in both health and disease. Our approach combines
cutting-edge structural biology techniques, including cryo-EM and X-ray
crystallography, with biochemical, biophysical, and cell biological methods
to investigate the structure and function of myosin motors, as well as
their regulation by cytoskeletal proteins.



Our laboratories are well equipped with state-of-the-art instrumentation
for the proposed studies and have generous access to a Titan Krios G3i
Cryo-TEM equipped with a BioQuantum imaging filter and a K3 direct electron
detector, imaging phase plates, and an image spherical aberration
corrector. In addition, our labs have access to a Glacios with a Falcon III
detector and a cryo-FIB at the world-class Center for Electron Microscopy
and Analysis (CEMAS) at the Ohio State University.



To be eligible for this position, candidates must hold a Ph.D. degree and
possess considerable experience in structural biology. If you also have a
background in molecular biology techniques, and/or high-resolution imaging,
it would be highly desirable. To apply for this exciting opportunity,
kindly email us your CV, a short cover letter detailing your research
experience and interests, and the contact information for three references
to Sarah Heissler (sarah.heiss...@osumc.edu) and Krishna Chinthalapudi (
krishna.chinthalap...@osumc.edu).



Best,

Krishna



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[ccp4bb] Postdoctoral Position(s) - Mechanisms of Assemblies Formation Essential to Muscle Function

2023-09-12 Thread Kristina Djinovic Carugo

*Postdoctoral **Position**(s) - Mechanisms of Assemblies Formation 
Essential to Muscle Function*


**

EMBL Grenoble specializes in fundamental research in structural biology, 
and in developing state-of-the art instrumentation, methods and 
services. The site is located on the dynamic European Photon and Neutron 
science campus (EPN campus), together with other international and 
French research institutions.**


We are recruiting a highly motivated Post-Doctoral Scientist to join the 
Head of Unit’s Research Group at EMBL Grenoble, Kristina Djinovic 
Carugo. The Djinovic group is interested in the molecular mechanisms 
underlying the architecture and assembly of muscle sarcomeres, 
particular Z-discs.


The sarcomere - the basic contractile unit of myocytes - assembles from 
nascent actin-rich Z-bodies into paracrystalline multiprotein structures 
called Z-discs. Yet, the assembly rules and protein components 
regulating these complex structures remain largely unknown. We recently 
discovered that two main Z-disc proteins form phase-separated liquid 
condensates in vitro, which gives rise to the exciting hypothesis that 
phase separation is the driving force behind Z-disc assembly by bringing 
together its proteins to facilitate interactions.


*Djinovic Group is a member of the collaborative project “From disorder 
to order: mechanism of specialised assemblies formation essential for 
muscle function” supported by HFSP Award. Its aim is to investigate how 
highly ordered sarcomeric Z-disc structure arises from disordered 
Z-bodies. We will determine the biophysical and structural principles 
underlying sarcomere cytoskeleton assembly in biogenesis, molecular 
components, and regulators and integrate the data into a 4D multiscale 
integrative molecular model.*


The collaborative team united by HFSP Award will capitalise on 
complementary and synergistic expertise in structural biology and 
modelling (Kristina Djinovic Carugo, EMBL Grenoble; France and Toshiyuki 
Oda, University of Tokyo, Japan), advanced imaging (Jonas Ries, 
University of Vienna, Austria) and cardiovascular development and 
disease (Travis Hinson, The Jackson Laboratory, Farmington, CT, USA) and 
adopt a multifaceted and multiscale approach to tackle the central 
questions on sarcomere cytoskeleton assembly in biogenesis at the 
molecular and structural level.


*Your role*

You will embark on an exciting journey to decipher the structures of 
selected reconstituted complexes and macromolecular condensates using an 
integrative structural biology approach, which encompasses molecular 
biophysics characterisation, combined with small angles X-ray 
scattering, macromolecular crystallography, and cryo-electron 
microscopy/tomography, depending on their size and dynamics. As a team 
member, you will play a crucial role in uncovering the detailed 
biophysical and structural principles that regulate complex assembly. 
Joining collaborative efforts, you will contribute to the generation of 
a 4D multiscale integrative molecular model.


Apply now 



*Closing date:*31 October 2023

 * Contract duration: 3 years
 * Grading: stipend
 * Reference number: GR00215

*Related*

 * View all EMBL jobs 
 * Sign up for job alerts 
 * View openings from partners 

*You have*

 * PhD degree in a relevant field with strong background in structural
   biology.
 * Experience in molecular cloning, expression, and purification of
   protein complexes is essential.
 * Prior knowledge of crystallography and/or single-particle electron
   microscopy is needed.
 * Track record of writing papers as evidenced by publications or
   submitted manuscripts.
 * Ability to work independently and also to interact within a group.
 * Excellent communication skills, including the ability to write for
   publication and present results at scientific meetings.

*You might also have*

 * Previous experience in complementary structural biology methods
   (e.g. SAXS), molecular and cell biophysics approaches and cell
   culture will be considered an advantage.
 * Experience with cryo-electron tomography.
 * Experience with working in multidisciplinary research teams.

*Why join us*

EMBL is curiosity-driven, community-oriented and international. As an 
inclusive, equal opportunity employer, we believe that diversity enables 
us to collaborate more effectively and be innovative in our approaches. 
We are, therefore, committed to creating an inclusive and flexible 
culture - one where everyone can realise their full potential and make a 
positive contribution to our organisation.


We encourage applications from individuals who can complement our 
existing team – we believe that success is built on having teams whose 
backgrounds and personal experiences reflect the

[ccp4bb] Postdoctoral position in Structural Biology of Dynamic Membrane Pores

2023-09-01 Thread Tobias Raisch

A fully funded postdoctoral position is available in the project group of Dr. 
Tobias Raisch in the Department of Structural Biochemistry (Director: Prof. 
Stefan Raunser) at the Max Planck Institute of Molecular Physiology in 
Dortmund, Germany. The position is available from November 2023 onwards and is 
initially limited to 3 years. The successful candidate will work in a dynamic 
international team situated in a world-renowned institute with cutting-edge 
infrastructure for cryo-EM and cryo-ET.


Summary:

The goal of the project is to understand the structural architecture and 
dynamic assembly of a eukaryotic pore-forming membrane attack complex that 
induces cell death. We aim to determine high-resolution structures of 
reconstituted pores in vitro from purified components as well as to visualize 
the pore arrangement in situ in its native membrane. To this end, a combination 
of methods including membrane complex reconstitution and isolation, single 
particle electron cryo-microscopy (cryo-EM), cryogenic focused ion beam 
(cryo-FIB) milling and electron cryo-tomography (cryo-ET) will be applied. The 
candidate will be part of a multidisciplinary research team involving 
researchers at MPI Dortmund and University of Geneva (Switzerland) that is 
funded by a SINERGIA grant of the Swiss National Fund (SNF) and aims at 
integrating multi-scale data to visualize the dynamic assembly and growth of 
medically highly important membrane pores.

The group of Tobias Raisch combines biochemical reconstitution and 
characterization with in vitro and in situ structural elucidation of medically 
relevant membrane proteins and membrane protein complexes in order to 
understand their function and dynamic mechanism. The Department of Structural 
Biochemistry is on the forefront of cryo-EM and cryo-ET, with expertise ranging 
from method development to applying electron microscopy techniques to 
challenging biological systems.
More information on the Raisch group: 
https://www.mpi-dortmund.mpg.de/4347197/raisch 
[https://www.mpi-dortmund.mpg.de/4347197/raisch]

Requirements:
Ideal candidates should hold an excellent PhD in structural biology, 
biochemistry, biophysics or in an equivalent area. Experience in membrane 
protein biochemistry, single particle cryo-EM or cryo-ET is an asset, curiosity 
and willingness to learn new methods and adjust to technological developments a 
must.

Strong written and oral communication skills in English as well as ability to 
work independently and in a collaborative project with multiple scientists from 
diverse backgrounds are required.

Why join us?
Being a part of the community at the Max Planck Institute is more than just a 
job. Our dynamic research environment, distinct culture, and diverse community 
foster collaboration and excellence in every corner of science. We offer an 
extensive range of benefits and resources such as:
* access to state-of-the-art research facilities
* opportunities to collaborate on cutting-edge research
* an international and exciting working atmosphere
* an integrated training program that includes lectures, advanced scientific 
workshops, complementary skill courses and opportunities for career development
* a mentoring program to guide and promote young scientists

Salary:
Payment depends on personal conditions and qualification according to the 
directive of the TVöD. Social benefits correspond to those of the public 
service.
 
How to Apply:
Applicants should submit a CV, a motivation letter outlining research 
experiences and interests and two reference letters by September 30th, 2023 to 
Tobias Raisch at tobias.rai...@mpi-dortmund.mpg.de
 
Additional Information:
The Max Planck Society (Max Planck Gesellschaft – MPG) is committed to 
increasing the number of individuals with disabilities in its workforce and 
therefore encourages applications from such qualified individuals.

The MPG seeks to increase the number of women in those areas where they are 
underrepresented and therefore explicitly encourages women to apply.

Furthermore, the MPG strives to foster an inclusive culture and diversity 
within its workforce. Therefore, all qualified applicants are encouraged to 
apply and will receive consideration for employment without regard to 
ethnicity, religion, skin color, national origin, age, sex, sexual orientation, 
disability status, or any other characteristic protected by applicable law.




Dr. Tobias Raisch (he/him)
Project Group Leader - Structural Biochemistry of Membrane Proteins

Max Planck Institute of Molecular Physiology
Department of Structural Biochemistry
Tel: +49 (231) 133-2315
Otto-Hahn-Str. 11
D-44227 Dortmund
Germany

tobias.rai...@mpi-dortmund.mpg.de [mailto:tobias.rai...@mpi-dortmund.mpg.de]



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[ccp4bb] postdoctoral position - time-resolved serial crystallography

2023-08-29 Thread Przemysław Nogły

Dear All,

We have an exciting opening for a postdoctoral position in my group at the 
Jagiellonian University to investigate photoreceptor proteins with 
time-resolved serial crystallography.

For details and applications:
https://www.nature.com/naturecareers/job/12803466/postdoctoral-researcher-at-the-dioscuri-centre-for-structural-dynamics-of-receptors/?LinkSource=PremiumListing
Closing date is 15.09.2023

Best regards,
Przemek

Przemyslaw Nogly, Ph.D.
Group Leader of the Dioscuri Centre for Structural Dynamics of Receptors
Faculty of Biochemistry, Biophysics and Biotechnology
Jagiellonian University
Gronostajowa 7, Room C041
30-387 Kraków, Poland
+48 12 664 6339
https://noglylab.eu/
 [https://noglylab.eu/]



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[ccp4bb] Postdoctoral Position

2023-08-18 Thread Katsunori Sugimoto

Dear Colleagues,

A postdoctoral position is available at Rutgers University, New Jersey
Medical School, USA.

This position will focus on the role of the Mre11 complex in DNA
double-strand break repair and ATM activation.

The project uses biochemical methods in combination with genetic and
structural approaches.

We are looking for a highly-motivated individual who meets the
qualification below

• Strong experience in biochemical experiments, including protein
purification and in vitro reconstitution
• Expertise or keen Interest in combining genetic approaches with protein
structure studies, such as cryo-EM imaging or software analysis
• Ph.D. in biochemistry-related disciplines

An electron microscope is being installed in our building. Our institute is
a 45 min train ride and walk from the Manhattan New York Penn station.

Please submit your application including a cover letter, CV, and names of
three references to Dr. Katsunori Sugimoto (sugim...@njms.rutgers.edu).

Best,

Katsunori Sugimoto

https://njms.rutgers.edu/departments/molecular_genetics/faculty/sugimoto/

Department of Microbiology, Biochemistry and Molecular Genetics

New Jersey Medical School

Rutgers, The State University of New Jersey
225 Warren St.
Newark NJ 07103 USA



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[ccp4bb] Postdoctoral position in drug discovery

2023-08-02 Thread Harp, Joel M

Postdoctoral position in drug discovery An opening is available in the drug 
discovery laboratory of Dr. Stephen Fesik for a post-doc in the field of 
protein x-ray crystallography.  Responsibilities will include protein 
production, fragment screening by NMR, and all aspects of x-ray crystallography 
including preparation of protein-ligand complexes, crystallization, 
home/synchrotron data collection, and structure determination. Additional 
experience in molecular biology including construct design, cloning, 
site-directed mutagenesis and modeling is a plus.  The ideal candidate should 
be self-motivated and be able to communicate efficiently in a highly 
collaborative environment. Please send cv to 
jason.p...@vanderbilt.edu


The Vanderbilt campus is located in Nashville Tennessee. Also known as Music 
City, Nashville is a fast growing and dynamic environment with plenty of 
cultural attractions and opportunities for outdoor recreation.




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[ccp4bb] Postdoctoral Position

2023-08-01 Thread Krishna Chinthalapudi

Dear All,



We are excited to announce the opening of a joint postdoctoral scientist
position in the laboratories of Dr. Sarah Heissler and Dr. Krishna
Chinthalapudi at the Ohio State University. This exceptional opportunity
focuses on groundbreaking research to unravel the role of myosin motors and
cytoskeletal proteins in both health and disease. Our approach combines
cutting-edge structural biology techniques, including cryo-EM and X-ray
crystallography, with biochemical, biophysical, and cell biological methods
to deeply investigate the structure and function of myosin motors, as well
as their regulation by cytoskeletal proteins.



Our laboratories are well equipped with state-of-the-art instrumentation
for the proposed studies and have generous access to a Titan Krios G3i
Cryo-TEM equipped with a BioQuantum imaging filter and a K3 direct electron
detector, imaging phase plates, and an image spherical aberration
corrector. In addition, our labs have access to a Glacios with a Falcon III
detector and a Ceta-D camera for MicroED analysis at the world-class Center
for Electron Microscopy and Analysis (CEMAS) at the Ohio State University.



To be eligible for this position, candidates must hold a Ph.D. degree and
possess considerable experience in structural biology. If you also have a
background in molecular biology techniques, and/or high-resolution imaging,
it would be highly desirable. To apply for this exciting opportunity,
kindly email us your CV, a short cover letter detailing your research
experience and interests, and the contact information for three references
to Sarah Heissler (sarah.heiss...@osumc.edu) and Krishna Chinthalapudi (
krishna.chinthalap...@osumc.edu).



Best,

Krishna



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[ccp4bb] Postdoctoral position in virology/structural biology

2023-07-27 Thread Forwood, Jade

Dear All,

Please find below a postdoctoral position in structural biology/virology. The
closing date is 28th July.

https://external-jobs.csu.edu.au/cw/en/job/496499/research-fellow-in-molecular-virology-or-structural-biology

More information about the lab can be found here:

https://csusap.csu.edu.au/~jforwood/

Best,
Jade.

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[ccp4bb] Postdoctoral position at the University of Pavia in Italy

2023-07-06 Thread Hugo de Jonge

Dear colleagues,

 

The unit of Immunology and General Pathology of the department of Molecular
Medicine of the University of Pavia, in Northern Italy, is looking for a
post-doctoral researcher in structural biology for a three-year appointment.

Our laboratory has worked, since co-discovering the Hepatocyte Growth
Factor/Scatter Factor in the mid-1980s, on the structural aspects of HGF/SF
binding to and activation of the MET tyrosine kinase receptor and the role
of the co-receptor heparan sulphate. The work has yielded insights into the
structures of these complex proteins and formed the basis for the design of
novel inhibitors and recombinant agonists. We recently developed, through
structure-based rational design, a potent agonist called K1K1 that is
currently being tested for treatment of common chronic and acute diseases
affecting lung and liver in collaboration with academic groups in France and
a large international pharmaceutical company.

The project will focus on the full structural characterisation and
mechanistic understanding of receptor activation by K1K1 and the role of
heparan in this using cryo-EM, SAXS, and protein crystallography. The
department of Molecular Medicine is fully equipped for structural biology
with protein expression and crystallisation facilities, a Glacios 200 kV
cryo-EM microscope, and regular access to the ESRF and other European
beamlines. Expertise is shared among several groups working in the field of
biochemistry and protein structure. The University of Pavia, one of the
oldest academic institutions in the world, offers a stimulating environment
while the city itself is vibrant and conveniently located between the Alps,
the Apennines, and the stunning Ligurian coast.

Applicants can apply through the following link:
https://pica.cineca.it/unipv where the project is identified as
medmol-2023-b03 (responsible person: Hugo de Jonge).

For additional information, please do not hesitate to contact me at
hugo.dejo...@unipv.it  .

 

Sincerely,

 

Hugo de Jonge

 

Unit of Immunology and General Pathology

Department of Molecular Medicine  

Pavia University

Italy

 




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[ccp4bb] Postdoctoral position at the University of York

2023-07-05 Thread Julie Tucker

An exciting (if short term) position has become available in the Hitchcock
Lab, which is part of the Centre for Blood Research at York and the York
Biomedical Research Institute at the University of York.

For further details and to apply see the University's jobs pages here:
https://jobs.york.ac.uk/vacancy/postdoctoral-researcher-in-structural-biology-and-biophysics-529388.html

Happy to answer informal enquiries,
Best wishes
Julie

-- 
Julie Tucker
York Biomedical Research Institute
Department of Biology and HYMS
University of York

*My normal working days are Monday-Tuesday and Thursday-Friday. Please be
patient if you do not hear from me promptly. I choose to work flexibly;
please only respond to this message when convenient for you to do so.*

Email disclaimer




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[ccp4bb] Postdoctoral position in method development (York Structural Biology Laboratory)

2023-06-27 Thread Jon Agirre

Dear all,

Applications are invited for a Postdoctoral Research Associate position,
funded by the Royal Society, for up to 30 months to work with Dr Jon Agirre in
the Department of Chemistry. The successful applicant will join a vibrant
team of researchers at the heart of the world-leading York Structural
Biology Laboratory (YSBL). The work of the laboratory over the years has
included the delivery of world-leading methods and experimental
discoveries, training and nurturing hundreds of outstanding scientists in
the process.

