[NMusers] Open position as Data Programmer at Pharmetheus

Dear all, The Pharmetheus team is growing! Pharmetheus is a pharmacometrics consultancy company supporting drug development of compounds in all phases and in most therapeutic areas, through strategic support as well as hands on modelling and simulation performed within a reproducible

[NMusers] ISoP Request for Comments: Exposure-Response Analysis in Drug Development and Regulatory Decision Making

Dear all, As you are probably aware, FDA recently announced a public docket entitled "Exposure-Response Analysis in Drug Development and Regulatory Decision Making; Request for Comments" (https://go.usa.gov/xQ4m2) to give interested parties an opportunity to identify areas of scientific policy

[NMusers] Using Root-finding techniques to find Cmax/Tmax

Dear nmusers: Because of the recent discussions (topic "Cmax/Tmax in the DES block") on the proper way of obtaining tmax and cmax with ODE solvers, I have been motivated to provide some examples utilizing root-finding techniques available in ADVAN14 (CVODES) and ADVAN15 (IDAS). Please read

[NMusers] LAST CALL!!! FINAL REGISTRATION for 1-day NONMEM Advanced Methods Workshop - PAGE 2018 - May 28, 2018 - Montreux, Switzerland

THIS IS THE FINAL CALL FOR REGISTRATION! Registration ends on May 23, 2018 Below is the website link for our 1-day workshop to be presented at the annual PAGE meeting. This year the workshop will be held in Montreux, Switzerland on Monday, May 28, 2018. The location, fees and agenda are

[NMusers] RE: Please help Winnie unsubscribe

To Subscribe or unsubscribe, please send an e-mail to nmusers-requ...@iconplc.com Robert J. Bauer, Ph.D. Senior Director Pharmacometrics R ICON Early Phase 820 W. Diamond Avenue Suite 100 Gaithersburg, MD 20878 Office: (215) 616-6428 Mobile: (925) 286-0769

[NMusers] RE: Using Root-finding techniques to find Cmax/Tmax

Hi Bob, Thanks for preparing the examples. I found the “nonmem reserved general” file something of a challenge – I could barely understand a line of it. Any chance you could zip up all the files into one archive file? I find myself faced with downloading a couple of pages of files one file at

[NMusers] RE: Using Root-finding techniques to find Cmax/Tmax

Nick: A cmax_root_finder.zip file is now supplied. nonmem_reserved_general is not intended to be humanly read, but used in the control stream for easy access of reserved variables. A copy is also in ..\util of your NONMEM installation. Use of it is described in ..\guides\intro7.pdf Robert

[NMusers] RE: Using Root-finding techniques to find Cmax/Tmax

Bob, Thanks for the zip file. And for the motivation to explore intro7.pdf – always something interesting to learn in the modelling world (unlike those stuck in the NCA doldrums). Nick From: Bauer, Robert Sent: Monday, May 14, 2018 7:16 PM To: Nick Holford

[NMusers] Please help Winnie unsubscribe

From: Sohn, Winnie Sent: Monday, May 14, 2018 8:41 PM To: Nick Holford Subject: RE: Using Root-finding techniques to find Cmax/Tmax Hi Nick, I have tried to unsubscribe multiple times to NMusers. Can you please help? Thanks, Winnie From: