Re: [ccp4bb] small molecule library

2009-10-28 Thread Flip Hoedemaeker
2009 01:41:22 + From: hlsilves...@gmail.com Subject: Re: [ccp4bb] small molecule library To: CCP4BB@JISCMAIL.AC.UK You have several companies out there that sell that. You have Enamine - large collection, good but$, Maybridge - good but Zenobia Inc - good

[ccp4bb] small molecule library

2009-10-27 Thread c.weinert
Dear all. I am looking for a library of small (biologically relevant) compounds to test binding to a protein. Does somebody know, if there is a company that sells such a library for fragment based library screening? (to a reasonable price). And does anybody has experience with screening

Re: [ccp4bb] small molecule library

2009-10-27 Thread Jurgen Bosch
Try Emerald, reasonable price, nö comment. Jürgen .. Jürgen Bosch Johns Hopkins Bloomberg School of Public Health Department of Biochemistry Molecular Biology Johns Hopkins Malaria Research Institute 615 North Wolfe Street, W8708 Baltimore, MD 21205 Phone: +1-410-614-4742

Re: [ccp4bb] small molecule library

2009-10-27 Thread Shao-Yang Ku
informahealthcare.com/doi/pdf/10.1517/17460441.1.1.1 Quoting c.weinert c.wein...@bioc.uzh.ch: Dear all. I am looking for a library of small (biologically relevant) compounds to test binding to a protein. Does somebody know, if there is a company that sells such a library for fragment

Re: [ccp4bb] small molecule library

2009-10-27 Thread Hernani Silvestre
You have several companies out there that sell that. You have Enamine - large collection, good but$, Maybridge - good but Zenobia Inc - good, and not so leo On 27 Oct 2009, at 14:58, c.weinert wrote: Dear all. I am looking for a library of small (biologically relevant)

Re: [ccp4bb] small molecule library

2009-10-27 Thread Pascal Egea
I can suggest the following reading Discovering novel ligands for macromolecules uisng X-ray crystallographic screening Nienaber VL et al, Nature Biotechnology vol 18 october 2000 pp1105 -- Pascal F. Egea, PhD Assistant Professor UCLA, David Geffen School of Medicine Department of Biological

Re: [ccp4bb] small molecule library

2009-10-27 Thread Sridhar Prasad
Zenobia is a good place to look for, they can even customize it your needs. www.zenobiatherapeutics.com Sridhar Date: Wed, 28 Oct 2009 01:41:22 + From: hlsilves...@gmail.com Subject: Re: [ccp4bb] small molecule library To: CCP4BB@JISCMAIL.AC.UK You have several companies out

Re: [ccp4bb] small molecule library

2009-10-27 Thread Jürgen Bosch
Hi Christopher, have a look at this paper and the references. Using fragment cocktail crystallography to assist inhibitor design of Trypanosoma brucei nucleoside 2-deoxyribosyltransferase. J Med Chem (2006) vol. 49 (20) pp. 5939-46 The SEC after soaking is a bad idea, you will loose your

Re: [ccp4bb] small molecule library

2009-10-27 Thread Artem Evdokimov
be adjusted to the 21st century version: fifteen minutes online saves $5000 spent on a CRO). Artem _ From: CCP4 bulletin board [mailto:ccp...@jiscmail.ac.uk] On Behalf Of Jürgen Bosch Sent: Tuesday, October 27, 2009 10:53 PM To: CCP4BB@JISCMAIL.AC.UK Subject: Re: [ccp4bb] small molecule