Role
The AlphaFold software for protein model prediction has revolutionised
workflows in structural biology. However, while high-accuracy models are
now available for most human proteins of medical relevance, up to 50% of
those proteins are expected to be glycosylated – a modification whose
structure AlphaFold does not predict. Protein glycosylation is greatly
important, with implications for protein folding and molecular recognition
including, as evidenced by the spike glycoprotein of SARS-CoV-2, viral
infection. In collaboration with other scientists, we have extended the
Privateer software to interactively build missing glycosylation onto
precalculated AlphaFold models. In parallel, we have developed analyses
that allow us to get a clear picture of glycans and their interactions,
including H-bonds and XH-Pi interactions. We expect that these methods will
enable us to, based on existing glycobiological knowledge, extend the
Privateer software to automatically complete AlphaFold models with crucial
missing glycosylation components.

We are seeking a person with an interest in both biology and coding, who
can collaborate with others in a very diverse team with a mission to
further our knowledge of glycobiology and seize the opportunities presented
by a deeper understanding of it.

Main duties and responsibilities
To develop and extend the Privateer software to complete AlphaFold models
with the missing glycan components.
To further our existing collaborations with CCP4, CCP-EM, PDB-REDO, the
Protein Data Bank and the AlphaFold Protein Structure Database.

Department
The Department of Chemistry is one of the largest and most successful
departments at York and we are renowned internationally for our research.
As a department, we strive to provide a working environment that allows all
staff and students to contribute fully, to flourish, and to excel. We are
proud of our Athena Swan Gold Award. The Department of Chemistry values all
employees for the qualities and skills they bring to the workplace and aims
to be a diverse and egalitarian community in which all can thrive.

For informal enquiries: please contact Dr Jon Agirre, jon.agi...@york.ac.uk
To apply: https://jobs.york.ac.uk/vacancy/research-associate-529961.html
Deadline for applications: 20 August 2023.

Many thanks for making it this far in the advert!

With best wishes,
Jon
-- 
Dr Jon Agirre
Royal Society University Research Fellow (assistant professor)
CCP4 WG2 co-chair | instruct-ERIC representative @ 3D-Bioinfo SC (Elixir)
York Structural Biology Laboratory, Department of Chemistry
University of York, Heslington, YO10 5DD, York, UK



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[ccp4bb] Postdoctoral position

2023-06-26 Thread Nadendla Eswarkumar

A postdoctoral position is available at St. Jude Children’s Research
Hospital for an outstanding and highly motivated candidate to investigate
the proteins of the innate immune system biochemically and structurally.
We are particularly interested in assessing proteins involved in innate
immune responses and cell death (NLRs, caspases, inflammasomes,
inflammatory cell death, PANoptosis).  Please see the following articles:

Cell (2023) [Epub ahead of print]

Science Immunology (2022) 7(74):eabo6294.

Nature (2021) 597(7876):415-9.Cell (2021) 184(1)_149-168.e17.

Cell (2020) 181(3):674-687.e13.

Nature (2019) 573(7775):590-4.

Nature Microbiology (2019) 4(2):316-27.

Cell (2018) 173:1–14.

Journal of Experimental Medicine (2018) 215(4):1023-34.

Nature (2016) 540:583-7.

Science Immunology (2016) 1(2):aag204-5.

The ideal candidate will have experience with biochemical and biophysical
methodologies, such as:

   - Protein purification
   - Protein tagging and expression in multiple cell lines, including
   baculovirus and mammalian expression system experience
   - Cryo-EM
   - Mass spectrometry sample preparation pipelines
   - Protein-protein interaction studies
   - Co-immunoprecipitation experiments

The laboratory of Dr. Thirumala-Devi Kanneganti
 offers a remarkable training
environment for postdoctoral fellows focused on the innate immune system,
including an opportunity to collaborate with researchers in the departments
of Immunology, Structural Biology, Infectious Diseases, and cancer biology.
Generous salary support and a benefits package that includes professional
development funds for journal subscriptions and travel to meetings are
available. St. Jude Children's Research Hospital has state-of-the-art
facilities including core laboratories for proteomics, metabolomics,
RNAseq, transgenic/knock-out technology, and animal facilities.


*Minimum Education*
Candidates should have a recent PhD, DVM, MD/PhD in biomedical sciences,
ideally Biochemistry, Structural Biology, or Immunology, and must be
hard-working and highly motivated.

Apply for Postdoctoral Research Associate using the link below:

https://talent.stjude.org/careers/jobs/11363?lang=en-us



*Best regards*

*Nadendla Eswar kumar*
Scientist
St.Jude Children's Cancer Hospital and Research Center
262 Danny Thomas Place
Memphis, TN 38105



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[ccp4bb] Postdoctoral Position Available in the Karakas Lab at Vanderbilt University School of Medicine

2023-06-21 Thread Karakas, Erkan

The Karakas Lab at Vanderbilt University School of Medicine, located in 
Nashville, TN, is seeking a highly motivated individual to fill an NIH-funded 
postdoctoral position. Our research group is dedicated to unraveling the 
molecular mechanisms of ion channels using state-of-the-art structural biology 
approaches. The laboratory, situated within the Department of Molecular 
Physiology and Biophysics, offers access to cutting-edge cores specializing in 
crystallography, cryo-electron microscopy (cryo-EM), mass spectrometry, and a 
range of advanced biophysical instrumentation. 

We invite you to explore our recent research publications that demonstrate our 
significant contributions to understanding diverse ion channels and their 
underlying structural basis:

Structural basis for activation and gating of IP3 receptors 
(https://www.nature.com/articles/s41467-022-29073-2)
Cryo-EM structures of an LRRC8 chimera with native functional 
properties reveal heptameric assembly (https://elifesciences.org/articles/82431)

As a Postdoctoral Researcher in our lab, you will work closely with Dr. 
Karakas, utilizing cutting-edge technologies such as X-ray crystallography, 
cryo-EM, and various biophysical techniques. You will have the freedom to 
design and conduct experiments, analyze data, and contribute to the development 
of novel methodologies.

Candidates should have a Ph.D. in biochemistry, biophysics, or related fields. 
While prior experience in X-ray crystallography, cryo-EM, or electrophysiology 
would be advantageous, it is not required. We welcome applicants with diverse 
backgrounds and a strong interest in applying structural biology techniques to 
study ion channels.

To apply for this position, please submit the following documents via e-mail to 
Erkan Karakas at erkan.kara...@vanderbilt.edu:
*   Cover Letter: Please provide a cover letter that outlines your research 
interests, goals, and how your background aligns with our research focus.
*   CV: Attach a current curriculum vitae highlighting your educational 
background, research experience, and publications.
*   References: Include the contact information (2-3 references) who can 
provide insight into your qualifications and potential as a postdoctoral 
researcher.

We encourage interested candidates to apply as soon as possible. The position 
will remain open until filled.

For any additional inquiries or further information, please do not hesitate to 
contact Erkan Karakas at erkan.kara...@vanderbilt.edu or by phone at (615) 
343-4494.

Sincerely,

-

Erkan Karakas, PhD
Assistant Professor of Molecular Physiology and Biophysics
Vanderbilt University School of Medicine 
2215 Garland Avenue
Light Hall 741A
Nashville, TN 37232

e-mail: erkan.kara...@vanderbilt.edu
Phone: (615) 343-4494



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[ccp4bb] Postdoctoral Position at the Ohio State University

2023-06-20 Thread Krishna Chinthalapudi

Dear All,



Applications are invited for a joint postdoctoral scientist position in the
laboratories of Dr. Sarah Heissler and Dr. Krishna Chinthalapudi at the
Ohio State University. The research project focuses on understanding the
role of myosin motors and cytoskeletal proteins in health and disease. We
combine state-of-the-art structural biology approaches including cryo-EM,
and X-ray crystallography with biochemical, biophysical, and cell
biological methods to investigate the structure and function of myosin
motors and their regulation by cytoskeletal proteins.



 Our laboratories are equipped with state-of-the-art instrumentation for
the proposed studies and have generous access to a Titan Krios G3i Cryo-TEM
equipped with a BioQuantum imaging filter and a K3 direct electron
detector, imaging phase plates, and an image spherical aberration
corrector. In addition, our labs have access to a Glacios with a Falcon III
detector and a Ceta-D camera for MicroED analysis at the world-class Center
for Electron Microscopy and Analysis (CEMAS) at the Ohio State University.



 Candidates must have a Ph.D. degree and strong practical experience in
structural biology. Experience in molecular biology techniques, structural
biology, and/or high-resolution imaging are desirable. To be considered for
this position, please email your curriculum vitae, a short cover letter
with research experience and interests, and contact information for three
references to Sarah Heissler (sarah.heiss...@osumc.edu) and Krishna
Chinthalapudi (krishna.chinthalap...@osumc.edu).



Best,

Krishna



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[ccp4bb] Postdoctoral position available

2023-05-23 Thread Herwig Schüler

A postdoctoral position in biochemistry and structural biology is available at 
Lund University, Sweden.
The focus of the position will be bacterial toxin-antitoxin systems and we will 
use X-ray crystallography, cryo-EM and NMR within the project.
Please email me for further details and how to apply.
Sincerely, Herwig Schüler
herwig.schuler(at)biochemistry.lu.se



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[ccp4bb] Postdoctoral position

2023-05-09 Thread Carlos CONTRERAS-MARTEL


Dear all,

A 2.5-year postdoctoral research position financed by the French 
National Research Agency (ANR) is available at the Bacterial 
Pathogenesis Group (A. Dessen) at the IBS (Institut de Biologie 
Structurale) in Grenoble. Our group uses structural biology tools to 
understand mechanisms employed by bacteria to initiate infections and to 
synthesize their cell wall. Candidates should have experience in 
molecular biology, soluble and membrane protein biochemistry and X-ray 
crystallography. This structural biology project will take advantage of 
the expertise in the lab working with virulence factors and their 
complexes in an environment with dedicated X-ray crystallography and 
electron microscopy facilities.


Deadline June 9th

CVs (including publication list and reference names) and queries should 
be sent to: andrea.des...@ibs.fr






--
 Carlos CONTRERAS MARTEL, Ph.D.
 (CRHC CNRS)

 carlos.contreras-mar...@ibs.fr

 "Bacterial Pathogenesis Group"
Institut de Biologie Structurale
 UMR5075 CEA-CNRS-UGA

  IBS (PATBAC)
  Campus EPN
  71, avenue des Martyrs
  CS 10090
  38044 Grenoble CEDEX 9
  FRANCE


 tel : (+33) (0)4 57 42 86 41

http://www.ibs.fr/groupes/groupe-pathogenie-bacterienne/?lang=fr
http://www.ibs.fr/groups/bacterial-pathogenesis-group/?lang=en



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[ccp4bb] Postdoctoral position in cryoEM at KU Leuven (Belgium)

2023-05-04 Thread Sergei Strelkov

Applications are invited for a postdoctoral opening in the Laboratory for 
Biocrystallography at KU Leuven (Belgium), to work on two ongoing projects 
mainly using cryoelectron microscopy.

KU Leuven is a leading Belgian University, located in the charming town of 
Leuven just 20km east of Brussels. Laboratory for Biocrystallography, led by 
Prof. Sergei Strelkov, is active in structural biology and rational drug 
design. The working language is English. In addition to superb facilities for 
molecular biology and X-ray crystallography, there are two brand-new 200kV 
cryoelecton microscopes on campus and a good access to 300kV microscopes in 
Brussels and at European facilities.

The new postdoctoral researcher will focus on cryoEM studies of intermediate 
filament proteins and a novel protein target for cancer drug development. The 
successful candidate will have a track record in structural biology, experience 
with cryoEM and a capacity to work independently. Support on molecular biology 
and computation will be provided by other team members.

The contract will be up to three years, with yearly extension. Please send your 
motivation letter, including a detailed CV and a list of publications, to: 
sergei.strel...@kuleuven.be

Lab page: https://pharm.kuleuven.be/Biocrystallography




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[ccp4bb] Postdoctoral Position at Indiana University School of Medicine

2023-05-04 Thread Takagi, Yuichiro

Dear All

We are looking for a highly motivated postdoctoral follow to work on NIH and 
ACS-funded projects aiming to discover and characterize small molecule 
degraders of oncoproteins and aging related proteins utilizing cryo-EM and 
computer-guided drug design.

Who We Are:
Our team led by Drs. Takagi, Bellail, and Hao, investigates targeted protein 
degradation for the discovery of small molecule degraders. The team has 
recently reported the first small molecule degraders of SUMO1 protein as novel 
anticancer drugs (Bellail et al. Science Translational Medicine 2021, 
13:e12947, DOI: 10.1126/scitranslmed.abh1486). The team are currently working 
on Cryo-EM structure guided and computer-aided drug design of small molecule 
degraders of oncoproteins and aging proteins.

What We Offer:
1) State-of-the art protein and protein complex expression technologies (patent 
pending) enabling expression of difficult-to-express, problematic proteins and 
protein complexes.

2) The opportunity to work with the projects regarding an emerging field of 
“protein degraders.”

3) The opportunity to learn or/and to be engaged in structure-guided and 
computer-aided drug design.

4) Accessibility to Glacios (in-house) and Titan Krios G4 housed in Purdue 
University (an hour drive from our lab) where we have plenty of guaranteed 
access time.  

5) Cryo-EM training (in-house) will be offered.

6) The opportunity to work with multiple outstanding collaborators (e.g., HHMI 
investigators). See our previous work (Fukudome at al., PNAS 2021, DOI: 
10.1073/pnas.2115899118)
 
Who Should Apply:
This position could be a great fit for you if:

You have the expertise and experience in structural biology (Cryo-EM, X-ray 
crystallography), and want to apply such skills toward structure determination 
of oncoproteins and aging related proteins complex to understand structural 
basis of how protein degraders work.

You are interested in the emerging field of protein degraders.

You are interested in learning and developing for the cutting-edge protein 
complex engineering and expression technologies.

You are interested in learning and implement computer-aided compound design.

You would like to extend your existing skill sets to cryo-EM.

You relish working on technically challenging problems, which often require an 
extended persistent effort to crack.

Job Description, Qualification, and Expectations:
Primary activities in this position include but are not limited to:
Expression and purification of the protein complexes for biochemical and 
structural studies related to protein degraders

Structure determination of the protein complexes mostly by cryo-EM or/and X-ray 
crystallography

Biochemical assays to characterize the recombinant protein complexes

Providing intellectual contributions to the projects including writing 
manuscripts, fellowship application and helping PI for grant applications

Ph.D. in structural biology (X-ray crystallography, cryo-EM) is strongly 
preferred. But someone with strong biochemistry background, who wants to expand 
his or her skills to cryo-EM would strongly be considered.
 

If interested, please apply to this position via the university job portal: 
https://indiana.peopleadmin.com/postings/18290 


Please make sure that you provide a cover letter, CV, and two reference letters.

If you have any question, please feel free to contact me at ytak...@iu.edu 

Applications will be screened until a suitable candidate is found.  Indiana 
University is an equal opportunity/affirmative action employer.


All the best

Yuichiro H. Takagi, Ph.D.
Associate Professor
Scientific advisor for cryo-EM 
Department of Biochemistry and Molecular Biology
Indiana University School of Medicine
https://twitter.com/LabTakagi 




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[ccp4bb] Postdoctoral Position at the Ohio State University

2023-05-01 Thread Krishna Chinthalapudi

Dear All,



Applications are invited for a joint postdoctoral scientist position in the
laboratories of Dr. Sarah Heissler and Dr. Krishna Chinthalapudi at the
Ohio State University. The research project focuses on understanding the
role of myosin motors and cytoskeletal proteins in health and disease. We
combine state-of-the-art structural biology approaches including cryo-EM,
and X-ray crystallography with biochemical, biophysical, and cell
biological methods to investigate the structure and function of myosin
motors and their regulation by cytoskeletal proteins.



Our laboratories are equipped with state-of-the-art instrumentation for the
proposed studies and have generous access to a Titan Krios G3i Cryo-TEM
equipped with a bioquantum imaging filter and a K3 direct electron
detector, imaging phase plates, and an image spherical aberration
corrector. In addition, our labs have access to a Glacios with a Falcon III
detector and a Ceta-D camera for MicroED analysis at the world-class Center
for Electron Microscopy and Analysis (CEMAS) at the Ohio State University.



Candidates must have a Ph.D. degree and strong practical experience in
structural biology. Experience in molecular biology techniques, structural
biology, and/or high-resolution imaging are desirable.



To be considered for this position, please email your curriculum vitae, a
short cover letter with research experience and interests, and contact
information for three references to Sarah Heissler (sarah.heiss...@osumc.edu)
and Krishna Chinthalapudi (krishna.chinthalap...@osumc.edu).



Best,

Krishna



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[ccp4bb] Postdoctoral position in the Lee lab at Duke University School of Medicine

2023-04-10 Thread Seok-Yong Lee

A NIH-funded postdoctoral research position is open in the laboratory of
Dr. Seok-Yong Lee at Duke University School of Medicine. The successful
candidate will have the opportunity to explore the molecular-level
mechanisms of the machinery that underpin membrane transport processes that
are critical to human health.

