I would strongly argue against protein crystals (in most cases) being
solid state. Most of the surface of a molecule is actually solvated and
protein crystals as they are miss some of the typical properties of
"solid state". Although in some cases oligomerization occuring upon
protein crystalliza
Here we are dealing with two different state of chemistry,
solid state and solution state, If one of the minima in solid state
resembles
the biological state minimum, then there is a possiblw way to clearly
define
the biology and its significant interaction of that particular 'mer' of a
protein, o
Mass action is on the crystal's side.
Two recent examples of proteins that are dimers by standard
solution assays, but form weak/transient/co-factor-dependent
tetramers to function, and those tetramers are seen in the
crystal. (There is good solution data to back up the
relevance of the tetramer i
