Hi Adrian
Does procalcitonin really distinguish bacterial from other
causes of SIRS/inflammation better than, say, CRP? Junior
doctors in the UK are taught that essentially you can't
ignore a CRP of 100mg/L or more without excluding
bacterial infection (ie. it's usually bugs that would do
that). Also, I think the half life is around about 24 -
36 hours.
Sorry if this is a silly question!
Tom Morris
Infectious Diseases SpR, Leicester, UK
On Fri, 9 Nov 2012 09:09:47 -0700
Adrian Verdin Z. <[email protected]> wrote:
Hello
In one of the hospitals that I work we used a lot
The level of procalcitonin in the blood stream of
healthy individuals is below the limit of detection (10
pg/mL) of clinical assays.The level of procalcitonin
raises in a response to a proinflammatory stimulus,
especially of bacterias origin. In this case, it is
produced mainly by the cells of the lung and the
intestine. It does not raise significantly with viral or
non-infectious inflammations. With the derangements that
a severe infeccion with an associated systemic response
brings, the blood levels of procalcitonin may rise to 100
ng/ml. In serum, procalcitonin has a half-life of 25 to
30 hours. Remarkably the high procalcitonin levels
produced during infections are not followed by a parallel
increase in calcitonin or serum calcium levels.
Rewarts
Dr. Adrián Verdín Z.
Terapia intensiva
Anestesia
614 159 3883 cell
614 1800 800 ext 16574
El 09/11/2012, a las 06:40, "patty jasper"
<[email protected]> escribió:
Hi Everyone,
We are just starting to use Procalcitonin at our
facility and I was wondering what has been the general
experience with it?
Has anyone used it in the OB population?
Has anyone used it in the pediatric population?
Thanks
Patty Garrity-Jasper, RN Clinical Educator
Mercy General
Sacramento, CA
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