The Lee Lab's research is currently centered around three main areas of
membrane transport: calcium permeation in somatosensation, drug/metabolite
transport, and polysaccharide transport in microbial cell wall synthesis.
The types of questions we ask are: what is the molecular basis of
temperature and irritant sensing and why is mint cooling and wasabi spicy?
How do fungi and bacteria construct their intricate cell walls, and how can
these mechanisms be targeted by drugs? How are nutrients and drugs taken up
into cells, and how can we improve drug specificity and potency? To probe
these questions the lab employs a diverse range of techniques, including
cryo-electron microscopy (cryo-EM), biochemistry, biophysics, chemical
biology, and computational approaches.

Recent notable publications from the lab include:

   - Yin et al., Science, 2022
   - Wright, Fedor, et al., Nature, 2022
   - Ren et al., Nat. Struct. & Mol. Biol., 2022
   - Kwon et al., Nat. Commun., 2022
   - Kwon et al., Nat. Struct. & Mol. Biol., 2021

For more information, visit the Lee Lab website:
https://sites.duke.edu/leelab/

This position presents an exceptional opportunity for skilled biochemists
or structural biologists with an interest in connecting structural biology
to membrane biology. Candidates will benefit from joining a diverse and
highly collaborative research group with excellent training opportunities
and research facilities. A strong background in either cryo-EM or membrane
protein biochemistry is advantageous, but not mandatory.

To apply, please submit the following materials to seok-yong@duke.edu:

   - Curriculum vitae or resume including a list of publications and
   contact information for three references
   - Statement of research interests

Durham, home to Duke University, is consistently ranked as one of the best
places to live in the United States with lush countryside and driving
distance to the Atlantic Ocean and Appalachian Mountains. For more
information on the city, consult the recent U.S. News and World Report
rating:
https://realestate.usnews.com/real-estate/slideshows/25-best-places-to-live-in-the-us



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[ccp4bb] Postdoctoral position at the Ohio State University

2023-04-05 Thread Krishna Chinthalapudi

Dear All,



Applications are invited for a joint postdoctoral scientist position in the
laboratories of Dr. Sarah Heissler and Dr. Krishna Chinthalapudi at the
Ohio State University. The research project focuses on understanding the
role of myosin motors and cytoskeletal proteins in health and disease. We
combine state-of-the-art structural biology approaches including cryo-EM,
and X-ray crystallography with biochemical, biophysical, and cell
biological methods to investigate the structure and function of myosin
motors and their regulation by cytoskeletal proteins.



Our laboratories are equipped with state-of-the-art instrumentation for the
proposed studies and have generous access to a Titan Krios G3i Cryo-TEM
equipped with a bioquantum imaging filter and a K3 direct electron
detector, imaging phase plates, STEM/TEM tomography, and an image spherical
aberration corrector. In addition, our labs have access to a Glacios with a
Falcon III detector and a Ceta-D camera for MicroED analysis at the
world-class Center for Electron Microscopy and Analysis (CEMAS) at the Ohio
State University.



Candidates must have a Ph.D. degree and strong practical experience in
structural biology. Experience in molecular biology techniques, structural
biology, and/or high-resolution imaging are desirable.



To be considered for this position, please email your curriculum vitae, a
short cover letter with research experience and interests, and contact
information for three references to Sarah Heissler (sarah.heiss...@osumc.edu)
and Krishna Chinthalapudi (krishna.chinthalap...@osumc.edu).



Best,

Krishna



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[ccp4bb] Postdoctoral position in structure of sugar and phytohormone transporting membrane proteins at Aarhus University, Denmark.

2023-04-03 Thread Bjørn Panyella Pedersen

Dear colleagues,
Please pass this along anyone who might be interested. Thanks!
/Bjørn

Postdoctoral position in structure of sugar and phytohormone transporting
membrane proteins at Aarhus University, Denmark.

online posting:
https://www.au.dk/om/stillinger/job/postdoctoral-position-in-structure-of-sugar-and-phytohormone-transporting-membrane-proteins-at-aarhus-university-denmark

We are looking for a highly skilled and motivated postdoc with an interest in
working on sugar and hormone transporting membrane transporters and preferably
with a proven track record in the area of structural and/or functional analysis
of membrane proteins.

The position will be open from summer 2023, but starting date is negotiable.
Funding is available for at least 2 years of employment, with an extension
possible for up to 4 years.

The position:
The position seeks to strengthen ongoing activities in the our group related to
the function and mechanism of sugar-transporting and hormone-transporting
membrane proteins in plants (pedersenlab.dk). Examples of our research can be
found in:
Bavnhøj et al. “Molecular mechanism of sugar transport in plants unveiled by
structures of glucose/H+ symporter STP10” Nature Plants 7 (2021)
Ung et al. “Structures and mechanism of the plant PIN-FORMED auxin transporter”
Nature 609 (2022).
The laboratory's interest is the interplay between structure and function of
transmembrane transport processes with a focus on metabolite uptake systems and
proton driven transport, and the methods uses are primarily structural biology
(cryo-EM, crystallography) and biochemistry. The group is part of the Section
of Structural Biology at Aarhus University.

The candidate:
A successful candidate has a relevant Ph.D. degree and a solid and documented
background in structural biology, biochemistry and/or biophysics. Experience
with membrane protein expression and purification is favored, and the candidate
must demonstrate an ability and interest to work with membrane proteins with a
structural aim. Applicants should be ambitious, show strong collaborative
skills, and be able to take initiatives and responsibility within the work
environment.

The successful candidate is offered:
- access to a well-developed research infrastructure.
- an exciting interdisciplinary environment with many national, international
and industrial collaborators.
- a research climate inviting lively, open and critical discussion within and
across different fields of research.
- a working environment with teamwork, close working relations, network
activities among young scientists and social activities.
- a workplace characterized by professionalism, equality and a healthy
work-life balance.

The city:
In Aarhus you have easy access to beautiful nature, an exciting culture and
city life as well as a safe environment for children - a great place for the
whole family. The city of Aarhus has everything you need: exciting national and
international jobs, delightful residential areas, a rich cultural life, and
beautiful surrounding landscape of woods and coastline that make Aarhus a
wonderful place to live and work. See “life in Denmark” at Aarhus and
surroundings for further details on the city and the university
(https://international.au.dk/life/locations/aarhusandsurroundings).

Deadline:
All applications must be made online and received by 15. May. 2023.
See deails here:
https://www.au.dk/om/stillinger/job/postdoctoral-position-in-structure-of-sugar-and-phytohormone-transporting-membrane-proteins-at-aarhus-university-denmark

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[ccp4bb] Postdoctoral position at the ODDI/CMD, University of Oxford

2023-03-07 Thread William Bradshaw

Hi All,

We have a postdoctoral position available at the Alzheimer's Research UK Oxford 
Drug Discovery 
Institute,
 part of the Centre for Medicines Discovery at the 
University of Oxford. The candidate will work on structures of proteins linked 
to neurodegeneration alongside cell biologists, chemists, and assay 
specialists, making use of the 
XChem 
facility at Diamond Light Source for the development of probes against novel 
targets.

The position is available for two years. Applications close on the 27th of 
March. Please see 
CoreHR
 for details and to apply. Contact Emma Murphy 
for queries.

Thanks
Will Bradshaw




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[ccp4bb] Postdoctoral position in University of Cambridge

2023-02-27 Thread Marko Hyvonen

Dear Colleagues,

We have a 12 month postdoctoral position in an exciting collaborative project 
with Apollo Therapeutics to use fragment-based methods on an new target, to 
validate existing hits and to establish crystallographic system to support hit 
validation and optimisation. Should the project be successful, funding could be 
extended further.

More details and links to application portal from here: 
https://www.jobs.cam.ac.uk/job/39691/

Happy to answer informal queries.

Best wishes, Marko

-
Marko Hyvonen
Department of Biochemistry
University of Cambridge
mh...@cam.ac.uk
https://hyvonen.bioc.cam.ac.uk
@HyvonenGroup




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[ccp4bb] Postdoctoral position, IBS Grenoble, France

2023-02-22 Thread Carlos CONTRERAS-MARTEL


Dear all,

A 3-year postdoctoral research position financed by the French National 
Research Agency (ANR) is available at the Bacterial Pathogenesis Group 
(A. Dessen) at the IBS (Institut de Biologie Structurale) in Grenoble. 
Our group uses structural biology tools to understand mechanisms 
employed by bacteria to initiate infections and to synthesize their cell 
wall. Candidates should have experience in membrane protein 
biochemistry, crystallography and electron microscopy. This structural 
biology project will take advantage of the expertise in the lab working 
with bacterial cell wall elongation complexes in an environment with 
dedicated cryo-EM and X-ray crystallography facilities.


Deadline March 7th

See details in :

https://emploi.cnrs.fr/Offres/CDD/UMR5075-CYNDAV-039/Default.aspx?lang=EN

kind regards

A. Dessen

--

Andréa Dessen, Ph.D.
Institut de Biologie Structurale
Bacterial Pathogenesis Group
71 avenue des Martyrs
CS 10090
38044 Grenoble
France
andrea.des...@ibs.fr
tel: (+33) (0)4 57 42 85 90
http://www.ibs.fr/groups/bacterial-pathogenesis-group/
http://www.ibs.fr/groupes/groupe-pathogenie-bacterienne/



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[ccp4bb] Postdoctoral position in room temperature fragment screening by X-ray crystallography

2023-02-22 Thread Hough, Michael (DLSLtd,RAL,LSCI)

Dear ccp4 community,

We are recruiting for a postdoctoral position at Diamond to work on developing
room temperature fragment screening as a tool in drug discovery. This is part
of a major international project funded by Horizon-Europe (see link below) so
has a lot of opportunity for international collaboration and/or travel. The
overall idea of the project is to investigate the binding fragments under
non-cryogenic conditions and to optimise methodology and pipelines to achieve
this in a time and sample efficient manner.

I'd be grateful if this could be brought to the attention of candidates who may
be interested in joining athe team.

https://vacancies.diamond.ac.uk/vacancy/pdra-vmxi-room-temperature-fragment-screening-infratech-503820.html

Thanks,

Mike

About the Role

We now have an excellent opportunity for a Post-Doctoral Research Associate
(PDRA) to conduct world-leading research aimed at developing room temperature
fragment screening into a key tool for the development of new therapies.

This role is part of a major EU funded international project called
'Fragment-Screen', involving six leading research centres across Europe
together with seven industrial partners including IBM and Astex
Pharmaceuticals. Working together we will make advances in the application of
X-ray crystallography, cryo-EM and NMR for fragment screening as well as
applying advanced computational approaches to hit identification and
development. The role therefore offers an excellent opportunity to be part of
an international, interdisciplinary research team.

Details on the overall project are available here:
https://instruct-eric.org/news/fragment-screen-a-new-european-project-coordinated-by-instruct-eric/

The Versatile Macromolecular Crystallography in-situ (VMXi) beamline at Diamond
is dedicated to room temperature data collection from macromolecular crystals.
It is an entirely automated facility for characterisation of, and data
collection directly from, crystallisation experiments in situ. Working with the
beamline team you will conduct experiments to determine and implement the most
effective pipelines to carry out fragment screens at room temperature. You will
investigate the differences between fragment binding under the usual cryogenic
conditions and at room temperature. This work will be within an overall part of
the project concerned with X-ray diffraction including other researchers at
Diamond and the ESRF, France.

The PDRA will be responsible for:

* Carrying out experiments to fulfil the aims of the research proposal.
This may vary from protein crystallisation, carrying out fragment campaigns and
X-ray crystallographic data analysis to pipeline optimisation.
* Managing the day-to-day running of a research project.
* Identifying research objectives.
* Attending scientific meetings including consortium meetings and
presenting your research.
* Leading in the analysis and authoring of scientific results in
international peer-reviewed journals.

This role is an 18-month fix term contract from appointment.

About You

You should hold a degree in science, with a PhD relevant to the research area.

You should demonstrate knowledge or experience of:

* Macromolecular crystallography
* Protein crystallisation
* Crystallographic data processing software
* Fragment screening / drug design methods (desirable)
* Synchrotron radiation-based research (desirable)

You will demonstrate good interpersonal, communication and presentational
skills, with the ability to interact effectively with staff and facility
users/collaborators at all levels.

Benefits

Diamond offers an exceptional benefits package to support staff in achieving a
positive work/life balance. This includes 25 days annual leave plus 13 days of
statutory and company holidays and 2 annual volunteering days, along with
flexible working hours and an excellent pension scheme. Staff also have access
to a range of amenities on site including a nursery, cafes, a restaurant and
sports and leisure facilities. A relocation allowance may also be available
where applicable.

To Apply

Please use the online application process to apply and tell us why you believe
you are suitable for this role.

The initial closing date for applications is 12th March 2023, however
applications will be reviewed and interviewed on an ongoing basis until this
vacancy is filled.

PDRA - Room temperature fragment screening, beamline VMXi

Harwell Science and Innovation Campus, Oxfordshire

Salary £33,963 - £39,955 per annum

Full time / Flexible hours considered

18 months fixed term

Ref: 10931

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[ccp4bb] postdoctoral position at UCalgary with Omid Haji-Ghassemi and Matt (Mathilakth) Vijayan

2023-02-03 Thread Omid Haji-Ghassemi

Dear CCP4BB list,

A position is available for a highly motivated and skilled Post-doctoral Fellow 
(PDF) at the University of Calgary in Calgary, Alberta, Canada. The successful 
candidate will lead X-ray and potentially cryo-EM experiments to understand 
receptor complex biology and drug targeting. The position will be held within 
the Departments of Biological Sciences under the co-supervision of Dr. Matt 
(Mathilakth) Vijayan and Dr. Omid Haji-Ghassemi.

The successful applicant must have a Ph.D. in structural biology or related 
fields. Excellent theoretical knowledge and practical skills in either X-ray 
crystallography or other protein biophysical methods are required. This 
includes familiarity with the expression and purification of proteins.  The 
position forms part of a collaborative, multidisciplinary effort between the 
Vijayan and Haji-Ghassemi laboratories. As such, excellent oral and written 
English communication skills, the proven ability to work and as part of a team, 
and strong individual research productivity are essential.

Calgary is one of the sunniest and cleanest cities in North America. and has 
been named as one of the world’s most livable cities. Hence it is a great place 
to do research and build a career while living in an affordable city. Calgary 
is about an hour drive from the majestic Rocky Mountains and Banff. 

Qualified Applicants should submit a cover letter including contact information 
for three professional references, and a curriculum vitae including a list of 
publications. Application materials should be combined into a single PDF 
document and submitted via email to 
omid.hajighass...@calgary.ca.

The position is available immediately. The appointment will be at the rank of 
Postdoctoral Fellow with a 50,000 salary, plus benefits.

Equity and diversity are essential to academic excellence. An open and diverse 
community fosters the inclusion of voices that have been underrepresented or 
discouraged. We encourage applications from members of groups that have been 
marginalized on any the basis of sex, sexual orientation, gender identity or 
expression, racialization, disability, political belief, religion, marital or 
family status, age, and/or status as a First Nation, Metis, Inuit, or 
Indigenous person.
---
---
Omid Haji-Ghassemi, PhD
Assistant Professor
Department of Biological Sciences
University of Calgary
Libin Cardiovascular Institute
https://hajighassemilab.org




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[ccp4bb] Postdoctoral position in YSBL, University of York

2023-01-31 Thread Jon Agirre

Dear all,

Applications are invited for a Postdoctoral Research Associate position,
funded by the Royal Society, for up to 30 months to work with Dr Jon Agirre
in the Department of Chemistry. The successful applicant will join a
vibrant team of researchers at the heart of the world-leading York
Structural Biology Laboratory (YSBL). The work of the laboratory over the
years has included the delivery of world-leading methods and experimental
discoveries, training and nurturing hundreds of outstanding scientists in
the process.

Role
In collaboration with Dr. Elisa Fadda (Maynooth University, Ireland), we
have developed proof-of-concept software that models protein glycosylation
into AlphaFold models. This task has been automated and integrated into the
new Python interface of the carbohydrate-specific Privateer software. In
parallel, we have developed infrastructure and analyses that allow us to
get a clear picture of glycans and their interactions. We expect that this
technology will enable the successful applicant to, based on existing
glycobiological knowledge, extend the Privateer software to predict, build
and adapt models of glycans onto AlphaFold models.

Main duties and responsibilities:
- To develop and extend the Privateer software to predict, build and adapt
models of glycans onto AlphaFold models.
- To further our existing collaborations with CCP4, CCP-EM, PDB-REDO, the
Protein Data Bank and the AlphaFold Protein Structure Database.

For informal enquiries: please contact Dr Jon Agirre, jon.agi...@york.ac.uk
To apply: https://jobs.york.ac.uk/vacancy/research-associate-513495.html

Department
The Department of Chemistry is one of the largest and most successful
departments at York and we are renowned internationally for our research.
As a department, we strive to provide a working environment that allows all
staff and students to contribute fully, to flourish, and to excel. We are
proud of our Athena Swan Gold Award. The Department of Chemistry values all
employees for the qualities and skills they bring to the workplace and aims
to be a diverse and egalitarian community in which all can thrive.

Many thanks for making it this far in the advert!
With best wishes,
Jon
-- 
Dr Jon Agirre [image: A button with "Hear my name" text for name playback
in email signature]  
Royal Society Olga Kennard Research Fellow
CCP4 ED champion | instruct-ERIC representative @ 3D-Bioinfo (Elixir)
York Structural Biology Laboratory, Department of Chemistry
University of York, Heslington, YO10 5DD, York, UK
http://www.york.ac.uk/chemistry/research/ysbl/people/staff/jagirre/
Office: /B/K/065 Phone: +44 (0) 1904 32 8252
Twitter: @glycojones



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[ccp4bb] Postdoctoral position to characterise novel plastic degrading enzymes

2023-01-25 Thread Marko Hyvonen

Dear Colleagues.

