[ccp4bb] Post doc position available at Florida State University

[Adarsh Kumar]

Dear all

One postdoctoral position is available immediately in an enzymology laboratory 
to elucidate mechanisms of DNA/RNA synthesis, DNA lesion bypass, and base 
excision repair catalyzed by various human and viral DNA/RNA polymerases, and 
to mechanistically investigate gene editing enzymes including CRISPR/Cas9 and 
Cas13a. Background in structural biology (X-ray crystallography and/or CryoEM), 
biophysics, protein purification, and recombinant DNA techniques is preferred. 
An important criterion for selection will be the ability of the desired 
individual to pursue independent research in an active multi-disciplinary 
setting. Interested candidates should send a CV and a statement describing 
experience, goals, and reasons for the interest in this position, and arrange 
to have three letters of recommendation sent to Dr. Zucai Suo, Eminent 
Professor and Dorian and John Blackmon Chair of Biomedical Science, Department 
of Biomedical Sciences, College of Medicine, Florida State University, 
Tallahassee, FL. Dr. Suo can be contacted by email (zucai@med.fsu.edu). 
Further information about the research projects in the Suo Lab can be obtained 
from https://med.fsu.edu/index.cfm?page=suolab.research.

Employer: Florida State University College of Medicine
Location: Tallahassee, Florida
Salary: NIH guidelines for post-doctoral salaries + benefits
Discipline: Life Sciences, Biochemistry, Biology, Biophysics, Structural 
Biology, and Biomedical Sciences
Position Type: Full Time
Organization Type: Academia
Job Type: Postdoc



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Re: [ccp4bb] Post Doc position available in Denmark

[Bjørn Panyella Pedersen]

Just a brief reminder of the following open position. Deadline is in ten days. 

All the best,
-Bjørn


From: CCP4 bulletin board  on behalf of Bjørn Panyella 
Pedersen 
Sent: Monday, August 13, 2018 13:31
To: CCP4BB@JISCMAIL.AC.UK
Subject: [ccp4bb] Post Doc position available in Denmark

Postdoctoral position in Structure of Sterol Transporting Membrane
Proteins at Aarhus University, Denmark.

online posting:
http://www.pedersenlab.dk/source/bp_lab_postdoc_position.pdf


The Pedersen group is looking for a highly skilled and motivated postdoc
with an interest in working on sterol and hormone transporting membrane
transporters and with a proven track record in the area of structural
and/or functional analysis of membrane proteins.

The position will be open from fall 2018, and starting date is
negotiable. Funding is available for at least 2 years of employment,
with an automatic extension possible for up to a total maximum of 4 years.

The position:
The position seeks to strengthen ongoing activities in the laboratory of
Bjørn P. Pedersen on structure, related to the function and mechanism of
sterol-transporting membrane proteins (pedersenlab.dk). The laboratory's
interest is the interplay between structure and function of
transmembrane transport processes with a focus on metabolite uptake
systems, and the methods uses are primarily crystallography, cryo-EM and
biochemistry. The group is part of the Section of Structural Biology at
Aarhus University.

The candidate:
A successful candidate has a relevant Ph.D. degree and a solid and
documented background in structural biology, biochemistry and/or
biophysics. Experience with membrane protein expression and purification
is favored, and the candidate must demonstrate an ability and interest
to work with membrane proteins with a structural aim. Finally,
applicants should be ambitious, show strong collaborative skills, and
should also be able to take initiatives and responsibility within the
work environment.

Deadline:
All applications must be made online and received by 16/09/2018.




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[ccp4bb] Post Doc position available in Denmark

[Bjørn Panyella Pedersen]

Postdoctoral position in Structure of Sterol Transporting Membrane 
Proteins at Aarhus University, Denmark.

online posting:
http://www.pedersenlab.dk/source/bp_lab_postdoc_position.pdf


The Pedersen group is looking for a highly skilled and motivated postdoc 
with an interest in working on sterol and hormone transporting membrane 
transporters and with a proven track record in the area of structural 
and/or functional analysis of membrane proteins.

