[NMusers] Advanced level course in pharmacokinetic and pharmacodynamic data analysis - A FEW PLACES LEFT

Time is running out to register for the eleventh Advanced Level Workshop on Pharmacokinetic - Pharmacodynamic Data Analysis: A hands-on course using WinNonlin to be held at Madingley Hall, Cambridge, UK from 17 to 21 May 2009, presented by the Royal Pharmaceutical Society of Great Britain and

[NMusers] 20 variable limit in $INPUT

I am looking for a solution to get around the limit of 20 input variables in nonmem. The message you get with more than 20 variables in $INPUT is this: 16 $INPUT: NO. OF DATA ITEMS EXCEEDS 20. STOP 4 statement executed I did not find anything in the archives or on the Web. I recall having

RE: [NMusers] 20 variable limit in $INPUT

If you are not looking for workarounds, you'll need to wait for Nonmem VII to be released. Regards, Katya - Ekaterina Gibiansky Senior Director, PKPD, Modeling Simulation ICON Development Solutions ekaterina.gibian...@iconplc.com

RE: [NMusers] 20 variable limit in $INPUT

Andreas,You are correct that there isn't an easy way to change the limit of 20 data itemsBut, I know of 2 possible solutions:1. The official way. There is a way to do continuation lines in nonmem data sets, documentation below. But I have found this pretty cumbersome.2. The hack. When I've needed

Re: [NMusers] 20 variable limit in $INPUT

Look in your NONMEM html\cont.htm. The CONT data item lets you specify additional input records which can be continued to allow more than 20 data items. Here is a description in more detail. http://www.cognigencorp.com/nonmem/nm/99aug272005.html I found this by searching with Google for

Betr.: [NMusers] 20 variable limit in $INPUT

Dear Andreas, Isn't the limit you're referring to the maximum amount of etas/thetas, these can be adjusted (see: http://www.icondevsolutions.com/nonmem_tip20.htm ) As far as I known the amount of data items can not be adjusted. If some of them are not in use, you can use the DROP data item.

RE: [NMusers] 20 variable limit in $INPUT

Dear Andreas, Before NM VII, PsN is a solution. [create_cont_data.bat] is used to generate cont data set. [execute -wrap_data modelfile] will run automatically. But it depends on the structures of model and data set. If it doesn't work, maybe we should add cont item manually.

RE: [NMusers] 20 variable limit in $INPUT

Hi All, PsN does this automatically when using the '-wrap_data' option of the 'execute' command. See http://psn.sourceforge.net/PDF_docs/common_options_defaults_versions_psn.pdf for more details. Best regards, Andy Andrew Hooker, Ph.D. Associate Professor of Pharmacometrics Div. of

RE: [NMusers] 20 variable limit in $INPUT

Andreas, PsN has functionality for automatically applying the CONT-data-item approach mentioned by Mark and Nick. To run your model in nonmem with more than 20 input variables, you would simply type: execute --wrap_data run1.mod In a subdirectory PsN will create a new dataset and model file

Betr.: [NMusers] 20 variable limit in $INPUT

Andreas, Some months ago I spent a few hours investigating this same problem. Below are my notes. Currently I use the last approach (which is actually a workaround, sorry...), that will hopefully be redundant when NM7 arrives, best regards, Ron approaches for using more covariates in

RE: Betr.: [NMusers] 20 variable limit in $INPUT

Hi Ron, Thanks for your summary. In my case, it always shows an error that DV is positive and MDV is 1. Maybe this indicates that in NMVI a new rule to check DV and MDV have been added. The problem could be solved when CONT is 1 and MDV is 1, DV is set to '.'. Best regards, Guangli