Still six days to apply for an exciting opening in our group for a postdoc to 
work on characterisation of new plastic degrading enzymes ("plastizymes") in a 
BBSRC-funded sLoLa project lead by Florian Hollfelder and in collaboration with 
Christine Orengo (UCL) and Rob Finn (EMBL-EBI).

We are looking for someone with significant expertise on producing hard to make 
proteins and in characterisation of these biochemically, biophysically and 
structurally (X-ray crystallography, NMR, cryo-EM are all as options). Some 
exciting chemical biology thrown into the mix as well.

More details and application from University of Cambridge job portal: 
https://www.jobs.cam.ac.uk/job/38770/

Feel free to drop a line if you have specific questions.

best, Marko
-
Marko Hyvonen
Department of Biochemistry
University of Cambridge
mh...@cam.ac.uk
https://hyvonen.bioc.cam.ac.uk
@HyvonenGroup




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[ccp4bb] Postdoctoral position in Structural Biology at the University of Toronto

2023-01-19 Thread Jeffrey Lee

Postdoctoral position in Structural Biology at the University of Toronto

We are seeking an enthusiastic and self-motivated Postdoctoral Fellow to study 
the mechanisms of fertilization and cell-cell fusion in the Lee Lab at the 
University of Toronto, Department of Laboratory Medicine and Pathobiology. The 
Postdoctoral Fellow will lead research efforts on a Bill and Melinda Gates 
Foundation funded project to develop non-hormonal contraceptives targeting 
essential membrane glycoproteins involved in human sperm and egg attachment. 
The research will entail protein-protein interaction studies, crystallography, 
protein engineering, and/or cryo-EM.

Qualifications:
*PhD in Biochemistry, Structural Biology, Biophysics, or a related field
*Experience with cloning, protein expression, and protein purification methods
*Experience with insect or mammalian cell culture is a benefit
*Solid practical and theoretical understanding in X-ray crystallography and/or 
cryo-EM
*Strong publication record
*Fluent in English (written and oral)
*Strong scientific writing skills
*Excellent problem solving, interpersonal, communication and presentation skills

The position is available immediately. University of Toronto is well equipped 
with state-of-the-art equipment for molecular biology, protein expression and 
purification, biophysics and structural biology (crystallography, NMR and 
cryo-EM). Please visit the Lee Lab website (https://www.leelab-utoronto.com) 
for more information.

Interested candidates are invited to send your CV, a brief description of 
research interest and experience, names of three references by email to: Prof. 
Jeff Lee
jeff@utoronto.ca All qualified candidates are 
encouraged to apply by February 10, 2023. We thank all applicants for their 
interest, however only those shortlisted for interviews will be contacted.




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[ccp4bb] Postdoctoral position at the ODDI/CMD, University of Oxford

2023-01-17 Thread William Bradshaw

Hi All,

We have a postdoctoral position available at the Alzheimer's Research UK Oxford 
Drug Discovery 
Institute,
 part of the Centre for Medicines Discovery at the 
University of Oxford. The candidate will work on structures of proteins linked 
to neurodegeneration alongside cell biologists, chemists, and assay 
specialists, making use of the 
XChem 
facility at Diamond Light Source for the development of probes against novel 
targets.

The position is available for two years. Applications close on the 6th of 
February. Please see 
CoreHR
 for details and to apply. Contact Emma Murphy 
for queries.

Thanks
Will Bradshaw




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[ccp4bb] Postdoctoral Position in Structural Biology of Pol I and Pol III Transcription, EMBL Heidelberg

2023-01-11 Thread Christoph Mueller


Dear Colleagues,

The Müller group at EMBL Heidelberg is seeking a highly motivated 
postdoctoral researcher to pursue a cutting-edge experimental research 
project in the structure-function analysis of Pol I and Pol III 
transcription complexes. Depending on the interests of the applicant, 
possible projects will focus on biochemical characterization and 
structure determination by single-particle cryo-EM i/n vitro/ or on 
imaging by cryo-ET, fluorescence microscopy and correlative approaches 
/in situ/.


Further details on the research group can be found at 
https://www.embl.org/groups/mueller/


Applicants should have a PhD in structural molecular biology and 
experience in cryo-EM (single-particle or cryo-ET). To apply and read 
further details on the job description: 
https://www.embl.org/jobs/position/HD02330


Best wishes,
Christoph

__
Dr. Christoph W. Müller
Head of Structural and Computational Biology Unit

EMBL
Meyerhofstrasse 1
69117 Heidelberg, Germany

email:cmuel...@embl.de,christoph.muel...@embl.org
phone: 0049-6221-387-8320
https://www.embl.org
https://www.embl.org/groups/mueller/
___




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[ccp4bb] Postdoctoral position at the Protein Structure Prediction Center, UC Davis

2023-01-11 Thread Andriy Kryshtafovych

A one-year position focused on large scale analysis of model accuracy 
with respect to applications in structural biology and biology in general.
The UC Davis Protein Structure Prediction Center provides the 
infrastructure to the Critical Assessment of protein Structure 
Prediction program (CASP), dedicated to cutting-edge science in modeling 
of protein structure. It brings together approximately 100 research 
groups from more than 20 countries world-wide.

Desirable skills:
1. In depth knowledge of protein structure
2. Fluency in programming (Perl, PostgreSQL, Python, R and C)
3. Familiarity with Linux
4. Ability to write and run scripts processing data
5. Basic knowledge of computer system administration, including 
multi-processor clusters
6. Knowledge of cgi scripting, web design, and online data visualization 
tools is also desirable


The position is available immediately. With inquiries, please contact 
Krzysztof Fidelis (kfide...@ucdavis.edu).




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[ccp4bb] Postdoctoral position available at UCL/Birkbeck ISMB to work on bacterial secretion systems

2023-01-09 Thread Gabriel Waksman

Postdoctoral Researcher – cryo-Electron Microscopy - fixed term – for up to 33 
months

At Birkbeck/UCL -ISMB- Gabriel Waksman Lab

The ISMB is seeking a Post-Doctoral Research Assistant to carry out structural 
analysis of the Type IV Secretion System by cryo-electron microscopy with 
Professor Gabriel Waksman. The laboratory has been exceptionally productive 
over the years in this area (see Science, 2009, 323:266-268; Nature, 2009, 
462:1011-1015; Nature, 2014, 508:550-553; Cell, 2016, 166:1436–1444; Cell, 
2017, 169:708–721; Nature. 2022, 607:191-196). The research programme is funded 
by a grant from the Wellcome Trust. Further details on the research group and 
on type IV secretion can be found at 
http://www.ismb.lon.ac.uk/gabriel-waksman/homepage.htm 
.

Applicants should have a PhD in Structural Molecular Biology, and experience in 
Electron Microscopy, Image Processing, Biophysics, Biochemistry or related 
areas.

To apply (and read further details on job description), click on the following 
link: https://cis7.bbk.ac.uk/vacancy/postdoctoral-researcher-511711.html 


Closing date: 15th February 2023 - Tentative interview date: 28th February 2023


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[ccp4bb] Postdoctoral Position: Structural biology of the actin cytoskeleton

2022-12-19 Thread Kristina Djinovic Carugo


*Postdoctoral Position: Structural biology of the actin cytoskeleton*

Djinovic lab isinterested in the molecular mechanisms underlying the 
architecture and assembly of the actin based cytoskeleton. Thisproject 
focuses on ubiquitous human proteins α-actinin-1 and -4, which 
self-associate to form a homo- and hetero dimeric units that cross-link 
actin filaments in calcium-regulated manner. The projectis jointly 
funded by Austrian and Slovene Science Funds and is a close 
collaboration between Djinovic group at Vienna, Austria, and Pavsic 
group at University of Ljubljana, Slovenia. The two young and dynamic 
groups will join forces to understand the detailed molecular mechanism 
of regulation of this essential F-actin crosslinking protein by calcium 
and specific phosphoprylation events.


We employ an integrated approach by combining biochemistry, cell, 
chemical and structural biology approaches, including X-ray 
crystallography, small angle scattering and (starting) cryo-EM. The 
successful candidates will be involved in all aspects of the project, 
including protein expression, purification, biophysical, biochemical 
characterization and integrative structural biology.


*Qualifications and experience: *The applicants should hold a PhD degree 
in a relevant field and two years of post-doctoral experience in a 
structural biology lab. Strong background in molecular cloning, 
expression, and purification of protein complexes is essential. Prior 
knowledge of crystallography and/or single-particle electron microscopy 
is needed. Excellent spoken and written English are required.


The successful applicants will work in a stimulating scientific 
environment: Department for Structural and Computational Biology 
at Max Perutz Labs 
, a joint venture between University 
of Vienna and Medical University of Vienna. The Labs are located at 
Vienna BioCenter , the largest 
molecular life science hub in Austria. We are equipped equipped with 
/state-of-the-art/ research infrastructure 
for 
experimental and computational work, and have access to facilities at 
Vienna Biocenter Core Facilities 
, which includes 
mass-spectrometry, a blend of Protein technologies and electron 
microscopy instruments (Glacios, Krios). The group has in addition 
access to cryo-EM Titan-Krios through BAG at ESRF and to major European 
synchrotron high-brilliance X-ray sources.


1.A concise description of research experience, including a list of 
published peer-reviewed articles.


2.Copyof the PhD diploma (or equivalent).

3.Contact details for *three references*, of which one should be your 
PhD supervisor.


Please preparethe applicationas a*single package in PDF format*, and 
send it to <*admin.v...@univie.ac.at* >, 
subject Postdoctoral position in Djinovic Lab.


Further information can be obtained from Kristina Djinovic 
carugokristina.djino...@univie.ac.at 
.


*Closing date:*review of applications begins immediately and will 
continue until the position is filled.


*WEB-PAGES*

https://www.maxperutzlabs.ac.at/research/research-groups/djinovic

https://www.maxperutzlabs.ac.at/

https://structbio.univie.ac.at/

https://structbio.univie.ac.at/research-infrastructure-facilities/

https://www.viennabiocenter.org/

https://www.viennabiocenter.org/facilities/

--
Department of Structural and Computational Biology
Max Perutz Labs
University of Vienna
Campus Vienna Biocenter 5
A-1030 Vienna
Austria


e-mail:kristina.djino...@univie.ac.at
Phone: +43-1-4277-52203
Phone: +43-1-4277-52201 (secretary)
Mobile A: +43-664-817 5259
Fax: +43-1-4277-9522

--
Department of Structural and Computational Biology
Max Perutz Labs
University of Vienna
Campus Vienna Biocenter 5
A-1030 Vienna
Austria


e-mail:kristina.djino...@univie.ac.at
Phone: +43-1-4277-52203
Phone: +43-1-4277-52201 (secretary)
Mobile A: +43-664-817 5259
Fax: +43-1-4277-9522



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[ccp4bb] Postdoctoral position protein crystallography available at the Institute of Cancer Research, London UK

2022-12-09 Thread Rob Van Montfort

The Institute of Cancer Research (ICR), London, is one of the world’s most
influential cancer research institutes, with an outstanding record of
achievement dating back more than 100 years. We provided the first convincing
evidence that DNA damage is the basic cause of cancer, laying the foundation
for the now universally accepted idea that cancer is a genetic disease. Today,
The ICR leads the world at isolating cancer-related genes and discovering new
targeted drugs for personalised cancer treatment. Together with our hospital
partner The Royal Marsden, we are rated in the top four centres for cancer
research and treatment worldwide. As well as being a world-class institute, we
are a college of the University of London. We came top in the league table of
university research quality compiled from the Research Excellence Framework and
second in 2021 (REF 2014 and 2021). The ICR is committed to attracting,
developing and retaining the best minds in the world to join us in our mission
– to make the discoveries that defeat cancer.

The Cancer Research UK Cancer Therapeutics Unit (CTU), within the Division of
Cancer Therapeutics, is a multidisciplinary 'bench to bedside' centre,
comprising around 200 staff dedicated to the discovery and development of novel
therapeutics for the treatment of cancer. The CTU’s exciting goal is to
discover high quality small molecule drug candidates and to progress these to
clinical trial. All the scientific disciplines are in place to make this
possible, including medicinal chemistry, biology, structural biology, assay
scientists, drug metabolism and clinical specialists. This is an exciting and
fast-moving research setup and offers the opportunity to work within a
multi-disciplinary environment using state-of-the-art techniques and equipment.

A postdoctoral position (ID459) is available in Dr Rob van Montfort’s Hit
Discovery and Structural Design Team within the CTU. The Post-doc will be
involved in the structure determination of proteins and protein/small molecule
complexes by X-ray crystallography (and potentially cryoEM) as part of one of
the CTU’s drug discovery programmes. The post holder will be responsible for
protein production and purification, protein crystallisation, structure
determination by X-ray crystallography and subsequent structural analysis. The
successful candidate will be an integral member of a multidisciplinary project
team within the CTU at the ICR Sutton site, and will interact closely with
biologists, computational chemists, medicinal chemists, assay scientists and
structural biologists. The successful candidate will have access to
state-of-the-art facilities for protein production and purification, as well as
biophysical characterisation and crystallisation. We also benefit from
excellent access to Diamond Light Source synchrotron at the Harwell Science and
Innovation campus, Didcot, UK, for X-ray data collection. The postholder will
be expected to work across the two sites in Chelsea, London and Sutton, Surrey.
The starting salary will be in the range £40,107 to £46,724 p.a. inclusive
(based on previous postdoctoral experience).

The post is offered on a fixed term contract of 2 years. Informal enquiries to
rob.vanmontf...@icr.ac.uk or
yann-vai.lebi...@icr.ac.uk.
Please DO NOT send your application to Dr van Montfort or Dr Le Bihan, but
apply via the e-recruitment system on our website
www.icr.ac.uk.
For more details see the following link:
https://jobs.icr.ac.uk/vacancies/459/postdoctoral-training-fellow--x-ray-crystallography-id459.html

Closing date: 8 January 2023

Dr. Rob van Montfort
Reader in Structural Biology and Cancer Drug Discovery
Team Leader Hit Discovery and Structural Design
Centre for Cancer Drug Discovery, Divisions of Cancer Therapeutics and
Structural Biology
The Institute of Cancer Research
15 Cotswold Road
Sutton SM2 5NG
UK

Tel:
+44-(0)20-8722-4364
Email: rob.vanmontf...@icr.ac.uk

The Institute of Cancer Research: Royal Cancer Hospital, a charitable Company
Limited by Guarantee, Registered in England under Company No. 534147 with its
Registered Office at 123 Old Brompton Road, London SW7 3RP.

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[ccp4bb] Postdoctoral position in Structural Virology at the Institut Pasteur

2022-12-03 Thread Pablo Guardado Calvo

*A two-year postdoctoral position is available in the group of Structural
Biology of Infectious Diseases (SBID) at the Institut Pasteur (Paris,
France)*

SBID is a new lab at the Institut Pasteur headed by Pablo Guardado-Calvo.
In the SBID we investigate the molecular mechanism of poxvirus entry into
target cells. We combine structural biology, biophysics and virology
approaches to characterise protein complexes. We aim to use the resulting
information to develop vaccines and therapies. For more information, you
can check our previous work done with bunyaviruses and flaviviruses (PMIDs:
32937107, 29097548, 27783711, 25581790).

We are looking for a person with excellent track record and motivation to
pursue a career in structural virology. The postdoctoral fellow will be in
charge of characterising large protein complexes using cryo-electron
tomography or SPA and of setting up functional assays to characterise their
activity in vitro. The postdoc will work in close collaboration with a
research engineer focused on related projects. The project will involve
protein and virus production, functional characterisation of ligands using
neutralisation and fusion assays and structural studies using cryo-electron
microscopy and crystallography. The group is hosted in friendly and dynamic
environment with extensive opportunities to learn new techniques and
establish collaborations. We have fully equipped P1 and P2 labs and the
Institut Pasteur is equipped with start-of-the-art microscopes, including
two 200 kV Glacios and a 300 kV Titan Krios equipped with a Falcon 4
detector and an energy filter. The synchrotron Soleil is less than 1 hour
from the Institut and we have fluid access to the crystallography and
biophysics platforms, which are excellently equipped.

Required qualifications
• A PhD in structural biology, biochemistry, biophysics or virology.
• Documented experience in at least one of the following techniques:
structural biology (cryo-electron microscopy), virology (manipulation of
poxviruses would be particularly appreciated, neutralisation assays) or
biophysical techniques (viral fusion assays).
• Good interpersonal skills

The application should contain
1. A letter of motivation (1 page) with a short description of your
research interests.
2. A CV, including a list of relevant skills, experiences and a full
publication list.
3. Names and e-mail addresses of 2-3 reference persons, indicating their
professional relation to you.

The starting date is negotiable. Ideally around March 2023, no later than
September.

Informal inquiries and application should be sent to Pablo Guardado-Calvo (
guard...@pasteur.fr)



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[ccp4bb] Postdoctoral position in structural biology, Bethesda, MD

2022-11-28 Thread Pazgier, Marzena

There is an immediate opportunity to join a research team at the Uniformed
Services University of the Health Sciences (USU, https://www.usuhs.edu/) in
Bethesda, Maryland, to provide the molecular underpinnings of the adaptive
immune responses to HIV-1 and SARS-Cov-2 with the ultimate goal of
developing new protein/antibody-based therapies and new vaccines. Strong
research interests and experience in structural biology/ immunology,
including molecular cloning, protein/antibody/envelope glycoprotein
expression, protein engineering, X-ray crystallography and/or Cryo-EM are
required for this position. Qualified candidates should have a doctorate in
structural biology, chemistry, biochemistry, immunology or a
closely-related field. Candidates at any career stage are invited.