The position will be open from fall 2018, and starting date is 
negotiable. Funding is available for at least 2 years of employment, 
with an automatic extension possible for up to a total maximum of 4 years.

The position:
The position seeks to strengthen ongoing activities in the laboratory of 
Bjørn P. Pedersen on structure, related to the function and mechanism of 
sterol-transporting membrane proteins (pedersenlab.dk). The laboratory's 
interest is the interplay between structure and function of 
transmembrane transport processes with a focus on metabolite uptake 
systems, and the methods uses are primarily crystallography, cryo-EM and 
biochemistry. The group is part of the Section of Structural Biology at 
Aarhus University.

The candidate:
A successful candidate has a relevant Ph.D. degree and a solid and 
documented background in structural biology, biochemistry and/or 
biophysics. Experience with membrane protein expression and purification 
is favored, and the candidate must demonstrate an ability and interest 
to work with membrane proteins with a structural aim. Finally, 
applicants should be ambitious, show strong collaborative skills, and 
should also be able to take initiatives and responsibility within the 
work environment.

Deadline:
All applications must be made online and received by 16/09/2018.



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[ccp4bb] Post Doc position available

[Przemyslaw Grudnik]

We have a job opening for a highly-motivated postdoctoral fellow who holds  
a Ph.D. degree for no longer than five years.
The successful candidate will be involved in projects carried out in the  
newly established Structural Biology Core Facility at Jagiellonian  
University in Krakow, Poland.


Job offer website:  
https://www.fnp.org.pl/assets/Job-offer-1_FIRST-TEAM_S-Glatt.pdf

Laboratory website: http://www.mcb.uj.edu.pl/en/mpl

The ideal candidate should:
- hold a doctoral degree for no longer than 5 years
- have a strong expertise in structural biology (Macromolecular  
Crystallography) and biochemistry
- Have excellent written and oral communication skills in English  
(essential)
- Have good presentation skills (ideally having presented on at least one  
international research conference)

- Enjoy working in a highly collaborative and interdisciplinary environment
- Enjoy scientifically supporting and actively interacting with other  
members of the lab
- Have published at least one publications as first author in an  
international peer reviewed journal


We offer:

- Position for three years with possible extension after the project ends
- Excellent training: In our diverse group you will be able to network  
with international researchers, experience and learn new skills in  
cellular & molecular biology.
- State-of the-art research center with access to the full suite of  
equipment necessary for cell biology, molecular biology,
biochemistry and structural biology research and a network of  
international collaborators in Europe and beyond.


Interested applicants should send a cover letter and CV with the names of  
two references to Sebastian Glatt sebastian.gl...@uj.edu.pl




--
Przemyslaw Grudnik Ph.D.
Structural Biology Core Facility
Malopolska Centre of Biotechnology (MCB)
Jagiellonian University

ul. Gronostajowa 7a 30-387 Krakow, Poland
+48 12 664-61-06



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[ccp4bb] Post-doc position available at University of Texas Medical Branch (UTMB)

[Choi, Kyung]

Post-doc position at University of Texas Medical Branch (UTMB), TX, USA

Postdoctoral positions in structural biology are available in Dr. Kay Choi's 
laboratory at the University of Texas Medical Branch (UTMB) to participate in 
virus replication projects. We use a combination of X-ray crystallography, 
cryo-electron microscopy (cryo-EM), and biochemistry to investigate the 
structure and mechanism of viral macromolecular complexes. Experience in either 
X-ray crystallography, cryo-EM or biochemistry is required.  For more 
information please see ‘https://bmb.utmb.edu/faculty/choi.asp’

The X-ray crystallography resources at UTMB include two X-ray area detector 
systems, a Phoenix crystallization robot, a Minstrel crystal imaging robot, and 
an Alchemist liquid handling robot. The cryo-EM includes two JOEL 200 keV 
cryo-EM microscopes for high-resolution imaging work, an FEI vitrobot, and a 
BSL-3 room for viral and pathogen work.  For more information, please see 
‘https://scsb.utmb.edu/resources/default.asp’

Interested parties should send a cover letter, CV and a list of 2-3 references 
to Dr. Kay Choi via e-mail at kyc...@utmb.edu.

