ADVANs in my experience have little effect on OF (except convergence:
ADVAN13 may work in cases when ADVAN6 fails). So method is FOCEI, IMP,
IMPMAP etc. In general, with rare exceptions that could be discussed
separately, you would expect the same OF for FOCEI fit with ADVAN6, 8,
9, 13, 14,
Hi Leonid,
Thanks for the tips. When you talk about Methods, are you referring to
different ADVANs? e.g. FOCEI ADVAN6 vs. IMP ADVAN6.
Mark
On Wed, Sep 23, 2020 at 5:52 PM Leonid Gibiansky
wrote:
>
> Within one method, FOCEI or IMP models can be compared by OF, but not
> between methods.
It seems there have been two different questions posed on the same subject
line. I will deal with each one separately.
1) The original question from Mark Tepeck has been answered by Leonid
Gibiansky, that generally when covariate model comparisons are performed, the
OFV from the same
orm, and
> ADVAN6 will be (I believe) numerically calculated.
>
>
>
> Steve
>
>
>
> *From:* owner-nmus...@globomaxnm.com *On
> Behalf Of *Dennis Fisher
> *Sent:* Wednesday, September 23, 2020 5:36 PM
> *To:* Mark Tepeck
> *Cc:* nmusers@globomaxnm.com
> *Subject:* R
will be (I believe) numerically calculated.
Steve
From: owner-nmus...@globomaxnm.com On Behalf Of Dennis FisherSent: Wednesday, September 23, 2020 5:36 PMTo: Mark Tepeck Cc: nmusers@globomaxnm.comSubject: Re: [NMusers] OFV from different algorithms
Distinguished Scientist, Pharmacometrics
Cognigen Corporation, a Simulations Plus company
From: owner-nmus...@globomaxnm.com On Behalf Of
Dennis Fisher
Sent: Wednesday, September 23, 2020 8:36 PM
To: Mark Tepeck
Cc: nmusers@globomaxnm.com
Subject: Re: [NMusers] OFV from different algorithms
Mark
Within one method, FOCEI or IMP models can be compared by OF, but not
between methods. FOCEI and IMP OF are similar by the order of magnitude,
but should not be used for comparison between methods.
SAEM OF should not be used for model comparison at all. Among two models
that differ by SAEM
: Wednesday, September 23, 2020 5:36 PM
To: Mark Tepeck
Cc: nmusers@globomaxnm.com
Subject: Re: [NMusers] OFV from different algorithms
Mark
I posed a variant of this question to Stu Beal (Sheiner's statistician) > 20
years ago. He answered that one cannot compare ADVAN's, e.g., between ADV
Mark
I posed a variant of this question to Stu Beal (Sheiner's statistician) > 20
years ago. He answered that one cannot compare ADVAN's, e.g., between ADVAN4
and ADVAN6 for the identical model.
I verified this today when I ran a model with those two ADVAN's -- both
converged, they yielded
Hi NMusers,
I believe below is a very common question, but I could not find a
clear answer in literature.
Sometimes, we want to find out which algorithm offers the better model
fitting for a given dataset.
Is it possible to use the objective function value (OFV) to compare
the model fitting
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