Candidates need to be highly motivated individuals who enjoy working as
part of a dynamic, collaborative and multidisciplinary team. Preference
will be given to candidates with exceptionally strong experimental skills,
a strong record of peer-reviewed publications, and a demonstrated
commitment to basic and translational research.


USU is in Bethesda, MD directly across the street from the NIH, and is
therefore part of an extraordinarily vibrant local biomedical research
community. Our research projects take advantage of recently established
Core facilities for Nextgen sequencing, Bioinformatics and Structural
Biology analyses. USU has a strongly collaborative environment, with weekly
Immunology data club and journal club meetings, as well as regular research
seminars featuring local and invited speakers.


For more information, please contact Dr. Pazgier at
marzena.pazg...@usuhs.edu.



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[ccp4bb] Postdoctoral position in Structural Biology at Uppsala University

2022-11-23 Thread Sebastian Deindl

Dear all,

I have an opening for a postdoctoral fellow (funded by a stipend) in my group 
at the Department of Cell and Molecular Biology, Uppsala University, Sweden.

The postdoctoral fellow will be working towards the structure determination of 
nucleosomes in complex with chromatin-binding factors. The focus will be on 
using novel cryo-EM approaches (such as time-resolved sample preparation) to 
gain new mechanistic insights into chromatin-associated processes.

The successful candidate should have documented experience in single-particle 
cryo-electron microscopy including sample preparation, data acquisition, image 
processing, and atomic model
building/refinement.

For more information about the position please see the attached document. 
Please note that suitable candidates must have obtained their PhD no earlier 
than 6 years ago.

Informal inquiries and applications should be sent to Martha Schattenhofer, 
martha.schattenho...@icm.uu.se, with subject header “Postdoc in Structural 
Biology”, no later than January 31, 2023.

Best wishes,

Sebastian


=
Sebastian Deindl, Ph.D.
Professor of Molecular Biophysics
EMBO Young Investigator
Wallenberg Academy Fellow

Department of Cell and Molecular Biology
Uppsala University
Phone: +46 (0) 70 840 0496
Email: sebastian.dei...@icm.uu.se

Web: http://deindl-lab.com








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Postdoc in Structural Biology.pdf
Description: Postdoc in Structural Biology.pdf

[ccp4bb] Postdoctoral Position: Structural biology of the actin cytoskeleton

2022-11-17 Thread Kristina Djinovic Carugo


*Postdoctoral Position: Structural biology of the actin cytoskeleton*

Djinovic group isinterested in the molecular mechanisms underlying the 
architecture and assembly of the actin based cytoskeleton. Thisproject 
focuses on ubiquitous human proteins α-actinin-1 and -4, which 
self-associate to form a homo- and hetero dimeric units that cross-link 
actin filaments in calcium-regulated manner. The projectis jointly 
funded by Austrian and Slovene Science Funds and is a close 
collaboration between Djinovic group at Vienna, Austria, and Pavsic 
group at University of Ljubljana, Slovenia. The two young and dynamic 
groups will join forces to understand the detailed molecular mechanism 
of regulation of this essential F-actin crosslinking protein by calcium 
and specific phosphoprylation events.


We employ an integrated approach by combining biochemistry, cell, 
chemical and structural biology approaches, including X-ray 
crystallography, small angle scattering and (starting) cryo-EM. The 
successful candidates will be involved in all aspects of the project, 
including protein expression, purification, biophysical, biochemical 
characterization and integrative structural biology.


*Qualifications and experience: *The applicants should hold a PhD degree 
in a relevant field and two years of post-doctoral experience in a 
structural biology lab. Strong background in molecular cloning, 
expression, and purification of protein complexes is essential. Prior 
knowledge of crystallography and/or single-particle electron microscopy 
is needed. Excellent spoken and written English are required.


The successful applicants will work in a stimulating scientific 
environment: Department for Structural and Computational Biology 
at Max Perutz Labs 
, a joint venture between University 
of Vienna and Medical University of Vienna. The Labs are located at 
Vienna BioCenter , the largest 
molecular life science hub in Austria. We are equipped equipped with 
/state-of-the-art/ research infrastructure 
for 
experimental and computational work, and have access to facilities at 
Vienna Biocenter Core Facilities 
, which includes 
mass-spectrometry, a blend of Protein technologies and electron 
microscopy instruments (Glacios, Krios). The group has in addition 
access to cryo-EM Titan-Krios through BAG at ESRF and to major European 
synchrotron high-brilliance X-ray sources.


1.A concise description of research experience, including a list of 
published peer-reviewed articles.


2.Copyof the PhD diploma (or equivalent).

3.Contact details for *three references*, of which one should be your 
PhD supervisor.


Please preparethe applicationas a*single package in PDF format*, and 
send it to <*admin.v...@univie.ac.at* >, 
subject Postdoctoral position in Djinovic Lab.


Further information can be obtained from Kristina Djinovic 
carugokristina.djino...@univie.ac.at 
.


*Closing date:*review of applications begins immediately and will 
continue until the position is filled.


*WEB-PAGES*

https://www.maxperutzlabs.ac.at/research/research-groups/djinovic

https://www.maxperutzlabs.ac.at/

https://structbio.univie.ac.at/

https://structbio.univie.ac.at/research-infrastructure-facilities/

https://www.viennabiocenter.org/

https://www.viennabiocenter.org/facilities/

--

Kristina Djinovic Carugo
Head of EMBL Grenoble

Email:  kristina.djino...@embl.org  
Website:http://www.embl.fr  
Tel:+33 4 76 20 7876   Secretary +33 4 76 20 7123   
Mobile: +33 6 60 72 71 61   
EMBL Grenoble, 71 Avenue des Martyrs, CS 90181, 38042 Grenoble Cedex 9, France
---



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[ccp4bb] postdoctoral position

2022-11-14 Thread Phoebe A. Rice

[Text  Description automatically generated]
Postdoctoral Position in the Rice Lab at the University of Chicago.

Mechanism, Engineering, and Structural Biology of Large Serine Integrases
A postdoctoral position is available immediately the laboratory of Dr. Phoebe 
Rice.


Large serine integrases (LSIs; derived from lysogenic phages) mediate precise 
site-specific DNA recombination (integration, excision, or inversion), leaving 
not a single nick in the DNA backbone.  Control of LSI directionality is 
uniquely simple.  The integrase itself catalyzes phage insertion, but not the 
reverse (excision) reaction. Excision requires a 2nd protein called a 
recombination directionality factor (RDF), that binds its cognate integrase and 
alters its conformation in an unknown manner that somehow inhibits integration 
and activates excision. LSI-RDF pairs can catalyze the insertion of large 
payloads without relying on host DNA repair (unlike CRISPR-Cas-based systems) 
and can scarlessly and controllably reverse those insertions (unlike any other 
system).


This project seeks to (1) understand, through cryo electron microscopy and 
biochemistry, how an RDF interacts with its cognate integrase to control the 
reaction direction; (2) through bioinformatics and protein engineering, 
eliminate the current bottleneck in identifying cognate RDFs for individual 
LSIs and (3) enhance the usefulness of RDFs by engineering new control 
mechanisms into them.  The project is funded by a new large, collaborative NSF 
+ UKRI/BBSRC award to the Rice (https://voices.uchicago.edu/phoebericelab/) and 
Olorunniji (Olorunniji 
lab)
 labs.



Successful applicants will have a Ph.D. or MD/PhD in the broadly defined fields 
of Biochemistry, Biophysics, and/or Molecular Biology.  Experience with the 
tools of structural biology and / or nucleic acid biochemistry is preferred.  
Applicants should be eager to learn new skills and systems, and should have 
effective communication, teamworking and problem-solving skills.



The postdoctoral fellow will be part of the vibrant local structural biology, 
protein engineering and microbiology communities, with access to our 
state-of-the-art electron microscopy facilities 
https://voices.uchicago.edu/advancedem/.  Mentorship will be tailored to the 
fellow’s goals and can include, for instance, participation in the University’s 
MyChoice career development program and guided mentorship of diverse 
undergraduate students.


To apply, email Dr. Rice at pr...@uchicago.edu and include a cover letter 
explaining relevant work experience and interest in this position, a CV and the 
contact information of 2-3 references.

Compensation in the Biological Sciences Division follows the NIH NRSA Stipend 
scale. Additional information on benefits and being a postdoc in the University 
of Chicago Biological Sciences Division can be found at 
https://bsdpostdoc.uchicago.edu/.

The University of Chicago is an Affirmative Action/Equal 
Opportunity/Disabled/Veterans Employer and does not discriminate on the basis 
of race, color, religion, sex, sexual orientation, gender identity, national or 
ethnic origin, age, status as an individual with a disability, protected 
veteran status, genetic information, or other protected classes under the law. 
For additional information please see the University's Notice of 
Nondiscrimination at: 
www.uchicago.edu/non-discrimination 
. Job seekers in need of a reasonable accommodation to complete the application 
process should call +1 773-834-6693 or email hmcgu...@bsd.uchicago.edu with 
their request.





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[ccp4bb] Postdoctoral Position in small molecule and antibody modulation of ion channels

2022-11-04 Thread Paul Miller

Applications are invited for a postdoctoral researcher position in the 
laboratory of Dr Paul Miller at the Department of Pharmacology, University of 
Cambridge, beginning from January – April 2023.


The project will study small molecule and/or antibody modulators of ion 
channels as research tools and therapeutic leads, in order to study channel 
subtype contributions to CNS physiology and disease and empower drug discovery. 
This is a great opportunity to gain experience in one or more aspects of 
handling challenging membrane proteins, understanding small molecule and/or 
antibody modulation, and cryo-EM, ideal for follow-on academic and 
biotechnology careers. The lab utilises mammalian cell protein expression 
systems, membrane protein purification, and cryo-EM via Arctica and Krios 
microscopes with K2/K3 direct detectors, and also has manual and automated 
electrophysiology equipment,. More information about the laboratory is 
available at https://www.phar.cam.ac.uk/research/miller.


The applicant will be about to obtain a PhD or have obtained a PhD within the 
last 5 years. Experience in molecular biology, protein production, purification 
and structural biology (X-ray crystallography or cryo-EM) is required. You must 
be a careful and methodical worker, paying attention to accuracy, be able to 
take responsibility and interact as part of a tightly knit team, and be willing 
to work in a collaborative environment. You should be self-motivated and able 
to organise, perform and analyse experiments with minimal instruction.


A recent relevant publication from the lab is:

Kasaragod VB, Mortensen M, Hardwick SW, Wahid AA, Dorovykh V, Chirgadze DY, 
Smart TG, Miller PS.

Mechanisms of inhibition and activation of extrasynaptic alpha-beta GABA-A 
receptors.

Nature. 2022 Feb;602(7897):529-533. PMID: 35140402

Application Closing date: 30th November 2022
Project start date: January-April 2023
For more details and to apply: https://www.jobs.cam.ac.uk/job/37880/

Informal enquiries about the position can be made to Dr Paul Miller 
(pm...@cam.ac.uk)

For enquiries about the online application process please contact Debbie 
Stanley, phar...@lists.cam.ac.uk


Paul Miller, PhD
University Lecturer in Pharmacology
Department of Pharmacology
University of Cambridge
Tennis Court Road
Cambridge
CB2 1PD
+44 1223 761267
https://www.phar.cam.ac.uk/research/miller



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[ccp4bb] Postdoctoral position at LNBio/CNPEM, Brazil

2022-11-02 Thread Andre LB Ambrosio

Dear all,

My colleague Dr. Sandra Dias and I would like to bring to your attention a
collaborative postdoctoral opportunity on the filamentous proteins involved
in the metabolic adaptation process of tumors.

The Sao Paulo Research Foundation (FAPESP) sponsors the fellowship.

Please find all the details at https://fapesp.br/oportunidades/5522/en
or send inquiries to sandra.d...@lnbio.cnpem.br

Best wishes,

-- 
Andre LB Ambrosio
Associate Professor, IFSC/USP - Brazil
www.ifsc.usp.br/alba



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[ccp4bb] Postdoctoral position at University of Konstanz

2022-10-30 Thread Olga Mayans

Postdoctoral Position: molecular structural biology of mechano-signalling 
cascades in muscle

** This position would suit an excellent candidate with ambition to transition 
to a team leader position ** 

We seek a highly motivated postdoctoral researcher to join our laboratory at 
the Department of Biology, University of Konstanz, Germany. Our laboratory 
studies the molecular mechanisms underpinning the architecture, stress 
response, adaptation and disease process of striated muscle. The successful 
applicant will work on profiling the cellular pathways that mediate the 
communication of the contractile sarcomere with other cellular organelles in 
function of mechanical activity. The work will involve the identification of 
new pathway components and the development of molecular tools to test 
mechanistic hypotheses both in vitro and in vivo. We apply an integrative 
approach to structural biology that combines a rich variety of biochemical, 
biophysical, computational and structural methodologies, with emphasis on X-ray 
crystallography. The work benefits from access to excellent experimental 
facilities and a highly interdisciplinary collaborative environment.

The position is available for 3 years in the first instance.  


Qualifications

Applicants should hold a Ph.D. in biophysics, biochemistry or related 
discipline and have a strong background in protein expression/purification, 
biophysical or biochemical characterization of protein samples and 
macromolecular X-ray crystallography. Experience in nanobody affinity binders, 
analysis of macromolecular complexes and/or cellular signalling will be of 
distinct advantage. Good command of written and spoken English, the ability to 
work in a team, and good communication and organizational skills are required. 
A publication record including first author manuscripts is expected. 


Application

Applications should contain the following documents in PDF format: 

1. Applicant's CV
2. Copies of original degree transcripts displaying marks obtained
2. A statement on how the applicant’s profile matches the position 
3. Contact details of two referees

Informal enquiries and application materials should be submitted by email to:

olga.may...@uni-konstanz.de

===
Prof. Olga Mayans
Biophysics and Structural Biology
Dept of Biology 
University of Konstanz
D-78457 Konstanz, 
Germany 
Tel: +49 7531 88-2212



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[ccp4bb] Postdoctoral position at CIBIO - Italy

2022-10-20 Thread Graziano Lolli


A postdoctoral position is available in the Laboratory of Protein 
Crystallography - CIBIO - University of Trento, Italy. The project aims to 
generate new classes of tool compounds for cancer drug discovery. Candidates 
should have a PhD in a relevant subject area and experience in protein 
expression and purification. Experience in one or more of the following is an 
advantage:

- Protein crystallization / X-ray crystallography

- Structural/functional analyses using biochemical/biophysical techniques

- Mammalian cell culture and high-throughput/high content screening

- Molecular docking


If interested, please email your CV, a description of past research 
experiences, and 2 references to graziano.lo...@unitn.it 


Additional information on the lab can be found at: 
http://www.cibio.unitn.it/504/protein-crystallography-and-structure-based-drug-design
 



Additional information on CIBIO can be found at: http://www.cibio.unitn.it/ 




Best regards,
Graziano


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[ccp4bb] Postdoctoral position available at UCL/Birkbeck ISMB to work on bacterial secretion systems

2022-10-18 Thread Gabriel Waksman

Postdoctoral Researcher – cryo-Electron Microscopy - fixed term – for up to 36 
months

At Birkbeck/UCL -ISMB- Gabriel Waksman Lab

The ISMB is seeking a Post-Doctoral Research Assistant to carry out structural 
analysis of the Type IV Secretion System by cryo-electron microscopy with 
Professor Gabriel Waksman. The laboratory has been exceptionally productive 
over the years in this area (see Science, 2009, 323:266-268; Nature, 2009, 
462:1011-1015; Nature, 2014, 508:550-553; Cell, 2016, 166:1436–1444; Cell, 
2017, 169:708–721; Nature. 2022, 607:191-196). The research programme is funded 
by a grant from the Wellcome Trust. Further details on the research group and 
on type IV secretion can be found at 
http://www.ismb.lon.ac.uk/gabriel-waksman/homepage.htm.

Applicants should have a PhD in Structural Molecular Biology, and experience in 
Electron Microscopy, Image Processing, Biophysics, Biochemistry or related 
areas.

To apply (and read further details on job description), click on the following 
link: https://cis7.bbk.ac.uk/vacancy/postdoctoral-researcher-503868.html 


Closing date: 15th November 2022 - Tentative interview date: 29th November 2022




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[ccp4bb] Postdoctoral position in drug discovery

2022-10-06 Thread Harp, Joel M

Postdoctoral position in drug discovery An opening is available in the drug 
discovery laboratory of Dr. Stephen Fesik for a post-doc in the field of 
protein x-ray crystallography.  Responsibilities will include protein 
production, fragment screening by NMR, and all aspects of x-ray crystallography 
including preparation of protein-ligand complexes, crystallization, 
home/synchrotron data collection, and structure determination. Additional 
experience in molecular biology including construct design, cloning, 
site-directed mutagenesis and modeling is a plus.  The ideal candidate should 
be self-motivated and be able to communicate efficiently in a highly 
collaborative environment. Please send cv to 
jason.p...@vanderbilt.edu


The Vanderbilt campus is located in Nashville Tennessee. Also known as Music 
City, Nashville is a fast growing and dynamic environment with plenty of 
cultural attractions and opportunities for outdoor recreation.