Kay

Kay Choi
Associate Professor
Department of Biochemistry and Molecular Biology
6.614C Basic Science phone 
: 409-747-1402
The University of Texas Medical Branch fax : 
409-747-1404
301 University Blvd.  
email : kay.c...@utmb.edu
Galveston, TX 77555-0647

Re: [ccp4bb] Post-Doc Position Available at the Weizmann Institute of Science

[Joel Sussman]

Post-Doc Position: Structure-aided redesigning of an enzyme: molecular biology, 
protein expression/purification  crystallography

Immediate opening, in the Sussman lab at the Weizmann Institute of Science,  
for a postdoctoral fellow with experience in cloning and in protein expression, 
purification and characterization. Interest or experience in protein 
crystallography would be an advantage. The appointment will be for 2-3 years, 
and the project, which will focus on structure-aided redesigning of an enzyme, 
will be implemented in close collaboration with Prof Dan Tawfik (Dept of 
Biological Chemistry) and the Israel Structural Proteomics Center (ISPC).

-
Prof. Joel L. Sussman 
joel.suss...@weizmann.ac.ilmailto:joel.suss...@weizmann.ac.il
Pickman Prof. of Structural Biology   +972 (8) 934 4531 - tel
Head, The Israel Structural Proteomics Center (ISPC)  +972 (8) 934 6312 - fax
Department of Structural Biology  
www.weizmann.ac.il/~joelhttp://www.weizmann.ac.il/~joel
Weizmann Institute of Science 
www.weizmann.ac.il/ISPChttp://www.weizmann.ac.il/ISPC
Rehovot 76100 ISRAEL  
proteopedia.orghttp://www.proteopedia.org/
-

[ccp4bb] Post-doc position available at University of Texas Medical Branch

[Choi, Kyung]

A post-doctoral position is available in Dr. Kay Choi’s laboratory at the 
University of Texas Medical Branch for either an X-ray crystallographer or a 
Biochemist to study the structure and mechanism of viral replication complexes. 
 We use a combination of X-ray crystallography, cryo-electron microscopy, 
protein chemistry, and bioinformatics to determine the structure of viral 
replication machinery and to develop antiviral therapeutics.

The X-ray crystallography resources include two X-ray area detector systems, a 
Phoenix crystallization robot, a Minstrel crystal imaging robot, and an 
Alchemist liquid handling robot.  The cryoEM facility includes two JOEL 200 keV 
cryoEM microscopes for high-resolution imaging work, FEI vitrobot, and a BSL-3 
room for viral and pathogen work.


Applicants should possess a PhD in structural biology or biochemistry with a 
sound knowledge of protein purification.  Individual with a biochemistry 
background who wishes to gain expertise in structural biology is encouraged to 
apply.   Interested parties should send a cover letter, a CV and a list of 2-3 
references to Dr. Kyung (Kay) Choi via e-mail at 
kyc...@utmb.edumailto:kyc...@utmb.edu.



Kay Choi
Assistant Professor
Department of Biochemistry and Molecular Biology
6.614C Basic Science phone 
: 409-747-1402
The University of Texas Medical Branch fax : 
409-747-1404
301 University Blvd.  
email : kay.c...@utmb.edumailto:kay.c...@utmb.edu
Galveston, TX 77555-0647

[ccp4bb] Post-doc position available

[Meng-Chiao Ho]

Dear All,

The Ho lab at the Institute of Biological Chemistry of Academia Sinca in Taiwan 
seeks a motivated structural biologist at post-doctoral level with interest in 
structure and activity studies of pharmaceutically important enzymes.

