Agree- we need to know more about how PCT changes human behaviour.
On Fri, Nov 16, 2012 at 3:45 PM, Watson Duncan (RKB) Consultant in Critical
Care Medicine <[email protected]> wrote:
> ** ** **
>
> We are currently trying to answer this these specific questions. There
> appears to be evidence re good de-escalation and benefit in the patients
> with pyrexia / elevated CRP but normal wcc in that a PCT of <0.25 reassures
> the clinician and discourages antibiotics and is it is <0.1 there is a good
> feeling of security in with-holding antibiotics.****
>
> ** **
>
> Duncan****
>
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> ------------------------------
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> *From:* [email protected] [mailto:
> [email protected]] *On Behalf Of *Ron Daniels
> *Sent:* 14 November 2012 14:41
> *To:* Thomas Morris
> *Cc:* [email protected]
> *Subject:* Re: [Sepsis Groups] Proacalcitonin****
>
> ** **
>
> Agree. There's minimal evidence imho that PCT is more specific than CRP,
> and still less that it is a more rapid marker of bacterial infection.****
>
> ** **
>
> To my mind, the manufacturers of the assay have sold this wrong. What I'd
> like to know from studies is how PCT modifies human behaviour in a)
> starting antimicrobials in non-critical cases and b) ceasing, de-escalating
> or changing antimicrobials as conditions progress.****
>
> ** **
>
> KR****
>
> ** **
>
> Ron****
>
> On Tue, Nov 13, 2012 at 7:34 PM, Thomas Morris <
> [email protected]> wrote:****
>
> Hi Adrian
>
> Does procalcitonin really distinguish bacterial from other causes of
> SIRS/inflammation better than, say, CRP? Junior doctors in the ****UK****are
> taught that essentially you can't ignore a CRP of 100mg/L or more
> without excluding bacterial infection (ie. it's usually bugs that would do
> that). Also, I think the half life is around about 24 - 36 hours.
>
> Sorry if this is a silly question!
>
> Tom Morris
> Infectious Diseases SpR, ****Leicester**, **UK********
>
>
>
>
> On Fri, 9 Nov 2012 09:09:47 -0700
> Adrian Verdin Z. <[email protected]> wrote:****
>
> Hello
> In one of the hospitals that I work we used a lot
> The level of procalcitonin in the blood stream of healthy individuals is
> below the limit of detection (10 pg/mL) of clinical assays.The level of
> procalcitonin raises in a response to a proinflammatory stimulus,
> especially of bacterias origin. In this case, it is produced mainly by the
> cells of the lung and the intestine. It does not raise significantly with
> viral or non-infectious inflammations. With the derangements that a severe
> infeccion with an associated systemic response brings, the blood levels of
> procalcitonin may rise to 100 ng/ml. In serum, procalcitonin has a
> half-life of 25 to 30 hours. Remarkably the high procalcitonin levels
> produced during infections are not followed by a parallel increase in
> calcitonin or serum calcium levels.
>
> Rewarts
>
> Dr. Adrián Verdín Z.
> Terapia intensiva
> Anestesia
> 614 159 3883 cell
> 614 1800 800 ext 16574
>
>
> El 09/11/2012, a las 06:40, "patty jasper" <[email protected]>
> escribió:****
>
> Hi Everyone, We are just starting to use Procalcitonin at our facility
> and I was wondering what has been the general experience with it?
> Has anyone used it in the **OB** population?
> Has anyone used it in the pediatric population?
> Thanks
> Patty Garrity-Jasper, RN Clinical Educator
> Mercy General Sacramento, CA
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> ****
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> ** **
>
> --
> Dr Ron Daniels
> ****
>
> CEO: Global Sepsis ****Alliance****
> Chair: United Kingdom Sepsis Group****
>
> Principal Trustee: U.K Sepsis Trust
> Founding Director: Survive Sepsis
> Fellow: NHS Improvement Faculty****
>
> ****
>
> ****
>
> ** **
>
> *Suspect Sepsis: save someone's life today.*****
>
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> ** **
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> ** **
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>
--
Dr Ron Daniels
CEO: Global Sepsis Alliance
Chair: United Kingdom Sepsis Group
Principal Trustee: U.K Sepsis Trust
Founding Director: Survive Sepsis
Fellow: NHS Improvement Faculty
*Suspect Sepsis: save someone's life today.
*
*Join us for World Sepsis Day on September
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