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[ccp4bb] Postdoctoral position available in Bethesda, MD, US

2022-09-28 Thread Marzena Pazgier

A postdoctoral position is available immediately to participate in an
interdisciplinary research program in structural immunology in the
laboratory of Dr. Pazgier (https://www.usuhs.edu/node/68252) at the
Uniformed Services University of the Health Sciences (USU) in Bethesda, MD.
Candidates are expected to work on ongoing research projects in structural
biology with the aim to understand the molecular basis of the adaptive
immune response to HIV-1 and Sars-Cov-2 and the ultimate goal to develop
new protein-based therapeutics and novel vaccine concepts. Strong research
interests and experience in molecular cloning, protein expression,
molecular interaction analysis, X-ray crystallography and/or Cryo-EM, as
well as outstanding interpersonal, oral, and written communication skills,
are required for this post. Candidates with an immunological background are
invited to apply.

Candidates need to be highly motivated individuals who enjoy working as
part of a dynamic, collaborative and multidisciplinary team. Preference
will be given to candidates with exceptionally strong experimental skills,
a strong record of peer-reviewed publications, and a demonstrated
commitment to basic and translational research. Qualified candidates should
have a doctorate in chemistry/biochemistry, microbiology, immunology or a
closely-related field. Candidates at any career stage are invited.

USU is in Bethesda, MD directly across the street from the NIH, and is
therefore part of an extraordinarily vibrant local biomedical research
community. Our research projects take advantage of recently established
Core facilities for Nextgen sequencing, Bioinformatics and Structural
Biology analyses. USU has a strongly collaborative environment, with weekly
Immunology data club and journal club meetings, as well as regular research
seminars featuring local and invited speakers.

Please contact Dr. Pazgier directly at marzena.pazg...@usuhs.edu.



--



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[ccp4bb] Postdoctoral position available in the Laboratory of Cell Biology, National Cancer Institute, NIH

2022-09-24 Thread Xia, Di (NIH/NCI) [E]

Dear structural biologists,

The Section of Structural Biology in the Laboratory of Cell Biology, Center for 
Cancer Research, National Cancer Institute, NIH has an opening for a 
Postdoctoral Fellow with a recent Ph.D. This individual will be working on 
"structure and function of proteins involving in cancer drug resistance ".  Our 
group is equipped with start-of-the-art instruments for carrying out molecular 
and cellular biology experiments and has assured access to a synchrotron beam 
line at APS and to an intramural EM facility equipped with an FEI Krios 
microscope and Gatan K3 detector. The successful candidate should have training 
in molecular biology, biochemistry, and protein purification for target protein 
production. Experience in cryo-EM and/or X-ray crystallography is a plus. NIH 
has a welcoming, collaborative and vibrant environment for biomedical research. 
Our campus is located in Bethesda, Maryland. Interested individuals should send 
their applications, consisting of a CV, a statement of research interest, and 
three letters of recommendation, to Dr. Di Xia via Email at 
x...@mail.nih.gov. The application deadline is 
October 31st, 2022.




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[ccp4bb] Postdoctoral position at UT Southwestern Med with Elizabeth Goldsmith

2022-09-21 Thread Elizabeth J. Goldsmith

Structural studies of WNK kinase drug discovery and pressure and ion sensing 
mechanisms

A fully funded postdoctoral position is available in the laboratory of 
Elizabeth Goldsmith, in the Department of Biophysics at University of Texas 
Southwestern Medical Center in Dallas.
We seek a passionate, self-motivated, writing-friendly, and just plain friendly 
researcher with a background in structural biology, and biophysics, 
biochemistry, or chemistry. We are very excited about our studies of WNK 
kinases because of their central role in cellular homeostasis of osmotic and 
hydrostatic pressure and ions, and their status as drug targets in cancer and 
hypertension.  The Biophysics Department has outstanding core laboratories in 
structural biology, including Cryo-EM and in other biophysical techniques, and 
professors using NMR spectroscopy. The environment is collaborative such that 
any of these avenues can be pursued as desired. UT Southwestern is a 
world-class research institution and medical center.


Send inquiries to elizabeth.goldsm...@utsouthwestern.edu




UT Southwestern

Medical Center

The future of medicine, today.



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[ccp4bb] Postdoctoral Position in Protein Engineering in Hebrew University of Jerusalem, Israel

2022-09-08 Thread Julia Shifman

Postdoctoral position in Protein Engineering
If you are an enthusiastic, committed and responsible student with a love for 
science and if you are looking for an opportunity to develop novel therapeutic 
proteins to battle cancer, then our team is looking for you. The Shifman lab in 
the Hebrew University of Jerusalem is an international and interdisciplinary 
group located at the in the Givat Ram campus of the Hebrew University as part 
of the Biological Chemistry Department. 
(https://openscholar.huji.ac.il/shifmanlab/ 
). We offer a 3-year fully funded 
postdoctoral position in our lab.  

Project description

The goal of this project is to engineer high-affinity specific binders to a 
known oncogene Ras, whose mutations are found in 30% of all human cancers. Such 
proteins will be constructed starting from a natural human protein that is able 
not only to inhibit Ras pro-cancer activities and but also exhibits anticancer 
activity of its own. Furthermore, the protein will be engineered with 
capabilities to penetrate tumor environment and to enter cancer cells, where 
mutated Ras is located. All our projects are interdisciplinary and utilize a 
combination of structural modeling, experimental directed evolution, 
biophysical and structural methods for protein characterization, and cellular 
biology.

 Requirements

Ph. D. in Biochemistry, Biophysics, Biotechnology or Biology. Experience in 
molecular biology, protein expression/purification and cellular biology. 
Computational biology experience is a plus.

Contact Julia Shifman: jshif...@mail.huji.ac.il


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[ccp4bb] Postdoctoral position in structural biology of Comammox in Vienna

2022-09-04 Thread Kristina Djinovic Carugo


*Postdoctoral position in structural biology of Comammox in Vienna*

For 120 years, microbiologists had strongly assumed that nitrification 
must be performed by two distinct groups of microorganisms 
(‘nitrifiers’) in cooperation: the ammonia oxidizers and the nitrite 
oxidizers, respectively. This scientific dogma broke in 2016, when 
‘complete ammonia oxidizers’ were discovered (1). In collaboration with 
the research lab of Daims/Wagner that discovered the Comammox bacterium, 
the Djinovic lab in Vienna plans to structurally and biochemically 
characterize selected enzymes of the Comammox, to decipher the catalytic 
mechanism and identify the structural determinants of the substrate 
affinity and specificity.


*Job Description*: Active participation in research, teaching and 
administration. This includes: + Involvement in a research project on 
the structural and biochemical characterization of selected enzymes from 
Comammox and other nitrifying microorganisms + Publications and 
presentations + Involvement in project applications for third-party 
funding + Involvement in public outreach + Teaching of courses as 
defined by the collective agreement + Supervision of trainees and students


*Qualifications and experience: *The applicants should hold a PhD degree 
in Biology, Molecular Biology, Structural Biology, Biochemistry, or 
relevant fields. Strong experience in molecular cloning, expression, and 
purification of protein complexes is essential. Prior knowledge of 
crystallography and/or single-particle electron microscopy is needed. In 
addition, we expect the successful candidate to have excellent 
communication and organizational skills, the capacity to interact with 
other researchers, experience in working on collaborative research 
projects, publications in international scientific journals, and 
international presentation experience. Excellent team-working ability is 
needed.



*Please send the following application:*

- Letter of motivation

- Academic curriculum vitae

- List of publications, a list of courses and a list of talks given

- Contact details of at least 2 persons who could provide a letter of 
reference


To: jobcen...@univie.ac.at*with reference number 13475.*

*Duration*of employment: 3years

*Deadline*: 30^th September 2022

For details in the project contact please contact: Kristina Djinovic 
Carugo kristina.djino...@univie.ac.at


1. Daims, H., Lebedeva, E. V., Pjevac, P., Han, P., Herbold, C., 
Albertsen, M., Jehmlich, N., Palatinszky, M., Vierheilig, J., Bulaev, 
A., Kirkegaard, R. H., Von Bergen, M., Rattei, T., Bendinger, B., 
Nielsen, P. H., and Wagner, M. (2015) Complete nitrification by 
Nitrospira bacteria. /Nature/ *528*, 504-509; 10.1038/nature16461


--
Department of Structural and Computational Biology
Max Perutz Labs
University of Vienna
Campus Vienna Biocenter 5
A-1030 Vienna
Austria


e-mail:kristina.djino...@univie.ac.at
Phone: +43-1-4277-52203
Phone: +43-1-4277-52201 (secretary)
Mobile A: +43-664-602 77-522 03
Fax: +43-1-4277-9522




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[ccp4bb] Postdoctoral position at ICTER in Warsaw, Poland – Final warning

2022-08-05 Thread Humberto Fernandes

Dear all

This is a final reminder for this post. The closing date is the 11th of August.

A second postdoctoral position in the Integrated Structural Biology lab at The 
International Center for Translational Eye Research (ICTER) in Warsaw, Poland, 
is available for highly motivated biologists, biochemists, or structural 
biologists, funded until the end of 2023. The position involves cloning, 
protein production, purification, characterization, and structural elucidation 
of proteins of the phototransduction pathway and the visual cycle.

For details and how to apply, until the 11th of August, see:
https://ichf.edu.pl/en/job/mcbo-63-2022-international-centre-for-translational-eye-research-mcbo-63-2022

Feel free to spread this information at your institutes and to interested 
colleagues. And please do not hesitate to contact me if you have any questions.

Thank you, and have a great day,

Humberto



[cid:c27ba2cc-3575-4dbd-9aa7-fb691b686977]

ul. Kasprzaka 44/52   www.icter.pl

01-224 Warszawa  email: 
hfernan...@ichf.edu.pl


The controller of your personal data is the International Centre for 
Translational Eye Research with its registered office in Warsaw, NIP: 
108002 (ICTER). ICTER will process your data for the purpose of carrying 
out scientific and research activities, providing services and contact with the 
Institute, on the basis of a contract (in connection with the performance of 
the contract or in order to take action on your request before the contract is 
concluded – Article 6, paragraph 1, letter b) of GDPR), the legitimate interest 
of the Institute (Article 6, paragraph 1, letter f) of the GDPR) and legal 
provisions (Article 6, paragraph 1, letter c) of the GDPR) - depending on the 
circumstances.

You have the right to: request access to your data, receive a copy of it; 
rectify (correct) it; delete it; limit its processing; transfer it; lodge a 
complaint to the supervisory body; withdraw your consent for processing at any 
time (withdrawal of consent does not affect the lawfulness of the processing 
carried out prior to its withdrawal) or to lodge an objection to data 
processing. More information is available on the Institute's website: 
https://www.icter.pl/blob/ICTER_GICR.pdf



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[ccp4bb] Postdoctoral position at the VIB-VUB Center for Structural Biology

2022-08-05 Thread Wim VERSEES

Dear colleagues,
At the VIB-VUB Center for Structural Biology (Vrije Universiteit Brussel / VIB 
- Brussels - Belgium), we are looking for a highly qualified and motivated 
postdoctoral researcher with a strong background in Cryo-EM and/or X-ray 
crystallography, biochemistry and biophysics, and interested in biochemical and 
structural studies on bacterial persistence pathways.
Project description: Due to the development of resistance to antibiotics, 
bacterial infections are becoming more life-threatening every year. In addition 
to resistance, bacterial persistence offers an important means to avoid 
clearance of infections. Persisters are formed by phenotypic switching to an 
antibiotic-tolerant state, rendering a small subset of cells within an isogenic 
population capable of surviving antibiotic treatment. Within this ongoing 
research project we want to gain more insight into the mechanisms of 
persistence by unravelling the associated molecular pathways down to atomic 
resolution (e.g. Verstraeten et al. Mol. Cell 2015; Gkekas et al. J. Biol. 
Chem. 2017; Verstraeten et al. Mol. Microbiol. 2019). The project is part of an 
interdisciplinary Excellence of Science program in collaboration with the teams 
of Jan Michiels, Régis Hallez, Françoise Van Bambeke, Steven Ballet and Jörg 
Vogel. Within this consortium you will use single particle cryo-EM and X-ray 
crystallography, in combination with biophysical methods and enzyme kinetics, 
to gain insight in the role of important persistence proteins and their 
interactions. This information will subsequently be used to intervene with 
these proteins and processes to devise new potential therapeutic strategies.

For more information about the Versées lab see 
https://verseeslab.sites.vib.be/en

Required skills and experience:

  *   PhD in Biochemistry, Molecular Biology, Bio-engineering or equivalent
  *   Strong background in protein expression, purification and characterization
  *   Experience in Cryo-EM and/or X-ray crystallography is mandatory
  *   Proficient in written and spoken English
  *   Strong organizational and interpersonal skills
Contact: Please send applications (including CV, research experience, and at 
least two names and contact information for references) to: 
wim.vers...@vub.be.
About CSB: The VIB-VUB Center for Structural Biology focusses on the structure 
and dynamics of macromolecular complexes in health and disease. Our 
multidisciplinary team of about 100 researchers is housed in new laboratory 
facilities and combines extensive expertise in structural biology (state of the 
art in-house cryo-EM, X-ray crystallography, NMR, SAXS, and atomic force 
microscopy), biophysics, enzymology and molecular biology.
Best regards,

Wim

--
Prof. Dr. ir. Wim Versées
Research group Structural Biology Brussels
Faculty of Science and Bioengineering Sciences
Vrije Universiteit Brussel

VIB-VUB Center for Structural Biology

Building E, Room E4.2
Pleinlaan 2, 1050 Brussel
Belgium
Phone: +32 2 6291849
Fax: +32 2 6291963
Email: wim.vers...@vub.be




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[ccp4bb] Postdoctoral Position available at the Ohio State University

2022-08-01 Thread Krishna Chinthalapudi

Dear All,



Applications are invited for a postdoctoral scientist position in the
laboratory of Dr. Krishna Chinthalapudi at the Ohio State University. The
research project focuses on understanding the role of cytoskeletal proteins
in health and disease. We combine state-of-the-art structural biology
approaches including cryo-EM and X-ray crystallography with biochemical,
biophysical, and cell biological methods to investigate how protein
structure is related to its function. Our laboratory is equipped with
state-of-the-art instrumentation for the proposed studies and has generous
access to a Titan Krios G3i Cryo-TEM and a K3 direct electron detector,
imaging phase plates, STEM/TEM tomography, and an image spherical
aberration corrector. In addition, my lab has access to Glacios with a
falcon III detector and Ceta-D camera for MicroED analysis at the
world-class Center for Electron Microscopy and Analysis (CEMAS) at the Ohio
State University.



Candidates with a recent Ph.D. degree and prior experience in structural
biology with interests in cytoskeletal protein structure-function studies
are encouraged to apply.



To be considered for this position, please email your curriculum vitae and
a short cover letter with research experience and interests to Krishna
Chinthalapudi (*krishna.chinthalap...@osumc.edu
*).



Thank you,
Krishna



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[ccp4bb] Postdoctoral position at ICTER in Warsaw, Poland -– final warning

2022-07-26 Thread Humberto Fernandes

Dear all

This is a final reminder for this post. The closing date is the 27th of July.

A postdoctoral position in the Integrated Structural Biology lab at The 
International Center for Translational Eye Research (ICTER) in Warsaw, Poland, 
is available for highly motivated biologists, biochemists, or structural 
biologists, funded until the end of 2023. The position involves cloning, 
protein production, purification, characterization, and structural elucidation 
of proteins of the phototransduction pathway.

For details and how to apply, until the 27th of July, see:
https://icter.pl/jobs/junior-postdoctoral-researcher-in-structural-biology/

Feel free to spread this information at your institutes and to interested 
colleagues. And please do not hesitate to contact me if you have any questions.

Thank you, and have a great day,

Humberto



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Re: [ccp4bb] postdoctoral position in the MRC Laboratory of Molecular Biology

2022-07-22 Thread jens j birktoft

Jens has passed away. Please cancel whatever account he has and/or remove
his email from your list. Thank you
*++ *
*Jens J. Birktoft *
*e-mail: jens.kn...@gmail.com ; Phone: 212-749-5057 *
*slow-mail: 350 Central Park West, Suite 9F, New York, NY 10025*
**


On Fri, Jul 22, 2022 at 10:05 AM Roger Williams - MRC LMB <
r...@mrc-lmb.cam.ac.uk> wrote:

> Our group has an opening for a postdoctoral fellow to be funded on a
> Cancer Research UK programme aimed at understanding lysosomal control of
> cell proliferation and stress responses in cancer cells. The programme
> involves cryo-electron microscopy, X-ray crystallography, H/D exchange mass
> spectrometry, molecular dynamics as well as other biophysical and
> biochemical approaches.
>
> The post will focus on the reconstitution of large signalling assemblies
> that detect nutritional and stress signals on and off membranes. The
> candidate will join a team of researchers investigating structures,
> regulation, kinetics and dynamics of phosphoinositide 3-kinase family
> members reconstituted with their regulators on membrane surfaces. This
> programme concerns regulation of the lipid kinase VPS34 and protein kinase
> mTOR and ATM-containing complexes. The research combines biochemical,
> biophysical and cell biological methods with structural approaches. This is
> a unique opportunity to play a major role in exciting programme, introduce
> new ideas, and disseminate research results, while working in a
> collaborative and supportive environment.
>
> The position is available immediately, with an application closing date of
> 21st August 2022. For more details, see
>
>
> https://urldefense.com/v3/__https://www.nature.com/naturecareers/job/postdoctoral-scientist-pnac-dr-roger-williams-lmb-1898-mrc-laboratory-of-molecular-biology-761415__;!!BhJSzQqDqA!QVlKmQIs2wgGW5qRrCBeCXejlJuO3tMr4YzocSdNvY6ah3sLZt58iY9eaIMhp4ZP0ftTTB_c7Z5-oSzCBucL$
>
>  Please contact me at r...@mrc-lmb.cam.ac.uk, if you have any questions.
>
> Roger Williams
>
> Dr. Roger Williams, FMedSci, FRS
> r...@mrc-lmb.cam.ac.uk
> MRC Laboratory of Molecular Biology
> Francis Crick Avenue
> Cambridge CB2 0QH
> UK
> Phone: +44 1223 267094
>
> 
>
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[ccp4bb] postdoctoral position in the MRC Laboratory of Molecular Biology

2022-07-22 Thread Roger Williams - MRC LMB

Our group has an opening for a postdoctoral fellow to be funded on a Cancer
Research UK programme aimed at understanding lysosomal control of cell
proliferation and stress responses in cancer cells. The programme involves
cryo-electron microscopy, X-ray crystallography, H/D exchange mass
spectrometry, molecular dynamics as well as other biophysical and biochemical
approaches.