The laboratory currently works on the structure/function studies of protein 
arginine methyltransferases and inhibitor design for glucuronidase and 
caspase-7.

Applicant should have a strong background in protein expression and 
purification. Some experience in protein crystallography is required. Candidate 
possessing experience in high-throughput protein production, protein thermal 
assay, or fragment-based screening are preferred. This position provides the 
opportunity or broad training in protein expression, crystallization, small 
angle X-ray scattering, NMR, enzymology and protein-protein interaction.

Applicants should submit the curriculum vitae and the names and contact 
information of three professional references via email to:  
sbddintai...@gmail.com

For more information about the lab, please visit  http://ho.ibc.sinica.edu.tw/
We are looking forward to receiving your application!

Joseph Ho

[ccp4bb] Post-doc position available

[Stewart Turley]

A position is available now in the laboratory of Wim Hol, as described below. Please respond to the address at the end of the advertisement.

Postdoctoral Position
Available 

Laboratory of Wim Hol

Department of Biochemistry,
School of Medicine

University of Washington, Seattle, USA



Structural
Biology of the type II secretion system 

from
pathogenic bacteria 



 The projects in Wim Hol’s protein
crystallography group at the University of Washington are all focused on
providing a basis for development of new therapeutics for tropical diseases.
This particular available postdoctoral position is part of a major effort to
unravel the architecture, mechanism of action and biogenesis of the “type II
secretion system” (T2SS). 



The sophisticated T2SS occurs in many pathogenic bacteria. This machinery is responsible for
translocating a wide variety of proteins in a folded state from the periplasm
across the outer membrane into the extracellular milieu. One of these proteins
is cholera toxin which has been studied intensively in the Hol lab. The large
T2SS consists of multiple copies of ~14 different proteins that span the inner and
the outer membrane, and is associated with
a secretion ATPase in the cytoplasm which provides the energy for the
secretion process. Another remarkable feature of the T2SS is a helical sub-assembly
in the periplasm which is likely serving as a piston pushing cholera toxin and
other exoproteins through a pore in the outer membrane.



 The successful candidate will have
the opportunity to: 

(i) carry
out protein _expression_ and protein chemistry studies to obtain insight into
protein-protein interactions involving the T2SS from pathogenic bacteria like Vibrio cholera, enterotoxigenic E. coli, and other bacteria;

(ii)
purify and characterize multi-protein and multi-membrane protein complexes;

(iii)
determine high resolution crystal structures of these complexes; 

(iv) analyze
these structures and combine this with other biochemical data;

(v)
interact with several collaborating groups which are using other methods to
obtain structural and functional insight into the mechanism of this
sophisticated secretion system.



For more
information regarding the laboratory of Wim Hol see the following website:

http://www.bmsc.washington.edu/WimHol/



For more
information regarding the type II secretion system see our recent review:

Korotkov, K. V., Sandkvist, M. and Hol, W. G. J. 

The type II secretion system: biogenesis, molecular architecture
and mechanism. Nature Reviews
Microbiology 10, 336-351 (2012) 





START
DATE: Immediately



INSTITUTION:  Department
of Biochemistry 

 Biomolecular Structure Center

 School of Medicine

 Box 357742

 University of Washington

 Seattle, WA, 98195 USA





Requirements

Experience
with membrane protein preparation, including molecular biology techniques, membrane
protein characterization and protein crystallography.



Application

If you are
interested, please send your CV, including a description of your experience and
technical know-how, a list of publications and presentations, and names and
email addresses of three references able to assess your scientific experience
and capabilities to: wg...@u.washington.edu

[ccp4bb] Post-Doc Position available at the BMLS, University Frankfurt, Germany

[Martin Grininger]

At the Buchmann Institute of Molecular Life Sciences (former Frankfurt  
Institute of Molecular Life Sciences; Goethe University  
Frankfurt/Main) there is an opening for a Post Doctoral Position (E13  
TV-G-U, fulltime). The position is available from April 1, 2012, and  
the initial appointment is for 1 year, with an option of extension for  
up to three years. Consideration of applications will continue until  
the position is filled.


The newly installed working group performs research on large  
multifunctional protein complexes. In projects funded by the  
Volkswagen Foundation, the German Research Foundation and the CEF  
Adjunct Investigatorship Program, structural analysis will be  
performed on fatty acid synthases and polyketide synthases. The  
successful post-doc candidate should be experienced in collecting and  
processing low resolution X-ray data, and in performing hybrid method  
approaches for structure solution by e.g. integrating electron  
microscopic data obtained in collaboration.


The Buchmann Institute for Molecular Life Sciences (BMLS) is a  
dedicated research institute and the candidate will be able to spend  
about 80% of his/her time in self-determined research in structural  
biology, particularly in X-ray crystallography, as well as in  
presentation and publication of scientific achievements. Additional  
tasks and duties are (20% of time): Contribution and acceptance of  
responsibility in co-supervision of PhD students and undergraduates,  
support in general tasks and duties of the working group, maintenance  
of scientific instruments and computers, and contribution in teaching,  
supervision of practical courses and supervision of students.


The BMLS is located at the Riedberg campus in the north of  
Frankfurt/Main. The building with its labs, facilities and offices is  
brand-new and extremely well equipped. The campus harbors the life  
science faculties of the university, lecture and library buildings,  
and the Max-Planck-Institutes of Biophysics and Brain Research  
comprising all disciplines and methods of life sciences. At this  
campus, the successful candidate finds an encouraging and inspiring  
atmosphere.


The successful candidate will join a small lab which is currently  
moving from the Max-Planck-Institute of Biochemistry  
(www.biochem.mpg.de/oesterhelt/grininger) to the BMLS  
(http://www.fmls-institute.de), and will approximately grow to a size  
of 5 to 8 people within this year.


If you are interested and highly motivated, submit your CV and further  
information (list of publications, contact of three referees, etc.)  
per e-mail to: grinin...@chemie.uni-frankfurt.de; Prof. M. Grininger,  
Goethe University Frankfurt, BMLS Building, Max-von-Laue-Str. 15,  
60438 Frankfurt.

[ccp4bb] Post-doc position available

[Karen Fulan Discola]

A 2-year postdoctoral position is available in the laboratory of Dr. A.
Dessen at the Institut de Biologie Structurale in Grenoble, France, to study
structure and function of new bacterial virulence factors.

The laboratory has state-of-the-art equipment for biochemistry and
crystallography studies, and the postdoctoral fellowship will involve
protein purification, crystallization, data collection at the synchrotron,
and structure solution and refinement.

The IBS is a member of the Partnership for Structural Biology and thus has
preferential access to equipment and techniques available on the PSB site,
which also includes the EMBL, the ILL, and the ESRF.

Any inquiries should be sent to andrea.des...@ibs.fr.

[ccp4bb] Post-doc position available at the Sanford-Burnham Institute

[Fraydoon Rastinejad]

Postdoc: Protein Biochemistry, Protein Crystallography and Drug Discovery

We hare recruiting a Postdoctoral Associate in the area of nuclear hormone 
receptor biology and structural biology to join the Rastinejad lab at the 
Sanford‐Burnham Medical Research Institute in Orlando, Florida. The 
responsibilities will be to express  members of the nuclear receptor family of 
proteins and to conduct biochemical and cell-based assays searching for novel 
ligands, and to use protein crystallography / X-ray diffraction to understand 
stero-specific interactions. Applicant is expected to have solid previous 
background in the areas of cloning, protein expression and isolation, and with 
additional experience in X-ray crystallography.   Applicants: please make sure 
to forward 2-3 names for letters of reference from persons knowledgeable with 
your prior experience in science, together with your C.V. and cover letter to 
Ms. Stephanie Dickstein e‐mail address:
sdickst...@burnham.org

[ccp4bb] Post-doc position available at Umeå University, Sweden

[Elisabeth Sauer-Eiksson]

A postdoctoral position is available for an experienced molecular
biologist/macromolecular crystallographer in the laboratory of Erik
Johansson and Elisabeth Sauer-Eriksson at Umeå University. The project
involves structure-function studies of DNA polymerase epsilon.