The post will focus on the reconstitution of large signalling assemblies that
detect nutritional and stress signals on and off membranes. The candidate will
join a team of researchers investigating structures, regulation, kinetics and
dynamics of phosphoinositide 3-kinase family members reconstituted with their
regulators on membrane surfaces. This programme concerns regulation of the
lipid kinase VPS34 and protein kinase mTOR and ATM-containing complexes. The
research combines biochemical, biophysical and cell biological methods with
structural approaches. This is a unique opportunity to play a major role in
exciting programme, introduce new ideas, and disseminate research results,
while working in a collaborative and supportive environment.

The position is available immediately, with an application closing date of 21st
August 2022. For more details, see

https://www.nature.com/naturecareers/job/postdoctoral-scientist-pnac-dr-roger-williams-lmb-1898-mrc-laboratory-of-molecular-biology-761415

Please contact me at r...@mrc-lmb.cam.ac.uk, if you have any questions.

Roger Williams

Dr. Roger Williams, FMedSci, FRS
r...@mrc-lmb.cam.ac.uk
MRC Laboratory of Molecular Biology
Francis Crick Avenue
Cambridge CB2 0QH
UK
Phone: +44 1223 267094

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[ccp4bb] Postdoctoral position at ICTER in Warsaw, Poland

2022-07-14 Thread Humberto Fernandes

Dear all

A second postdoctoral position in the Integrated Structural Biology lab at The 
International Center for Translational Eye Research (ICTER) in Warsaw, Poland, 
is available for highly motivated biologists, biochemists, or structural 
biologists, funded until the end of 2023. The position involves cloning, 
protein production, purification, characterization, and structural elucidation 
of proteins of the phototransduction pathway and the visual cycle.

For details and how to apply, until the 11th of August, see:
https://ichf.edu.pl/en/job/mcbo-63-2022-international-centre-for-translational-eye-research-mcbo-63-2022

Feel free to spread this information at your institutes and to interested 
colleagues. And please do not hesitate to contact me if you have any questions.

Thank you, and have a great day,

Humberto



[cid:44557680-2f0c-4987-b4d6-b01cb3d577b8]

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The controller of your personal data is the International Centre for 
Translational Eye Research with its registered office in Warsaw, NIP: 
108002 (ICTER). ICTER will process your data for the purpose of carrying 
out scientific and research activities, providing services and contact with the 
Institute, on the basis of a contract (in connection with the performance of 
the contract or in order to take action on your request before the contract is 
concluded – Article 6, paragraph 1, letter b) of GDPR), the legitimate interest 
of the Institute (Article 6, paragraph 1, letter f) of the GDPR) and legal 
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You have the right to: request access to your data, receive a copy of it; 
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time (withdrawal of consent does not affect the lawfulness of the processing 
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[ccp4bb] Postdoctoral position in drug discovery

2022-07-12 Thread Harp, Joel M

Postdoctoral position in drug discovery


An opening is available in the drug discovery laboratory of Dr. Stephen Fesik 
for a post-doc in the field of protein x-ray crystallography.  Responsibilities 
will include protein production, fragment screening by NMR, and all aspects of 
x-ray crystallography including preparation of protein-ligand complexes, 
crystallization, home/synchrotron data collection, and structure determination. 
Additional experience in molecular biology including construct design, cloning, 
site-directed mutagenesis and modeling is a plus.  The ideal candidate should 
be self-motivated and be able to communicate efficiently in a highly 
collaborative environment. Please send cv to 
jason.p...@vanderbilt.edu





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[ccp4bb] Postdoctoral position on function and regulation of macromolecular assemblies - Dept of Structural Biology, Genentech

2022-07-08 Thread Yoana Dimitrova (DIMITRY4)

Dear all,



I’m looking for a talented and highly motivated postdoctoral fellow to join
my group in the Department of Structural Biology at Genentech to study the
function and regulation of macromolecular assemblies important in
fundamental cellular processes and human disease.



The position is available immediately and fully funded for up to four
years. The postdoc will have the unique opportunity to work in a highly
collaborative research environment on diverse projects such as
investigating T cell receptor signaling and the regulation of kinetochore
assembly and function. The postdoc will be able to independently pursue
projects and grow their expertise in X-ray crystallography and cryo-EM, with
access to state-of-the-art lab equipment, high resolution cryo-EM
technology and a virtually unlimited computer cluster for data processing.



The Department of Structural Biology at Genentech is a scientifically rich
and highly stimulating research environment that has a strong track record
in mentoring postdocs and collaborating with other research groups at
Genentech and in the academic community.



*Who you are:*


   - Completed or in the last year of a Ph.D. in structural biology,
   biochemistry or a related field of research.
   -  Demonstrated expertise in protein purification, biophysical
   characterization and structure determination by X-ray crystallography
   and/or single-particle cryoEM of multi-protein complexes as shown by a
   strong record of first-author publications in high quality journals.
   - Experience in protein engineering, biophysical characterization
   methods for protein-protein and protein-nucleic acid interactions, such as
   surface-plasmon resonance (SPR), Isothermal Titration Calorimetry (ITC), or
   bio-layer interferometry (BLI) and i*n vitro* assay development will be
   beneficial.

   - Self-motivated and detail-oriented, driven to solve complex scientific
   problems independently and in a collaborative environment.
   -  Strong oral and written communication skills are required.

*If interested, please contact me directly (dimitrova.yoana at gene.com
) and include a copy of your CV.*



The Genentech Postdoctoral Program is unique in the pharmaceutical industry
with a vibrant community of mentors and fellows.
*More Information about the Genentech Postdoctoral Program: *
http://www.gene.com/careers/academic-programs/postdocs



Best regards,
Yoana Dimitrova

--
*Yoana Dimitrova*
Principal Scientist
Genentech, Department of Structural Biology
1 DNA Way, MS: 27
South San Francisco, CA 94080
(cell) 650 534 5216



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[ccp4bb] Postdoctoral position at ICTER in Warsaw, Poland

2022-07-06 Thread Humberto Fernandes

Dear all

A postdoctoral position in the Integrated Structural Biology lab at The 
International Center for Translational Eye Research (ICTER) in Warsaw, Poland, 
is available for highly motivated biologists, biochemists, or structural 
biologists, funded until the end of 2023. The position involves cloning, 
protein production, purification, characterization, and structural elucidation 
of proteins of the phototransduction pathway.

For details and how to apply, until the 27th of July, see:
https://icter.pl/jobs/junior-postdoctoral-researcher-in-structural-biology/

Feel free to spread this information at your institutes and to interested 
colleagues. And please do not hesitate to contact me if you have any questions.

Thank you, and have a great day,

Humberto



[cid:d7e82745-1898-43ea-b5cd-da1ef63f6851]

ul. Kasprzaka 44/52   www.icter.pl

01-224 Warszawa  email: 
hfernan...@ichf.edu.pl


The controller of your personal data is the International Centre for 
Translational Eye Research with its registered office in Warsaw, NIP: 
108002 (ICTER). ICTER will process your data for the purpose of carrying 
out scientific and research activities, providing services and contact with the 
Institute, on the basis of a contract (in connection with the performance of 
the contract or in order to take action on your request before the contract is 
concluded – Article 6, paragraph 1, letter b) of GDPR), the legitimate interest 
of the Institute (Article 6, paragraph 1, letter f) of the GDPR) and legal 
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time (withdrawal of consent does not affect the lawfulness of the processing 
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[ccp4bb] Postdoctoral position at RCSB PDB San Diego

2022-07-01 Thread Jose Duarte

We are seeking a talented, highly motivated postdoctoral researcher to join
the multidisciplinary team of the RCSB Protein Data Bank at UC San Diego,
San Diego Supercomputer Center (SDSC).

Fast and accurate search of protein structures by 3-dimensional shape in
large databases continues to be a challenge in Bioinformatics. This has
been exacerbated by the recent appearance of accurate methods to predict
protein structures from sequence. Those methods, when applied to existing
protein sequence databases, produce numbers of structures many orders of
magnitude larger than the existing experimental knowledge in the PDB
database. The incumbent will research novel methods to compare
macromolecular structures that are scalable to the deluge of structural
data and that work at any level: domains, chains or assemblies. The
ultimate aim of this project is to improve the findability of data in the
PDB by building the next generation search engine for structural molecular
biology.

Note, this position is reviewed annually on the basis of performance and
can be renewed.
Requirements

Qualifications: Ph.D. in one of the following research areas

   -

   Computer Science with a focus on Bioinformatics
   -

   Structural Bioinformatics, or related field with a focus on software
   development
   -

   Structural Biology with a focus on software development


Demonstrated proficiency in a high-level programming language, such as
Java, Python, C++, and experience with state of the art software
engineering tools. Strong skills in problem solving and algorithm design
are required. Experience in Machine Learning/Deep Learning is desirable. A
background in NoSQL database technologies would be beneficial. Experience
in development of modern web applications, user interface design, or
scientific visualization would also be a plus. We expect candidates to have
shown high productivity demonstrated by publications and contributions to
open source software projects. Excellent written and oral communication
skills are required.
About the RCSB

Our group supports RCSB Protein Data Bank (PDB) operations at UC San Diego.
The RCSB PDB (http://www.rcsb.org) represents the preeminent source of
experimentally determined macromolecular structure information for research
and teaching in fundamental biology, biomedicine, bioenergy, and
biotechnology. With millions of unique users from over 160 countries around
the world, the RCSB PDB is one of the leading worldwide Biological
Databases.



As an Organized Research Unit of UC San Diego, SDSC is a world leader in
data-intensive computing and cyber infrastructure, providing resources,
services, and expertise to the national research community, including
industry and academia.

http://www.rcsb.org/pages/jobs




Jose Duarte
RCSB Protein Data Bank
San Diego Supercomputing Center, UC San Diego
9500 Gilman Drive
La Jolla CA 92093, USA



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[ccp4bb] Postdoctoral Position in CNS antibody-ion channel mechanisms and design

2022-06-20 Thread Paul Miller

Applications are invited for a postdoctoral researcher position in the 
laboratory of Dr Paul Miller at the Department of Pharmacology, University of 
Cambridge, beginning from around October 2022.

The project will focus on studying the molecular basis of antibody modulation 
of ion channel function and applying structure-guided approaches to engineer 
new research tools. This is vital to define channel subtype contributions to 
CNS physiology and disease and to discover new therapeutic modalities. This is 
a great opportunity to gain experience in one or more aspects of handling 
challenging membrane proteins, structure-guided antibody engineering, and 
cryo-EM, ideal for follow-on academic and biotechnology careers. The lab 
utilises mammalian cell protein expression systems, membrane protein 
purification, and cryo-EM via Arctica and Krios microscopes with K2/K3 direct 
detectors, and also has manual and automated electrophysiology equipment,. More 
information about the laboratory is available at 
https://www.phar.cam.ac.uk/research/miller.

The applicant will be about to obtain a PhD or have obtained a PhD within the 
last 3 years. Experience in molecular biology, protein production, purification 
and structural biology (X-ray crystallography or cryo-EM) is required. You must 
be a careful and methodical worker, paying attention to accuracy, be able to 
take responsibility and interact as part of a tightly knit team, and be willing 
to work in a collaborative environment. You should be self-motivated and able 
to organise, perform and analyse experiments with minimal instruction.

A recent relevant publication from the lab is:
Kasaragod VB, Mortensen M, Hardwick SW, Wahid AA, Dorovykh V, Chirgadze DY, 
Smart TG, Miller PS.
Mechanisms of inhibition and activation of extrasynaptic alpha-beta GABA-A 
receptors.
Nature. 2022 Feb;602(7897):529-533. PMID: 35140402

Application Closing date: 15th July 2022
Project start date: Approximately 1st October 2022
For more details and to apply: https://www.https://www.jobs.cam.ac.uk/job/35285/
Informal enquiries about the position can be made to Dr Paul Miller 
(pm...@cam.ac.uk)
For enquiries about the online application process please contact Debbie 
Stanley, phar...@lists.cam.ac.uk


Paul Miller, PhD
University Lecturer in Pharmacology
Department of Pharmacology
University of Cambridge
Tennis Court Road
Cambridge
CB2 1PD
+44 1223 761267
https://www.phar.cam.ac.uk/research/miller



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[ccp4bb] Postdoctoral position at Lehigh University

2022-06-16 Thread Oriana Fisher

Dear all,
A postdoctoral fellow position is open in Prof. Oriana Fisher’s laboratory 
(https://sites.google.com/a/lehigh.edu/fisher-lab/home 
) in the Department of 
Chemistry at Lehigh University in Bethlehem, PA (centrally located between NYC 
and Philadelphia). The candidate’s research will focus on investigating the 
structural and biophysical basis for copper acquisition and its regulation by 
bacteria. Applicants should have (or expect to soon have) a PhD in 
Biochemistry, Structural Biology, Microbiology, or a related discipline. 
Experience in protein expression and purification, X-ray crystallography, 
biochemistry, and/or microbiology is desired, as are strong written and oral 
communication skills. The individual will also be expected to work closely with 
and mentor graduate and undergraduate students. Prospective candidates should 
send a current CV, a brief description of their research interests and 
experience, and contact information for 3 references to Dr. Fisher at 
orf...@lehigh.edu. Applications will be reviewed on a rolling basis, starting 
immediately.

Thank you!

Oriana


---
Oriana S. Fisher
Assistant Professor of Chemistry
Lehigh University
6 E Packer Ave
Bethlehem, PA 18015
Email: orf...@lehigh.edu 
Phone: (610)-758-6259


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[ccp4bb] postdoctoral position in structural biology of the tubulin code

2022-06-15 Thread Antonina Roll-Mecak

A postdoctoral fellowship opportunity is available in the Cell Biology and
Biophysics Unit headed by Dr. Antonina Roll-Mecak to work on the tubulin
code using in vitro reconstitution and superresolution microscopy to
capture the dynamic behavior of cytoskeletal complexes coupled with
cryo-EM, single particle, and tomography to obtain structural information
in vitro and in cells. For more information please visit:
https://research.ninds.nih.gov/roll-mecak-lab*. * We are looking for Ph.D.
graduates with a strong record of accomplishments and expertise in
biochemistry and cell biology. Expertise with cryo-EM is not needed. We are
happy to teach!  The NIH has an outstanding cell and structural biology
community, and the lab has regular access to state-of-the-art resources
such as a Chameleon, Krios with K3 camera, Glacios, TIRF and lattice sheet
microscopes, as well as cryo-FIB SEM. Please send your CV, a one-page
research experience summary and contact information of three references to
anton...@nih.gov  Please write “Tubulin code fellowship” in the subject
header.



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[ccp4bb] Postdoctoral Position Available

2022-06-15 Thread Troy Johnson

Hi All, 
This post is to bring your attention to a postdoctoral position currently 
available in the Structural Chemistry group, part of the Institute for Applied 
Cancer Science (IACS) within the Therapeutics Discovery Division of MD Anderson 
Cancer Center. The highly collaborative teams within IACS are focused on 
discovering and developing the next generation of small-molecule therapeutics 
targeting unmet medical needs in oncology and neurodegeneration. 

This is a unique opportunity to learn how structural biology contributes to the 
development of novel therapeutics by participating in the drug discovery 
process as a team member. The postdoctoral researcher will have the opportunity 
to work in a project-driven environment with a multi-disciplinary team of 
scientists from several functional groups (eg. in vitro pharmacology, medicinal 
and computational chemistry) all within a highly respected academic and 
clinical setting.

We are seeking an individual with a background in structural biology, including 
protein expression and purification, protein crystallization, and X-ray 
crystallography structure determination. Experience with biophysical techniques 
to measure binding interactions (eg. ITC, SPR, MST), fragment based drug 
discovery and/or structure determination of membrane proteins is not required, 
but would be advantageous. We want a motivated individual to join us in our 
quest to discover, develop, and deliver more effective treatments to our 
patients.

Interested individuals should send an introductory email and CV to 
therapeut...@mdanderson.org

To apply visit the link below:
https://www.mdanderson.org/about-md-anderson/careers/open-trainee-positions.html
Applied Cancer Science - Req #: 600140-202204261644



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[ccp4bb] Postdoctoral position available in Bethesda, MD, US

2022-06-14 Thread Pazgier, Marzena

A postdoctoral position is available immediately to participate in an
interdisciplinary research program in structural immunology in the
laboratory of Dr. Pazgier (https://www.usuhs.edu/node/68252) at the
Uniformed Services University of the Health Sciences (USU) in Bethesda, MD.
Candidates are expected to work on ongoing research projects in structural
biology with the aim to understand the molecular basis of the adaptive
immune response to HIV-1 and Sars-Cov-2 and the ultimate goal to develop
new protein-based therapeutics and novel vaccine concepts. Strong research
interests and experience in molecular cloning, protein expression,
molecular interaction analysis, X-ray crystallography and/or Cryo-EM, as
well as outstanding interpersonal, oral, and written communication skills,
are required for this post. Candidates with an immunological background are
invited to apply.