For information and application instructions, please visit

http://www8.umu.se/umu/aktuellt/arkiv/lediga_tjanster/223-2185-2188-09.html

or contact erik.johans...@medchem.umu.se or
elisabeth.sauer-eriks...@chem.umu.se


Your complete application, marked with appropriate reference no, should be
sent to me...@diariet.umu.se (state the reference number as subject) or to
the Registrar, Umeå University, SE-901 87 Umeå, Sweden to arrive September
30, 2009 at the latest.

[ccp4bb] post-doc position available

[R. J. Lewis]

dear BBers

there is a post-doc position available in my lab, funded
by the BBSRC for 3 years in the first instance, to study
the biosynthesis of the cell wall in the model bacterium,
Bacillus subtilis. the cell wall, apart from being the
target of penicillin and vancomycin, defines the shape
of the bacterial cell and provides it with a protective
outer layer. there are a host of proteins involved in
the formation of the wall, some - but not all - of which
are membrane proteins. consequently, there is an
opportunity in newcastle for a talented and dedicated
post-doc with demonstrable previous experience of the
structural biology of membrane proteins. further
particulars of this post can be found on newcastle's
vacancies website: http://www.ncl.ac.uk/vacancies/jobs/
with reference code A397R (ICAMB). please apply for
the post by following the instructions on the website,
the closing date for which is 25th may 2009.

please also note that in addition to the post in my lab,
there is a second post available, funded on the same
grant, in the lab of richard daniel for someone with
a more biological focus. applicants to me should
specify that they are applying for 'post 2'.

cheers


rick

--
R. J. Lewis
Professor of Structural Biology
Institute for Cell and Molecular Biosciences
Faculty of Medical Sciences   Tel: +44 (0)191 222 5482
University of Newcastle   Fax: +44 (0)191 222 7424
Newcastle upon Tyne, NE2 4HH, UKEmail: r.le...@ncl.ac.uk

[ccp4bb] Post-doc position available

[Van Den Berg, Bert]

A postdoctoral position is available in the laboratory of Bert van den Berg at 
UMass Medical School, Worcester (MA), to work on a NIH-funded project 
investigating the mechanism by which hydrophobic molecules, such as toxic 
xenobiotics, cross the bacterial outer membrane. The focus of the project will 
be on establishing in vivo transport assays for (mono) aromatic hydrocarbons, 
and the purification, crystallization and structure determination of FadL 
homologues from biodegrading bacteria. In addition, channel-substrate complexes 
and site-directed mutants of the toluene channels TodX and TbuX will be 
subjected to structural studies. For more information please see Hearn et al., 
Nature 1 Feb 2009, and Hearn et al., PNAS 105, 8601-8606 (2008), or contact me 
directly.
 
We are looking for a dedicated and enthusiastic person with a strong background 
in molecular biology. Experience with cloning in Pseudomonas species would be 
ideal. Experience in membrane protein biochemistry and X-ray crystallography 
would be advantageous, but is not required. Please send applications and the 
names of two or three references to: bert.vandenb...@umassmed.edu.
 
Bert van den Berg
University of Massachusetts Medical School
Program in Molecular Medicine
Biotech II, 373 Plantation Street, Suite 115
Worcester MA 01605
Phone: 508 856 1201 (office); 508 856 1211 (lab)
e-mail: bert.vandenb...@umassmed.edu
http://www.umassmed.edu/pmm/faculty/vandenberg.cfm



From: CCP4 bulletin board on behalf of Peer Mittl
Sent: Tue 2/24/2009 7:26 AM
To: CCP4BB@JISCMAIL.AC.UK
Subject: [ccp4bb] Open Post-Doc and technician positions



Applications are invited for four positions at various levels at the
University of Zürich (Switzerland). Currently there are four vacant
positions at the postdoctoral and research assistant levels (2 Post-Docs
and 2 research assistants) in the lab of Prof. Markus Grütter in the
Department of Biochemistry. We are focusing on the investigation of the
structure/function relationship of proteins involved in apoptosis,
innate immunity and trans-membrane signaling (PNAS (2008) 105:20251,
Structure (2008) 16:1443, Structure (2007) 15:625, PLoS Biol (2007) 5:e7).

We seek enthusiastic team players with experience in at least one of the
following disciplines: protein X-ray crystallography, protein expression
and purification, and eukaryotic expression systems. Experiences in
membrane protein biochemistry will be an advantage. Good knowledge of
English is mandatory. Candidates applying for the Post-Doc position
should hold a PhD in a life science-related subject. All positions are
time limited for three years. Salary will be according to the
regulations of the Swiss National Science Foundation scheme.

Please submit your electronic application including a CV, a list of
publications (for the Post-Doc positions) and the names of two to three
referees to Mrs. Salome Rittmeyer at the following address:
secgruet...@bioc.uzh.ch

Best regards,
Peer Mittl

[ccp4bb] POST DOC position available at MRC France (BM14 at the ESRF)

[Martin A. Walsh]

Dear all we have an opening for a post-doc at BM14 for 1 year duration. A
summary is given below but please don't hesistate to contact me if you would
like more details  (please direct inquiries to me from the 18th august
onwards as I'm on holidays from tomorrow)

 

 

OVERVIEW:

Beamline 14 (BM14) is a bending magnet beamline at the ESRF dedicated to
macromolecular crystallography and is one of the premier MAD beam lines in
Europe. The beam line is funded as a joint collaboration by the UK Research
Councils (MRC  BBSRC) and the EMBL outstation in Grenoble. In addition to
fostering the use of anomalous phasing methods, for in particular UK and
EMBL member state groups, the beamline has an active in-house structural
biology research group coupled to a programme of beamline directed
developments, in collaboration with groups at the polygone scientique
campus, that provides state of the art facilities for the determination of
protein structures.

 

==

POST-DOCTORAL OPPORTUNITY AT BM14

==   

Contract duration: 1 year

Closing date: 5th September 2008

 

Structural biology research at BM14 is focused on understanding the
molecular basis for adherence in the human pathogen Streptococcus
pneumoniae.We are looking for a highly motivated crystallographer and/or
molecular biologist to contribute to this research program. The successful
candidate would also be expected to drive and contribute to beamline
developments through a full hands-on approach as well as participate to the
BM14 user program.

 

REQUIREMENTS:

 Applicants should have a PhD in a relevant field.  We are searching for a
person with excellent team and communication skills. A proven track record
of macromolecular structure determination; experience in molecular biology,
protein purification and crystallization are desirable. 

The position would suit a highly motivated and energetic individual who is
keen to work in a multidisciplinary environment geared towards structural
biology research. 

 

Applications should include a detailed CV, covering letter and contact
details of three referees to Martin Walsh ([EMAIL PROTECTED], please include
''post doc vacancy in the email subject header). Informal inquiries and
further details about the post can also be directed to Martin Walsh either
by telephone or email ([EMAIL PROTECTED], tel: +33-4-38 88 19 69)

 

 

 

 

-

Martin Walsh,

MRC Group Leader and BM14 Responsible

Medical Research Council (MRC) France,

CRG BM14,

c/o ESRF,

6, rue Jules Horowitz,

B.P. 220

38043 Grenoble CEDEX

France

Tel:   +33 4 38.88.19.69

Fax:  +33 4 76.88.23.80

email1:  mailto:[EMAIL PROTECTED] [EMAIL PROTECTED]

email2:  mailto:[EMAIL PROTECTED] [EMAIL PROTECTED]