Candidates need to be highly motivated individuals who enjoy working as
part of a dynamic, collaborative and multidisciplinary team. Preference
will be given to candidates with exceptionally strong experimental skills,
a strong record of peer-reviewed publications, and a demonstrated
commitment to basic and translational research. Qualified candidates should
have a doctorate in chemistry/biochemistry, microbiology, immunology or a
closely-related field. Candidates at any career stage are invited.


USU is in Bethesda, MD directly across the street from the NIH, and is
therefore part of an extraordinarily vibrant local biomedical research
community. Our research projects take advantage of recently established
Core facilities for Nextgen sequencing, Bioinformatics and Structural
Biology analyses. USU has a strongly collaborative environment, with weekly
Immunology data club and journal club meetings, as well as regular research
seminars featuring local and invited speakers.


Candidates should apply to the Henry M. Jackson Foundation:
http://careers.hjf.org submitting a CV plus names and contact information
for 3 references.

Note: you may also directly contact Dr. Pazgier directly,
marzena.pazg...@usuhs.edu.

--



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[ccp4bb] Postdoctoral position in Manchester

2022-06-08 Thread Harshwardhan Poddar

Hi everyone,
There is a PostDoc position available in the laboratory of Prof Nigel Scrutton 
based at Manchester Institute of Biotechnology. This is an exciting opportunity 
to characterise some newly discovered light-sensitive proteins using 
time-resolved structural techniques. 
More details can be found here-
Research Associate in Structural Biology : Manchester Institute of 
Biotechnology (MIB) 
  
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Research Associate in Structural Biology : Manchester Institute of 
Biotechnology (MIB)
 

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Best
Harshwardhan 



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[ccp4bb] Postdoctoral position at the University of the Free State, South Africa

2022-06-07 Thread Carmien Tolmie

Good morning everyone,

The *Biocatalysis and Structural Biology* group within the *Department of
Microbiology and Biochemistry (University of the Free State, South Africa)* is
looking for a post-doctoral candidate interested in biocatalysis and
structural biology.

We are interested in understanding the structure-function relationship of
various biocatalysts in oxyfunctionalization reactions.

We are looking for highly motivated and enthusiastic candidates with a
background in biochemistry, enzymology, biotechnology, or related fields
and with an interest in biocatalysis and structural biology. Previous
experience in molecular biology, protein purification and enzyme
characterization is desired. Knowledge and experience in X-ray
crystallography will be advantageous. We offer close supervision in a
stimulating and interdisciplinary atmosphere.
Applicants should hold a PhD degree conferred no more than 3 years ago.
Applications should include a cover letter with a statement of your
research interests, a CV and the names and contact details of two
references. Successful candidates will be required to start as soon as
possible.

*Please apply via e-mail to *

*Prof. Dirk Opperman at oppe...@ufs.ac.za .*

Best wishes,
Carmien Tolmie



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[ccp4bb] Postdoctoral position - Ion Channels

2022-06-01 Thread Krishna Chinthalapudi

Dear All,



Applications are invited for a joint postdoctoral scientist position in the
laboratories of Dr. Isabelle Deschenes and Dr. Krishna Chinthalapudi at the
Ohio State University. The research project focuses on understanding the
role of ion channels in health and disease. We combine state-of-the-art
structural biology approaches including cryo-EM, X-ray crystallography, and
electrophysiology with biochemical, biophysical, and cell biological
methods to investigate how ion channels function in health and disease.



Our laboratories are equipped with state-of-the-art instrumentation for the
proposed studies and have generous access to a Titan Krios G3i Cryo-TEM
equipped with a K3 direct electron detector, imaging phase plates, and an
image spherical aberration corrector. In addition, our labs have access to
Glacios with a falcon III detector and Ceta-D camera for MicroED analysis
at the world-class Center for Electron Microscopy and Analysis (CEMAS) at
the Ohio State University.



Applicants must have a Ph.D. in structural biology, biochemistry, or a
related field. Expertise in molecular biology techniques, membrane protein
expression and purification, electrophysiology, and/or high-resolution
imaging are desirable.



To be considered for this position, please email your curriculum vitae, a
short cover letter with research experience and interests, and contact
information for three references to Krishna Chinthalapudi (
krishna.chinthalap...@osumc.edu) and Isabelle Deschenes (
isabelle.desche...@osumc.edu).



Thank you,

Krishna



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[ccp4bb] Postdoctoral position in cryoEM at the University of Toronto

2022-05-30 Thread Walid Houry

The Houry group at the University of Toronto is looking for an excellent 
postdoctoral fellow to study chaperone complexes using cryoEM.
Strong expertise in protein biochemistry and structural biology using cryoEM is 
a must.

For details contact:
Dr. Walid A. Houry, PhD
Department of Biochemistry, Temerty Faculty of Medicine
Department of Chemistry, Faculty of Arts and Science
University of Toronto
661 University Avenue
MaRS Centre, West Tower, Room 1612
Toronto, ON M5G 1M1
CANADA

Email walid.ho...@utoronto.ca
Web http://lab.walidhoury.com





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[ccp4bb] Postdoctoral position protein crystallography available at the Institute of Cancer Research, London UK

2022-05-30 Thread Rob Van Montfort

A postdoctoral position (ID263) is available in Dr Rob van Montfort’s Hit
Discovery and Structural Design Team within the CTU. The Post-doc will be
involved in the structure determination of proteins and protein/small molecule
complexes by X-ray crystallography as part of one of the CTU’s drug discovery
programmes. The post holder will be responsible for protein production and
purification, protein crystallisation, structure determination by X-ray
crystallography and subsequent structural analysis. The successful candidate
will be an integral member of a multidisciplinary project team within the CTU
at the ICR Sutton site, and will interact closely with biologists,
computational chemists, medicinal chemists, assay scientists and structural
biologists. The successful candidate will have access to state-of-the-art
facilities for protein production and purification, as well as biophysical
characterisation and crystallisation. We also benefit from excellent access to
Diamond Light Source synchrotron at the Harwell Science and Innovation campus,
Didcot, UK, for X-ray data collection. The postholder will be expected to work
across the two sites in Chelsea, London and Sutton, Surrey. The starting salary
will be in the range £38,607 to £42,534 p.a. inclusive (based on previous
postdoctoral experience).

The post is offered on a fixed term contract of 2 years. Informal enquiries to
rob.vanmontf...@icr.ac.uk or
yann-vai.lebi...@icr.ac.uk.
Please DO NOT send your application to Dr van Montfort or Dr Le Bihan, but
apply via the e-recruitment system on our website
www.icr.ac.uk.
For more details see the following link:
https://jobs.icr.ac.uk/vacancies/263/postdoctoral-training-fellow--x-ray-crystallography-id263.html

Closing date: 21 June 2022

Dr. Rob van Montfort
Reader in Structural Biology and Cancer Drug Discovery
Team Leader Hit Discovery and Structural Design
Divisions of Cancer Therapeutics and Structural Biology
The Institute of Cancer Research
15 Cotswold Road
Sutton SM2 5NG
UK

Tel:
+44-(0)20-8722-4364
Email: rob.vanmontf...@icr.ac.uk

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[ccp4bb] Postdoctoral position on multidisciplinary structural biology

2022-05-24 Thread Yongna Xing

Postdoctoral Fellow on Multidisciplinary Structural Biology
Laboratory of Dr. Yongna Xing

McArdle Laboratory of Cancer Research
Wisconsin Institutes for Medical Research (WIMR) II 6451
University of Wisconsin-Madison

 Highland Ave
Madison, WI 53705

A postdoctoral position on multidisciplinary structural biology is available to 
investigate the mechanisms and functions of phosphatase signaling complexes and 
their disease mutations in cancer and intellectual disability. We combine 
cryo-EM, x-ray crystallography, cell biology, system biology, biochemistry, 
computational biology, machine learning, and bioinformatics to gain critical 
knowledge on complex phosphatase signaling network dictated by both allosteric 
structured cores and versatile signaling motifs. The research is performed in a 
highly multidisciplinary setting with basic scientists with expertise on 
Cryo-EM, biochemistry, cell biology, bioinformatics and chemical biology. We 
are well equipped for multidisciplinary research, such as powerful GPU 
computers, liquid handling crystallization robot, and live cell imaging system. 
In addition, our lab is conveniently located near multiple shared facilities. 
Our research is built on collaborations with more than 10 groups from US and 
Europe as well as dynamic collaborations on campus in both basic and clinical 
research. UW-Madison has highly collaborative research environment that easily 
establish novel collaborations.

We are seeking productive, and motivated individuals with excellent 
organizational, interpersonal, and communication skills. We expect our 
candidates have strong expertise in cryo-EM, x-ray crystallography, and protein 
biochemistry. We also expect our candidates feel comfortable to expand their 
expertise and apply in-house bioinformatic tools and machine learning 
algorithms developed in the lab and work both independently and by 
collaboration toward personalized medicine for phosphatase diseases.



The starting salary for promising candidate will be $54,000 or above.



Review of applications will begin immediately and continue until the position 
is filled. To apply: Please send a cover letter, CV and the names and contact 
information for three references to Dr. Yongna Xing via email: 
x...@oncology.wisc.edu.

Under-represented minorities are encouraged to apply.

Warm regards,

Yongna

___

Yongna Xing, PhD

Professor of Oncology

McArdle Laboratory for Cancer Research

School of Medicine and Public Health

University of Wisconsin-Madison


Tel: 608-262-8376

Email: x...@oncology.wisc.edu



https://mcardle.wisc.edu/who-we-are/mcardle-faculty/yongna-xing-phd

https://mcardle.oncology.wisc.edu/xing/



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[ccp4bb] Postdoctoral position at the University of Pittsburgh, School of Pharmacy

2022-05-23 Thread Cheng Zhang

Post for a colleague:

We are seeking a highly trained and self-motivated postdoctoral
associate/biomedical scientist (PhD or other doctoral degrees) to
participate in chemogenomics-based drug research projects (
http://www.cbligand.org/XieLab). To advance our *CELL*-published technology
of 3D Cryo-EM Structure of Human Cannabinoid Receptor CB2-Gi Signaling
Complex *(*PMID:32004460), we are seeking an individual with the following
expertise and qualifications:

   - must have the expertise and working experience in molecular
   biology/microbiology (e.g., cloning, site-directed mutagenesis,
   CRISPR-Cas9, etc.)
   - working experience in autophagy, cell fate decision-making, and cell
   signaling studies that can be applied to targeting cannabinoid CB2
   receptor, squestosome-1/p62, Ink4c/p18 proteins for drug research projects
   focusing on the following diseases: immune/inflammatory diseases (e.g.,
   GVHD, IBD), acute myeloid leukemia (AML), multiple myeloma (MM), kidney
   fibrosis, Alzheimer’s diseases, hematopoietic stem cells, COVID-19, and
   osteoporosis;
   - experience working with cells at BSL2/BSL2+ is essential; experience
   with receptor binding affinity bioassay and cellular functional bioassays
   is desirable;
   - experience with *Baculovirus *(sf9) and/or *E coli *expression
   systems, IMAC, SEC, and other novel purification protocols; as well as AKTA
   purification and LC-MS/MS systems to provide functional proteins for
   bioassays and structural characterizations; experience with X-ray
   crystallographic biophysics and/or CryoEM is a plus;
   - must have demonstrated independent ability to design and execute
   experiments, prepare figures of results, analyze & interpret those results,
   and present them in a professional scientific manner;
   - must have experience in performing literature searches and can assist
   with scientific writing (manuscripts and grant proposals); meticulous
   record-keeping of research work is required;
   - good verbal and interpersonal skills are also necessary; individuals
   may be required to assist and guide graduate students and other post-docs
   in the lab.


Salary is commensurate with experience. Please apply through the University
of Pittsburgh Talent Center at www.join.pitt.edu. Also, please email your
CV, letter, and three references to Prof. Sean Xie, sean@pitt.edu, and
his assistant Dr. Terry McGuire t...@pitt.edu with *“Manager-Postdoc*” in
the subject line.


The University of Pittsburgh is an Affirmative Action/ Equal Opportunity
Employer and values equality of opportunity, human dignity, and diversity,
EOE, including disability/vets.
-- 
-
Cheng Zhang



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[ccp4bb] Postdoctoral position at the National Institutes of Health in Bethesda, Maryland

2022-05-18 Thread Ville Uski

On behalf of Dr Marius Clore:

A postdoctoral position is available in the lab of Marius Clore in the
Laboratory of Chemical Physics at the National Institutes of Health in
Bethesda, Maryland.

Particular emphasis within the lab concerns the study of excited states
involved in molecular recognition and fibril assembly using
state-of-the-art NMR and EPR spectroscopy.  Current focus is on the
study of the mechanism of aggregation of huntingtin and the study of
various chaperones with anti-aggregation and disaggregation properties.
Additional work is also being carried out using time resolved DEER EPR
and solid state NMR in combination with sub-millisecond freeze quenching
to probe complex transient kinetic pathways involved in molecular
recognition.

Some recent papers are listed below.

Applicants should e-mail their interest directly to
mari...@intra.niddk.nih.gov include their CV/bibliography and the names
of two references.

Recent papers from the lab of Marius Clore:

Kotler, S.A, Tugarinov, V., Schmidt, T., Ceccon, A., Libich, D.S.,
Ghirlando, R., Schwieters, C.D. and Clore, G.M. (2019) Probing initial
transient oligomerization events facilitating Huntingtin fibril
nucleation at atomic resolution by relaxation-based NMR. Proc. Natl.
Acad. Sci. U. S. A. 116, 3562-3571.

Karamanos, T.K., Tugarinov, V. & Clore, G.M. (2019) Unraveling the
structure and dynamics of the human DNAJB6b chaperone by NMR reveals
insights into Hsp40-mediated proteostasis. Proc. Natl. Acad. Sci. U.S.A.
116, 21529-21538.

Ceccon, A., Tugarinov, V., Ghirlando, R. & Clore, G.M. (2020) Abrogation
of pre-nucleation, transient oligomerization of the Huntingtin exon-1
protein by human profilin-I. Proc. Natl. Acad. Sci. U.S.A. 117,
5844-5852.

Ceccon, A., Tugarinov, V. & Clore, G.M. (2021) Quantitative exchange
NMR-based analysis of Huntingtin-SH3 interactions suggests an allosteric
mechanism of inhibition of Huntingtin Aggregation. J. Am. Chem. Soc.
143, 9672-9681.

Walti, M.A., Kotler, S.A. & Clore, G.M. (2021)  Probing the interacttion
of huntingtin exon-1 polypeptides with the chaperonin nanomachine GroEL.
ChemBioChem 22, 1985-1991

Okuno, Y., Yoo, J., Schwieters, C.D., Best, R.B., Chung, H.S. & Clore,
G.M. (2021) Atomic view of cosolute-induced protein denaturation probed
by NMR solvent paramagnetic relaxation enhancement. Proc. Natl. Acad.
Sci. U.S.A. 118, e211202118

Schmidt, T., Jeon, J., Yau, W.-M., Schwiters, C.D., Tycko, R. & Clore,
G.M. (2022) Time-resolved DEER EPR and solid-state NMR afford kinetic
and structural elucidation of substrate binding to Ca2+-ligated
calmodulin. Proc. Natl. Acad. Sci. U.S.A. 119, e2122308119.

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[ccp4bb] Postdoctoral Position in Structural Biology of Ion Channels at OHSU/Portland

2022-05-11 Thread Francis Valiyaveetil


Postdoctoral Position in Structure-FunctionStudies on Ion channels 

   Apostdoctoral position is available in the Valiyaveetil group at 
Oregon Healthand Science University in Portland, Oregon. The Valiyaveetil group 
investigatesstructure and function of ion channels and transporters using a 
combination of structuralbiology, spectroscopy, protein engineering and 
electrophysiology.  See references [Sci Adv. 2022, 8(16):eabm8804; PNAS. 2022, 
119(19):e2121653119; J MolBiol. 2021, 433(23):167296] for examples of recent 
research. The group is a part of the Program in Chemical Biology in the 
Departmentof Chemical Physiology and Biochemistry.

 Theposition is suitable for highly motivated candidates with a 
recent (less than 1year) Ph.D. in Biochemistry, Biophysics, Physiology or a 
relateddiscipline.  The candidate willinvestigate voltage gated potassium 
channels using structural and functional approaches.  Expertise in membrane 
protein biochemistry orin structural studies using crystallography or cryoEM is 
desired.

 The Valiyaveetil lab is wellequipped to carry out structural and functional 
studies of ion channels andtransporters.  OHSU provides an excellentscientific 
environment and world-class facilities for cryoEM.  Portland is consistently 
rated as one of themost livable cities in the US.  

 Toapply send CV, a 1-2 page description of graduate research and 
contactinformation for three references by email to: valiy...@ohsu.edu

    OHSU is an equal opportunity, affirmative action institution.




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[ccp4bb] Postdoctoral position available in Australia

2022-05-09 Thread Forwood, Jade

Dear All,

We have a 3 year postdoctoral position in our lab investigating viral:host 
protein interactions. Our lab uses X-ray crystallography and cryoEM approaches, 
and we have regular access to the Australian Synchrotron. We are based in Wagga 
Wagga, NSW, Australia. For further information, please see our website, and/or 
feel free to contact me on jforw...@csu.edu.au.

http://csusap.csu.edu.au/~jforwood/

Kind regards,

Jade.

Prof Jade Forwood
ARC Future Fellow
School of Biomedical Sciences
Charles Sturt University
Wagga Wagga 2650
Australia
Ph: +61 2 693 32317
Fx:  +61 2 693 32587
http://csusap.csu.edu.au/~jforwood/


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