 

 

 

[ccp4bb] post-doc position available at University of Texas Medical Branch

[Kay Choi]

A post-doctoral position is available in Dr. Choi laboratory at University 
of Texas Medical Branch (UTMB) at Galveston to study the structure and 
mechanism of virus infection.  We use a combination of cryo-electron 
microscopy, X-ray crystallography, protein chemistry, and bioinformatics 
to determine the structures of viruses and viral replication machinery, 
and to develop antiviral therapeutics.   Individuals trained in structural 
biology (i.e., X-ray crystallography or cryo-electron microscopy) are 
encouraged to apply.  

The cryo-electron microscopy facility includes two JOEL 200 keV cryo-
electron microscopes (a JEM2200FS equipped with an in-column energy filter 
and JEM2100), a 100 keV JEM 1010, and FEI vitrobot.  The JEM 2200FS is 
located in a biosafety level 3 environment to facilitate imaging of 
infectious agents.  The X-ray crystallography resources include two X-ray 
area detector systems, a Phoenix crystallization robot, a Minstrel crystal 
imaging robot, and an Alchemist liquid handling robot. 
  
Interested parties should send a CV and a list of 2-3 references to Dr. 
Kyung (Kay) Choi at 301 University Blvd, 6.614 Basic Science Building, 
Galveston, Texas 77555-0647, or via e-mail at [EMAIL PROTECTED]

[ccp4bb] Post-doc position available

[Ines Gallay]

*Post-doc position available, from Jan 2008*

*Title : *Crystallography of /B. subtilis/ ribonucleases
*Group :* Ciarán Condon, under supervision of Inés Li de la Sierra-Gallay.
*Address :* CNRS UPR9073/IFR550, Institut de Biologie Physico-Chimique, 
13 rue Pierre et Marie Curie, 75005 Paris.
*Contact :* [EMAIL PROTECTED] mailto:[EMAIL PROTECTED]_ or 
[EMAIL PROTECTED] mailto:[EMAIL PROTECTED]_

*Web-site :* http://www.ibpc.fr/UPR9073/condon/index_en.html
*Financed by :* Agence Nationale de la Recherche (ANR) for 2 years
*Description :* It has recently become clear/ /that the pathways of RNA 
maturation and decay in the Gram-positive bacterium /B. subtilis/ are 
very different from those of the generally accepted bacterial paradigm, 
the Gram-negative /E. coli/. As such, /B. subtilis/ is a rich source of 
new bacterial ribonucleases. We have recently solved the crystal 
structure of one of these : RNase Z, both free and in complex with its 
tRNA product (Li de la Sierra-Gallay et al., 2006; Li de la 
Sierra-Gallay et al., 2005). We now hope to persue this study with other 
recently identified /B. subtilis/ RNases and their substrates. Among 
these are the 5S rRNA maturase RNase M5, the 23S rRNA maturase YazC, and 
the 3’ to 5’ exoribonuclease KapD. We would like to solve the crystal 
structures of RNase Z in complex with its precursor (rather than 
product) species and that of the endo/exoribonuclease RNase J1 in 
complex with RNA.
Candidates should have some experience in protein purification, 
crystallography and structure resolution.

*References :*
Li de la Sierra-Gallay, I., Mathy, N., Pellegrini, O. and Condon, C. 
(2006) Structure of the ubiquitous 3' processing enzyme RNase Z bound to 
transfer RNA. /Nat Struct Mol Biol/, *13*, 376-377.
Li de la Sierra-Gallay, I., Pellegrini, O. and Condon, C. (2005) 
Structural basis for substrate binding, cleavage and allostery in the 
tRNA maturase RNase Z. /Nature/, *433*, 657-661.



--
Ines Gallay
CNRS FRC550
Institut de Biologie Physico-Chimique
13 rue Pierre et Marie Curie
75005 Paris
FRANCE
e-mail: [EMAIL PROTECTED]